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The map label for this gene is hrcA

Identifier: 74318050

GI number: 74318050

Start: 2123146

End: 2124165

Strand: Direct

Name: hrcA

Synonym: Tbd_2032

Alternate gene names: 74318050

Gene position: 2123146-2124165 (Clockwise)

Preceding gene: 74318046

Following gene: 74318051

Centisome position: 72.97

GC content: 66.96

Gene sequence:

>1020_bases
ATGCTCAATGACCGTGCCCGCATCCTGCTCAAGACCCTCGTTGAACGCTACATCAGCGAAGGCGAGCCGGTCGGGTCGCG
GACCCTGTCGAAGCACGCCGGGCTGGATCTGTCGCCTGCGAGCATTCGCAACATCATGTCCGACCTCGAGGAGATGGGCT
TCGTCGCCAGCCCGCACACCTCGGCGGGCCGGGTGCCGACGCCGCGCGGCTACCGCTTCTTCGTCGACACGCTGCTGACC
GTGCGCCCCCTCGACCAGGTCTCGGTCAATCACCTCGAGAACAGCCTCGCGGCCTCCGACCCGCAGCGGCTGATGACGGC
GGCGTCGACGCTGCTGTCGGATCTGAGCCAGTTCGCCGGGCTGGTCATGACGCCGCGACGCAATCCGGCGTTCCGCCAGA
TCGAATTCCTCACCCTGTCGGACAAGCGCGTCCTGCTCATCATCGTCACGATGGAAGGCGAGGTCGAGAACCGCGTCATC
GTCACCGAGCAGTCCTATAGCGCGGCCGCGCTGACCGAGGCCGCCAATTACTTCAACCAGAATTTCGCCGGCCACAGCTT
CGACCACGTGCGCAGCAAGCTGCGCGACGAACTCGGCCGCATGCGCGACGACATCACGCGACTCATGGCCGCGGCCGTCG
ACGCCGGCACCCAGGCGCTCGATGCGAGCCAGGACAACGTCGTCGTCTCGGGGAGCCGCAAGCTGCTCGACGTCGAGGAG
CTGTCGAGCAACATGCGCAGCCTGCGCCGCCTGTTCGACGCCTTCGAGAAGAAGACCGGCCTGCTGCAGCTGCTCGACCA
GTCGCGCAGCGCGGCCGGCGTGCAGATCTTCATCGGCGGCGAGTCCGAACTGCTGCCGCTCGACGAATGCAGCCTCGTCA
CCGCGCCCTACTCGGTCGACGGCGTCGTCGTCGGCACGCTCGGCGTCGTCGGCCCGACGCGCATGGCCTACGAGCGCGTC
GTGCCGATCGTCGACGTCACCGCGAAAATCCTCTCCAGCGCCCTCTCCCAACACAAATGA

Upstream 100 bases:

>100_bases
GGGGCCGGACGAGGATTCCGGACCCGCGCGTGTGCCGCCTCGCTGGCCGCGGCCGAAGCGGGTCTGACCGGAGCCGCCGT
CCCTAGATATAATCTTCCGC

Downstream 100 bases:

>100_bases
AATACGCCGAAGAGCCCGAATACGCGCACGGAACGCCGCTGTGCGCAGGCGTCCTGCTGGTCAATCTGGGCACCCCCGAG
GCGCCGACGGCCGCTGCCCT

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLNDRARILLKTLVERYISEGEPVGSRTLSKHAGLDLSPASIRNIMSDLEEMGFVASPHTSAGRVPTPRGYRFFVDTLLT
VRPLDQVSVNHLENSLAASDPQRLMTAASTLLSDLSQFAGLVMTPRRNPAFRQIEFLTLSDKRVLLIIVTMEGEVENRVI
VTEQSYSAAALTEAANYFNQNFAGHSFDHVRSKLRDELGRMRDDITRLMAAAVDAGTQALDASQDNVVVSGSRKLLDVEE
LSSNMRSLRRLFDAFEKKTGLLQLLDQSRSAAGVQIFIGGESELLPLDECSLVTAPYSVDGVVVGTLGVVGPTRMAYERV
VPIVDVTAKILSSALSQHK

Sequences:

>Translated_339_residues
MLNDRARILLKTLVERYISEGEPVGSRTLSKHAGLDLSPASIRNIMSDLEEMGFVASPHTSAGRVPTPRGYRFFVDTLLT
VRPLDQVSVNHLENSLAASDPQRLMTAASTLLSDLSQFAGLVMTPRRNPAFRQIEFLTLSDKRVLLIIVTMEGEVENRVI
VTEQSYSAAALTEAANYFNQNFAGHSFDHVRSKLRDELGRMRDDITRLMAAAVDAGTQALDASQDNVVVSGSRKLLDVEE
LSSNMRSLRRLFDAFEKKTGLLQLLDQSRSAAGVQIFIGGESELLPLDECSLVTAPYSVDGVVVGTLGVVGPTRMAYERV
VPIVDVTAKILSSALSQHK
>Mature_339_residues
MLNDRARILLKTLVERYISEGEPVGSRTLSKHAGLDLSPASIRNIMSDLEEMGFVASPHTSAGRVPTPRGYRFFVDTLLT
VRPLDQVSVNHLENSLAASDPQRLMTAASTLLSDLSQFAGLVMTPRRNPAFRQIEFLTLSDKRVLLIIVTMEGEVENRVI
VTEQSYSAAALTEAANYFNQNFAGHSFDHVRSKLRDELGRMRDDITRLMAAAVDAGTQALDASQDNVVVSGSRKLLDVEE
LSSNMRSLRRLFDAFEKKTGLLQLLDQSRSAAGVQIFIGGESELLPLDECSLVTAPYSVDGVVVGTLGVVGPTRMAYERV
VPIVDVTAKILSSALSQHK

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_THIDA (Q3SHA4)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315790.1
- HSSP:   Q9WZV5
- ProteinModelPortal:   Q3SHA4
- SMR:   Q3SHA4
- STRING:   Q3SHA4
- GeneID:   3672203
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2032
- NMPDR:   fig|292415.3.peg.2172
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   TDEN292415:TBD_2032-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 37105; Mature: 37105

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDRARILLKTLVERYISEGEPVGSRTLSKHAGLDLSPASIRNIMSDLEEMGFVASPHT
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEECCCC
SAGRVPTPRGYRFFVDTLLTVRPLDQVSVNHLENSLAASDPQRLMTAASTLLSDLSQFAG
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
LVMTPRRNPAFRQIEFLTLSDKRVLLIIVTMEGEVENRVIVTEQSYSAAALTEAANYFNQ
EEECCCCCCCHHEEEEEEECCCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHC
NFAGHSFDHVRSKLRDELGRMRDDITRLMAAAVDAGTQALDASQDNVVVSGSRKLLDVEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEECCCCEEEHHH
LSSNMRSLRRLFDAFEKKTGLLQLLDQSRSAAGVQIFIGGESELLPLDECSLVTAPYSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCC
GVVVGTLGVVGPTRMAYERVVPIVDVTAKILSSALSQHK
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLNDRARILLKTLVERYISEGEPVGSRTLSKHAGLDLSPASIRNIMSDLEEMGFVASPHT
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEECCCC
SAGRVPTPRGYRFFVDTLLTVRPLDQVSVNHLENSLAASDPQRLMTAASTLLSDLSQFAG
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
LVMTPRRNPAFRQIEFLTLSDKRVLLIIVTMEGEVENRVIVTEQSYSAAALTEAANYFNQ
EEECCCCCCCHHEEEEEEECCCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHC
NFAGHSFDHVRSKLRDELGRMRDDITRLMAAAVDAGTQALDASQDNVVVSGSRKLLDVEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEECCCCEEEHHH
LSSNMRSLRRLFDAFEKKTGLLQLLDQSRSAAGVQIFIGGESELLPLDECSLVTAPYSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCC
GVVVGTLGVVGPTRMAYERVVPIVDVTAKILSSALSQHK
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA