Click here to switch to the map view.

The map label for this gene is hisB [H]

Identifier: 77456551

GI number: 77456551

Start: 369562

End: 370155

Strand: Direct

Name: hisB [H]

Synonym: Pfl01_0323

Alternate gene names: 77456551

Gene position: 369562-370155 (Clockwise)

Preceding gene: 77456550

Following gene: 77456552

Centisome position: 5.74

GC content: 61.11

Gene sequence:

>594_bases
ATGGCCGAACGTAAGGCGTCTGTCGAGCGCGACACTCTGGAAACCCAGATCAAAGCCTCGATCAACCTTGATGGCACCGG
AAAGGCCCGATTCAATATCGGTGTTCCTTTTCTTGAGCACATGCTGGATCAGATCGCCCGTCACGGGTTGATCGACCTGG
ATATCGAATGCAAGGGCGATCTGCATATCGACGACCACCACACGGTGGAAGACGTCGGTATCACCCTCGGCCAGGCCTTC
GCGCAAGCCATTGGCGACAAGAAAGGCATCCGTCGCTACGGCCACGCCTACGTGCCGCTCGATGAAGCGCTGTCGCGCGT
GGTGATCGACTTCTCCGGCCGGCCGGGCCTGCAGATGCACGTGCCGTACACCCGCGCCACCGTTGGCGGCTTCGACGTCG
ACCTGTTCCAGGAATTCTTCCAGGGCTTCGTCAACCACGCACTGGTCAGTCTGCACATCGACAACCTGCGCGGCACCAAC
ACCCACCACCAGATCGAAACCGTGTTCAAGGCTTTCGGCCGCGCGCTGCGCATGGCCGTCGAGCTGGACGAGCGCATGGC
CGGCCAGATGCCTTCGACCAAGGGCGTCCTGTAA

Upstream 100 bases:

>100_bases
GGCTTCTATCCGTCTGCCATATCACCTCTCGTGTTTCTGTTTCGGCCCCGCGCCCCTATAATGGCTGCCTTTTTCGCCCA
ATGATTTTGCGGAGCTGGTG

Downstream 100 bases:

>100_bases
TGCAGACGGTTGCAGTTATCGACTACGGCATGGGCAACCTGCACTCGGTGGCCAAGGCCCTCGAGCACGTTGGTGCCGGC
AAGGTGCTGATCACCAGCGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MAERKASVERDTLETQIKASINLDGTGKARFNIGVPFLEHMLDQIARHGLIDLDIECKGDLHIDDHHTVEDVGITLGQAF
AQAIGDKKGIRRYGHAYVPLDEALSRVVIDFSGRPGLQMHVPYTRATVGGFDVDLFQEFFQGFVNHALVSLHIDNLRGTN
THHQIETVFKAFGRALRMAVELDERMAGQMPSTKGVL

Sequences:

>Translated_197_residues
MAERKASVERDTLETQIKASINLDGTGKARFNIGVPFLEHMLDQIARHGLIDLDIECKGDLHIDDHHTVEDVGITLGQAF
AQAIGDKKGIRRYGHAYVPLDEALSRVVIDFSGRPGLQMHVPYTRATVGGFDVDLFQEFFQGFVNHALVSLHIDNLRGTN
THHQIETVFKAFGRALRMAVELDERMAGQMPSTKGVL
>Mature_196_residues
AERKASVERDTLETQIKASINLDGTGKARFNIGVPFLEHMLDQIARHGLIDLDIECKGDLHIDDHHTVEDVGITLGQAFA
QAIGDKKGIRRYGHAYVPLDEALSRVVIDFSGRPGLQMHVPYTRATVGGFDVDLFQEFFQGFVNHALVSLHIDNLRGTNT
HHQIETVFKAFGRALRMAVELDERMAGQMPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=46.1538461538462, Blast_Score=176, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=40.7239819004525, Blast_Score=166, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21903; Mature: 21772

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERKASVERDTLETQIKASINLDGTGKARFNIGVPFLEHMLDQIARHGLIDLDIECKGD
CCCCHHHHHHHHHHHHHHEEEECCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEECCC
LHIDDHHTVEDVGITLGQAFAQAIGDKKGIRRYGHAYVPLDEALSRVVIDFSGRPGLQMH
EEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCEEE
VPYTRATVGGFDVDLFQEFFQGFVNHALVSLHIDNLRGTNTHHQIETVFKAFGRALRMAV
CCHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
ELDERMAGQMPSTKGVL
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AERKASVERDTLETQIKASINLDGTGKARFNIGVPFLEHMLDQIARHGLIDLDIECKGD
CCCHHHHHHHHHHHHHHEEEECCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEECCC
LHIDDHHTVEDVGITLGQAFAQAIGDKKGIRRYGHAYVPLDEALSRVVIDFSGRPGLQMH
EEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCEEE
VPYTRATVGGFDVDLFQEFFQGFVNHALVSLHIDNLRGTNTHHQIETVFKAFGRALRMAV
CCHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
ELDERMAGQMPSTKGVL
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA