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The map label for this gene is thrB

Identifier: 75909006

GI number: 75909006

Start: 3448371

End: 3449279

Strand: Direct

Name: thrB

Synonym: Ava_2794

Alternate gene names: 75909006

Gene position: 3448371-3449279 (Clockwise)

Preceding gene: 75909003

Following gene: 75909007

Centisome position: 54.17

GC content: 50.61

Gene sequence:

>909_bases
ATGTCTGTTGTTTCTTCTGTCACGGTTAAGGTTCCTGGCACAACTGCTAACTTGGGGCCTGGTTTTGACTGCATCGGTGC
AGCCTTGACTATATATAATCAATTCCAGTTCACCCGCCTGGAAACGAGTGAGTTAATTATTCAAGCCACAGGCGCGGAAG
CTGAACGCGTACCAACTGATGAGAGTAATTTACTTTATCAGGCGTTTGTCAAGTTATATCAATATATAGATCAGACACCA
CCAGGGGTAAAAGTCGAGATTGAGTTGGGTGTACCACTGGCGCGGGGTTTGGGGAGTTCGGCTACGGCGATTGTTGGAGG
TTTGGTGGCGGCGAATCGATTGGCGGGTGAGCCGTTGTCTCAGGCGCAGGTGATGGAATTAGCGATCGCCATTGAAGGAC
ATCCTGATAATGTCGTACCCGCGTTGGTGGGGGGATGTCGTCTGGCGGCCACCGGTGCTATGGGTTGGGAAATTTGTGAT
GTTCCCTGGCATGGTGATATTGTCCCAGTGCTGGCAATTCCCGATTTTGAATTGTCCACCTCAGAAGCACGGCGAGTTTT
ACCAACAGAATATAGTCGCGCAGATGCGATTTTTAATACTGCTCATTTGGGGTTATTGTTGCGCGGCTTGCAAACAGGTA
AGGGAGAATGGTTAAGGGCAGCTTTACAAGATAAGTTACATCAGCCCTATCGCCAAGCTTTAATTCCTGGTTACGATGCT
GTGAATACTGCGGCTGTGGCTGCTGGTGCTTACGGTATGGTGATTAGTGGCGCGGGGCCGACACTGTTGGCTTTAGCGGA
TGTATCTCATGCGGCAGCTGTTGCGGCGGCAATGTCCACAGCTTGGCGAGAGGCGGGAATTAAGGCTGTAGTGCGATCGC
TTGCTCTCGATACTCATGGCGCAACTTAA

Upstream 100 bases:

>100_bases
TGAGCAGTTACGTGGGATGCTGGTTGATTGGTAATGTGAGTAGTCCATAGTTCAAAAGCTAATGACTATTGACTAATGAC
TGTTAGGTGAGTATTTATAA

Downstream 100 bases:

>100_bases
CAATTCAAAATTCAATATGAAAGAACTTAATCCCAGCTTGCCTTTAAAGCAAATTCAGTCGGAGATGACAGCACTCCAGT
CGCAAATTCAGGTGCTTGAG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSVVSSVTVKVPGTTANLGPGFDCIGAALTIYNQFQFTRLETSELIIQATGAEAERVPTDESNLLYQAFVKLYQYIDQTP
PGVKVEIELGVPLARGLGSSATAIVGGLVAANRLAGEPLSQAQVMELAIAIEGHPDNVVPALVGGCRLAATGAMGWEICD
VPWHGDIVPVLAIPDFELSTSEARRVLPTEYSRADAIFNTAHLGLLLRGLQTGKGEWLRAALQDKLHQPYRQALIPGYDA
VNTAAVAAGAYGMVISGAGPTLLALADVSHAAAVAAAMSTAWREAGIKAVVRSLALDTHGAT

Sequences:

>Translated_302_residues
MSVVSSVTVKVPGTTANLGPGFDCIGAALTIYNQFQFTRLETSELIIQATGAEAERVPTDESNLLYQAFVKLYQYIDQTP
PGVKVEIELGVPLARGLGSSATAIVGGLVAANRLAGEPLSQAQVMELAIAIEGHPDNVVPALVGGCRLAATGAMGWEICD
VPWHGDIVPVLAIPDFELSTSEARRVLPTEYSRADAIFNTAHLGLLLRGLQTGKGEWLRAALQDKLHQPYRQALIPGYDA
VNTAAVAAGAYGMVISGAGPTLLALADVSHAAAVAAAMSTAWREAGIKAVVRSLALDTHGAT
>Mature_301_residues
SVVSSVTVKVPGTTANLGPGFDCIGAALTIYNQFQFTRLETSELIIQATGAEAERVPTDESNLLYQAFVKLYQYIDQTPP
GVKVEIELGVPLARGLGSSATAIVGGLVAANRLAGEPLSQAQVMELAIAIEGHPDNVVPALVGGCRLAATGAMGWEICDV
PWHGDIVPVLAIPDFELSTSEARRVLPTEYSRADAIFNTAHLGLLLRGLQTGKGEWLRAALQDKLHQPYRQALIPGYDAV
NTAAVAAGAYGMVISGAGPTLLALADVSHAAAVAAAMSTAWREAGIKAVVRSLALDTHGAT

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=308, Percent_Identity=31.8181818181818, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321814, Length=355, Percent_Identity=29.5774647887324, Blast_Score=142, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_ANAVT (Q3M9C9)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_323302.1
- HSSP:   Q58504
- ProteinModelPortal:   Q3M9C9
- SMR:   Q3M9C9
- STRING:   Q3M9C9
- GeneID:   3681630
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_2794
- NMPDR:   fig|240292.3.peg.1374
- eggNOG:   COG0083
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- PhylomeDB:   Q3M9C9
- ProtClustDB:   PRK01212
- BioCyc:   AVAR240292:AVA_2794-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 31492; Mature: 31361

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVSSVTVKVPGTTANLGPGFDCIGAALTIYNQFQFTRLETSELIIQATGAEAERVPTD
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCCCCC
ESNLLYQAFVKLYQYIDQTPPGVKVEIELGVPLARGLGSSATAIVGGLVAANRLAGEPLS
CHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCHHHHHHHHHHHHHHCCCCCH
QAQVMELAIAIEGHPDNVVPALVGGCRLAATGAMGWEICDVPWHGDIVPVLAIPDFELST
HHHHEEEEEEEECCCCCHHHHHHCCCCEEECCCCCCEEECCCCCCCEEEEEEECCCCCCH
SEARRVLPTEYSRADAIFNTAHLGLLLRGLQTGKGEWLRAALQDKLHQPYRQALIPGYDA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
VNTAAVAAGAYGMVISGAGPTLLALADVSHAAAVAAAMSTAWREAGIKAVVRSLALDTHG
HHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AT
CC
>Mature Secondary Structure 
SVVSSVTVKVPGTTANLGPGFDCIGAALTIYNQFQFTRLETSELIIQATGAEAERVPTD
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCCCCC
ESNLLYQAFVKLYQYIDQTPPGVKVEIELGVPLARGLGSSATAIVGGLVAANRLAGEPLS
CHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCHHHHHHHHHHHHHHCCCCCH
QAQVMELAIAIEGHPDNVVPALVGGCRLAATGAMGWEICDVPWHGDIVPVLAIPDFELST
HHHHEEEEEEEECCCCCHHHHHHCCCCEEECCCCCCEEECCCCCCCEEEEEEECCCCCCH
SEARRVLPTEYSRADAIFNTAHLGLLLRGLQTGKGEWLRAALQDKLHQPYRQALIPGYDA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
VNTAAVAAGAYGMVISGAGPTLLALADVSHAAAVAAAMSTAWREAGIKAVVRSLALDTHG
HHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA