Click here to switch to the map view.

The map label for this gene is pgl [H]

Identifier: 74318139

GI number: 74318139

Start: 2209309

End: 2209995

Strand: Reverse

Name: pgl [H]

Synonym: Tbd_2121

Alternate gene names: 74318139

Gene position: 2209995-2209309 (Counterclockwise)

Preceding gene: 74318140

Following gene: 74318136

Centisome position: 75.95

GC content: 69.72

Gene sequence:

>687_bases
GTGAGCCTGCCCGAGGTACGGGTCTTCCCCGACCCCGAACATCTCGTGGCGGCGCTTGCCGACGCCTTGTGCGCCGAGGC
CGAGGCCGACATCCGGGCGCGCGGCAGCTTCCATCTGGTGCTCGCGGGCGGCAACACGCCGCGTGAGCTGTATCGGGCGC
TCGCCGCGCGCGGTGCCGGCGACGCGCACTGGGTCGTCTGGTACGGCGACGAACGCTGCGTCGCCGCCGACCACCCTGAA
CGCAACAGCGTGATGGCGGAAATGGCGTGGCTCGCGGCATCGCGGATTCCGCCGATAAATCGTCATGCAATACCGGCCGA
GTGCGGCGCACGCGACGCGGCCGACGCGTATTCGAAGCGACTCGAAGGAGTGGGGGATTTCGACCTCGTGCTGCTCGGGA
TGGGCGAAGACGGGCATACCGCGAGCCTGTTTCCGGGACAGGCTTGGGGCGAGACGGCCGACAGCGCCGATGCGCTCGCC
GTCCATGATTCGCCGAAGCCGCCGCCCGAGCGGGTGAGCCTGTCTGCGGCGCGCCTCAACCGTAGTCGACGGGTCTGGTT
TCTCGTCGGCGGCGCGTCCAAGCGCGAAGCGATGCGGCGTTGGCGCGATGGCGAGCGCCTTCCGGTGGGGGCAATTCACG
CACGCACAGAAACCCTGGTCTGGCTCGATCGCGCTGCCGCACCCTAG

Upstream 100 bases:

>100_bases
TCGAACGCGAGTTCATCCCGACCTACCCCGCGGGCAGCTGGGGGCCGGCCGAGGCCAACCGCCTGTTCGACAGCGACGAT
CAGACCTGGCGCAACGAACT

Downstream 100 bases:

>100_bases
GGCGATTGGTCTGCGCCGTTCTCCGCGCCAGCGGTGTTCGTCGGCGCTCCGCCAGCGAGCATCGCGCGGCGTGAATCCGG
CGTCTCGAGGCTGATCCGGC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSLPEVRVFPDPEHLVAALADALCAEAEADIRARGSFHLVLAGGNTPRELYRALAARGAGDAHWVVWYGDERCVAADHPE
RNSVMAEMAWLAASRIPPINRHAIPAECGARDAADAYSKRLEGVGDFDLVLLGMGEDGHTASLFPGQAWGETADSADALA
VHDSPKPPPERVSLSAARLNRSRRVWFLVGGASKREAMRRWRDGERLPVGAIHARTETLVWLDRAAAP

Sequences:

>Translated_228_residues
MSLPEVRVFPDPEHLVAALADALCAEAEADIRARGSFHLVLAGGNTPRELYRALAARGAGDAHWVVWYGDERCVAADHPE
RNSVMAEMAWLAASRIPPINRHAIPAECGARDAADAYSKRLEGVGDFDLVLLGMGEDGHTASLFPGQAWGETADSADALA
VHDSPKPPPERVSLSAARLNRSRRVWFLVGGASKREAMRRWRDGERLPVGAIHARTETLVWLDRAAAP
>Mature_227_residues
SLPEVRVFPDPEHLVAALADALCAEAEADIRARGSFHLVLAGGNTPRELYRALAARGAGDAHWVVWYGDERCVAADHPER
NSVMAEMAWLAASRIPPINRHAIPAECGARDAADAYSKRLEGVGDFDLVLLGMGEDGHTASLFPGQAWGETADSADALAV
HDSPKPPPERVSLSAARLNRSRRVWFLVGGASKREAMRRWRDGERLPVGAIHARTETLVWLDRAAAP

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=224, Percent_Identity=36.1607142857143, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI6912586, Length=238, Percent_Identity=34.453781512605, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115533058, Length=240, Percent_Identity=27.5, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115533060, Length=240, Percent_Identity=27.5, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321687, Length=217, Percent_Identity=27.6497695852535, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321957, Length=225, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324362, Length=183, Percent_Identity=30.6010928961749, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641119, Length=200, Percent_Identity=33, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 24711; Mature: 24580

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPEVRVFPDPEHLVAALADALCAEAEADIRARGSFHLVLAGGNTPRELYRALAARGAG
CCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCC
DAHWVVWYGDERCVAADHPERNSVMAEMAWLAASRIPPINRHAIPAECGARDAADAYSKR
CCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHH
LEGVGDFDLVLLGMGEDGHTASLFPGQAWGETADSADALAVHDSPKPPPERVSLSAARLN
HCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCHHHEEHHHHHCC
RSRRVWFLVGGASKREAMRRWRDGERLPVGAIHARTETLVWLDRAAAP
CCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEECCCEEEEEEECCCCC
>Mature Secondary Structure 
SLPEVRVFPDPEHLVAALADALCAEAEADIRARGSFHLVLAGGNTPRELYRALAARGAG
CCCCEEECCCHHHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCC
DAHWVVWYGDERCVAADHPERNSVMAEMAWLAASRIPPINRHAIPAECGARDAADAYSKR
CCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHH
LEGVGDFDLVLLGMGEDGHTASLFPGQAWGETADSADALAVHDSPKPPPERVSLSAARLN
HCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCHHHEEHHHHHCC
RSRRVWFLVGGASKREAMRRWRDGERLPVGAIHARTETLVWLDRAAAP
CCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEECCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]