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The map label for this gene is pyrC [H]

Identifier: 75676198

GI number: 75676198

Start: 2195887

End: 2197188

Strand: Direct

Name: pyrC [H]

Synonym: Nwi_2008

Alternate gene names: 75676198

Gene position: 2195887-2197188 (Clockwise)

Preceding gene: 75676197

Following gene: 75676199

Centisome position: 64.55

GC content: 66.74

Gene sequence:

>1302_bases
ATGCTGAGCGGCCATCGCCCGATCCTGCTCGCCAATGCCCGCATTGTCGATCCCGCGCGCGATCTCGACGGCCCCGGCGA
CGTGCTCATCGCCGATGGGGTTATTCGCGATGCGCGGCACGGCATCGGCGCGGCGGGCGCGCCCGAAGGCACCGACATCA
TCAACTGCGCCGGCATGATCGTCACGCCGGGCCTGATCGACATCCGCGCCTTCGTCGGCGAACCGGGCGCGGGCCATCGC
GAAACCTTCGCATCGGCAAGCTGCGCCGCCGCCGCCGGCGGGATCACCACCATTGTCTGCCAGCCTGACACCTCGCCGGT
GATCGACAATTCTGCCACCGTCGATTTCGTGCTGCGCCGCGCGCGGGATACCGCGATCGTCAACATTCATCCGATGGCGG
CGCTGACCAAGGGTCTTGCCGGCAAGGAGATGACCGAGTTCGGCCTCCTGAAGGAAGCGGGCGCGGTCGCCTTCACCGAC
GGCGCCCGCAGCGTGATGAACGCGCAGGTGATGCGCCGCGCCCTCACCTATGCCCGCGACTTCGACGCGCTGATCGTCCA
TCATACCGAGGATGCTCATCTCGTCGGCGACGGCGTCATGAACGAGGGCGAACTGTCTTCCCGCCTCGGATTGACGGGTG
TTCCGGCGACCGCGGAAGCGGTGATGCTGGAGCGCGACATGCGGCTCGTCGGGCTGACCGGCGGCCGTTACCACGCGGCG
TCCCTGACCTGCGCGGAATCGCTCGATATCCTCATGCGAGCGCGCGACGCCGGGCTCCCGGTCAGCGCATCCGCATCGAT
CAATCATCTGACGCTGAATGAGAACGATATCGGTCCGTACCGGACGTTTCTGAAATTGTCGCCGCCGCTGCGCGGCGAGG
ACGACCGACGCGCGCTGGTCGCAGCGCTGGCGTCGGGCCTGATCGATGTGGTGATGTCCGACCATAACCCGCAGGACGTG
GAAACCAAGCGGCTGCCGTTCGCGGAAGCCGCCGCAGGCGCGATCGGGCTGGAGACCATGCTGACGGCCGCGCTGCGGCT
CGTGCACAACGCGGAACTCGACTTCAAGACGCTGATCCGGGCGATGTCGACGCGGCCCGCGGAGCTGCTGGGTTTGCCGG
GCGGATCGCTGCGACCGGGCGCGCCCGCCGATGTCATCGTGATCGATCCTGACGTGCCATGGATTCTCGATCCCGCCGAT
CTCAAATCGCAATGCAAGAATACGCCATTCGACGAATCCCGGTTCTCGGGTCGGGTTGTTCGGACGATCGTCGGCGGACG
CACGGTTTTCGAGCACGCCTGA

Upstream 100 bases:

>100_bases
GAGGAACCTGCCGAATGCATGAACCCGAGCCCTCCCACCGATTTGCACGGCGAGCATTGTCACGCGCGATGTTAGCGAAC
AGTTCGCAAAGGTGCGGCAT

Downstream 100 bases:

>100_bases
CGCGACAGGTTTTGATCGAAAGAAAATTCCATTATCTCGAAAATATCCGTTAATAATCAAAACCATAGGGCCTTCGCCTC
CGATACCGTCAGAAGAAGGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLSGHRPILLANARIVDPARDLDGPGDVLIADGVIRDARHGIGAAGAPEGTDIINCAGMIVTPGLIDIRAFVGEPGAGHR
ETFASASCAAAAGGITTIVCQPDTSPVIDNSATVDFVLRRARDTAIVNIHPMAALTKGLAGKEMTEFGLLKEAGAVAFTD
GARSVMNAQVMRRALTYARDFDALIVHHTEDAHLVGDGVMNEGELSSRLGLTGVPATAEAVMLERDMRLVGLTGGRYHAA
SLTCAESLDILMRARDAGLPVSASASINHLTLNENDIGPYRTFLKLSPPLRGEDDRRALVAALASGLIDVVMSDHNPQDV
ETKRLPFAEAAAGAIGLETMLTAALRLVHNAELDFKTLIRAMSTRPAELLGLPGGSLRPGAPADVIVIDPDVPWILDPAD
LKSQCKNTPFDESRFSGRVVRTIVGGRTVFEHA

Sequences:

>Translated_433_residues
MLSGHRPILLANARIVDPARDLDGPGDVLIADGVIRDARHGIGAAGAPEGTDIINCAGMIVTPGLIDIRAFVGEPGAGHR
ETFASASCAAAAGGITTIVCQPDTSPVIDNSATVDFVLRRARDTAIVNIHPMAALTKGLAGKEMTEFGLLKEAGAVAFTD
GARSVMNAQVMRRALTYARDFDALIVHHTEDAHLVGDGVMNEGELSSRLGLTGVPATAEAVMLERDMRLVGLTGGRYHAA
SLTCAESLDILMRARDAGLPVSASASINHLTLNENDIGPYRTFLKLSPPLRGEDDRRALVAALASGLIDVVMSDHNPQDV
ETKRLPFAEAAAGAIGLETMLTAALRLVHNAELDFKTLIRAMSTRPAELLGLPGGSLRPGAPADVIVIDPDVPWILDPAD
LKSQCKNTPFDESRFSGRVVRTIVGGRTVFEHA
>Mature_433_residues
MLSGHRPILLANARIVDPARDLDGPGDVLIADGVIRDARHGIGAAGAPEGTDIINCAGMIVTPGLIDIRAFVGEPGAGHR
ETFASASCAAAAGGITTIVCQPDTSPVIDNSATVDFVLRRARDTAIVNIHPMAALTKGLAGKEMTEFGLLKEAGAVAFTD
GARSVMNAQVMRRALTYARDFDALIVHHTEDAHLVGDGVMNEGELSSRLGLTGVPATAEAVMLERDMRLVGLTGGRYHAA
SLTCAESLDILMRARDAGLPVSASASINHLTLNENDIGPYRTFLKLSPPLRGEDDRRALVAALASGLIDVVMSDHNPQDV
ETKRLPFAEAAAGAIGLETMLTAALRLVHNAELDFKTLIRAMSTRPAELLGLPGGSLRPGAPADVIVIDPDVPWILDPAD
LKSQCKNTPFDESRFSGRVVRTIVGGRTVFEHA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923821, Length=463, Percent_Identity=24.4060475161987, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786722, Length=401, Percent_Identity=24.4389027431421, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87082175, Length=443, Percent_Identity=25.0564334085779, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=402, Percent_Identity=24.6268656716418, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24642586, Length=419, Percent_Identity=23.3890214797136, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45598; Mature: 45598

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSGHRPILLANARIVDPARDLDGPGDVLIADGVIRDARHGIGAAGAPEGTDIINCAGMI
CCCCCCCEEEECCEEECHHHCCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCEEECCCE
VTPGLIDIRAFVGEPGAGHRETFASASCAAAAGGITTIVCQPDTSPVIDNSATVDFVLRR
ECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHH
ARDTAIVNIHPMAALTKGLAGKEMTEFGLLKEAGAVAFTDGARSVMNAQVMRRALTYARD
CCCCEEEEECHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCC
FDALIVHHTEDAHLVGDGVMNEGELSSRLGLTGVPATAEAVMLERDMRLVGLTGGRYHAA
CCEEEEEECCCCEEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEECCCCEEEE
SLTCAESLDILMRARDAGLPVSASASINHLTLNENDIGPYRTFLKLSPPLRGEDDRRALV
EEHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCHHHHEEEECCCCCCCCHHHHHH
AALASGLIDVVMSDHNPQDVETKRLPFAEAAAGAIGLETMLTAALRLVHNAELDFKTLIR
HHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHH
AMSTRPAELLGLPGGSLRPGAPADVIVIDPDVPWILDPADLKSQCKNTPFDESRFSGRVV
HHCCCCHHEEECCCCCCCCCCCCCEEEECCCCCEEECHHHHHHHHCCCCCCCHHHCCEEE
RTIVGGRTVFEHA
EHHHCCCHHHCCC
>Mature Secondary Structure
MLSGHRPILLANARIVDPARDLDGPGDVLIADGVIRDARHGIGAAGAPEGTDIINCAGMI
CCCCCCCEEEECCEEECHHHCCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCEEECCCE
VTPGLIDIRAFVGEPGAGHRETFASASCAAAAGGITTIVCQPDTSPVIDNSATVDFVLRR
ECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHH
ARDTAIVNIHPMAALTKGLAGKEMTEFGLLKEAGAVAFTDGARSVMNAQVMRRALTYARD
CCCCEEEEECHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCC
FDALIVHHTEDAHLVGDGVMNEGELSSRLGLTGVPATAEAVMLERDMRLVGLTGGRYHAA
CCEEEEEECCCCEEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEECCCCEEEE
SLTCAESLDILMRARDAGLPVSASASINHLTLNENDIGPYRTFLKLSPPLRGEDDRRALV
EEHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCHHHHEEEECCCCCCCCHHHHHH
AALASGLIDVVMSDHNPQDVETKRLPFAEAAAGAIGLETMLTAALRLVHNAELDFKTLIR
HHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHH
AMSTRPAELLGLPGGSLRPGAPADVIVIDPDVPWILDPADLKSQCKNTPFDESRFSGRVV
HHCCCCHHEEECCCCCCCCCCCCCEEEECCCCCEEECHHHHHHHHCCCCCCCHHHCCEEE
RTIVGGRTVFEHA
EHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA