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The map label for this gene is hmeD [H]

Identifier: 74318496

GI number: 74318496

Start: 2554622

End: 2556145

Strand: Reverse

Name: hmeD [H]

Synonym: Tbd_2478

Alternate gene names: 74318496

Gene position: 2556145-2554622 (Counterclockwise)

Preceding gene: 74318497

Following gene: 74318495

Centisome position: 87.85

GC content: 62.14

Gene sequence:

>1524_bases
GTGGCGGCTGCTGAATTTGACGTTCCGGAACTGAAGGACGACATCGAAGTTCCCAAGATAAGGGAAGGCTCGATGGCGCA
CGCCAAGTCGTTCCTCGCGCCGAAGCCCGTTCAGGATTTCATGGGTTACCCCCACGAACTGAGCGAAGACTGGAAAGAGC
GCGCCATCGACAAGATGGGCGACCTGCTGGGCAAATACCGCTCGCTCAAGGTGTTCCTCGACGCCTGCGTCCACTGCGGC
GCTTGCACCGACAAATGCCACTACTATCTCGGCACGTCGGACCCGAAGAACATGCCGGTCGCGCGCCAGGATCTGATGCG
TCAGGTCTACCGTCGCTATTTCACGACCCCGGGCAAGCTGTTCCCGAAGCTGGTCGGCGCCAAGGATCTGACCAAGGAGA
CGCTGGACGACTGGTACAGCTACTACCACCAGTGTTCCGAGTGCCGTCGCTGCTCGGTGTTCTGCCCGTACGGCATCGAC
ACCGCCGAGATCACGATGGCCGGCCGCGAGATCCTCAACCACGTCGGCATGGGTCAGAAGTACTCGAACGAAATCCTCGG
CAAGGTGCAGAAGATCGGCAACAACCTCGGCCTGCCCGGCCCCGCGCTGGAAGACACGCTCGAAGGTCTGGAAGAGGACA
TCGAGGCCGACACCGGCGTGCCGGTGAAGCTGCCGATCGACGTGCAGGGCGCCGAAGTGCTGTTGGTCACGCCGTCTGCC
GACTTCTTCTCCGAGCCGCACGTCGAGTCGCTGATCGGTTACGCCAAGGTGTTCCACGCCGCCGGCATCAGCTGGACGCT
GTCGTCGCACGCGTCGGAAGCCGGTAACTTCGGCCTCTTCAACGGCAACTACGAGACCATGCGCAAGGTCGCGATGCGCA
TCCGCGACGCCGCGCTCGAACTCGGCGTCAAGCGTATCGTCGTCGGCGAATGCGGCCACGCCTGGCGCGTCGCGTACAGC
TTCTGGAACACGCTGACCGGCATCGGCTACGGCGGCAACGATCCGTTCTCGATCGAACTGCAGAAGCAGCTCGACCCGAA
CTACCCGCAGCCGCAGCACATCTGCGAACTGACCAACGATCTGATCAAGCAGGGCAAGATCGCGGTCGACCCCTCGGCGA
ACGACGATCTCGTCGTGACCTATCACGATTCGTGCAACGTCGCGCGTGCGTCGCGCATGGGCGACGAGCCCGGCGGGCAG
TTCGCGATCCCGCGCGAACTGATCCAATCGGTGGCGAACAACTTCCACAACATGGCCGAGGAGACGATCTACGAATCGAC
CTTCTGCTGTGGCGGCGGCGGCGGCCTGCTGACCGACGATCTGATGGAAGTCCGCGTCAAGGGCGCCATGCCGCGCATGA
CGGCGTTGAACAACGTGGTGAAGGAACACCAGGTGAACTTCATGGCGACCATCTGCGCGATCTGCAAGGCGCAATTCACC
AAGGTTCTGCCCAAGTACGGCTTCGATATGAGCATGGTGGGCGGGGTGCATCAATTGGTCAGCAAGGCGATCAAGCTCGA
CTGA

Upstream 100 bases:

>100_bases
CGAACGTCGCCACGTCGCGGCCTGGGCTGCGAGGCTGGATCAAGGCAATTGAGTCGTCGAGCGATCGACGCGCATTTAAG
CAAGGACAAAGGACTCTCAC

Downstream 100 bases:

>100_bases
CCATATTTGACAACTTATTCAATTCGTAGGCGTTAGGAGAACCAACATGGCTGTCACGACGAACAAAGCAGCAAAGACCG
AAGGCATGACGTGGCGTCGC

Product: reductase, iron-sulfur binding subunit

Products: NA

Alternate protein names: Hme subunit D [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MAAAEFDVPELKDDIEVPKIREGSMAHAKSFLAPKPVQDFMGYPHELSEDWKERAIDKMGDLLGKYRSLKVFLDACVHCG
ACTDKCHYYLGTSDPKNMPVARQDLMRQVYRRYFTTPGKLFPKLVGAKDLTKETLDDWYSYYHQCSECRRCSVFCPYGID
TAEITMAGREILNHVGMGQKYSNEILGKVQKIGNNLGLPGPALEDTLEGLEEDIEADTGVPVKLPIDVQGAEVLLVTPSA
DFFSEPHVESLIGYAKVFHAAGISWTLSSHASEAGNFGLFNGNYETMRKVAMRIRDAALELGVKRIVVGECGHAWRVAYS
FWNTLTGIGYGGNDPFSIELQKQLDPNYPQPQHICELTNDLIKQGKIAVDPSANDDLVVTYHDSCNVARASRMGDEPGGQ
FAIPRELIQSVANNFHNMAEETIYESTFCCGGGGGLLTDDLMEVRVKGAMPRMTALNNVVKEHQVNFMATICAICKAQFT
KVLPKYGFDMSMVGGVHQLVSKAIKLD

Sequences:

>Translated_507_residues
MAAAEFDVPELKDDIEVPKIREGSMAHAKSFLAPKPVQDFMGYPHELSEDWKERAIDKMGDLLGKYRSLKVFLDACVHCG
ACTDKCHYYLGTSDPKNMPVARQDLMRQVYRRYFTTPGKLFPKLVGAKDLTKETLDDWYSYYHQCSECRRCSVFCPYGID
TAEITMAGREILNHVGMGQKYSNEILGKVQKIGNNLGLPGPALEDTLEGLEEDIEADTGVPVKLPIDVQGAEVLLVTPSA
DFFSEPHVESLIGYAKVFHAAGISWTLSSHASEAGNFGLFNGNYETMRKVAMRIRDAALELGVKRIVVGECGHAWRVAYS
FWNTLTGIGYGGNDPFSIELQKQLDPNYPQPQHICELTNDLIKQGKIAVDPSANDDLVVTYHDSCNVARASRMGDEPGGQ
FAIPRELIQSVANNFHNMAEETIYESTFCCGGGGGLLTDDLMEVRVKGAMPRMTALNNVVKEHQVNFMATICAICKAQFT
KVLPKYGFDMSMVGGVHQLVSKAIKLD
>Mature_506_residues
AAAEFDVPELKDDIEVPKIREGSMAHAKSFLAPKPVQDFMGYPHELSEDWKERAIDKMGDLLGKYRSLKVFLDACVHCGA
CTDKCHYYLGTSDPKNMPVARQDLMRQVYRRYFTTPGKLFPKLVGAKDLTKETLDDWYSYYHQCSECRRCSVFCPYGIDT
AEITMAGREILNHVGMGQKYSNEILGKVQKIGNNLGLPGPALEDTLEGLEEDIEADTGVPVKLPIDVQGAEVLLVTPSAD
FFSEPHVESLIGYAKVFHAAGISWTLSSHASEAGNFGLFNGNYETMRKVAMRIRDAALELGVKRIVVGECGHAWRVAYSF
WNTLTGIGYGGNDPFSIELQKQLDPNYPQPQHICELTNDLIKQGKIAVDPSANDDLVVTYHDSCNVARASRMGDEPGGQF
AIPRELIQSVANNFHNMAEETIYESTFCCGGGGGLLTDDLMEVRVKGAMPRMTALNNVVKEHQVNFMATICAICKAQFTK
VLPKYGFDMSMVGGVHQLVSKAIKLD

Specific function: Has menaquinol-oxidizing activity. The hmeC and hmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane [H]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR009051 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 56109; Mature: 55978

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAEFDVPELKDDIEVPKIREGSMAHAKSFLAPKPVQDFMGYPHELSEDWKERAIDKMG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
DLLGKYRSLKVFLDACVHCGACTDKCHYYLGTSDPKNMPVARQDLMRQVYRRYFTTPGKL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
FPKLVGAKDLTKETLDDWYSYYHQCSECRRCSVFCPYGIDTAEITMAGREILNHVGMGQK
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCH
YSNEILGKVQKIGNNLGLPGPALEDTLEGLEEDIEADTGVPVKLPIDVQGAEVLLVTPSA
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCH
DFFSEPHVESLIGYAKVFHAAGISWTLSSHASEAGNFGLFNGNYETMRKVAMRIRDAALE
HHCCCCCHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHH
LGVKRIVVGECGHAWRVAYSFWNTLTGIGYGGNDPFSIELQKQLDPNYPQPQHICELTND
HHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHH
LIKQGKIAVDPSANDDLVVTYHDSCNVARASRMGDEPGGQFAIPRELIQSVANNFHNMAE
HHHCCCEEECCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ETIYESTFCCGGGGGLLTDDLMEVRVKGAMPRMTALNNVVKEHQVNFMATICAICKAQFT
HHHHHHCCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVLPKYGFDMSMVGGVHQLVSKAIKLD
HHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAAEFDVPELKDDIEVPKIREGSMAHAKSFLAPKPVQDFMGYPHELSEDWKERAIDKMG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
DLLGKYRSLKVFLDACVHCGACTDKCHYYLGTSDPKNMPVARQDLMRQVYRRYFTTPGKL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
FPKLVGAKDLTKETLDDWYSYYHQCSECRRCSVFCPYGIDTAEITMAGREILNHVGMGQK
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCH
YSNEILGKVQKIGNNLGLPGPALEDTLEGLEEDIEADTGVPVKLPIDVQGAEVLLVTPSA
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCH
DFFSEPHVESLIGYAKVFHAAGISWTLSSHASEAGNFGLFNGNYETMRKVAMRIRDAALE
HHCCCCCHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHH
LGVKRIVVGECGHAWRVAYSFWNTLTGIGYGGNDPFSIELQKQLDPNYPQPQHICELTND
HHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHH
LIKQGKIAVDPSANDDLVVTYHDSCNVARASRMGDEPGGQFAIPRELIQSVANNFHNMAE
HHHCCCEEECCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ETIYESTFCCGGGGGLLTDDLMEVRVKGAMPRMTALNNVVKEHQVNFMATICAICKAQFT
HHHHHHCCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVLPKYGFDMSMVGGVHQLVSKAIKLD
HHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA