Click here to switch to the map view.

The map label for this gene is hmuU [H]

Identifier: 74318066

GI number: 74318066

Start: 2136463

End: 2137203

Strand: Direct

Name: hmuU [H]

Synonym: Tbd_2048

Alternate gene names: 74318066

Gene position: 2136463-2137203 (Clockwise)

Preceding gene: 74318065

Following gene: 74318067

Centisome position: 73.42

GC content: 73.95

Gene sequence:

>741_bases
ATGCAGACGCTGTTTCGCAACCCGCTCGCCGAGCCTTACCTGCTCGGCGTTTCCGGCGGCGCCGGGCTGCTCGCGCTGCT
CGGCATGGCAGCCGGGCTCGCCTGGCCCTGGATCTCGCTGCTCGCCTTCGCCGGCAGCTTGCTCGCGCTCGCGCTCGCGG
CCGCGCTCGGCGGGCGACTGCTCGCACGCGATCACACCCCCTTGCTGCTCGCCGGCGTGATGCTCGCCGCAGGCTTCGGC
GCGCTGATCGCCCTCGTGCTCTCCGTAGCGCCGGCCGAACGCCTCCCCGGCATGCTGTTCTTCCTGATGGGCGACCTCGC
CTGGGTGGGCTACCCAGCACTGCTGTGGGCCGTGCTCGCGCTCGCGCTCGCCGTTGCGCTGGCGCTGGCGGCGCGGCTCG
ACGTGCTGCAGCTCGCGCCGCTCAAGGCGGCTTCGCTCGGGGTCGCCGTCGCGCCGACGCGGTGGACCCTGTTCGCGCTC
GCCGGCGCCTGCACCGCGCTCGTCGTCGCACAGGCCGGCAGCATCGGCTTCGTCGGCCTGATGGTCCCGCATGCGCTCCG
GCGTCTCGGCTTTTCCGGCCACCGGCTCCTGCTTCCGGCAGCGGCGCTCGGCGGCGGCAGTCTGCTGGTGCTCGCGGACG
CGCTGGCGCGCACCCTGATCGCGCCGCGGGAGTTGCCCGTCGGGGTGCTCACGGCCTTGCTCGGCGTCCCCCTCATGTTG
TGGCTGCTGCGCAAGCCGTGA

Upstream 100 bases:

>100_bases
CGACAGGGAGCTCGCGGTCGAGATCCTGACCGCGCTGCGCGGACCGCGCGTCGCCGCGGCCTTCGCCTGCGGCGGCCTGC
TCGCGCTCGCCGGGGCGCTG

Downstream 100 bases:

>100_bases
GCCTCGCCGCGCACGCGCTCGGCCTGCAGGTGAACGGCCGCAGCCTCGTCGACGCACTCGAACTCACGCTCGAGCCCGGC
GAAGTCGTCGGCATCCTCGG

Product: putative transmembrane ABC transporter permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MQTLFRNPLAEPYLLGVSGGAGLLALLGMAAGLAWPWISLLAFAGSLLALALAAALGGRLLARDHTPLLLAGVMLAAGFG
ALIALVLSVAPAERLPGMLFFLMGDLAWVGYPALLWAVLALALAVALALAARLDVLQLAPLKAASLGVAVAPTRWTLFAL
AGACTALVVAQAGSIGFVGLMVPHALRRLGFSGHRLLLPAAALGGGSLLVLADALARTLIAPRELPVGVLTALLGVPLML
WLLRKP

Sequences:

>Translated_246_residues
MQTLFRNPLAEPYLLGVSGGAGLLALLGMAAGLAWPWISLLAFAGSLLALALAAALGGRLLARDHTPLLLAGVMLAAGFG
ALIALVLSVAPAERLPGMLFFLMGDLAWVGYPALLWAVLALALAVALALAARLDVLQLAPLKAASLGVAVAPTRWTLFAL
AGACTALVVAQAGSIGFVGLMVPHALRRLGFSGHRLLLPAAALGGGSLLVLADALARTLIAPRELPVGVLTALLGVPLML
WLLRKP
>Mature_246_residues
MQTLFRNPLAEPYLLGVSGGAGLLALLGMAAGLAWPWISLLAFAGSLLALALAAALGGRLLARDHTPLLLAGVMLAAGFG
ALIALVLSVAPAERLPGMLFFLMGDLAWVGYPALLWAVLALALAVALALAARLDVLQLAPLKAASLGVAVAPTRWTLFAL
AGACTALVVAQAGSIGFVGLMVPHALRRLGFSGHRLLLPAAALGGGSLLVLADALARTLIAPRELPVGVLTALLGVPLML
WLLRKP

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=252, Percent_Identity=39.2857142857143, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788004, Length=252, Percent_Identity=40.0793650793651, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1786805, Length=256, Percent_Identity=37.109375, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786347, Length=253, Percent_Identity=33.9920948616601, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1790741, Length=257, Percent_Identity=35.0194552529183, Blast_Score=82, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 25055; Mature: 25055

Theoretical pI: Translated: 11.60; Mature: 11.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLFRNPLAEPYLLGVSGGAGLLALLGMAAGLAWPWISLLAFAGSLLALALAAALGGRL
CCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LARDHTPLLLAGVMLAAGFGALIALVLSVAPAERLPGMLFFLMGDLAWVGYPALLWAVLA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LALAVALALAARLDVLQLAPLKAASLGVAVAPTRWTLFALAGACTALVVAQAGSIGFVGL
HHHHHHHHHHHHHHHHHHCCCHHHHCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
MVPHALRRLGFSGHRLLLPAAALGGGSLLVLADALARTLIAPRELPVGVLTALLGVPLML
HHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
WLLRKP
HHHCCC
>Mature Secondary Structure
MQTLFRNPLAEPYLLGVSGGAGLLALLGMAAGLAWPWISLLAFAGSLLALALAAALGGRL
CCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LARDHTPLLLAGVMLAAGFGALIALVLSVAPAERLPGMLFFLMGDLAWVGYPALLWAVLA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LALAVALALAARLDVLQLAPLKAASLGVAVAPTRWTLFALAGACTALVVAQAGSIGFVGL
HHHHHHHHHHHHHHHHHHCCCHHHHCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
MVPHALRRLGFSGHRLLLPAAALGGGSLLVLADALARTLIAPRELPVGVLTALLGVPLML
HHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
WLLRKP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]