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The map label for this gene is hemH [H]

Identifier: 75675121

GI number: 75675121

Start: 1016317

End: 1017360

Strand: Direct

Name: hemH [H]

Synonym: Nwi_0928

Alternate gene names: 75675121

Gene position: 1016317-1017360 (Clockwise)

Preceding gene: 75675119

Following gene: 75675122

Centisome position: 29.87

GC content: 61.69

Gene sequence:

>1044_bases
ATGGACATGACTGTCGCCATTCCTATCGACAAGGCTGGAACCGCGGCGTGCGCGCCGCGCGAGCGCGTCGGCGTTCTGCT
CGTCAATCTTGGCACCCCGGATACGGCCGATGCTCGCGGCGTGCGGGTGTATCTGAAGGAGTTTCTGTCGGATCCGCGCG
TCATCGAGAAGCAGAGCCTGGGCTGGAAGCTGGTGCTGAACGGCATCATCCTGAACACCCGTCCGCGCCGCAAGGCGCTC
GATTACCTGAAGATCTGGAATACCGAGCTCGACGAGTCACCGCTCAAGACGATCACCCGCTCGCAGTCGGACAAGCTTAC
CGCCGCGCTTGAAGGTCACGACCATGTCGTCGTCGATTGGGCGATGCGCTATGGCAATCCGTCGATGCAATCGCGTATCG
CGGCGATGGCGGCTCAGGGCTGCGACAGGCTGCTGGTGGTGCCGCTCTATCCGCAATACTCTGCGACGACATCCGCCACG
GTATGTGACGAGGCATTTCGCATTCTCAGCGAGATGCGTGCGCAGCCGACGTTGCGGGTGACGCCGCCCTACTACGACGA
TCCCGATTATATCGATGCGCTGGCGGTTTCGATCGAGACTCATCTCGCCTCGCTGTCGTTCACGCCCGAGATCATCATGG
CGTCGTTCCACGGCATGCCGCAGGCCTATGTCGCCAAGGGCGATCCGTATCAGGGGCATTGCGTCGCGACCACCGAGGCG
TTGCGCAAGCGGATGGGGCTTGATGCGTCGAAGCTGATGCTGACGTTCCAGTCGCGCTTCGGCTTCGATGAGTGGTTGCA
GCCCTACACCGACAAGACCGTCGAGAAACTCGCGAAGGACGGCGTGAAGCGTCTCGCTGTCGTCACCCCCGGATTCTCCG
CCGATTGCTTGGAGACGCTGGAGGAAATCGCGCAGGAAAACGCGCATATCTTCCGCCAGAACGGGGGCGAGGAGTTCACC
GCGATACCATGCCTGAACGATAGCGATCCCGGCATGGACGTGATCCGAAAGCTGGTGCTGCGCGAGCTTCAGGGCTGGAT
TTAG

Upstream 100 bases:

>100_bases
ACCATTCAGCGATCGTCATCGCAACTCCCTCAGCCCCCGGTTCGCAAACCTATCGGCAGATGCACGGGCTTGACAAGAAC
GGACCGGCGCGCGAAGCCAG

Downstream 100 bases:

>100_bases
GCGGACTTCCTTTTAGCTATTCTAGAGCATTCGCGCTTTTTGTTGAATCAGAAGCGAAAGCTCCAGGTTTTTGCCAGATT
CTCTGCGCGTTTTGCTTTCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDMTVAIPIDKAGTAACAPRERVGVLLVNLGTPDTADARGVRVYLKEFLSDPRVIEKQSLGWKLVLNGIILNTRPRRKAL
DYLKIWNTELDESPLKTITRSQSDKLTAALEGHDHVVVDWAMRYGNPSMQSRIAAMAAQGCDRLLVVPLYPQYSATTSAT
VCDEAFRILSEMRAQPTLRVTPPYYDDPDYIDALAVSIETHLASLSFTPEIIMASFHGMPQAYVAKGDPYQGHCVATTEA
LRKRMGLDASKLMLTFQSRFGFDEWLQPYTDKTVEKLAKDGVKRLAVVTPGFSADCLETLEEIAQENAHIFRQNGGEEFT
AIPCLNDSDPGMDVIRKLVLRELQGWI

Sequences:

>Translated_347_residues
MDMTVAIPIDKAGTAACAPRERVGVLLVNLGTPDTADARGVRVYLKEFLSDPRVIEKQSLGWKLVLNGIILNTRPRRKAL
DYLKIWNTELDESPLKTITRSQSDKLTAALEGHDHVVVDWAMRYGNPSMQSRIAAMAAQGCDRLLVVPLYPQYSATTSAT
VCDEAFRILSEMRAQPTLRVTPPYYDDPDYIDALAVSIETHLASLSFTPEIIMASFHGMPQAYVAKGDPYQGHCVATTEA
LRKRMGLDASKLMLTFQSRFGFDEWLQPYTDKTVEKLAKDGVKRLAVVTPGFSADCLETLEEIAQENAHIFRQNGGEEFT
AIPCLNDSDPGMDVIRKLVLRELQGWI
>Mature_347_residues
MDMTVAIPIDKAGTAACAPRERVGVLLVNLGTPDTADARGVRVYLKEFLSDPRVIEKQSLGWKLVLNGIILNTRPRRKAL
DYLKIWNTELDESPLKTITRSQSDKLTAALEGHDHVVVDWAMRYGNPSMQSRIAAMAAQGCDRLLVVPLYPQYSATTSAT
VCDEAFRILSEMRAQPTLRVTPPYYDDPDYIDALAVSIETHLASLSFTPEIIMASFHGMPQAYVAKGDPYQGHCVATTEA
LRKRMGLDASKLMLTFQSRFGFDEWLQPYTDKTVEKLAKDGVKRLAVVTPGFSADCLETLEEIAQENAHIFRQNGGEEFT
AIPCLNDSDPGMDVIRKLVLRELQGWI

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=244, Percent_Identity=25.8196721311475, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI60499021, Length=244, Percent_Identity=25.8196721311475, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=41.1949685534591, Blast_Score=239, Evalue=1e-64,
Organism=Drosophila melanogaster, GI17864156, Length=339, Percent_Identity=24.188790560472, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38610; Mature: 38610

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMTVAIPIDKAGTAACAPRERVGVLLVNLGTPDTADARGVRVYLKEFLSDPRVIEKQSL
CCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEHHHCC
GWKLVLNGIILNTRPRRKALDYLKIWNTELDESPLKTITRSQSDKLTAALEGHDHVVVDW
CEEEEEECEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEECCCCEEEEEE
AMRYGNPSMQSRIAAMAAQGCDRLLVVPLYPQYSATTSATVCDEAFRILSEMRAQPTLRV
HHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
TPPYYDDPDYIDALAVSIETHLASLSFTPEIIMASFHGMPQAYVAKGDPYQGHCVATTEA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEECCCCCCCCEEEHHHH
LRKRMGLDASKLMLTFQSRFGFDEWLQPYTDKTVEKLAKDGVKRLAVVTPGFSADCLETL
HHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHH
EEIAQENAHIFRQNGGEEFTAIPCLNDSDPGMDVIRKLVLRELQGWI
HHHHHCCCCEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDMTVAIPIDKAGTAACAPRERVGVLLVNLGTPDTADARGVRVYLKEFLSDPRVIEKQSL
CCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEHHHCC
GWKLVLNGIILNTRPRRKALDYLKIWNTELDESPLKTITRSQSDKLTAALEGHDHVVVDW
CEEEEEECEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEECCCCEEEEEE
AMRYGNPSMQSRIAAMAAQGCDRLLVVPLYPQYSATTSATVCDEAFRILSEMRAQPTLRV
HHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
TPPYYDDPDYIDALAVSIETHLASLSFTPEIIMASFHGMPQAYVAKGDPYQGHCVATTEA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEECCCCCCCCEEEHHHH
LRKRMGLDASKLMLTFQSRFGFDEWLQPYTDKTVEKLAKDGVKRLAVVTPGFSADCLETL
HHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHH
EEIAQENAHIFRQNGGEEFTAIPCLNDSDPGMDVIRKLVLRELQGWI
HHHHHCCCCEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA