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The map label for this gene is pepP [H]

Identifier: 74318352

GI number: 74318352

Start: 2407753

End: 2409054

Strand: Reverse

Name: pepP [H]

Synonym: Tbd_2334

Alternate gene names: 74318352

Gene position: 2409054-2407753 (Counterclockwise)

Preceding gene: 74318353

Following gene: 74318351

Centisome position: 82.79

GC content: 67.59

Gene sequence:

>1302_bases
ATGCAGCCTGATTCCGCGATTCATCGCGCGCGTCGCGAACGCGTGCTCGAACAGATGGGCGAGGGCGTGATGGTCATCGC
GACCGCGCCCGAGGTCCCGCGCAACCGCGACACGCACTACCCCTACCGGCACGACAGCTACTTCTACTGGCTGACCGGCT
TCAACGAGCCCGAAGCGGTCGTCGTGCTGATCGGCGGCAAGCACCCGCGCCACGTCCTCTTCTGCCGCGAGCGCAACGAG
GAAAGGGAGATCTGGGACGGCTTCCGCTACGGACCGCAGGCCGCGCGCGAGACATTCGCGTTTGACGAGGCCTACGCTTA
CGACACGCTGCAGACCGAAGTGCCGCGGCTGCTCGAAAACCAGCCGCTGCTCGCCTACATCATCGGTCGCGACATGGCAT
GGGACACGCAGGTCATGGGCTGGCTCAACGTCGTGCGCAGCAAGGCGCGCAGCGGCGTGCGCGCGCCCGACCGCCTGGTC
GACGCGCGGGTCTGGCTCGACGAGTTCCGGCTCGTCAAGGACGCCCACGAACTCGCGCTGATGCGGCGTGCCGCGGAAAT
CTCCGACGGCGCACACCGCGCGGCGATGCGCGCGACGCGTCCCGGCCGCCACGAATACGAGATCGAAGCCGAGCTTCTGT
GCGCGTTCAGGAGCGGCGGGGCCGAGTCGCCGGCCTACACCTCGATCGTCGCGAGCGGTGCCAACGCCTGCGTGCTGCAC
TACGTCTTCAACAACCAACCGCTGCGCGAAGGCGACTTGCTGCTGATCGACGCGGCGGCCGAATTCGGCAGCTATGCCGC
CGACATCACGCGGACCTTTCCGGTCAGCGGGCGCTACACGGCGGCGCAAAAAGACGTCTATGAACTCGTGCTGGCTGCCC
AGCGCGCTGCGATCGACGCCGTGCGCCCGGGCAACCACTGGAACACGCCGCACGAGACGGCGGTGCGCGTACTGACCCAG
GGTCTCGTCGACCTCGGCCTGCTCGCGGGCGCGGTCGACGGCCTGATCGAGTCGCAGGCCTATAGTCGTTTTTACATGCA
CCGCACCGGGCACTGGCTCGGCATGGACGTCCACGACGCCGGCGAATACAAGCTGCATGGCGAATGGCGCTCGCTCCAGC
CGGGCATGACGCTCACGGTCGAGCCCGGCCTCTACATCCGTCCGGCGGACGATGTGCCGCAGGCGTTCTGGAACATCGGC
ATTCGCATCGAGGACGACGTCGCCGTGACCGAATCCGCGTGCGAGGTGCTGACCCATGCACCGAAGACCGTCGCCGAGAT
CGAGGCGTGGATGCGTCCGTGA

Upstream 100 bases:

>100_bases
ATGGACGCGGCCCGGGTCAGCGGCGAACATTACAGCGGGCGCTGGACCGACGTCGGCACGCCGGCGCGTCTTGCCGCGCT
CGACGAGGAACTGAGACGAC

Downstream 100 bases:

>100_bases
ACGAGGTCATCGTCGTCGGCGCCGGACCCGTGGGAGCCGTCAGTGCGCTGGCCTTGCAACAGCACGGCGTCGCCGCGCGC
GTGCTCGAAGCGCGCGCCGA

Product: putative XAA-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MQPDSAIHRARRERVLEQMGEGVMVIATAPEVPRNRDTHYPYRHDSYFYWLTGFNEPEAVVVLIGGKHPRHVLFCRERNE
EREIWDGFRYGPQAARETFAFDEAYAYDTLQTEVPRLLENQPLLAYIIGRDMAWDTQVMGWLNVVRSKARSGVRAPDRLV
DARVWLDEFRLVKDAHELALMRRAAEISDGAHRAAMRATRPGRHEYEIEAELLCAFRSGGAESPAYTSIVASGANACVLH
YVFNNQPLREGDLLLIDAAAEFGSYAADITRTFPVSGRYTAAQKDVYELVLAAQRAAIDAVRPGNHWNTPHETAVRVLTQ
GLVDLGLLAGAVDGLIESQAYSRFYMHRTGHWLGMDVHDAGEYKLHGEWRSLQPGMTLTVEPGLYIRPADDVPQAFWNIG
IRIEDDVAVTESACEVLTHAPKTVAEIEAWMRP

Sequences:

>Translated_433_residues
MQPDSAIHRARRERVLEQMGEGVMVIATAPEVPRNRDTHYPYRHDSYFYWLTGFNEPEAVVVLIGGKHPRHVLFCRERNE
EREIWDGFRYGPQAARETFAFDEAYAYDTLQTEVPRLLENQPLLAYIIGRDMAWDTQVMGWLNVVRSKARSGVRAPDRLV
DARVWLDEFRLVKDAHELALMRRAAEISDGAHRAAMRATRPGRHEYEIEAELLCAFRSGGAESPAYTSIVASGANACVLH
YVFNNQPLREGDLLLIDAAAEFGSYAADITRTFPVSGRYTAAQKDVYELVLAAQRAAIDAVRPGNHWNTPHETAVRVLTQ
GLVDLGLLAGAVDGLIESQAYSRFYMHRTGHWLGMDVHDAGEYKLHGEWRSLQPGMTLTVEPGLYIRPADDVPQAFWNIG
IRIEDDVAVTESACEVLTHAPKTVAEIEAWMRP
>Mature_433_residues
MQPDSAIHRARRERVLEQMGEGVMVIATAPEVPRNRDTHYPYRHDSYFYWLTGFNEPEAVVVLIGGKHPRHVLFCRERNE
EREIWDGFRYGPQAARETFAFDEAYAYDTLQTEVPRLLENQPLLAYIIGRDMAWDTQVMGWLNVVRSKARSGVRAPDRLV
DARVWLDEFRLVKDAHELALMRRAAEISDGAHRAAMRATRPGRHEYEIEAELLCAFRSGGAESPAYTSIVASGANACVLH
YVFNNQPLREGDLLLIDAAAEFGSYAADITRTFPVSGRYTAAQKDVYELVLAAQRAAIDAVRPGNHWNTPHETAVRVLTQ
GLVDLGLLAGAVDGLIESQAYSRFYMHRTGHWLGMDVHDAGEYKLHGEWRSLQPGMTLTVEPGLYIRPADDVPQAFWNIG
IRIEDDVAVTESACEVLTHAPKTVAEIEAWMRP

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=445, Percent_Identity=31.685393258427, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI149589008, Length=472, Percent_Identity=32.6271186440678, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI260593665, Length=299, Percent_Identity=39.7993311036789, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI260593663, Length=316, Percent_Identity=34.8101265822785, Blast_Score=173, Evalue=3e-43,
Organism=Escherichia coli, GI1789275, Length=427, Percent_Identity=44.9648711943794, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1788728, Length=324, Percent_Identity=32.0987654320988, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790282, Length=321, Percent_Identity=30.5295950155763, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17508215, Length=432, Percent_Identity=34.4907407407407, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71989583, Length=370, Percent_Identity=27.5675675675676, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=438, Percent_Identity=29.2237442922374, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6321118, Length=451, Percent_Identity=29.2682926829268, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19920384, Length=417, Percent_Identity=34.052757793765, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21357079, Length=444, Percent_Identity=32.4324324324324, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48827; Mature: 48827

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPDSAIHRARRERVLEQMGEGVMVIATAPEVPRNRDTHYPYRHDSYFYWLTGFNEPEAV
CCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCEE
VVLIGGKHPRHVLFCRERNEEREIWDGFRYGPQAARETFAFDEAYAYDTLQTEVPRLLEN
EEEECCCCCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPLLAYIIGRDMAWDTQVMGWLNVVRSKARSGVRAPDRLVDARVWLDEFRLVKDAHELAL
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MRRAAEISDGAHRAAMRATRPGRHEYEIEAELLCAFRSGGAESPAYTSIVASGANACVLH
HHHHHHHCCCHHHHHHHCCCCCCCCEEEHHHHHEEECCCCCCCCCHHHHHHCCCCEEEEE
YVFNNQPLREGDLLLIDAAAEFGSYAADITRTFPVSGRYTAAQKDVYELVLAAQRAAIDA
EEECCCCCCCCCEEEEECCHHHCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHC
VRPGNHWNTPHETAVRVLTQGLVDLGLLAGAVDGLIESQAYSRFYMHRTGHWLGMDVHDA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
GEYKLHGEWRSLQPGMTLTVEPGLYIRPADDVPQAFWNIGIRIEDDVAVTESACEVLTHA
CCEEECCCHHCCCCCCEEEECCCEEEECCHHHHHHHHHCCCEEECCCHHHHHHHHHHHCC
PKTVAEIEAWMRP
CHHHHHHHHHCCC
>Mature Secondary Structure
MQPDSAIHRARRERVLEQMGEGVMVIATAPEVPRNRDTHYPYRHDSYFYWLTGFNEPEAV
CCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCEE
VVLIGGKHPRHVLFCRERNEEREIWDGFRYGPQAARETFAFDEAYAYDTLQTEVPRLLEN
EEEECCCCCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPLLAYIIGRDMAWDTQVMGWLNVVRSKARSGVRAPDRLVDARVWLDEFRLVKDAHELAL
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MRRAAEISDGAHRAAMRATRPGRHEYEIEAELLCAFRSGGAESPAYTSIVASGANACVLH
HHHHHHHCCCHHHHHHHCCCCCCCCEEEHHHHHEEECCCCCCCCCHHHHHHCCCCEEEEE
YVFNNQPLREGDLLLIDAAAEFGSYAADITRTFPVSGRYTAAQKDVYELVLAAQRAAIDA
EEECCCCCCCCCEEEEECCHHHCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHC
VRPGNHWNTPHETAVRVLTQGLVDLGLLAGAVDGLIESQAYSRFYMHRTGHWLGMDVHDA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
GEYKLHGEWRSLQPGMTLTVEPGLYIRPADDVPQAFWNIGIRIEDDVAVTESACEVLTHA
CCEEECCCHHCCCCCCEEEECCCEEEECCHHHHHHHHHCCCEEECCCHHHHHHHHHHHCC
PKTVAEIEAWMRP
CHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]