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The map label for this gene is hemH

Identifier: 74318051

GI number: 74318051

Start: 2124162

End: 2125265

Strand: Direct

Name: hemH

Synonym: Tbd_2033

Alternate gene names: 74318051

Gene position: 2124162-2125265 (Clockwise)

Preceding gene: 74318050

Following gene: 74318052

Centisome position: 73.0

GC content: 68.21

Gene sequence:

>1104_bases
ATGAAATACGCCGAAGAGCCCGAATACGCGCACGGAACGCCGCTGTGCGCAGGCGTCCTGCTGGTCAATCTGGGCACCCC
CGAGGCGCCGACGGCCGCTGCCCTGCGGCCTTATCTCAAGGAATTCCTGTCCGACCCGCGCGTGGTCGAAATCCCGCGCG
CGCTCTGGTGGCTCGTGCTGAACGGCATCATTCTCAACACCCGGCCGCGCAAGTCGGCCGAAAAATACGCCGCGATCTGG
ACCAGCGAGGGGTCACCGCTGAAGGTCCACACCGAAAAGCAGGCGAAACTCCTCAAGGGCTGGCTCGGTGAGCACGCCGC
CGCGCCGGTCGTCGTCGACTACGCGATGCGCTACGGCCGGCCGGGGATCCCGGAGGTTCTCGCACGAATGAAGGCCGCCG
GCTGCGACCGTATCCTCGTACTGCCGGCCTATCCGCAATACGCCGCGTCGAGCACGGCGACCGCGTTCGACGCGGCGTTC
GACTGGCTGCGCAGAACGCGCAATCAGCCGGCACTGCGCACGCTCAAGCACTACCACGACCACCCCGAGTACATCCGCGC
ACTCGCCGCCAACCTGCGCGACTACTGGCAGATGCACGGCCGCCCCGACGTCCTCGTCATGAGCTTCCACGGCGTGCCGC
GCTACACGCTCGACAAGGGCGACCCCTATCACTGCGAATGCCAGAAGACGGCGCGCCTGCTCGCCGCCGCACTCGGCCTC
GAGCCGGGTCAGTTCCGCGTGACCTTCCAGTCGCGCTTCGGCCGGGCCGAATGGCTCAAACCCTATACCGACAAGACGCT
CGAAGCGCTCGGCCGCGAGGGCGTCGGACGGGTCGACGTCGTTGCGCCGGGTTTCACGGCCGATTGCCTGGAGACGCTCG
AGGAACTCGCGATGGAGGGACGCGCGAGCTTTCTCGCCGCCGGCGGCAAGGAATTCCACTACGTCCCCGCGCTCAACGAG
CACCCGCAATGGATCGCCGCACTCGGCAGGATCGCGCTCGCCAACCTCGCGGGCTGGCTCGACGAGGGCTGGACACCCGA
CGCCGACGAGGCGTCGCGTCAGCTCAGCAGAAGCCGCGCGCTCGCGCTGGGCGCGCAACGCTGA

Upstream 100 bases:

>100_bases
CGCTCGGCGTCGTCGGCCCGACGCGCATGGCCTACGAGCGCGTCGTGCCGATCGTCGACGTCACCGCGAAAATCCTCTCC
AGCGCCCTCTCCCAACACAA

Downstream 100 bases:

>100_bases
GAAATACGCTATAAAAAAACCTGTCCGCGCCGCGGGCCCCTCGGAAGCCGAACCGACCAACCCAAATGACGCCGTCCTCC
GCCGTCGCAAGCTGTCTGCT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKYAEEPEYAHGTPLCAGVLLVNLGTPEAPTAAALRPYLKEFLSDPRVVEIPRALWWLVLNGIILNTRPRKSAEKYAAIW
TSEGSPLKVHTEKQAKLLKGWLGEHAAAPVVVDYAMRYGRPGIPEVLARMKAAGCDRILVLPAYPQYAASSTATAFDAAF
DWLRRTRNQPALRTLKHYHDHPEYIRALAANLRDYWQMHGRPDVLVMSFHGVPRYTLDKGDPYHCECQKTARLLAAALGL
EPGQFRVTFQSRFGRAEWLKPYTDKTLEALGREGVGRVDVVAPGFTADCLETLEELAMEGRASFLAAGGKEFHYVPALNE
HPQWIAALGRIALANLAGWLDEGWTPDADEASRQLSRSRALALGAQR

Sequences:

>Translated_367_residues
MKYAEEPEYAHGTPLCAGVLLVNLGTPEAPTAAALRPYLKEFLSDPRVVEIPRALWWLVLNGIILNTRPRKSAEKYAAIW
TSEGSPLKVHTEKQAKLLKGWLGEHAAAPVVVDYAMRYGRPGIPEVLARMKAAGCDRILVLPAYPQYAASSTATAFDAAF
DWLRRTRNQPALRTLKHYHDHPEYIRALAANLRDYWQMHGRPDVLVMSFHGVPRYTLDKGDPYHCECQKTARLLAAALGL
EPGQFRVTFQSRFGRAEWLKPYTDKTLEALGREGVGRVDVVAPGFTADCLETLEELAMEGRASFLAAGGKEFHYVPALNE
HPQWIAALGRIALANLAGWLDEGWTPDADEASRQLSRSRALALGAQR
>Mature_367_residues
MKYAEEPEYAHGTPLCAGVLLVNLGTPEAPTAAALRPYLKEFLSDPRVVEIPRALWWLVLNGIILNTRPRKSAEKYAAIW
TSEGSPLKVHTEKQAKLLKGWLGEHAAAPVVVDYAMRYGRPGIPEVLARMKAAGCDRILVLPAYPQYAASSTATAFDAAF
DWLRRTRNQPALRTLKHYHDHPEYIRALAANLRDYWQMHGRPDVLVMSFHGVPRYTLDKGDPYHCECQKTARLLAAALGL
EPGQFRVTFQSRFGRAEWLKPYTDKTLEALGREGVGRVDVVAPGFTADCLETLEELAMEGRASFLAAGGKEFHYVPALNE
HPQWIAALGRIALANLAGWLDEGWTPDADEASRQLSRSRALALGAQR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=329, Percent_Identity=26.1398176291793, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI60499021, Length=329, Percent_Identity=26.1398176291793, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=45.2830188679245, Blast_Score=282, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6324750, Length=330, Percent_Identity=22.7272727272727, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17864156, Length=333, Percent_Identity=24.3243243243243, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24651774, Length=262, Percent_Identity=23.6641221374046, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_THIDA (Q3SHA3)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315791.1
- ProteinModelPortal:   Q3SHA3
- SMR:   Q3SHA3
- STRING:   Q3SHA3
- GeneID:   3672204
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2033
- NMPDR:   fig|292415.3.peg.2173
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   IRPAKSA
- PhylomeDB:   Q3SHA3
- ProtClustDB:   PRK00035
- BioCyc:   TDEN292415:TBD_2033-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 40793; Mature: 40793

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYAEEPEYAHGTPLCAGVLLVNLGTPEAPTAAALRPYLKEFLSDPRVVEIPRALWWLVL
CCCCCCCCCCCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
NGIILNTRPRKSAEKYAAIWTSEGSPLKVHTEKQAKLLKGWLGEHAAAPVVVDYAMRYGR
CCEEECCCCCHHHHHHEEEEECCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
PGIPEVLARMKAAGCDRILVLPAYPQYAASSTATAFDAAFDWLRRTRNQPALRTLKHYHD
CCHHHHHHHHHHCCCCEEEEEECCCCHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
HPEYIRALAANLRDYWQMHGRPDVLVMSFHGVPRYTLDKGDPYHCECQKTARLLAAALGL
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCEECHHHHHHHHHHHHCC
EPGQFRVTFQSRFGRAEWLKPYTDKTLEALGREGVGRVDVVAPGFTADCLETLEELAMEG
CCCCEEEEEHHHCCCHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHC
RASFLAAGGKEFHYVPALNEHPQWIAALGRIALANLAGWLDEGWTPDADEASRQLSRSRA
CHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LALGAQR
HHCCCCC
>Mature Secondary Structure
MKYAEEPEYAHGTPLCAGVLLVNLGTPEAPTAAALRPYLKEFLSDPRVVEIPRALWWLVL
CCCCCCCCCCCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
NGIILNTRPRKSAEKYAAIWTSEGSPLKVHTEKQAKLLKGWLGEHAAAPVVVDYAMRYGR
CCEEECCCCCHHHHHHEEEEECCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
PGIPEVLARMKAAGCDRILVLPAYPQYAASSTATAFDAAFDWLRRTRNQPALRTLKHYHD
CCHHHHHHHHHHCCCCEEEEEECCCCHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
HPEYIRALAANLRDYWQMHGRPDVLVMSFHGVPRYTLDKGDPYHCECQKTARLLAAALGL
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCCCEECHHHHHHHHHHHHCC
EPGQFRVTFQSRFGRAEWLKPYTDKTLEALGREGVGRVDVVAPGFTADCLETLEELAMEG
CCCCEEEEEHHHCCCHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHC
RASFLAAGGKEFHYVPALNEHPQWIAALGRIALANLAGWLDEGWTPDADEASRQLSRSRA
CHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LALGAQR
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA