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The map label for this gene is spkB [H]

Identifier: 75909003

GI number: 75909003

Start: 3444972

End: 3447314

Strand: Direct

Name: spkB [H]

Synonym: Ava_2791

Alternate gene names: 75909003

Gene position: 3444972-3447314 (Clockwise)

Preceding gene: 75909000

Following gene: 75909006

Centisome position: 54.12

GC content: 42.08

Gene sequence:

>2343_bases
ATGGCGTACTGCATCAATCCCGATTGTTCGCAGCGAGAAAATTCTGATACTAGTGCAGTATGTCAAAACTGTGGAACGCC
ACTCATACTTCAAAATCACTATCGGCTTAGGCATCTGTTGCAAACTGATAGACGTAGCTATACAGAAGTATTTGAAATCG
AAGATTTAGTTAACCGAGATCAACCTAAAGTTCTCAAGTCGCTGAAAGAGGTAACGCCGCAACTAGAACGACTTTTTCAG
CAAGAAGCGTCGATATTGCAGACTTTGCGGCATCCTGGTTTACCTATTGGTGAAGCACTATTTCCCCTGGTTTTAAACAC
AGGTCGTCAATTATGGTGTTTTGTGATGGAGAAAATTCCTGGTGAAGATTTACAGACTTGGTTATCTCACCATCAATATG
TGACATCCTATAAAACAGCATTAGATTGGCTCAAACAACTAATGCAAATTCTCCAATTCGTACATCAGGAAAAGTTTTTC
CATCGGGATATCAAGCCAGCGAATATTATGGTTTGTCCTGATGGGAAACTGGTATTAATTGATTTTGGTGCGGCGCGTAA
AGTGACACAAACCATTATCAACCGTGAGCCTGTCACTATAATTAATTCCCTTGGTTATACTGCACCCGAACAACGTGATG
GTCATGCCGTTGTGCAGTCAGATTTTTATGCACTGGGTCGGACTGTAATCTATTTACTCACAGGTATTGACCCAACAGGC
GATCGCGTCCAAGATTTACTCAATTGGTCTAAATACATTCAAGACCCAAAAACTCCTAAAAAATTCATCTCTTTGCTTCA
GGCGATGACGGATTCTTATCCCCACCACCGTCCGCCTACAGCACAAGCAATTCTCGCAAAGATTGAAAATATTGAGCAGC
ATTCGTACCCATGGCCAAAATTATTGTTGGGTGCGGCTTGTGGTCTGTTGTTGCTGTTCGCGGGGAAATCCTTATATCAG
GAAATTACATTACCTCGGACTTGTGACAATATACTCAATGATTATCTGAGTTGTGGAGAAGAAAGCCTCACTCCTAGTAG
CTTTTGGGGTAATAGTCAGCCGCCACCAGCAAAGCAATTGGGAATGGAAGAGTATCGCCATCAAAATTTTGAGGCAGCTG
TAAAATTCTTAGAAACTGCTTTCCAGCAAGAATCAGATCCAGAAACCTTAATTTACCTAAATAATAGCAAGATTCACCAG
CAATTTCCCGTAAATCAGATTCATACTATCGCTGTTGCAGTCCCTCTAGAACGACGCACTGATATAGGTCGGGAAATACT
CAGGGGTGTCGCACAAGCTCAAACTGAGGCACTAAAACAAGGTCGAGCTTTACGCATTATCATTGCTGACGATAGTAATC
GGGAAGATAGCAGAACTGGCAATAATGCCCGTAAAATTGCCCAGCAGTTAGTCAAATATCCTGATTTAATCGCTGTTTTG
GGTCACTATAGCAGCGAAGCCACCAAAAATTCCTTACCGATTTATCGCCAAGCCGGAGTAGTGTTAATTTCTGCCACTAG
CACTTCTCAAAATCTCAAAGACCCTTTTTTCTTTCGTACTGTCCCCAGCGATCGCATTGCAGCCCAAAAAATGGTAACTT
ACTTGCTGTCTGAATTGAAACAGAATCAAGTAGCTATCTTTTATAGTCAAGGTAGTGAGTATGCTGAATCTCTTTCCCAG
GCTGTTCGAGAAAGCACAAAATCTCTTCCTTTGAAGGTGATTGATCATCAAGCGGCTTTTAATTTAGCCAGCGATCGCTT
CAATGCCATAACAGCGTTAAATCAAGCTCAAACCCAAGGTGCAAAGGCAATTGTCCTAATTCCTGATGCCGGAGTAGGGT
TATATAATGCAATTCCCAATGCCTTACGAGTGATTCAGACGAACATCAATCAAGTTTGGATTGTTGCCGGTGACAGTCTC
TACAGTTCTGACTCCTTCAAATCAGAGAAAGTTTTTTCCTCACCCGAAATCCAATACACAGCTTGGGCAGTTTTTTGGCA
TCCCCTTAACGAGATGAATTCAACCTTTGTCAAGGAAGTCCAAAACCTCTGGAAAATTGATCTATCCTCTCTTCTCCGCA
ACACTGACATTACTTGGCGAACAACAACCAGCTATGATGCAATGTTAGTTTTGAGTCAAGCCATCACCCAAAATCCTACT
CGCCTCGGTATTCAAAAAACACTCAGCCAACCCCAATTTTCCGTTACAGGTGCAACAGGAGTAATTCAATTTGCAGGAAG
CGATCGCCAAAATGGAAAAATTACGATGGTAAGATTCCAGCGTAATTGTGATGATAATGGTTTTGTTGTTATTCCCAGCG
ATCGCTCTTTACAATGTCGATAG

Upstream 100 bases:

>100_bases
AATCTGCGTGCATAAGCCCTAAAGTAATGGAAAAGGCTTTTTTTAACAGGTTGTAGTTTTAAAATACGTATATTGTTTGT
CGGCTTTTTGTCTTTACTTT

Downstream 100 bases:

>100_bases
TTGGTATGTTAGGTATGATTATGGAAGCGATCCCTACAGCAAGTCATGGAAAACGAGCCATTGGTTAGATTCCACAAGCT
AGTACTAGATAGGCTGTCAG

Product: serine/threonine protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 780; Mature: 779

Protein sequence:

>780_residues
MAYCINPDCSQRENSDTSAVCQNCGTPLILQNHYRLRHLLQTDRRSYTEVFEIEDLVNRDQPKVLKSLKEVTPQLERLFQ
QEASILQTLRHPGLPIGEALFPLVLNTGRQLWCFVMEKIPGEDLQTWLSHHQYVTSYKTALDWLKQLMQILQFVHQEKFF
HRDIKPANIMVCPDGKLVLIDFGAARKVTQTIINREPVTIINSLGYTAPEQRDGHAVVQSDFYALGRTVIYLLTGIDPTG
DRVQDLLNWSKYIQDPKTPKKFISLLQAMTDSYPHHRPPTAQAILAKIENIEQHSYPWPKLLLGAACGLLLLFAGKSLYQ
EITLPRTCDNILNDYLSCGEESLTPSSFWGNSQPPPAKQLGMEEYRHQNFEAAVKFLETAFQQESDPETLIYLNNSKIHQ
QFPVNQIHTIAVAVPLERRTDIGREILRGVAQAQTEALKQGRALRIIIADDSNREDSRTGNNARKIAQQLVKYPDLIAVL
GHYSSEATKNSLPIYRQAGVVLISATSTSQNLKDPFFFRTVPSDRIAAQKMVTYLLSELKQNQVAIFYSQGSEYAESLSQ
AVRESTKSLPLKVIDHQAAFNLASDRFNAITALNQAQTQGAKAIVLIPDAGVGLYNAIPNALRVIQTNINQVWIVAGDSL
YSSDSFKSEKVFSSPEIQYTAWAVFWHPLNEMNSTFVKEVQNLWKIDLSSLLRNTDITWRTTTSYDAMLVLSQAITQNPT
RLGIQKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRFQRNCDDNGFVVIPSDRSLQCR

Sequences:

>Translated_780_residues
MAYCINPDCSQRENSDTSAVCQNCGTPLILQNHYRLRHLLQTDRRSYTEVFEIEDLVNRDQPKVLKSLKEVTPQLERLFQ
QEASILQTLRHPGLPIGEALFPLVLNTGRQLWCFVMEKIPGEDLQTWLSHHQYVTSYKTALDWLKQLMQILQFVHQEKFF
HRDIKPANIMVCPDGKLVLIDFGAARKVTQTIINREPVTIINSLGYTAPEQRDGHAVVQSDFYALGRTVIYLLTGIDPTG
DRVQDLLNWSKYIQDPKTPKKFISLLQAMTDSYPHHRPPTAQAILAKIENIEQHSYPWPKLLLGAACGLLLLFAGKSLYQ
EITLPRTCDNILNDYLSCGEESLTPSSFWGNSQPPPAKQLGMEEYRHQNFEAAVKFLETAFQQESDPETLIYLNNSKIHQ
QFPVNQIHTIAVAVPLERRTDIGREILRGVAQAQTEALKQGRALRIIIADDSNREDSRTGNNARKIAQQLVKYPDLIAVL
GHYSSEATKNSLPIYRQAGVVLISATSTSQNLKDPFFFRTVPSDRIAAQKMVTYLLSELKQNQVAIFYSQGSEYAESLSQ
AVRESTKSLPLKVIDHQAAFNLASDRFNAITALNQAQTQGAKAIVLIPDAGVGLYNAIPNALRVIQTNINQVWIVAGDSL
YSSDSFKSEKVFSSPEIQYTAWAVFWHPLNEMNSTFVKEVQNLWKIDLSSLLRNTDITWRTTTSYDAMLVLSQAITQNPT
RLGIQKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRFQRNCDDNGFVVIPSDRSLQCR
>Mature_779_residues
AYCINPDCSQRENSDTSAVCQNCGTPLILQNHYRLRHLLQTDRRSYTEVFEIEDLVNRDQPKVLKSLKEVTPQLERLFQQ
EASILQTLRHPGLPIGEALFPLVLNTGRQLWCFVMEKIPGEDLQTWLSHHQYVTSYKTALDWLKQLMQILQFVHQEKFFH
RDIKPANIMVCPDGKLVLIDFGAARKVTQTIINREPVTIINSLGYTAPEQRDGHAVVQSDFYALGRTVIYLLTGIDPTGD
RVQDLLNWSKYIQDPKTPKKFISLLQAMTDSYPHHRPPTAQAILAKIENIEQHSYPWPKLLLGAACGLLLLFAGKSLYQE
ITLPRTCDNILNDYLSCGEESLTPSSFWGNSQPPPAKQLGMEEYRHQNFEAAVKFLETAFQQESDPETLIYLNNSKIHQQ
FPVNQIHTIAVAVPLERRTDIGREILRGVAQAQTEALKQGRALRIIIADDSNREDSRTGNNARKIAQQLVKYPDLIAVLG
HYSSEATKNSLPIYRQAGVVLISATSTSQNLKDPFFFRTVPSDRIAAQKMVTYLLSELKQNQVAIFYSQGSEYAESLSQA
VRESTKSLPLKVIDHQAAFNLASDRFNAITALNQAQTQGAKAIVLIPDAGVGLYNAIPNALRVIQTNINQVWIVAGDSLY
SSDSFKSEKVFSSPEIQYTAWAVFWHPLNEMNSTFVKEVQNLWKIDLSSLLRNTDITWRTTTSYDAMLVLSQAITQNPTR
LGIQKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRFQRNCDDNGFVVIPSDRSLQCR

Specific function: Protein kinase required for cell motility, but not for phototaxis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI4502557, Length=239, Percent_Identity=25.5230125523013, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI32698688, Length=223, Percent_Identity=25.5605381165919, Blast_Score=69, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193208793, Length=208, Percent_Identity=28.3653846153846, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193208795, Length=208, Percent_Identity=28.3653846153846, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI72000588, Length=178, Percent_Identity=28.6516853932584, Blast_Score=70, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17564378, Length=178, Percent_Identity=28.6516853932584, Blast_Score=70, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17564376, Length=178, Percent_Identity=28.6516853932584, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI161077455, Length=179, Percent_Identity=31.8435754189944, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161077453, Length=179, Percent_Identity=31.8435754189944, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221379848, Length=208, Percent_Identity=27.4038461538462, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551927, Length=208, Percent_Identity=27.4038461538462, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551925, Length=208, Percent_Identity=27.4038461538462, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551923, Length=208, Percent_Identity=27.4038461538462, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550768, Length=208, Percent_Identity=27.4038461538462, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001646
- InterPro:   IPR020636
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR016252 [H]

Pfam domain/function: PF00805 Pentapeptide; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 88004; Mature: 87873

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00108 PROTEIN_KINASE_ST ; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYCINPDCSQRENSDTSAVCQNCGTPLILQNHYRLRHLLQTDRRSYTEVFEIEDLVNRD
CCEECCCCCCCCCCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QPKVLKSLKEVTPQLERLFQQEASILQTLRHPGLPIGEALFPLVLNTGRQLWCFVMEKIP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCC
GEDLQTWLSHHQYVTSYKTALDWLKQLMQILQFVHQEKFFHRDIKPANIMVCPDGKLVLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEE
DFGAARKVTQTIINREPVTIINSLGYTAPEQRDGHAVVQSDFYALGRTVIYLLTGIDPTG
ECCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCH
DRVQDLLNWSKYIQDPKTPKKFISLLQAMTDSYPHHRPPTAQAILAKIENIEQHSYPWPK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
LLLGAACGLLLLFAGKSLYQEITLPRTCDNILNDYLSCGEESLTPSSFWGNSQPPPAKQL
HHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHC
GMEEYRHQNFEAAVKFLETAFQQESDPETLIYLNNSKIHQQFPVNQIHTIAVAVPLERRT
CHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEEEEECCHHHH
DIGREILRGVAQAQTEALKQGRALRIIIADDSNREDSRTGNNARKIAQQLVKYPDLIAVL
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHHH
GHYSSEATKNSLPIYRQAGVVLISATSTSQNLKDPFFFRTVPSDRIAAQKMVTYLLSELK
HHCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHC
QNQVAIFYSQGSEYAESLSQAVRESTKSLPLKVIDHQAAFNLASDRFNAITALNQAQTQG
CCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
AKAIVLIPDAGVGLYNAIPNALRVIQTNINQVWIVAGDSLYSSDSFKSEKVFSSPEIQYT
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEE
AWAVFWHPLNEMNSTFVKEVQNLWKIDLSSLLRNTDITWRTTTSYDAMLVLSQAITQNPT
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCH
RLGIQKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRFQRNCDDNGFVVIPSDRSLQCR
HHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
AYCINPDCSQRENSDTSAVCQNCGTPLILQNHYRLRHLLQTDRRSYTEVFEIEDLVNRD
CEECCCCCCCCCCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QPKVLKSLKEVTPQLERLFQQEASILQTLRHPGLPIGEALFPLVLNTGRQLWCFVMEKIP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCC
GEDLQTWLSHHQYVTSYKTALDWLKQLMQILQFVHQEKFFHRDIKPANIMVCPDGKLVLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEE
DFGAARKVTQTIINREPVTIINSLGYTAPEQRDGHAVVQSDFYALGRTVIYLLTGIDPTG
ECCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCH
DRVQDLLNWSKYIQDPKTPKKFISLLQAMTDSYPHHRPPTAQAILAKIENIEQHSYPWPK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
LLLGAACGLLLLFAGKSLYQEITLPRTCDNILNDYLSCGEESLTPSSFWGNSQPPPAKQL
HHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHC
GMEEYRHQNFEAAVKFLETAFQQESDPETLIYLNNSKIHQQFPVNQIHTIAVAVPLERRT
CHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEEEEECCHHHH
DIGREILRGVAQAQTEALKQGRALRIIIADDSNREDSRTGNNARKIAQQLVKYPDLIAVL
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHHH
GHYSSEATKNSLPIYRQAGVVLISATSTSQNLKDPFFFRTVPSDRIAAQKMVTYLLSELK
HHCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHC
QNQVAIFYSQGSEYAESLSQAVRESTKSLPLKVIDHQAAFNLASDRFNAITALNQAQTQG
CCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
AKAIVLIPDAGVGLYNAIPNALRVIQTNINQVWIVAGDSLYSSDSFKSEKVFSSPEIQYT
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEE
AWAVFWHPLNEMNSTFVKEVQNLWKIDLSSLLRNTDITWRTTTSYDAMLVLSQAITQNPT
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCH
RLGIQKTLSQPQFSVTGATGVIQFAGSDRQNGKITMVRFQRNCDDNGFVVIPSDRSLQCR
HHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12732981; 8905231 [H]