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The map label for this gene is gabT [H]

Identifier: 77456416

GI number: 77456416

Start: 226945

End: 228222

Strand: Direct

Name: gabT [H]

Synonym: Pfl01_0188

Alternate gene names: 77456416

Gene position: 226945-228222 (Clockwise)

Preceding gene: 77456415

Following gene: 77456417

Centisome position: 3.52

GC content: 61.66

Gene sequence:

>1278_bases
ATGAGCAAGACTAACGCTGAACTGATGGCCCGCCGTACCGCTGCTGTTCCACGGGGTGTTGGCCAGATTCACCCGATCTT
CGCCGAGTCCGCGAAGAACGCGACCGTAACCGACGTTGAAGGGCGTGAATTCATCGACTTCGCCGGCGGTATCGCTGTAC
TGAATACCGGCCACGTGCACCCGAAAATCATCGCCGCCGTGACCGAGCAGCTGAACAAGCTGACTCACACCTGCTTCCAG
GTTCTGGCTTATGAGCCGTACGTTGAGCTGTGCGAGAAAATCAACGCTCGCGTACCGGGCGACTTCGCCAAGAAAACCCT
GCTGGTGACCACCGGTTCCGAAGCTGTTGAAAACGCCGTGAAGATCGCTCGTGCTGCCACTGGCCGCGCTGGCGTGATCG
CCTTCACCGGCGCTTACCACGGTCGCACCATGATGACCCTGGGCCTGACCGGTAAAGTCGTGCCTTACTCGGCCGGCATG
GGCCTGATGCCAGGCGGCATCTTCCGCGCGTTGTACCCGAACGAACTGCACGGCGTGAGCATCGACGACTCGATCGCTTC
CATCGAACGCATCTTCAAGAACGACGCCGAGCCGAAAGACATCGCCGCGATCATTATCGAGCCTGTGCAGGGTGAAGGTG
GTTTCTACGTCGCACCGAAAGAATTCATGAAGCGCCTGCGCGCCCTGTGCGACCAGCACGGCATCCTGCTGATCGCTGAC
GAAGTGCAGACCGGCGCTGGCCGTACCGGCACCTTCTTCGCCATGGAACAGATGGGCGTTGCTGCCGACCTGACCACTTT
CGCCAAATCCATCGCTGGCGGCTTCCCGCTGGCCGGTGTGTGCGGCAAGGCCGAATACATGGACGCCATCGCGCCAGGCG
GCCTGGGCGGCACCTACGCCGGTAGCCCGATCGCTTGCGCTGCGGCCCTGGCCGTGATGGAAGTGTTCGAAGAAGAAAAA
CTGTTGGACCGCTGCAAGGCTGTTGGTGAGCGTCTGGTCACCGGCCTGAAAGCCATCCAGGCCAAGCACCCGGTGATCGG
TGAAGTCCGTGCCTTGGGCGCGATGATTGCCGTCGAGCTGTTCGAAAACGGCGACAGCCACAAGCCAAACCCGACCGCCG
TCGCGGCTGTCGTGGCCAAGGCGCGTGACAAGGGCCTGATCCTGCTGTCCTGCGGCACCTACGGCAACGTTCTGCGCGTC
CTGGTACCGCTGACCTCGCCGGACGAGCAACTGGACAAAGGTCTGGCGATCATCGAAGAGTGCTTCTCGGAGCTGTAA

Upstream 100 bases:

>100_bases
GGGAACGCCGTGGCAGTCGATCATCGCATGCTGCCACCGCCGATTCCTCCCGCTTTATCCTTGAACCACGCCGCCCGATG
AGCGGCGAATGAGGACTGTA

Downstream 100 bases:

>100_bases
TCCGTAGCACCGTGTGATCGGATCGACAAAAAACCCGCTTCGGCGGGTTTTTTCATGCCCGGGAAACACGGGCGCGGTTT
TCAGGTTGTACCGAAACGCC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSKTNAELMARRTAAVPRGVGQIHPIFAESAKNATVTDVEGREFIDFAGGIAVLNTGHVHPKIIAAVTEQLNKLTHTCFQ
VLAYEPYVELCEKINARVPGDFAKKTLLVTTGSEAVENAVKIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGM
GLMPGGIFRALYPNELHGVSIDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKEFMKRLRALCDQHGILLIAD
EVQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYAGSPIACAAALAVMEVFEEEK
LLDRCKAVGERLVTGLKAIQAKHPVIGEVRALGAMIAVELFENGDSHKPNPTAVAAVVAKARDKGLILLSCGTYGNVLRV
LVPLTSPDEQLDKGLAIIEECFSEL

Sequences:

>Translated_425_residues
MSKTNAELMARRTAAVPRGVGQIHPIFAESAKNATVTDVEGREFIDFAGGIAVLNTGHVHPKIIAAVTEQLNKLTHTCFQ
VLAYEPYVELCEKINARVPGDFAKKTLLVTTGSEAVENAVKIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGM
GLMPGGIFRALYPNELHGVSIDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKEFMKRLRALCDQHGILLIAD
EVQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYAGSPIACAAALAVMEVFEEEK
LLDRCKAVGERLVTGLKAIQAKHPVIGEVRALGAMIAVELFENGDSHKPNPTAVAAVVAKARDKGLILLSCGTYGNVLRV
LVPLTSPDEQLDKGLAIIEECFSEL
>Mature_424_residues
SKTNAELMARRTAAVPRGVGQIHPIFAESAKNATVTDVEGREFIDFAGGIAVLNTGHVHPKIIAAVTEQLNKLTHTCFQV
LAYEPYVELCEKINARVPGDFAKKTLLVTTGSEAVENAVKIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGMG
LMPGGIFRALYPNELHGVSIDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKEFMKRLRALCDQHGILLIADE
VQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYAGSPIACAAALAVMEVFEEEKL
LDRCKAVGERLVTGLKAIQAKHPVIGEVRALGAMIAVELFENGDSHKPNPTAVAAVVAKARDKGLILLSCGTYGNVLRVL
VPLTSPDEQLDKGLAIIEECFSEL

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=30.9756097560976, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI13994255, Length=431, Percent_Identity=30.1624129930394, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI37574042, Length=418, Percent_Identity=28.7081339712919, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=29.2746113989637, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI226442705, Length=418, Percent_Identity=27.9904306220096, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI24119277, Length=395, Percent_Identity=27.5949367088608, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=30.2180685358255, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI188536080, Length=404, Percent_Identity=26.7326732673267, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI38679950, Length=404, Percent_Identity=26.7326732673267, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI38679946, Length=404, Percent_Identity=26.7326732673267, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=73.9336492890995, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=55.1068883610451, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1789759, Length=408, Percent_Identity=34.0686274509804, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1788044, Length=399, Percent_Identity=35.0877192982456, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI145693181, Length=392, Percent_Identity=32.9081632653061, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786349, Length=386, Percent_Identity=32.1243523316062, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1786991, Length=408, Percent_Identity=29.1666666666667, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=420, Percent_Identity=33.8095238095238, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=29.5348837209302, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25144271, Length=408, Percent_Identity=30.3921568627451, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI25144274, Length=237, Percent_Identity=31.6455696202532, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=444, Percent_Identity=24.0990990990991, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323470, Length=416, Percent_Identity=31.4903846153846, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=30.5970149253731, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321456, Length=224, Percent_Identity=29.9107142857143, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=382, Percent_Identity=23.0366492146597, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161085790, Length=445, Percent_Identity=33.0337078651685, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI28574759, Length=427, Percent_Identity=33.2552693208431, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI21357415, Length=410, Percent_Identity=29.2682926829268, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21356575, Length=402, Percent_Identity=27.8606965174129, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281366494, Length=376, Percent_Identity=26.5957446808511, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24667139, Length=376, Percent_Identity=26.5957446808511, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24667143, Length=376, Percent_Identity=26.5957446808511, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 44826; Mature: 44695

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTNAELMARRTAAVPRGVGQIHPIFAESAKNATVTDVEGREFIDFAGGIAVLNTGHVH
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEECCCCCHHHHHCCCEEEEECCCCC
PKIIAAVTEQLNKLTHTCFQVLAYEPYVELCEKINARVPGDFAKKTLLVTTGSEAVENAV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHCCEEEEECCHHHHHHHH
KIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGMGLMPGGIFRALYPNELHGVS
HHHHHCCCCCCEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHCCCCCCCCCC
IDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKEFMKRLRALCDQHGILLIAD
CCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHCCCCEEEEEE
EVQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYA
CCCCCCCCCCCEEHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHCCCCCCCCCC
GSPIACAAALAVMEVFEEEKLLDRCKAVGERLVTGLKAIQAKHPVIGEVRALGAMIAVEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FENGDSHKPNPTAVAAVVAKARDKGLILLSCGTYGNVLRVLVPLTSPDEQLDKGLAIIEE
HHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHCCHHEEEECCCCHHHHHHHHHHHHH
CFSEL
HHHCC
>Mature Secondary Structure 
SKTNAELMARRTAAVPRGVGQIHPIFAESAKNATVTDVEGREFIDFAGGIAVLNTGHVH
CCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEECCCCCHHHHHCCCEEEEECCCCC
PKIIAAVTEQLNKLTHTCFQVLAYEPYVELCEKINARVPGDFAKKTLLVTTGSEAVENAV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHCCEEEEECCHHHHHHHH
KIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGMGLMPGGIFRALYPNELHGVS
HHHHHCCCCCCEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHCCCCCCCCCC
IDDSIASIERIFKNDAEPKDIAAIIIEPVQGEGGFYVAPKEFMKRLRALCDQHGILLIAD
CCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHCCCCEEEEEE
EVQTGAGRTGTFFAMEQMGVAADLTTFAKSIAGGFPLAGVCGKAEYMDAIAPGGLGGTYA
CCCCCCCCCCCEEHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHCCCCCCCCCC
GSPIACAAALAVMEVFEEEKLLDRCKAVGERLVTGLKAIQAKHPVIGEVRALGAMIAVEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FENGDSHKPNPTAVAAVVAKARDKGLILLSCGTYGNVLRVLVPLTSPDEQLDKGLAIIEE
HHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHCCHHEEEECCCCHHHHHHHHHHHHH
CFSEL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]