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The map label for this gene is csd [H]

Identifier: 77457484

GI number: 77457484

Start: 1431583

End: 1432794

Strand: Reverse

Name: csd [H]

Synonym: Pfl01_1257

Alternate gene names: 77457484

Gene position: 1432794-1431583 (Counterclockwise)

Preceding gene: 77457485

Following gene: 77457482

Centisome position: 22.25

GC content: 65.68

Gene sequence:

>1212_bases
GTGAACATCGATGACCTCTCGCGTCTGCGCGCAGCCACACCCGGCTGCGCTCAGGTGGTCCACTTCAACCACGCCGGCGC
TTCGTTGCCGAGTCAGGCCACCCTCGACGCGGTGATCGAACAGTTGCAACGCGAAGCGCTCGGCGGGCCGATGGAAGCGG
CGGACAACCGGGTACAGGCACGCGCGCGCAACGCGGCCGCCGCCCTGCTCAACGCCCAGCCCGAGGACATTGCCTTCGCC
AGCAGCGGCTCAGCGGCCTGGAGTCAGGCGTTCAACGCACTGGGGCCGTGGCAACCAGGCGAGCGGATTCTGGTGGGTCG
CCATGAATGGGCCGGCAATCTGGCGTGCATGGCCGAAGCGGTGAAGGCCGGCGCGCGGCTCGAAGTGATTCCTTGTGACG
CCCACGGGGCAGTCGACCCGCAAGCCCTGGCGCAGATGATCGACAGCCAGGTGCGGCTGATTGCCCTGACCTGGCTGCCG
GCCAACGGCGGCCTGATCAATCCCGCCGCGCAGATCGGCAATGTCGCGCGGCGTCACGGCATCCCTTATTTCATCGATGC
CGGTCAGGCGCTGGGGCAGTTGCCTTGCGATGTTCAAGACCTGCAGTGCGACGTGCTCAAGGGTGCCGGACGCAAGTTCC
TGCGCGGGCCTCGCGGCACGGCGTTGATGTACATCCGGGCGCAATTTCTGCAACGACTGCTCCCCGTGCAACGCGATGTA
TTGTCGGCGCCCTGGGACGGCAAGCGCTTTACCCTGCGTGACGACGCCCGCCGCTTTGAAACCAGTGAAGTGTCGCTGGC
GCTGCTGGCCGGGCTGGCCAATGCGCTGGAGGAGCACAATCGCCTCGGCGCGTTCGCGATCCGCCAACGCATCGCACACC
TGAGCAATGGACTGCGGCAACGCCTGAAGGCGATTCCCGGCCTGACGCTGCGGAATCTTGGCGCGGCCAATCAACAATCC
GGGCTGATCGCCTTCACGCTCGAAGGCTGGGACAGCGTGGCGCTGAAGCAGACGCTGGCCGAACGGCGAATCAACATCGG
CGCCAATGGCGTGGCCTACACGCCGCTGGACATGCAGGCGCGCGGGCTGACGAATATTGCGCGGGTGGCGTTGAGCTACT
TGAACACAGAAGAAGAGATCGACGTGCTGCTGGAAAACCTGACGGAACTGGCCGCCCGGCCTCAGATCTCGATATCGACC
CAAAGCCCCTGA

Upstream 100 bases:

>100_bases
TCCTCGGCGACAAGGGCCGGCACGTGCGCACCGCGGTCGGCGTGTCGAGTCTGCCGGCGGGCGTCGCGGTCGAGATCGAC
GCAATCTTCGAGCTCAAGCC

Downstream 100 bases:

>100_bases
CGCGGCTGATCTTCCATCAACGGCGCCACCGGTACGGTGTTGTCGGCATTCAGTTCGGTGCCGGGCACGGCGAGGTGCGC
TTCGGGGTCGTCGTCGGCTT

Product: aromatic amino acid beta-eliminating lyase/threonine aldolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNIDDLSRLRAATPGCAQVVHFNHAGASLPSQATLDAVIEQLQREALGGPMEAADNRVQARARNAAAALLNAQPEDIAFA
SSGSAAWSQAFNALGPWQPGERILVGRHEWAGNLACMAEAVKAGARLEVIPCDAHGAVDPQALAQMIDSQVRLIALTWLP
ANGGLINPAAQIGNVARRHGIPYFIDAGQALGQLPCDVQDLQCDVLKGAGRKFLRGPRGTALMYIRAQFLQRLLPVQRDV
LSAPWDGKRFTLRDDARRFETSEVSLALLAGLANALEEHNRLGAFAIRQRIAHLSNGLRQRLKAIPGLTLRNLGAANQQS
GLIAFTLEGWDSVALKQTLAERRINIGANGVAYTPLDMQARGLTNIARVALSYLNTEEEIDVLLENLTELAARPQISIST
QSP

Sequences:

>Translated_403_residues
MNIDDLSRLRAATPGCAQVVHFNHAGASLPSQATLDAVIEQLQREALGGPMEAADNRVQARARNAAAALLNAQPEDIAFA
SSGSAAWSQAFNALGPWQPGERILVGRHEWAGNLACMAEAVKAGARLEVIPCDAHGAVDPQALAQMIDSQVRLIALTWLP
ANGGLINPAAQIGNVARRHGIPYFIDAGQALGQLPCDVQDLQCDVLKGAGRKFLRGPRGTALMYIRAQFLQRLLPVQRDV
LSAPWDGKRFTLRDDARRFETSEVSLALLAGLANALEEHNRLGAFAIRQRIAHLSNGLRQRLKAIPGLTLRNLGAANQQS
GLIAFTLEGWDSVALKQTLAERRINIGANGVAYTPLDMQARGLTNIARVALSYLNTEEEIDVLLENLTELAARPQISIST
QSP
>Mature_403_residues
MNIDDLSRLRAATPGCAQVVHFNHAGASLPSQATLDAVIEQLQREALGGPMEAADNRVQARARNAAAALLNAQPEDIAFA
SSGSAAWSQAFNALGPWQPGERILVGRHEWAGNLACMAEAVKAGARLEVIPCDAHGAVDPQALAQMIDSQVRLIALTWLP
ANGGLINPAAQIGNVARRHGIPYFIDAGQALGQLPCDVQDLQCDVLKGAGRKFLRGPRGTALMYIRAQFLQRLLPVQRDV
LSAPWDGKRFTLRDDARRFETSEVSLALLAGLANALEEHNRLGAFAIRQRIAHLSNGLRQRLKAIPGLTLRNLGAANQQS
GLIAFTLEGWDSVALKQTLAERRINIGANGVAYTPLDMQARGLTNIARVALSYLNTEEEIDVLLENLTELAARPQISIST
QSP

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=344, Percent_Identity=22.6744186046512, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787970, Length=340, Percent_Identity=27.3529411764706, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789175, Length=404, Percent_Identity=25.990099009901, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994898, Length=167, Percent_Identity=26.3473053892216, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25143064, Length=169, Percent_Identity=28.4023668639053, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319831, Length=183, Percent_Identity=25.6830601092896, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI20129463, Length=183, Percent_Identity=26.775956284153, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43359; Mature: 43359

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDDLSRLRAATPGCAQVVHFNHAGASLPSQATLDAVIEQLQREALGGPMEAADNRVQA
CCHHHHHHHHHCCCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RARNAAAALLNAQPEDIAFASSGSAAWSQAFNALGPWQPGERILVGRHEWAGNLACMAEA
HHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCHHCCHHHHHHHH
VKAGARLEVIPCDAHGAVDPQALAQMIDSQVRLIALTWLPANGGLINPAAQIGNVARRHG
HHCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEEEEEEECCCCCEECHHHHHHHHHHHCC
IPYFIDAGQALGQLPCDVQDLQCDVLKGAGRKFLRGPRGTALMYIRAQFLQRLLPVQRDV
CCEEEECCHHHCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LSAPWDGKRFTLRDDARRFETSEVSLALLAGLANALEEHNRLGAFAIRQRIAHLSNGLRQ
HCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
RLKAIPGLTLRNLGAANQQSGLIAFTLEGWDSVALKQTLAERRINIGANGVAYTPLDMQA
HHHHCCCCHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCC
RGLTNIARVALSYLNTEEEIDVLLENLTELAARPQISISTQSP
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCC
>Mature Secondary Structure
MNIDDLSRLRAATPGCAQVVHFNHAGASLPSQATLDAVIEQLQREALGGPMEAADNRVQA
CCHHHHHHHHHCCCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RARNAAAALLNAQPEDIAFASSGSAAWSQAFNALGPWQPGERILVGRHEWAGNLACMAEA
HHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCHHCCHHHHHHHH
VKAGARLEVIPCDAHGAVDPQALAQMIDSQVRLIALTWLPANGGLINPAAQIGNVARRHG
HHCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEEEEEEECCCCCEECHHHHHHHHHHHCC
IPYFIDAGQALGQLPCDVQDLQCDVLKGAGRKFLRGPRGTALMYIRAQFLQRLLPVQRDV
CCEEEECCHHHCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LSAPWDGKRFTLRDDARRFETSEVSLALLAGLANALEEHNRLGAFAIRQRIAHLSNGLRQ
HCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
RLKAIPGLTLRNLGAANQQSGLIAFTLEGWDSVALKQTLAERRINIGANGVAYTPLDMQA
HHHHCCCCHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCC
RGLTNIARVALSYLNTEEEIDVLLENLTELAARPQISISTQSP
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]