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The map label for this gene is gcp

Identifier: 74318402

GI number: 74318402

Start: 2456410

End: 2457435

Strand: Reverse

Name: gcp

Synonym: Tbd_2384

Alternate gene names: 74318402

Gene position: 2457435-2456410 (Counterclockwise)

Preceding gene: 74318408

Following gene: 74318399

Centisome position: 84.45

GC content: 68.13

Gene sequence:

>1026_bases
ATGTTAGTGCTCGGTATCGAATCTTCCTGCGACGAAACCGGTGTCGCGCTGTACGACAGCGCAGAGGGCCTCGTGGCGCA
CGCCTTACATTCGCAGATCGCGATGCACAACGCGTACGGCGGTGTCGTGCCCGAGCTCGCCTCGCGTGACCATATTCGAC
GGATTCTGCCGCTGACCCGCCAGGTGTTCGAGGAAAGCGGCCGCCTGCTTTCCGAACTCGGCGGCGTCGCCTTCACGCAG
GGGCCAGGCCTGGCCGGTGCGCTCCTCGTCGGCGCTGGAATGGGCCGGGCGTTGGCGTTTGCCCTCCGCGTGCCGGCGAT
CGGCGTCCATCATCTCGAGGGGCATCTGTTGTCGCCGCTCATTTCCGATACGCCGCCGGCGTTCCCGTTCGTCGCCTTGC
TGGTATCGGGTGGCCACACCCAACTGATGCTCGTTTCGGCGGTGGGGCAATACACGCTCCTTGGCGAGACGCTCGACGAC
GCCGCGGGCGAAGCCTTCGACAAGACGGCGCAATTGCTCGGGCTCGGATACCCGGGGGGACCGGCTTTGTCGCGCCTCGC
GGCGGCGGGCGACGCAACGCGCTTCGCGCTGCCGCGGCCGATGCTCAATTCGGGGGACTTCGATTTCAGCTTCAGCGGCT
TGAAGACCGCAGTGCTGACGCTCGTGCGCAAACAGGGCCTGGGACAGGCGGCCGACATCGCCGCTGCGTTCGAAGCCGCC
GCGGTCGATGTGCTGGTCGGCAAAAGTCTTGCGGCGTGTCGGCACGCCGCGGCGAACCGTCTCGTCGTCGCCGGCGGCGT
CGGCGCCAACGCGCGGCTGCGCGAGCGGCTTACCGCCGAGGGCGGCCGCGCCGGCGTCAGCGTGTTCTATCCGTCGCTCG
AATTCTGCACCGACAACGGCGCAATGATCGCGTTCGCCGGGGCTCAGCGCCTGGCATCCGTGGCAGATCGTGTGGCGCGC
GCGTCAGACCTCGACTTCGCGGTCAAGCCGCGCTGGGCACTGGCTTCGCTTGGCCCGGTCGAGTGA

Upstream 100 bases:

>100_bases
GGGCATTGGAAGATGGGCTTTCTGGAAAGCTTCCTGTGAACTGGAAAAACAAGAATAATAACAAGCCCGCTGGGATTTTT
CCAGCCCAGTCCGTCTCCCT

Downstream 100 bases:

>100_bases
CCGTGCGCCGCCAACCGGCAGTCACGGGCGCAACGCAGGGTAGGCGTTGCGCAAGGCCCGGAGCCATTTCTCGCTGCCGG
TGAGTGCCGCGATCTGATCC

Product: o-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MLVLGIESSCDETGVALYDSAEGLVAHALHSQIAMHNAYGGVVPELASRDHIRRILPLTRQVFEESGRLLSELGGVAFTQ
GPGLAGALLVGAGMGRALAFALRVPAIGVHHLEGHLLSPLISDTPPAFPFVALLVSGGHTQLMLVSAVGQYTLLGETLDD
AAGEAFDKTAQLLGLGYPGGPALSRLAAAGDATRFALPRPMLNSGDFDFSFSGLKTAVLTLVRKQGLGQAADIAAAFEAA
AVDVLVGKSLAACRHAAANRLVVAGGVGANARLRERLTAEGGRAGVSVFYPSLEFCTDNGAMIAFAGAQRLASVADRVAR
ASDLDFAVKPRWALASLGPVE

Sequences:

>Translated_341_residues
MLVLGIESSCDETGVALYDSAEGLVAHALHSQIAMHNAYGGVVPELASRDHIRRILPLTRQVFEESGRLLSELGGVAFTQ
GPGLAGALLVGAGMGRALAFALRVPAIGVHHLEGHLLSPLISDTPPAFPFVALLVSGGHTQLMLVSAVGQYTLLGETLDD
AAGEAFDKTAQLLGLGYPGGPALSRLAAAGDATRFALPRPMLNSGDFDFSFSGLKTAVLTLVRKQGLGQAADIAAAFEAA
AVDVLVGKSLAACRHAAANRLVVAGGVGANARLRERLTAEGGRAGVSVFYPSLEFCTDNGAMIAFAGAQRLASVADRVAR
ASDLDFAVKPRWALASLGPVE
>Mature_341_residues
MLVLGIESSCDETGVALYDSAEGLVAHALHSQIAMHNAYGGVVPELASRDHIRRILPLTRQVFEESGRLLSELGGVAFTQ
GPGLAGALLVGAGMGRALAFALRVPAIGVHHLEGHLLSPLISDTPPAFPFVALLVSGGHTQLMLVSAVGQYTLLGETLDD
AAGEAFDKTAQLLGLGYPGGPALSRLAAAGDATRFALPRPMLNSGDFDFSFSGLKTAVLTLVRKQGLGQAADIAAAFEAA
AVDVLVGKSLAACRHAAANRLVVAGGVGANARLRERLTAEGGRAGVSVFYPSLEFCTDNGAMIAFAGAQRLASVADRVAR
ASDLDFAVKPRWALASLGPVE

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=335, Percent_Identity=35.2238805970149, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI8923380, Length=312, Percent_Identity=29.1666666666667, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1789445, Length=339, Percent_Identity=57.8171091445428, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17557464, Length=322, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71995670, Length=332, Percent_Identity=31.3253012048193, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320099, Length=377, Percent_Identity=31.8302387267904, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322891, Length=291, Percent_Identity=27.8350515463918, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20129063, Length=338, Percent_Identity=33.1360946745562, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI21357207, Length=325, Percent_Identity=30.1538461538462, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_THIDA (Q3SGB3)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_316142.1
- ProteinModelPortal:   Q3SGB3
- SMR:   Q3SGB3
- STRING:   Q3SGB3
- MEROPS:   M22.001
- GeneID:   3673551
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2384
- NMPDR:   fig|292415.3.peg.2457
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q3SGB3
- BioCyc:   TDEN292415:TBD_2384-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 35099; Mature: 35099

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLGIESSCDETGVALYDSAEGLVAHALHSQIAMHNAYGGVVPELASRDHIRRILPLTR
CEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
QVFEESGRLLSELGGVAFTQGPGLAGALLVGAGMGRALAFALRVPAIGVHHLEGHLLSPL
HHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCHHHHHH
ISDTPPAFPFVALLVSGGHTQLMLVSAVGQYTLLGETLDDAAGEAFDKTAQLLGLGYPGG
HCCCCCHHHHHHHHHCCCCCEEEEEEHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCC
PALSRLAAAGDATRFALPRPMLNSGDFDFSFSGLKTAVLTLVRKQGLGQAADIAAAFEAA
HHHHHHHHCCCCCEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AVDVLVGKSLAACRHAAANRLVVAGGVGANARLRERLTAEGGRAGVSVFYPSLEFCTDNG
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCEEEECCCC
AMIAFAGAQRLASVADRVARASDLDFAVKPRWALASLGPVE
CEEEEHHHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCCC
>Mature Secondary Structure
MLVLGIESSCDETGVALYDSAEGLVAHALHSQIAMHNAYGGVVPELASRDHIRRILPLTR
CEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
QVFEESGRLLSELGGVAFTQGPGLAGALLVGAGMGRALAFALRVPAIGVHHLEGHLLSPL
HHHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCHHHHHH
ISDTPPAFPFVALLVSGGHTQLMLVSAVGQYTLLGETLDDAAGEAFDKTAQLLGLGYPGG
HCCCCCHHHHHHHHHCCCCCEEEEEEHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCC
PALSRLAAAGDATRFALPRPMLNSGDFDFSFSGLKTAVLTLVRKQGLGQAADIAAAFEAA
HHHHHHHHCCCCCEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AVDVLVGKSLAACRHAAANRLVVAGGVGANARLRERLTAEGGRAGVSVFYPSLEFCTDNG
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCEEEECCCC
AMIAFAGAQRLASVADRVARASDLDFAVKPRWALASLGPVE
CEEEEHHHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA