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The map label for this gene is zwf [H]

Identifier: 74318140

GI number: 74318140

Start: 2209992

End: 2211482

Strand: Reverse

Name: zwf [H]

Synonym: Tbd_2122

Alternate gene names: 74318140

Gene position: 2211482-2209992 (Counterclockwise)

Preceding gene: 74318141

Following gene: 74318139

Centisome position: 76.0

GC content: 63.92

Gene sequence:

>1491_bases
ATGACGGTCACCAAGGACGCCAGCGTCGAAAACATGCCGTGCTCGTTCGTCATTTTCGGCGCCACCGGTAATCTCGCGTC
GAACAAGCTCCTGCCTGCGCTCTATCATCTCGAGGCGGCTGCGCGGCTCGCCGAATCCCTGAGCATCATCGCGTTTTCGC
GTCGCGACTGGGACACCGCGAGCTGGCGCGAACACATGCGCGAGGTCCTCCGCGACAAGATCAAGGGCCCGCTCGACACG
CCGACCTTCGACCGCTTTCTCGCGCGCTTCGCCTACCACAAAGGCGACCTCAACGATCCCCACGCCTACCACGCGCTCGC
CGAGCGTCTGCCGCCGGAAAGCTCATGTTCGGCGACGGTGTTCTACCTCGCGATCAAGCCTGCGGAATTCGGCGCGGTGA
TCCAGAATCTCGAGGCCGCTGGGCTGAACAAGCCGCGCGGACTCAACCGCGTGGTGATCGAAAAGCCTTTCGGCGAGGAT
CTCGAGTCGGCGCAGACGCTCAACCGCCTGCTCCACCAGCATTTCGAGGAGCAACAGGTCTACCGCATCGACCATTTCCT
CGGCAAGGAGACGGTGCAGAACCTACTCGTGTTCCGCTTTGCCAACACGCTGATCGAACCGCTGTGGAACCGCAATTTCA
TCGACCACGTGCAGATCACGGTCGCGGAGTCCGGAGGCATCGACAAGCGCGCCGACTATTACGATCGTGCCGGGGCCTTG
CGCGACATGCTGCAGAACCACCTCATGCAGCTGATGACGGTGGTCGCAATGGAGCCGCCGCCCGCGCTCGAGGCCGACGC
GCTGCGCGACGAGAAGGTCAAGGTTTTGCGCTCGGTCCGTCCGATCTCGAAGCGCGCGGTGCACGCCCATGCGGTGCGCG
CGCAATATTCGCGCGGCAGCGTCGAGGGGCAGATCGCGCGCGCGTACCAGCAGGAAGACAACGTCGAGGACAACTCGACG
ACCGAGACTTTCGTCGCCGCCAAGTTCTACATCGACAACTGGCGCTGGCGCGGCGTGCCGTTTTATCTGCGGACCGGCAA
GCGCATGCCGCGGCAGACGCAGATCATCGCGATCCGCTTCCGGCAGCCGCCACAGCAGCTGTTCCGCGAGACGCCCTTCG
AATCGGTTGCGCCGAACTGGGTGCTGCTCAGCATCCAGCCCGAGGAGTCCATGCATATGGAGATCCACGTCAAGCAGCCG
GGGCTCGACATGGGGACGCGCGTCATGCAGATGAATGCGAGCTTCCTCAAGACCGACGAGCAGACGCTCGATGCCTACGA
GACGCTGCTGCTCGACGTCATCGAGGGCGACCGCTCGCTGTTCATCCGTTTCGACGAGGTCGAATGGGCGTGGCGGGTGG
TCGACCCCATCCTCAAGAATTGGGCGGTCGAACGCGAGTTCATCCCGACCTACCCCGCGGGCAGCTGGGGGCCGGCCGAG
GCCAACCGCCTGTTCGACAGCGACGATCAGACCTGGCGCAACGAACTGTGA

Upstream 100 bases:

>100_bases
ATGATGCGTTTCGCCACCCAGGGCAAGAACGACTACGCGGCAAAGATGCTGGCAAAGATGCGGCAGGGTTTCGGCGGCCA
CGCCGTGAAGGAAGCTTGAC

Downstream 100 bases:

>100_bases
GCCTGCCCGAGGTACGGGTCTTCCCCGACCCCGAACATCTCGTGGCGGCGCTTGCCGACGCCTTGTGCGCCGAGGCCGAG
GCCGACATCCGGGCGCGCGG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTVTKDASVENMPCSFVIFGATGNLASNKLLPALYHLEAAARLAESLSIIAFSRRDWDTASWREHMREVLRDKIKGPLDT
PTFDRFLARFAYHKGDLNDPHAYHALAERLPPESSCSATVFYLAIKPAEFGAVIQNLEAAGLNKPRGLNRVVIEKPFGED
LESAQTLNRLLHQHFEEQQVYRIDHFLGKETVQNLLVFRFANTLIEPLWNRNFIDHVQITVAESGGIDKRADYYDRAGAL
RDMLQNHLMQLMTVVAMEPPPALEADALRDEKVKVLRSVRPISKRAVHAHAVRAQYSRGSVEGQIARAYQQEDNVEDNST
TETFVAAKFYIDNWRWRGVPFYLRTGKRMPRQTQIIAIRFRQPPQQLFRETPFESVAPNWVLLSIQPEESMHMEIHVKQP
GLDMGTRVMQMNASFLKTDEQTLDAYETLLLDVIEGDRSLFIRFDEVEWAWRVVDPILKNWAVEREFIPTYPAGSWGPAE
ANRLFDSDDQTWRNEL

Sequences:

>Translated_496_residues
MTVTKDASVENMPCSFVIFGATGNLASNKLLPALYHLEAAARLAESLSIIAFSRRDWDTASWREHMREVLRDKIKGPLDT
PTFDRFLARFAYHKGDLNDPHAYHALAERLPPESSCSATVFYLAIKPAEFGAVIQNLEAAGLNKPRGLNRVVIEKPFGED
LESAQTLNRLLHQHFEEQQVYRIDHFLGKETVQNLLVFRFANTLIEPLWNRNFIDHVQITVAESGGIDKRADYYDRAGAL
RDMLQNHLMQLMTVVAMEPPPALEADALRDEKVKVLRSVRPISKRAVHAHAVRAQYSRGSVEGQIARAYQQEDNVEDNST
TETFVAAKFYIDNWRWRGVPFYLRTGKRMPRQTQIIAIRFRQPPQQLFRETPFESVAPNWVLLSIQPEESMHMEIHVKQP
GLDMGTRVMQMNASFLKTDEQTLDAYETLLLDVIEGDRSLFIRFDEVEWAWRVVDPILKNWAVEREFIPTYPAGSWGPAE
ANRLFDSDDQTWRNEL
>Mature_495_residues
TVTKDASVENMPCSFVIFGATGNLASNKLLPALYHLEAAARLAESLSIIAFSRRDWDTASWREHMREVLRDKIKGPLDTP
TFDRFLARFAYHKGDLNDPHAYHALAERLPPESSCSATVFYLAIKPAEFGAVIQNLEAAGLNKPRGLNRVVIEKPFGEDL
ESAQTLNRLLHQHFEEQQVYRIDHFLGKETVQNLLVFRFANTLIEPLWNRNFIDHVQITVAESGGIDKRADYYDRAGALR
DMLQNHLMQLMTVVAMEPPPALEADALRDEKVKVLRSVRPISKRAVHAHAVRAQYSRGSVEGQIARAYQQEDNVEDNSTT
ETFVAAKFYIDNWRWRGVPFYLRTGKRMPRQTQIIAIRFRQPPQQLFRETPFESVAPNWVLLSIQPEESMHMEIHVKQPG
LDMGTRVMQMNASFLKTDEQTLDAYETLLLDVIEGDRSLFIRFDEVEWAWRVVDPILKNWAVEREFIPTYPAGSWGPAEA
NRLFDSDDQTWRNEL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=474, Percent_Identity=34.3881856540084, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI108773793, Length=474, Percent_Identity=34.3881856540084, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI52145310, Length=516, Percent_Identity=28.6821705426357, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1788158, Length=497, Percent_Identity=43.4607645875252, Blast_Score=411, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17538218, Length=481, Percent_Identity=34.9272349272349, Blast_Score=301, Evalue=8e-82,
Organism=Saccharomyces cerevisiae, GI6324088, Length=474, Percent_Identity=35.2320675105485, Blast_Score=281, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24643352, Length=487, Percent_Identity=34.2915811088296, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24643350, Length=481, Percent_Identity=34.7193347193347, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI221513548, Length=477, Percent_Identity=30.6079664570231, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57010; Mature: 56879

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00014 ER_TARGET

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTKDASVENMPCSFVIFGATGNLASNKLLPALYHLEAAARLAESLSIIAFSRRDWDTA
CCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHH
SWREHMREVLRDKIKGPLDTPTFDRFLARFAYHKGDLNDPHAYHALAERLPPESSCSATV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEE
FYLAIKPAEFGAVIQNLEAAGLNKPRGLNRVVIEKPFGEDLESAQTLNRLLHQHFEEQQV
EEEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
YRIDHFLGKETVQNLLVFRFANTLIEPLWNRNFIDHVQITVAESGGIDKRADYYDRAGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHH
RDMLQNHLMQLMTVVAMEPPPALEADALRDEKVKVLRSVRPISKRAVHAHAVRAQYSRGS
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCC
VEGQIARAYQQEDNVEDNSTTETFVAAKFYIDNWRWRGVPFYLRTGKRMPRQTQIIAIRF
CCHHHHHHHHHHCCCCCCCCCHHEEEEEEEEECEEECCCCEEEECCCCCCCCEEEEEEEE
RQPPQQLFRETPFESVAPNWVLLSIQPEESMHMEIHVKQPGLDMGTRVMQMNASFLKTDE
CCCHHHHHHHCCHHHCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHCHHHHHCCH
QTLDAYETLLLDVIEGDRSLFIRFDEVEWAWRVVDPILKNWAVEREFIPTYPAGSWGPAE
HHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
ANRLFDSDDQTWRNEL
HHHCCCCCCHHHHCCC
>Mature Secondary Structure 
TVTKDASVENMPCSFVIFGATGNLASNKLLPALYHLEAAARLAESLSIIAFSRRDWDTA
CCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHH
SWREHMREVLRDKIKGPLDTPTFDRFLARFAYHKGDLNDPHAYHALAERLPPESSCSATV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEE
FYLAIKPAEFGAVIQNLEAAGLNKPRGLNRVVIEKPFGEDLESAQTLNRLLHQHFEEQQV
EEEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
YRIDHFLGKETVQNLLVFRFANTLIEPLWNRNFIDHVQITVAESGGIDKRADYYDRAGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHH
RDMLQNHLMQLMTVVAMEPPPALEADALRDEKVKVLRSVRPISKRAVHAHAVRAQYSRGS
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCC
VEGQIARAYQQEDNVEDNSTTETFVAAKFYIDNWRWRGVPFYLRTGKRMPRQTQIIAIRF
CCHHHHHHHHHHCCCCCCCCCHHEEEEEEEEECEEECCCCEEEECCCCCCCCEEEEEEEE
RQPPQQLFRETPFESVAPNWVLLSIQPEESMHMEIHVKQPGLDMGTRVMQMNASFLKTDE
CCCHHHHHHHCCHHHCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHCHHHHHCCH
QTLDAYETLLLDVIEGDRSLFIRFDEVEWAWRVVDPILKNWAVEREFIPTYPAGSWGPAE
HHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
ANRLFDSDDQTWRNEL
HHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]