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The map label for this gene is pyrC' [H]

Identifier: 74318601

GI number: 74318601

Start: 2657951

End: 2659225

Strand: Direct

Name: pyrC' [H]

Synonym: Tbd_2583

Alternate gene names: 74318601

Gene position: 2657951-2659225 (Clockwise)

Preceding gene: 74318600

Following gene: 74318602

Centisome position: 91.34

GC content: 67.84

Gene sequence:

>1275_bases
ATGAAGATACATATCAAGAACGGCCGCGTCATCGACCCGGCGAGCGGTCGCGACGAAATCGCCGATCTGTTCATCGCCGC
GGGCAGGATCGTCACGAGCGACGCCCCGACCTTCCATGCCAACCGGACGATCGATGCGAGCGGACTCGTCGTCTGCCCAG
GTCTCGTCGACCTCTCGGTGCGCCTGCGCGAACCGGGCTTCGAGTACAAGGCGACGCTCGAATCGGAAATGCTTGCGGCC
GCGGCCGGCGGCGTCACCTCGCTCGCCTGTCCGCCCGACACCGACCCACCGCTCGACGAACCGGGCCTCGTCGAAATGCT
CAAATTCCGCGCGAAGAACCTGCCCGGTCCGCGGGTCTATCCGGTCGGCGCGCTGACGCAGAAGCTCGAAGGCAAGATGC
TCACCGAAATGGCCGAGCTGACCGAGGCCGGATGCCGCGCCTTCACCCAGGCCGACGCGCCCCTGACCGACACGCTGGTG
CTACTGCGCGCAATGGAATACGCGGCGACCTTCGGCTTCCGGTTGTGGTTGCGGGCGCAGGACGTCACGCTCGCACGCGG
CGGTATCGCCCACGATGGCGCCATCGCCTCGCGCCTCGGCCTGCCGGGGATTCCGGCGCTCGCAGAGACCGTCGCCCTCG
CGACCATCCTGCAGCTGATGCGCGAGACCGGCGCCCGCGTCCACCTCGCGCGCCTGTCGACCCGCGAGGGAATCGCGATG
GTGCAGGCCGCGAAGGCGCAAGGTCTCGCGGTGACCTGCGACGTCGCCACGACCCACGTGCACCTGTCCGAGAACGACCT
GGTCGGCTTCGACTCGCACCTGCATCTCGTGCCGCCGCTCAGGAGCTTGCGCGACCGCGACGCGATTCGCGAGGCACTGC
GCGACGGCGCGGTCGACGCGCTGTGCTCCGACCACACCCCGGTCGACGAGGACGAAAAGCAGGTGCCGTTCGGCGAATCA
TCGCCCGGCGCCTCGGGCGTCGAGCTGCTCTTGCCGCTGACCTTGAAATGGGCGCGCGAGATGAACGTGCCGCTGCCGCG
CGCACTCGCGCTGATCACGTGTGAGCCCGCGCGGATTCTCGACATCCCGGCGGGTGAACTCGCCGCGGGTGCCAACGCCG
ACGTCTGCATTTTCGACGCGCAGGCGGAATGGGTCGTGACCTCGAAAAGTCTTGCGAGCCAGGGCGACAACACGCCCTTC
CTCAACCACCCGATGCAAGGGCGCGTGCGCTATACCCTGATCGACGGACATATCGATTTTGAGTCGGCGCGCTGA

Upstream 100 bases:

>100_bases
ATGGCGCTGCTCGCCGGGGGAGCCTCGACTTGAAGCGGGCACTGCCCGCGCCGAACCGCGCGCTGCCGACATCACGCAGC
CGCCTTTGACCCAAACGCCC

Downstream 100 bases:

>100_bases
GGTCTTCGCCGGCACCGCGCCCGCCCTCCCGCGCCGCCTGCCGTTCGCGCAACTGCTGATCCCGCTTATCGCCGGCGTGG
CGGCAGTCGCGGGTTTTGCG

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKIHIKNGRVIDPASGRDEIADLFIAAGRIVTSDAPTFHANRTIDASGLVVCPGLVDLSVRLREPGFEYKATLESEMLAA
AAGGVTSLACPPDTDPPLDEPGLVEMLKFRAKNLPGPRVYPVGALTQKLEGKMLTEMAELTEAGCRAFTQADAPLTDTLV
LLRAMEYAATFGFRLWLRAQDVTLARGGIAHDGAIASRLGLPGIPALAETVALATILQLMRETGARVHLARLSTREGIAM
VQAAKAQGLAVTCDVATTHVHLSENDLVGFDSHLHLVPPLRSLRDRDAIREALRDGAVDALCSDHTPVDEDEKQVPFGES
SPGASGVELLLPLTLKWAREMNVPLPRALALITCEPARILDIPAGELAAGANADVCIFDAQAEWVVTSKSLASQGDNTPF
LNHPMQGRVRYTLIDGHIDFESAR

Sequences:

>Translated_424_residues
MKIHIKNGRVIDPASGRDEIADLFIAAGRIVTSDAPTFHANRTIDASGLVVCPGLVDLSVRLREPGFEYKATLESEMLAA
AAGGVTSLACPPDTDPPLDEPGLVEMLKFRAKNLPGPRVYPVGALTQKLEGKMLTEMAELTEAGCRAFTQADAPLTDTLV
LLRAMEYAATFGFRLWLRAQDVTLARGGIAHDGAIASRLGLPGIPALAETVALATILQLMRETGARVHLARLSTREGIAM
VQAAKAQGLAVTCDVATTHVHLSENDLVGFDSHLHLVPPLRSLRDRDAIREALRDGAVDALCSDHTPVDEDEKQVPFGES
SPGASGVELLLPLTLKWAREMNVPLPRALALITCEPARILDIPAGELAAGANADVCIFDAQAEWVVTSKSLASQGDNTPF
LNHPMQGRVRYTLIDGHIDFESAR
>Mature_424_residues
MKIHIKNGRVIDPASGRDEIADLFIAAGRIVTSDAPTFHANRTIDASGLVVCPGLVDLSVRLREPGFEYKATLESEMLAA
AAGGVTSLACPPDTDPPLDEPGLVEMLKFRAKNLPGPRVYPVGALTQKLEGKMLTEMAELTEAGCRAFTQADAPLTDTLV
LLRAMEYAATFGFRLWLRAQDVTLARGGIAHDGAIASRLGLPGIPALAETVALATILQLMRETGARVHLARLSTREGIAM
VQAAKAQGLAVTCDVATTHVHLSENDLVGFDSHLHLVPPLRSLRDRDAIREALRDGAVDALCSDHTPVDEDEKQVPFGES
SPGASGVELLLPLTLKWAREMNVPLPRALALITCEPARILDIPAGELAAGANADVCIFDAQAEWVVTSKSLASQGDNTPF
LNHPMQGRVRYTLIDGHIDFESAR

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=410, Percent_Identity=29.7560975609756, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786722, Length=440, Percent_Identity=24.5454545454545, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082175, Length=440, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193204318, Length=378, Percent_Identity=28.3068783068783, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=409, Percent_Identity=23.2273838630807, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24642586, Length=411, Percent_Identity=24.8175182481752, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI18859883, Length=204, Percent_Identity=24.5098039215686, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.3

Molecular weight: Translated: 45344; Mature: 45344

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHIKNGRVIDPASGRDEIADLFIAAGRIVTSDAPTFHANRTIDASGLVVCPGLVDLSV
CEEEECCCCEECCCCCHHHHHHHHHHCCEEEECCCCCEECCCEECCCCCEEECCCEEEEE
RLREPGFEYKATLESEMLAAAAGGVTSLACPPDTDPPLDEPGLVEMLKFRAKNLPGPRVY
EECCCCCCEEHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
PVGALTQKLEGKMLTEMAELTEAGCRAFTQADAPLTDTLVLLRAMEYAATFGFRLWLRAQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEC
DVTLARGGIAHDGAIASRLGLPGIPALAETVALATILQLMRETGARVHLARLSTREGIAM
CEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
VQAAKAQGLAVTCDVATTHVHLSENDLVGFDSHLHLVPPLRSLRDRDAIREALRDGAVDA
HHHHCCCCEEEEEEEEEEEEEECCCCEECCCCCEEECCCHHHHHHHHHHHHHHHCCCHHH
LCSDHTPVDEDEKQVPFGESSPGASGVELLLPLTLKWAREMNVPLPRALALITCEPARIL
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEEECCCEEE
DIPAGELAAGANADVCIFDAQAEWVVTSKSLASQGDNTPFLNHPMQGRVRYTLIDGHIDF
ECCCCHHCCCCCCCEEEEECCCCEEEECHHHHHCCCCCCCCCCCCCCCEEEEEEECEECC
ESAR
CCCC
>Mature Secondary Structure
MKIHIKNGRVIDPASGRDEIADLFIAAGRIVTSDAPTFHANRTIDASGLVVCPGLVDLSV
CEEEECCCCEECCCCCHHHHHHHHHHCCEEEECCCCCEECCCEECCCCCEEECCCEEEEE
RLREPGFEYKATLESEMLAAAAGGVTSLACPPDTDPPLDEPGLVEMLKFRAKNLPGPRVY
EECCCCCCEEHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
PVGALTQKLEGKMLTEMAELTEAGCRAFTQADAPLTDTLVLLRAMEYAATFGFRLWLRAQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEC
DVTLARGGIAHDGAIASRLGLPGIPALAETVALATILQLMRETGARVHLARLSTREGIAM
CEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
VQAAKAQGLAVTCDVATTHVHLSENDLVGFDSHLHLVPPLRSLRDRDAIREALRDGAVDA
HHHHCCCCEEEEEEEEEEEEEECCCCEECCCCCEEECCCHHHHHHHHHHHHHHHCCCHHH
LCSDHTPVDEDEKQVPFGESSPGASGVELLLPLTLKWAREMNVPLPRALALITCEPARIL
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEEECCCEEE
DIPAGELAAGANADVCIFDAQAEWVVTSKSLASQGDNTPFLNHPMQGRVRYTLIDGHIDF
ECCCCHHCCCCCCCEEEEECCCCEEEECHHHHHCCCCCCCCCCCCCCCEEEEEEECEECC
ESAR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]