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The map label for this gene is queC

Identifier: 74318220

GI number: 74318220

Start: 2283098

End: 2283772

Strand: Reverse

Name: queC

Synonym: Tbd_2202

Alternate gene names: 74318220

Gene position: 2283772-2283098 (Counterclockwise)

Preceding gene: 74318221

Following gene: 74318219

Centisome position: 78.49

GC content: 68.74

Gene sequence:

>675_bases
ATGAAGCCGTGTGCGATCGTCCTCTTGTCGGGTGGCCTCGATTCCGCCACCGCGCTCGCGATGGCGCGCGAGGCGGGCTT
TGCCTGCCACGCCCTGAGCCTCGATTACGGCCAGCGTCACACCGCCGAACTCGCCGCCGCGGCGCGCCTTGCCGCGCAGC
TCGGCGCGGTCGAGCATCGCGTGATCCGTCTCGGCCTCGGCGACTTCGGTGGTTCGGCGCTGACCGACGCGTCGATCGCC
GTGCCCGAGAGTCCTGTCGCGGGCATTCCCGTCACCTATGTGCCCGCCCGCAATACCGTCATGCTCGCCCTCGCGCTGGC
GTGGGCCGAGGTGCTCGGCGCGCGCGACATCTTCATCGGCGTCAACGCCGTCGACTATTCGGGCTATCCGGACTGCCGTC
CCGAATTCATCGAGGCTTTCGAGCGCATGGCGAATCTGGCAACCAAGGCCGGCGTCGAAGGTGCGCAACTCCGTATCCAC
GCCCCCCTGCAACACCTCTCGAAAGCCGAGATCATCCATCGCGGGACGGCGCTCGGTGTCGACTACGCGCAAACGGTGAG
CTGTTACCAGGCCGACGCCGAAGGGCGCGCCTGCGGACGCTGCGACGCCTGTCGCCTCAGGCGTGAGGGGTTTCTTGCCG
CCGGCTTGGCCGACCCCACGCGATACGCCCGGTGA

Upstream 100 bases:

>100_bases
TCGCGCCGGCGCAACTCGCCGAGTGGATCCTCGCCGACCGCCTGCCGGTGCGGATGCAGGTGCAGCTGCACAAGCTGTTG
TGGGGCAGCGCCCCGGGCCG

Downstream 100 bases:

>100_bases
CCTGAATCCGAAGGCCGGTCCGGCGGCCCGGCGAAGTGGTCGGAGCCGCGAAGGCGGCCGATTTGGGGCGCATGGACGGC
CGCTAATGGTACTTATTATC

Product: ExsB ATPase

Products: NA

Alternate protein names: 7-cyano-7-carbaguanine synthase; PreQ(0) synthase; Queuosine biosynthesis protein queC

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKPCAIVLLSGGLDSATALAMAREAGFACHALSLDYGQRHTAELAAAARLAAQLGAVEHRVIRLGLGDFGGSALTDASIA
VPESPVAGIPVTYVPARNTVMLALALAWAEVLGARDIFIGVNAVDYSGYPDCRPEFIEAFERMANLATKAGVEGAQLRIH
APLQHLSKAEIIHRGTALGVDYAQTVSCYQADAEGRACGRCDACRLRREGFLAAGLADPTRYAR

Sequences:

>Translated_224_residues
MKPCAIVLLSGGLDSATALAMAREAGFACHALSLDYGQRHTAELAAAARLAAQLGAVEHRVIRLGLGDFGGSALTDASIA
VPESPVAGIPVTYVPARNTVMLALALAWAEVLGARDIFIGVNAVDYSGYPDCRPEFIEAFERMANLATKAGVEGAQLRIH
APLQHLSKAEIIHRGTALGVDYAQTVSCYQADAEGRACGRCDACRLRREGFLAAGLADPTRYAR
>Mature_224_residues
MKPCAIVLLSGGLDSATALAMAREAGFACHALSLDYGQRHTAELAAAARLAAQLGAVEHRVIRLGLGDFGGSALTDASIA
VPESPVAGIPVTYVPARNTVMLALALAWAEVLGARDIFIGVNAVDYSGYPDCRPEFIEAFERMANLATKAGVEGAQLRIH
APLQHLSKAEIIHRGTALGVDYAQTVSCYQADAEGRACGRCDACRLRREGFLAAGLADPTRYAR

Specific function: Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))

COG id: COG0603

COG function: function code R; Predicted PP-loop superfamily ATPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the queC family

Homologues:

Organism=Escherichia coli, GI1786648, Length=223, Percent_Identity=39.9103139013453, Blast_Score=135, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): QUEC_THIDA (Q3SGT8)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315960.1
- ProteinModelPortal:   Q3SGT8
- SMR:   Q3SGT8
- STRING:   Q3SGT8
- GeneID:   3671593
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2202
- NMPDR:   fig|292415.3.peg.2090
- eggNOG:   COG0603
- HOGENOM:   HBG553284
- OMA:   GWAEVLG
- PhylomeDB:   Q3SGT8
- BioCyc:   TDEN292415:TBD_2202-MONOMER
- HAMAP:   MF_01633_B
- InterPro:   IPR018317
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF006293
- TIGRFAMs:   TIGR00364

Pfam domain/function: PF06508 ExsB

EC number: NA

Molecular weight: Translated: 23550; Mature: 23550

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPCAIVLLSGGLDSATALAMAREAGFACHALSLDYGQRHTAELAAAARLAAQLGAVEHR
CCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHE
VIRLGLGDFGGSALTDASIAVPESPVAGIPVTYVPARNTVMLALALAWAEVLGARDIFIG
EEEEECCCCCCCHHCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEE
VNAVDYSGYPDCRPEFIEAFERMANLATKAGVEGAQLRIHAPLQHLSKAEIIHRGTALGV
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCC
DYAQTVSCYQADAEGRACGRCDACRLRREGFLAAGLADPTRYAR
CHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEECCCCCHHCCC
>Mature Secondary Structure
MKPCAIVLLSGGLDSATALAMAREAGFACHALSLDYGQRHTAELAAAARLAAQLGAVEHR
CCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHE
VIRLGLGDFGGSALTDASIAVPESPVAGIPVTYVPARNTVMLALALAWAEVLGARDIFIG
EEEEECCCCCCCHHCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEE
VNAVDYSGYPDCRPEFIEAFERMANLATKAGVEGAQLRIHAPLQHLSKAEIIHRGTALGV
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCC
DYAQTVSCYQADAEGRACGRCDACRLRREGFLAAGLADPTRYAR
CHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEECCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA