BacMap

Definition	Thiobacillus denitrificans ATCC 25259 chromosome, complete genome.
Accession	NC_007404
Length	2,909,809

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The map label for this gene is fhuC [H]

Identifier: 74318067

GI number: 74318067

Start: 2137182

End: 2137919

Strand: Direct

Name: fhuC [H]

Synonym: Tbd_2049

Alternate gene names: 74318067

Gene position: 2137182-2137919 (Clockwise)

Preceding gene: 74318066

Following gene: 74318068

Centisome position: 73.45

GC content: 73.85

Gene sequence:

>738_bases
GTGGCTGCTGCGCAAGCCGTGAGCCTCGCCGCGCACGCGCTCGGCCTGCAGGTGAACGGCCGCAGCCTCGTCGACGCACT
CGAACTCACGCTCGAGCCCGGCGAAGTCGTCGGCATCCTCGGCGCCAACGGCGCGGGCAAGTCGACGCTGCTGAACGTAC
TGGGCGGCCTCAGGGCGCCTGAATCCGGCACGGTCACGCTCGACGGCCAGCCGCTCGGCGCGCTGTCGCCGCTTGCGCGG
GCGCGGCACATCGGCCTCCTGCCGCAGGGCGACGAAGCCGGCTTCTTCGGCGGCGTCGCCGACTTCGTCGCGCTCGGCCG
TCACCCTTTCGGCCGCGACCGATTCGACCTCGCACCGCTGCTGCACGAATGGGAACTCGACGCCTTCGCGCGGCGGCCGC
TGGACAGCCTGTCCGGCGGCGAGCGCCAGCGCGCACGCCTCGCACAACTCGCGGTGCAGGCGCCGCGCGTCGCGCTGCTC
GACGAGCCGCTGACGCATCTCGACCCGGCGCACCAGGCGCGCCTGCTCGCCTGGGTACGCGCCGAGGCCGACGCGGGCCG
CAGCGTCGCGCTGACACTGCACGATCCGAACTGGGCAGCGTGCCATTGCGATCGGCTGCTGTTCCTGTATGGGGACGGGC
GTTGGCGGCTCGGCGCGACCGCCGACCTGCTCACCCCGGCGTCGCTCGAGACCCTTTACGGGCCGGCGACCGCGGCCTTG
TGGCGCCGCGGTGCCTGA

Upstream 100 bases:

>100_bases
GTCTGCTGGTGCTCGCGGACGCGCTGGCGCGCACCCTGATCGCGCCGCGGGAGTTGCCCGTCGGGGTGCTCACGGCCTTG
CTCGGCGTCCCCCTCATGTT

Downstream 100 bases:

>100_bases
ACGCGCGGGCGCGCCATCGCCCGCGCCGGCCGCACCGCACCCAGCCTGTATAATCGGCCCTCTGCTCGACTCCGCTGCTT
CGCGCCCTCAATGATCCGCC

Product: putative Fe3+-siderophores transport system ATPase

Products: NA

Alternate protein names: Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MAAAQAVSLAAHALGLQVNGRSLVDALELTLEPGEVVGILGANGAGKSTLLNVLGGLRAPESGTVTLDGQPLGALSPLAR
ARHIGLLPQGDEAGFFGGVADFVALGRHPFGRDRFDLAPLLHEWELDAFARRPLDSLSGGERQRARLAQLAVQAPRVALL
DEPLTHLDPAHQARLLAWVRAEADAGRSVALTLHDPNWAACHCDRLLFLYGDGRWRLGATADLLTPASLETLYGPATAAL
WRRGA

Sequences:

>Translated_245_residues
MAAAQAVSLAAHALGLQVNGRSLVDALELTLEPGEVVGILGANGAGKSTLLNVLGGLRAPESGTVTLDGQPLGALSPLAR
ARHIGLLPQGDEAGFFGGVADFVALGRHPFGRDRFDLAPLLHEWELDAFARRPLDSLSGGERQRARLAQLAVQAPRVALL
DEPLTHLDPAHQARLLAWVRAEADAGRSVALTLHDPNWAACHCDRLLFLYGDGRWRLGATADLLTPASLETLYGPATAAL
WRRGA
>Mature_244_residues
AAAQAVSLAAHALGLQVNGRSLVDALELTLEPGEVVGILGANGAGKSTLLNVLGGLRAPESGTVTLDGQPLGALSPLARA
RHIGLLPQGDEAGFFGGVADFVALGRHPFGRDRFDLAPLLHEWELDAFARRPLDSLSGGERQRARLAQLAVQAPRVALLD
EPLTHLDPAHQARLLAWVRAEADAGRSVALTLHDPNWAACHCDRLLFLYGDGRWRLGATADLLTPASLETLYGPATAALW
RRGA

Specific function: Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system [H]

COG id: COG1120

COG function: function code PH; ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI9955963, Length=202, Percent_Identity=30.1980198019802, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI45446740, Length=211, Percent_Identity=31.2796208530806, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI47078218, Length=211, Percent_Identity=31.2796208530806, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI27477115, Length=197, Percent_Identity=26.9035532994924, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI153792144, Length=224, Percent_Identity=27.2321428571429, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI150417984, Length=197, Percent_Identity=32.48730964467, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI105990541, Length=199, Percent_Identity=29.1457286432161, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI31657092, Length=232, Percent_Identity=28.0172413793103, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI27881501, Length=197, Percent_Identity=27.4111675126904, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI30795238, Length=197, Percent_Identity=27.4111675126904, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI255708477, Length=182, Percent_Identity=26.3736263736264, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI21536376, Length=220, Percent_Identity=28.1818181818182, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI9961250, Length=181, Percent_Identity=27.0718232044199, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4505771, Length=181, Percent_Identity=27.0718232044199, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI9961252, Length=181, Percent_Identity=27.0718232044199, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI42741659, Length=183, Percent_Identity=26.775956284153, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786345, Length=237, Percent_Identity=40.5063291139241, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790739, Length=236, Percent_Identity=33.8983050847458, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786803, Length=235, Percent_Identity=33.1914893617021, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788002, Length=210, Percent_Identity=34.7619047619048, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI87081791, Length=196, Percent_Identity=31.6326530612245, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1786253, Length=205, Percent_Identity=32.6829268292683, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1787370, Length=207, Percent_Identity=28.5024154589372, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789593, Length=234, Percent_Identity=30.3418803418803, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI87081709, Length=213, Percent_Identity=28.6384976525822, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788225, Length=219, Percent_Identity=26.9406392694064, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87081834, Length=148, Percent_Identity=37.8378378378378, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786398, Length=193, Percent_Identity=32.6424870466321, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788165, Length=194, Percent_Identity=31.4432989690722, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI48994997, Length=192, Percent_Identity=31.7708333333333, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786563, Length=204, Percent_Identity=30.3921568627451, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081782, Length=197, Percent_Identity=27.9187817258883, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790544, Length=212, Percent_Identity=31.1320754716981, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789873, Length=207, Percent_Identity=30.9178743961353, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787972, Length=204, Percent_Identity=31.8627450980392, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI48995001, Length=204, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787712, Length=197, Percent_Identity=29.9492385786802, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788761, Length=201, Percent_Identity=31.3432835820896, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787792, Length=252, Percent_Identity=28.1746031746032, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI87082267, Length=214, Percent_Identity=27.1028037383178, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788472, Length=204, Percent_Identity=25.4901960784314, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082268, Length=217, Percent_Identity=27.6497695852535, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87082064, Length=191, Percent_Identity=35.0785340314136, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1786319, Length=181, Percent_Identity=28.1767955801105, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790467, Length=188, Percent_Identity=28.1914893617021, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789864, Length=223, Percent_Identity=27.8026905829596, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1787164, Length=228, Percent_Identity=30.2631578947368, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788897, Length=182, Percent_Identity=29.1208791208791, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994943, Length=238, Percent_Identity=26.890756302521, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788450, Length=194, Percent_Identity=29.3814432989691, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786872, Length=179, Percent_Identity=28.4916201117318, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=198, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17565938, Length=161, Percent_Identity=26.7080745341615, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71983523, Length=185, Percent_Identity=30.2702702702703, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983516, Length=185, Percent_Identity=30.2702702702703, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983510, Length=185, Percent_Identity=30.2702702702703, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510237, Length=220, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17558664, Length=172, Percent_Identity=27.3255813953488, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533592, Length=207, Percent_Identity=27.0531400966184, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650855, Length=199, Percent_Identity=28.1407035175879, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281362751, Length=199, Percent_Identity=28.1407035175879, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650853, Length=199, Percent_Identity=28.1407035175879, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920532, Length=186, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24580930, Length=186, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221512771, Length=226, Percent_Identity=28.3185840707965, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24641565, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653245, Length=197, Percent_Identity=27.4111675126904, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363262, Length=197, Percent_Identity=27.9187817258883, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666092, Length=213, Percent_Identity=27.6995305164319, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24662800, Length=178, Percent_Identity=28.0898876404494, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.34 [H]

Molecular weight: Translated: 25880; Mature: 25749

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAQAVSLAAHALGLQVNGRSLVDALELTLEPGEVVGILGANGAGKSTLLNVLGGLRAP
CCCHHHHHHHHHHHEEEECCHHHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHCCCCC
ESGTVTLDGQPLGALSPLARARHIGLLPQGDEAGFFGGVADFVALGRHPFGRDRFDLAPL
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHH
LHEWELDAFARRPLDSLSGGERQRARLAQLAVQAPRVALLDEPLTHLDPAHQARLLAWVR
HHHHCHHHHHHCCCHHCCCCHHHHHHHHHHHHCCCCEEECCCCHHHCCHHHHHHHHHHHH
AEADAGRSVALTLHDPNWAACHCDRLLFLYGDGRWRLGATADLLTPASLETLYGPATAAL
HHCCCCCEEEEEEECCCCCEEEECEEEEEEECCEEEECCCHHHCCCCHHHHHHCCHHHHH
WRRGA
HCCCC
>Mature Secondary Structure 
AAAQAVSLAAHALGLQVNGRSLVDALELTLEPGEVVGILGANGAGKSTLLNVLGGLRAP
CCHHHHHHHHHHHEEEECCHHHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHCCCCC
ESGTVTLDGQPLGALSPLARARHIGLLPQGDEAGFFGGVADFVALGRHPFGRDRFDLAPL
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHH
LHEWELDAFARRPLDSLSGGERQRARLAQLAVQAPRVALLDEPLTHLDPAHQARLLAWVR
HHHHCHHHHHHCCCHHCCCCHHHHHHHHHHHHCCCCEEECCCCHHHCCHHHHHHHHHHHH
AEADAGRSVALTLHDPNWAACHCDRLLFLYGDGRWRLGATADLLTPASLETLYGPATAAL
HHCCCCCEEEEEEECCCCCEEEECEEEEEEECCEEEECCCHHHCCCCHHHHHHCCHHHHH
WRRGA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503 [H]