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The map label for this gene is dcp [H]

Identifier: 75675119

GI number: 75675119

Start: 1013607

End: 1015685

Strand: Direct

Name: dcp [H]

Synonym: Nwi_0926

Alternate gene names: 75675119

Gene position: 1013607-1015685 (Clockwise)

Preceding gene: 75675113

Following gene: 75675121

Centisome position: 29.79

GC content: 65.46

Gene sequence:

>2079_bases
ATGTCAGACACGTCTCAATCGTCGCCTGTCGTTTCCGGCTCCGGTACGGACAACCCGCTGCTGATGCCGTGGCGGACGCC
TTTCCAGGCCCCGCCGTTCGGGGAGATCGCGCCTGACCACTTCCTGCCCGCCTTTGAGCGAGCGTTCATCGATCATGCCG
CCGAGATCGCCGCCATCGCCCATGATCCGTCGGCGCCGGACTTCGCCAACACCATCACCGCGCTGGAACGCTGCGGCAGG
CTGCTCGCGAAGGTCTCGGCCGTGTTTTACAATCTGGTGTCGGCGCACTCCAATCCGGCGCTGCTCGAGATCGACAAGGA
TGTCTCCTCGCGCATGGCGCGGCACTGGAATCCGATCCTGATGAACGCGGTGTTGTTCGGCCGCGTCGCGCAGCTCCACG
AGAATCGCGCAACGCTCGGACTGACCGCCGAACAGTCCCGGCTGCTGGAACGCACCTACACGCGCTTCCACCGGGCCGGC
GCGGGTCTCGACGAGACCGCGAAGGCGCGGATGGCCACGATCAACGAACGGTTGGCCGATCTCGGCACCACCTTCGGCCA
TCATCTCCTCGGCGACGAGCAGGAGTGGTTCCTCGAACTCGGCGAGGACGACATGGACGGCCTGCCGGACAGCTTCGTTG
CCGCGGCGCGCGCCGCGGCGGAGGAGCGCGCGCTGCCCGGCAAGGCCATCGTGACCACCTCGCGCTCATCAGTGGAGACC
TTTCTCAAGAGCTCGCGCCGCCGCGATCTGCGCGAGAAGGTTTACAAGGCGTTCACCGCCCGCGGCGACAACGGCAACGC
CAACGACAACAACGCGGCCATCGTGGAGATCCTCGCGCTTCGCGAGGAGGCTGCACGGCTTCTGGGCTATCCCGCTTTCG
CCGCCTATCGTCTGGAAGACTCGATGGCCAAGACGCCGGAAGCCGCGCGCGGCCTGCTGGAGCGGGTGTGGACGCCGGCC
CGCGCGCGGGCGCTCGCCGATCGCGATGCCTTGCAGGGGCTGATCGCGGAGGAGGGCGGCAACTTCACCCTCGCGCCCTG
GGACTGGCGCTACTACGCCGAAAAACTGCGGCAGATCCGTGCCGATTTCGACGACGCGGCGATCAAGCCGTATCTGACGC
TGGAGGGGATGATCGCCGCGGCCTTCGACTGCGCGCACCGGCTGTTCGGACTCACCTTCTCCGAGCGCAAGGACATCCCG
GTCTGGCATCCGGACGTCCGCGTCTTTGAGGTGAAGGATGAGGCCGGCGCGCATCGGGCGCTGTTCTACGGCGACTACTT
CGCCCGCGCATCGAAACGGTCCGGCGCATGGATGACCTCGCTGCGCGACCAGCAGACGCTCGACGGTGAGATCGCGCCGC
TGGTCGTGAACGTCTGCAATTTCGCCAAAGGCGCGGACGGCCAGCCCGCGCTGCTGTCTCCGGACGATGCGCGCACGCTG
TTCCATGAGTTCGGACATGGTCTGCACGGCATGCTGTCGAACGTCACCTATCCTTCGTTGTCGGGGACCAGCGTGTTTAC
CGATTTCGTCGAACTGCCCTCGCAACTCTACGAGCACTGGCAGGAACAGCCGCAGGTGCTGCGACAGTTCGCAAGGCACT
ACCAGACCGGAGAACCGCCGCCGGACGATCTGCTGGAGCGTTTCCTTGCGGCGCGACAGTTCAACCAGGGTTTCGCCACC
GTCGAATTCGTCGCTTCGGCGCTGATGGATCTGGAATTTCACAGCCAACCCGCCGCGGCGATCCGCGATGTCAGGGCTTT
CGAACGCGCCACCATGGGAAAGATCGGGATGCCGGCGGAAATCGCGATGCGGCACCGGCCGACTCAGTTCGGCCACATCT
TCTCCGGCGATCACTATGCGGCCGGCTATTACAGCTACATGTGGTCGGAGGTGATGGACGCCGATGCGTTCGGGGCTTTC
GAGGAGACCGGCGATATTTTCGATCCGGAGACCGCAAGGCGGCTGCACGATGATATTTACTCGTCGGGCGGATCGCGCGA
TCCGGAAGAAGCCTACATCGCCTTCCGCGGCCGCGGGCCGAAGCCGGAGGCGCTGTTGCGGCGACGTGGATTGCTATAG

Upstream 100 bases:

>100_bases
CAAGCGTCAAAGGCACCAAAGGGTTCTGTCGCGTGTTATAAGTTCCAGTGCCGCTGGATCGCGGCAAAAATGTGCAGCAG
CGGGCGAAAGCAAAAATATT

Downstream 100 bases:

>100_bases
CGTTTTCGAGCGAAGTGGAAACCGGTTCGCGTGAAGAAACGCGTCAGAACAAGATCATAGAGCCTCGCTTCTGATTCCAT
CAGAAGCGAAAAGGCTCTAG

Product: peptidase M3A and M3B, thimet/oligopeptidase F

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MSDTSQSSPVVSGSGTDNPLLMPWRTPFQAPPFGEIAPDHFLPAFERAFIDHAAEIAAIAHDPSAPDFANTITALERCGR
LLAKVSAVFYNLVSAHSNPALLEIDKDVSSRMARHWNPILMNAVLFGRVAQLHENRATLGLTAEQSRLLERTYTRFHRAG
AGLDETAKARMATINERLADLGTTFGHHLLGDEQEWFLELGEDDMDGLPDSFVAAARAAAEERALPGKAIVTTSRSSVET
FLKSSRRRDLREKVYKAFTARGDNGNANDNNAAIVEILALREEAARLLGYPAFAAYRLEDSMAKTPEAARGLLERVWTPA
RARALADRDALQGLIAEEGGNFTLAPWDWRYYAEKLRQIRADFDDAAIKPYLTLEGMIAAAFDCAHRLFGLTFSERKDIP
VWHPDVRVFEVKDEAGAHRALFYGDYFARASKRSGAWMTSLRDQQTLDGEIAPLVVNVCNFAKGADGQPALLSPDDARTL
FHEFGHGLHGMLSNVTYPSLSGTSVFTDFVELPSQLYEHWQEQPQVLRQFARHYQTGEPPPDDLLERFLAARQFNQGFAT
VEFVASALMDLEFHSQPAAAIRDVRAFERATMGKIGMPAEIAMRHRPTQFGHIFSGDHYAAGYYSYMWSEVMDADAFGAF
EETGDIFDPETARRLHDDIYSSGGSRDPEEAYIAFRGRGPKPEALLRRRGLL

Sequences:

>Translated_692_residues
MSDTSQSSPVVSGSGTDNPLLMPWRTPFQAPPFGEIAPDHFLPAFERAFIDHAAEIAAIAHDPSAPDFANTITALERCGR
LLAKVSAVFYNLVSAHSNPALLEIDKDVSSRMARHWNPILMNAVLFGRVAQLHENRATLGLTAEQSRLLERTYTRFHRAG
AGLDETAKARMATINERLADLGTTFGHHLLGDEQEWFLELGEDDMDGLPDSFVAAARAAAEERALPGKAIVTTSRSSVET
FLKSSRRRDLREKVYKAFTARGDNGNANDNNAAIVEILALREEAARLLGYPAFAAYRLEDSMAKTPEAARGLLERVWTPA
RARALADRDALQGLIAEEGGNFTLAPWDWRYYAEKLRQIRADFDDAAIKPYLTLEGMIAAAFDCAHRLFGLTFSERKDIP
VWHPDVRVFEVKDEAGAHRALFYGDYFARASKRSGAWMTSLRDQQTLDGEIAPLVVNVCNFAKGADGQPALLSPDDARTL
FHEFGHGLHGMLSNVTYPSLSGTSVFTDFVELPSQLYEHWQEQPQVLRQFARHYQTGEPPPDDLLERFLAARQFNQGFAT
VEFVASALMDLEFHSQPAAAIRDVRAFERATMGKIGMPAEIAMRHRPTQFGHIFSGDHYAAGYYSYMWSEVMDADAFGAF
EETGDIFDPETARRLHDDIYSSGGSRDPEEAYIAFRGRGPKPEALLRRRGLL
>Mature_691_residues
SDTSQSSPVVSGSGTDNPLLMPWRTPFQAPPFGEIAPDHFLPAFERAFIDHAAEIAAIAHDPSAPDFANTITALERCGRL
LAKVSAVFYNLVSAHSNPALLEIDKDVSSRMARHWNPILMNAVLFGRVAQLHENRATLGLTAEQSRLLERTYTRFHRAGA
GLDETAKARMATINERLADLGTTFGHHLLGDEQEWFLELGEDDMDGLPDSFVAAARAAAEERALPGKAIVTTSRSSVETF
LKSSRRRDLREKVYKAFTARGDNGNANDNNAAIVEILALREEAARLLGYPAFAAYRLEDSMAKTPEAARGLLERVWTPAR
ARALADRDALQGLIAEEGGNFTLAPWDWRYYAEKLRQIRADFDDAAIKPYLTLEGMIAAAFDCAHRLFGLTFSERKDIPV
WHPDVRVFEVKDEAGAHRALFYGDYFARASKRSGAWMTSLRDQQTLDGEIAPLVVNVCNFAKGADGQPALLSPDDARTLF
HEFGHGLHGMLSNVTYPSLSGTSVFTDFVELPSQLYEHWQEQPQVLRQFARHYQTGEPPPDDLLERFLAARQFNQGFATV
EFVASALMDLEFHSQPAAAIRDVRAFERATMGKIGMPAEIAMRHRPTQFGHIFSGDHYAAGYYSYMWSEVMDADAFGAFE
ETGDIFDPETARRLHDDIYSSGGSRDPEEAYIAFRGRGPKPEALLRRRGLL

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI14149738, Length=637, Percent_Identity=28.2574568288854, Blast_Score=236, Evalue=8e-62,
Organism=Homo sapiens, GI4507491, Length=582, Percent_Identity=30.4123711340206, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI156105687, Length=641, Percent_Identity=25.7410296411856, Blast_Score=177, Evalue=4e-44,
Organism=Escherichia coli, GI1787819, Length=681, Percent_Identity=41.2628487518355, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=33.9650145772595, Blast_Score=364, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI32565901, Length=589, Percent_Identity=24.4482173174873, Blast_Score=96, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319793, Length=618, Percent_Identity=26.8608414239482, Blast_Score=197, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6322715, Length=705, Percent_Identity=22.5531914893617, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI21356111, Length=491, Percent_Identity=26.4765784114053, Blast_Score=172, Evalue=9e-43,
Organism=Drosophila melanogaster, GI20129717, Length=554, Percent_Identity=25.812274368231, Blast_Score=149, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 76993; Mature: 76862

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTSQSSPVVSGSGTDNPLLMPWRTPFQAPPFGEIAPDHFLPAFERAFIDHAAEIAAIA
CCCCCCCCCEEECCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HDPSAPDFANTITALERCGRLLAKVSAVFYNLVSAHSNPALLEIDKDVSSRMARHWNPIL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHCCHHH
MNAVLFGRVAQLHENRATLGLTAEQSRLLERTYTRFHRAGAGLDETAKARMATINERLAD
HHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LGTTFGHHLLGDEQEWFLELGEDDMDGLPDSFVAAARAAAEERALPGKAIVTTSRSSVET
HHHHHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHH
FLKSSRRRDLREKVYKAFTARGDNGNANDNNAAIVEILALREEAARLLGYPAFAAYRLED
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SMAKTPEAARGLLERVWTPARARALADRDALQGLIAEEGGNFTLAPWDWRYYAEKLRQIR
HHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHH
ADFDDAAIKPYLTLEGMIAAAFDCAHRLFGLTFSERKDIPVWHPDVRVFEVKDEAGAHRA
HCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCEEEEECCCCCCCCE
LFYGDYFARASKRSGAWMTSLRDQQTLDGEIAPLVVNVCNFAKGADGQPALLSPDDARTL
EEEHHHHHHHCCCCCCHHHHHCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
FHEFGHGLHGMLSNVTYPSLSGTSVFTDFVELPSQLYEHWQEQPQVLRQFARHYQTGEPP
HHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PDDLLERFLAARQFNQGFATVEFVASALMDLEFHSQPAAAIRDVRAFERATMGKIGMPAE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHH
IAMRHRPTQFGHIFSGDHYAAGYYSYMWSEVMDADAFGAFEETGDIFDPETARRLHDDIY
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHH
SSGGSRDPEEAYIAFRGRGPKPEALLRRRGLL
HCCCCCCCHHCEEEEECCCCCHHHHHHHCCCC
>Mature Secondary Structure 
SDTSQSSPVVSGSGTDNPLLMPWRTPFQAPPFGEIAPDHFLPAFERAFIDHAAEIAAIA
CCCCCCCCEEECCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HDPSAPDFANTITALERCGRLLAKVSAVFYNLVSAHSNPALLEIDKDVSSRMARHWNPIL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHCCHHH
MNAVLFGRVAQLHENRATLGLTAEQSRLLERTYTRFHRAGAGLDETAKARMATINERLAD
HHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LGTTFGHHLLGDEQEWFLELGEDDMDGLPDSFVAAARAAAEERALPGKAIVTTSRSSVET
HHHHHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHH
FLKSSRRRDLREKVYKAFTARGDNGNANDNNAAIVEILALREEAARLLGYPAFAAYRLED
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SMAKTPEAARGLLERVWTPARARALADRDALQGLIAEEGGNFTLAPWDWRYYAEKLRQIR
HHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHH
ADFDDAAIKPYLTLEGMIAAAFDCAHRLFGLTFSERKDIPVWHPDVRVFEVKDEAGAHRA
HCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCEEEEECCCCCCCCE
LFYGDYFARASKRSGAWMTSLRDQQTLDGEIAPLVVNVCNFAKGADGQPALLSPDDARTL
EEEHHHHHHHCCCCCCHHHHHCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
FHEFGHGLHGMLSNVTYPSLSGTSVFTDFVELPSQLYEHWQEQPQVLRQFARHYQTGEPP
HHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PDDLLERFLAARQFNQGFATVEFVASALMDLEFHSQPAAAIRDVRAFERATMGKIGMPAE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHH
IAMRHRPTQFGHIFSGDHYAAGYYSYMWSEVMDADAFGAFEETGDIFDPETARRLHDDIY
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHH
SSGGSRDPEEAYIAFRGRGPKPEALLRRRGLL
HCCCCCCCHHCEEEEECCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]