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The map label for this gene is moeB [H]

Identifier: 74318408

GI number: 74318408

Start: 2462748

End: 2463503

Strand: Reverse

Name: moeB [H]

Synonym: Tbd_2390

Alternate gene names: 74318408

Gene position: 2463503-2462748 (Counterclockwise)

Preceding gene: 74318409

Following gene: 74318402

Centisome position: 84.66

GC content: 69.31

Gene sequence:

>756_bases
ATGGAGCTGAACGACGATCTGCTGCTGCGCTACAGCCGGCACATCCTCCTGCCTGAACTGGGTGTGACCGGCCAGATGCA
GATCTCGGCCGCTTCGGTGCTCGTCGTCGGCGCCGGCGGCCTGGGTTGTCCGGTCGCGCTCTACCTCGGTGCCGCCGGCG
TAGGACGACTCGTTCTGGCCGACGGCGACCGCGTCGACCTGAGCAACCTGCAGCGCCAGATCGGACACGGCAGCGCCGCC
ATCGGCGAGAACAAGGCAGAATCTCTTGCCCGCAGCGTGCAGGCGATCAATCCGACGATCGAAGTCGACGCACGCGGCGA
AGCGCTTGCCGGCGCCGCGCTCGAGGCGGCGGTCGCGCAGGTCGACGTCGTCGTCGACGCCTCCGACAACTTCGCCACCC
GCCACGCAGTCAATGCGGCGTGCGTGCGCTTCGGCAAGCCGCTCGTGTCGGGCGCGGCCATCGGCTTTTCGGGGCAGCTC
GCGGTGTTCGCCCCAGGCCGCGCCGGCAGCCCCTGCTACCACTGCCTGTTTCCGGACGAAGCCGGCGAGCCGGAATTGCG
CTGTGCCGAGGCCGGCGTGTTCTCCCCGCTCGTCGGCGTAATCGGCGCGATGCAGGCGTCCGAAGTTCTGAAGTTGTTGG
CCGGCGTCGGCGACCCTCTTGTCGGCCGGCTGCTGTTGTGGGACGGCTTGCGCAGCGACGCCCGCGTCATGAAACTGCGC
CGCGATCCCCTATGCCCGGTCTGTCGCTCGCGCTGA

Upstream 100 bases:

>100_bases
TCGCAGCAGGCCTTCATGCGGGTGTACGAACTTCATCTTCACGGGGACCGCGACGACACGCCGGAGGAGTGGCGCGGGTA
CAAGTAAGCCCGGGTTCTCG

Downstream 100 bases:

>100_bases
ACCTGTAGACGCGGCGTCTGCGAGCAGGTGTGACAGCATGAACGCGACGTCGCCCTCGGGGCCGCGCGTGAAGCCGCTCT
TCGCGTATTGGTGCCAACGA

Product: adenylyltransferase

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MELNDDLLLRYSRHILLPELGVTGQMQISAASVLVVGAGGLGCPVALYLGAAGVGRLVLADGDRVDLSNLQRQIGHGSAA
IGENKAESLARSVQAINPTIEVDARGEALAGAALEAAVAQVDVVVDASDNFATRHAVNAACVRFGKPLVSGAAIGFSGQL
AVFAPGRAGSPCYHCLFPDEAGEPELRCAEAGVFSPLVGVIGAMQASEVLKLLAGVGDPLVGRLLLWDGLRSDARVMKLR
RDPLCPVCRSR

Sequences:

>Translated_251_residues
MELNDDLLLRYSRHILLPELGVTGQMQISAASVLVVGAGGLGCPVALYLGAAGVGRLVLADGDRVDLSNLQRQIGHGSAA
IGENKAESLARSVQAINPTIEVDARGEALAGAALEAAVAQVDVVVDASDNFATRHAVNAACVRFGKPLVSGAAIGFSGQL
AVFAPGRAGSPCYHCLFPDEAGEPELRCAEAGVFSPLVGVIGAMQASEVLKLLAGVGDPLVGRLLLWDGLRSDARVMKLR
RDPLCPVCRSR
>Mature_251_residues
MELNDDLLLRYSRHILLPELGVTGQMQISAASVLVVGAGGLGCPVALYLGAAGVGRLVLADGDRVDLSNLQRQIGHGSAA
IGENKAESLARSVQAINPTIEVDARGEALAGAALEAAVAQVDVVVDASDNFATRHAVNAACVRFGKPLVSGAAIGFSGQL
AVFAPGRAGSPCYHCLFPDEAGEPELRCAEAGVFSPLVGVIGAMQASEVLKLLAGVGDPLVGRLLLWDGLRSDARVMKLR
RDPLCPVCRSR

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=230, Percent_Identity=50, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4885649, Length=144, Percent_Identity=32.6388888888889, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI38045948, Length=158, Percent_Identity=33.5443037974684, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI13376212, Length=259, Percent_Identity=26.2548262548263, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787048, Length=247, Percent_Identity=46.5587044534413, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI87082356, Length=246, Percent_Identity=48.3739837398374, Blast_Score=204, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17540406, Length=241, Percent_Identity=43.9834024896266, Blast_Score=210, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI193203301, Length=151, Percent_Identity=30.4635761589404, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI86565433, Length=144, Percent_Identity=29.8611111111111, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI86565431, Length=144, Percent_Identity=29.8611111111111, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=245, Percent_Identity=35.5102040816327, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322639, Length=167, Percent_Identity=30.5389221556886, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320598, Length=157, Percent_Identity=27.3885350318471, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24582879, Length=252, Percent_Identity=42.4603174603175, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24660640, Length=159, Percent_Identity=32.0754716981132, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI20129973, Length=172, Percent_Identity=31.3953488372093, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: 2.7.7.-

Molecular weight: Translated: 25942; Mature: 25942

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNDDLLLRYSRHILLPELGVTGQMQISAASVLVVGAGGLGCPVALYLGAAGVGRLVLA
CCCCHHHHHHHHCCEECCCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHCCCCCCEEEEE
DGDRVDLSNLQRQIGHGSAAIGENKAESLARSVQAINPTIEVDARGEALAGAALEAAVAQ
CCCEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHE
VDVVVDASDNFATRHAVNAACVRFGKPLVSGAAIGFSGQLAVFAPGRAGSPCYHCLFPDE
EEEEEECCCCCHHHHHHHHHHHHHCCHHHCCEEECCCCCEEEEECCCCCCCEEEEECCCC
AGEPELRCAEAGVFSPLVGVIGAMQASEVLKLLAGVGDPLVGRLLLWDGLRSDARVMKLR
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHH
RDPLCPVCRSR
CCCCCCCCCCC
>Mature Secondary Structure
MELNDDLLLRYSRHILLPELGVTGQMQISAASVLVVGAGGLGCPVALYLGAAGVGRLVLA
CCCCHHHHHHHHCCEECCCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHCCCCCCEEEEE
DGDRVDLSNLQRQIGHGSAAIGENKAESLARSVQAINPTIEVDARGEALAGAALEAAVAQ
CCCEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHE
VDVVVDASDNFATRHAVNAACVRFGKPLVSGAAIGFSGQLAVFAPGRAGSPCYHCLFPDE
EEEEEECCCCCHHHHHHHHHHHHHCCHHHCCEEECCCCCEEEEECCCCCCCEEEEECCCC
AGEPELRCAEAGVFSPLVGVIGAMQASEVLKLLAGVGDPLVGRLLLWDGLRSDARVMKLR
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHH
RDPLCPVCRSR
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]