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The map label for this gene is folB [H]

Identifier: 74318399

GI number: 74318399

Start: 2454550

End: 2454912

Strand: Reverse

Name: folB [H]

Synonym: Tbd_2381

Alternate gene names: 74318399

Gene position: 2454912-2454550 (Counterclockwise)

Preceding gene: 74318402

Following gene: 74318398

Centisome position: 84.37

GC content: 61.16

Gene sequence:

>363_bases
ATGGATATCTTATTTTTGCGGGACTTCCGTCTCGATCTGATTATCGGCATCTACGAATGGGAACGCAAAGTACCACAACC
GGTGCGGCTTGACCTCGAAATCGGCCTGCCGCACAACAAGGCTGGCGGCACCGACGACGTCGCCGACACCATCGACTACG
GGGCCGTGGCCACGCGCGTGAAGGCGTATCTGCACGACGCGCCGCAGCCGATCACGCTGGTCGAGTCGGTCGCCGAACAC
GTCGCGGCGATCGTGCGCAACGAATTCGGCGCACCCTGGGTGAAGGTTTCGGTGACCAAGTTCGCGATTGTCCCCGGCAT
CAAGGAACTCGGTATCACGATCGAACGCGGCGCGCGTCCTTGA

Upstream 100 bases:

>100_bases
CGAGCAGGTACGCGGCGACAACGAGCAACAGGTGGATCATAAGTCAGTAAGATAGCGGGTTTGGCAAGCGCGCCGAGTGG
CGCCCGTGAGGTTCGAGGCG

Downstream 100 bases:

>100_bases
GTTTCGAACACATGGCCGCCGCCGCGGCGATTCTGCTCGCGGCCTATTTCATCCGCGGCATCACCGGTTTCGGTTCGGGG
TTGATCGCGGTGCCGCTGCT

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 120; Mature: 120

Protein sequence:

>120_residues
MDILFLRDFRLDLIIGIYEWERKVPQPVRLDLEIGLPHNKAGGTDDVADTIDYGAVATRVKAYLHDAPQPITLVESVAEH
VAAIVRNEFGAPWVKVSVTKFAIVPGIKELGITIERGARP

Sequences:

>Translated_120_residues
MDILFLRDFRLDLIIGIYEWERKVPQPVRLDLEIGLPHNKAGGTDDVADTIDYGAVATRVKAYLHDAPQPITLVESVAEH
VAAIVRNEFGAPWVKVSVTKFAIVPGIKELGITIERGARP
>Mature_120_residues
MDILFLRDFRLDLIIGIYEWERKVPQPVRLDLEIGLPHNKAGGTDDVADTIDYGAVATRVKAYLHDAPQPITLVESVAEH
VAAIVRNEFGAPWVKVSVTKFAIVPGIKELGITIERGARP

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=117, Percent_Identity=35.8974358974359, Blast_Score=85, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13286; Mature: 13286

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILFLRDFRLDLIIGIYEWERKVPQPVRLDLEIGLPHNKAGGTDDVADTIDYGAVATRV
CCEEEEECCCEEEEEEEHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
KAYLHDAPQPITLVESVAEHVAAIVRNEFGAPWVKVSVTKFAIVPGIKELGITIERGARP
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHCEEEECCCCC
>Mature Secondary Structure
MDILFLRDFRLDLIIGIYEWERKVPQPVRLDLEIGLPHNKAGGTDDVADTIDYGAVATRV
CCEEEEECCCEEEEEEEHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
KAYLHDAPQPITLVESVAEHVAAIVRNEFGAPWVKVSVTKFAIVPGIKELGITIERGARP
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]