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The map label for this gene is trpC

Identifier: 75676029

GI number: 75676029

Start: 2012240

End: 2013034

Strand: Direct

Name: trpC

Synonym: Nwi_1838

Alternate gene names: 75676029

Gene position: 2012240-2013034 (Clockwise)

Preceding gene: 75676028

Following gene: 75676030

Centisome position: 59.15

GC content: 64.28

Gene sequence:

>795_bases
GTGGCCGACATCCTGACCAGGATCGAAACCTACAAGCGCGAGGAGATCGCGAGCGCAAAGCGTGCACGTCCCCTCGGCGA
GGTCACGGCCGCCGCGAAGGCCGCCCCGCCGCCGCGCGGTTTTACCGATACCATCCGCGCCAAACTCGCGCGAGGCGATT
ACGCCCTGATCGCCGAGATCAAGAAAGCCTCACCGTCCAAAGGACTGATCCGCGCCGACTTCGATCCGCCGTCGCTCGCC
CGCGCCTATGAGGCCGGCGGCGCGGCCTGCCTCTCCGTTCTGACCGATGCGCCGTCGTTTCAGGGCCATCTCGATTTCAT
GGTCGCCGCCCGCGCCGCGACATCGCTGCCGGTGCTGCGCAAGGACTTCATATTCGACACCTATCAGGTCGTCGAGGCGC
GGGCGCATGGAGCGGACTGCATCCTGATCATCATGGCCGCGCTCGATGATGACGCTGCGAAAGACATCGAGGCGACCGCG
CTCGATCTCGGCATGGATGTGCTGCTCGAAATCCATAACCGCGAGGAACTGGATCGTGCGCTCAAGCTTCGCTCGCCGAT
GATCGGCGTCAACAACCGCAATCTGCGCACCTTCGAGACGACGCTCGAAACCAGCGAAGGCCTGGCGCCGTACATCCCGA
AAGAACGGCTCATGGTCGGCGAAAGCGGTATCTTCACGCCCGCCGATCTCGCGCGGCTCGAACGGGTCGGCATCTCCACT
TTTCTGGTCGGCGAAAGCCTGATGCGGCAAGCCGACGTCACGGCCGCAACGCGCACGCTGCTTAAACATGCGTAG

Upstream 100 bases:

>100_bases
AAGGAGGGTGTCGCGCTTGGGGCGAAATCGCTCGACGGCGGCGGCGCGCTGAACAAGCTGAAGCAATTGATCGCGGTTTC
CAACGGTTGAGGACGATGGC

Downstream 100 bases:

>100_bases
CCTCCGTCTCGCCTCCTTTTCCTCTTGTGGGAGAGGGAAGCAACCAGCCTGGAGCCTTCACTTCCGATGGAATTCCATGA
TTCTAATTTGACGCGTTTTC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MADILTRIETYKREEIASAKRARPLGEVTAAAKAAPPPRGFTDTIRAKLARGDYALIAEIKKASPSKGLIRADFDPPSLA
RAYEAGGAACLSVLTDAPSFQGHLDFMVAARAATSLPVLRKDFIFDTYQVVEARAHGADCILIIMAALDDDAAKDIEATA
LDLGMDVLLEIHNREELDRALKLRSPMIGVNNRNLRTFETTLETSEGLAPYIPKERLMVGESGIFTPADLARLERVGIST
FLVGESLMRQADVTAATRTLLKHA

Sequences:

>Translated_264_residues
MADILTRIETYKREEIASAKRARPLGEVTAAAKAAPPPRGFTDTIRAKLARGDYALIAEIKKASPSKGLIRADFDPPSLA
RAYEAGGAACLSVLTDAPSFQGHLDFMVAARAATSLPVLRKDFIFDTYQVVEARAHGADCILIIMAALDDDAAKDIEATA
LDLGMDVLLEIHNREELDRALKLRSPMIGVNNRNLRTFETTLETSEGLAPYIPKERLMVGESGIFTPADLARLERVGIST
FLVGESLMRQADVTAATRTLLKHA
>Mature_263_residues
ADILTRIETYKREEIASAKRARPLGEVTAAAKAAPPPRGFTDTIRAKLARGDYALIAEIKKASPSKGLIRADFDPPSLAR
AYEAGGAACLSVLTDAPSFQGHLDFMVAARAATSLPVLRKDFIFDTYQVVEARAHGADCILIIMAALDDDAAKDIEATAL
DLGMDVLLEIHNREELDRALKLRSPMIGVNNRNLRTFETTLETSEGLAPYIPKERLMVGESGIFTPADLARLERVGISTF
LVGESLMRQADVTAATRTLLKHA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=261, Percent_Identity=38.3141762452107, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=227, Percent_Identity=38.7665198237885, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_NITWN (Q3SRJ3)

Other databases:

- EMBL:   CP000115
- RefSeq:   YP_318450.1
- HSSP:   Q56319
- ProteinModelPortal:   Q3SRJ3
- SMR:   Q3SRJ3
- STRING:   Q3SRJ3
- GeneID:   3674763
- GenomeReviews:   CP000115_GR
- KEGG:   nwi:Nwi_1838
- NMPDR:   fig|323098.3.peg.1892
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- PhylomeDB:   Q3SRJ3
- ProtClustDB:   PRK00278
- BioCyc:   NWIN323098:NWI_1838-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28634; Mature: 28503

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADILTRIETYKREEIASAKRARPLGEVTAAAKAAPPPRGFTDTIRAKLARGDYALIAEI
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHH
KKASPSKGLIRADFDPPSLARAYEAGGAACLSVLTDAPSFQGHLDFMVAARAATSLPVLR
HHCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
KDFIFDTYQVVEARAHGADCILIIMAALDDDAAKDIEATALDLGMDVLLEIHNREELDRA
HHHHHHHHHHHHHHCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LKLRSPMIGVNNRNLRTFETTLETSEGLAPYIPKERLMVGESGIFTPADLARLERVGIST
HHHCCCEECCCCCCCEEHHHHHHCCCCCCCCCCHHHEEECCCCCCCHHHHHHHHHHCHHH
FLVGESLMRQADVTAATRTLLKHA
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADILTRIETYKREEIASAKRARPLGEVTAAAKAAPPPRGFTDTIRAKLARGDYALIAEI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHH
KKASPSKGLIRADFDPPSLARAYEAGGAACLSVLTDAPSFQGHLDFMVAARAATSLPVLR
HHCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
KDFIFDTYQVVEARAHGADCILIIMAALDDDAAKDIEATALDLGMDVLLEIHNREELDRA
HHHHHHHHHHHHHHCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LKLRSPMIGVNNRNLRTFETTLETSEGLAPYIPKERLMVGESGIFTPADLARLERVGIST
HHHCCCEECCCCCCCEEHHHHHHCCCCCCCCCCHHHEEECCCCCCCHHHHHHHHHHCHHH
FLVGESLMRQADVTAATRTLLKHA
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA