Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 74317770

GI number: 74317770

Start: 1844034

End: 1845494

Strand: Reverse

Name: guaB [H]

Synonym: Tbd_1752

Alternate gene names: 74317770

Gene position: 1845494-1844034 (Counterclockwise)

Preceding gene: 74317772

Following gene: 74317769

Centisome position: 63.42

GC content: 66.46

Gene sequence:

>1461_bases
ATGCGTGTTCTGCAAAAAGCGCTGACGTTCGACGACGTTCTGCTCGTTCCGGCCCATTCCGCGATTCTGCCGCGCGAAGT
CAGCCTCGCCACCCAGTTGACCCGTTCGATCACGCTCAATCTGCCGCTCCTGTCGGCGGCGATGGACACGGTGACTGAAG
CGCGCCTCGCGATCGCGCTGGCTCAGGAAGGCGGCATCGGCATCGTCCACAAGAACATGAACACGGCCATGCAGGCCGCG
CAGGTGGCCGCAGTCAAACGCTTCGAGTCGGGTGTGGTGAAGGACCCGATCACCGTCGCGCCGCAAATGACCGTCCGCCA
GGTGCTCGAGATCACGCGGGCCAAGCGGATTTCGGGATTGCCCGTGATCGAGGACGGACGCGTCGTCGGCATCGTCACCA
ACCGCGACCTGCGCTTCGAATCCCGTCTCGACCAGCCCGTGTCGGCGATCATGACGCCGAAGGAACGGCTGGTGACCGTG
AAGGAAGGCGCCAACCGTGACGAAGCGATGGCGCTTCTTCACAAGCATCGACTCGAGCGCGTGCTCGTCGTCAACGACGA
CTTCGAGTTGCGCGGCCTGATCACCGTCAAGGACATCCAGAAGTCGACCGAGCATCCGCTGGCGTGCAAAGACGCGATGG
GTCGTCTGCGTGTCGGCGCCGCGGTCGGCACCGGCGAAGGTACCGAGGAGCGGGTCGCGGCGCTGGTCGAGGCCGGGGTC
GATGTCATCGTCGTCGACACGGCGCACGGGCATTCCAAGGGCGTGCTCGAGCGTGTGCGCTGGGTCAAGCAGACGTATCC
CGACGTGCAGGTCATCGGCGGCAACATCGCCACCGCCTCGGCGGCCGCGGCCCTGGTCGAACACGGCGCCGACGCGGTCA
AGGTCGGCATCGGCCCCGGCTCGATTTGCACCACCCGCATGGTCGCCGGCGTCGGCGTGCCGCAGATCTCGGCGGTCGCC
AACGTCGCCGACGCCCTGGCGGGCAGCGGCGTCGGCGTCATCGCCGACGGCGGCATCCGCTACTCAGGCGACATCGCCAA
GGCGCTCGCCGCCGGGGCGAACTGCGTCATGCTCGGTGGCCTCCTGGCCGGTACCGAAGAAGCGCCAGGCGAAGTCGAAC
TGTTCCAGGGCCGCTCGTACAAGTCCTACCGCGGCATGGGTTCGCTCGGCGCGATGCAGCAAGGCTCGAGTGACCGCTAC
TTCCAGGACAACGAAAAGAGCGCCGAGAAGCTCGTTCCCGAGGGGATCGAAGGCCGCGTGCCCTACAAGGGCAGCGTGCT
CGGCGTCATCCACCAGATGATGGGCGGGCTGCGCTCGAGCATGGGCTACCTCGGCGTCGCGACGATCACCGACATGCATG
CCAAGGCCGAGTTCGTCGAGATCACCTCCGCCGGCGTGCGCGAGTCGCACGTGCACGATGTGCAGATCACGAAGGAAGCG
CCCAATTACCGTGTCGAGTGA

Upstream 100 bases:

>100_bases
TGGGCTTCACCTTAGTAGATTACGACCAACGGCGCCTGCCCTGCGTTTGTGCCGCGCCGGACTGGCCGCGTATAATTCCG
CTTTGCATTAAGGAAAGCCC

Downstream 100 bases:

>100_bases
CAGGGATCAGGGGCCAGGATTCAGGGGTCAGGGAAAGTCACGCTGCGCGTGGCTTTTTCTTTTGCGCCACGCCGAATCCA
CCCCATCCCTGACCCCTGAA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRVLQKALTFDDVLLVPAHSAILPREVSLATQLTRSITLNLPLLSAAMDTVTEARLAIALAQEGGIGIVHKNMNTAMQAA
QVAAVKRFESGVVKDPITVAPQMTVRQVLEITRAKRISGLPVIEDGRVVGIVTNRDLRFESRLDQPVSAIMTPKERLVTV
KEGANRDEAMALLHKHRLERVLVVNDDFELRGLITVKDIQKSTEHPLACKDAMGRLRVGAAVGTGEGTEERVAALVEAGV
DVIVVDTAHGHSKGVLERVRWVKQTYPDVQVIGGNIATASAAAALVEHGADAVKVGIGPGSICTTRMVAGVGVPQISAVA
NVADALAGSGVGVIADGGIRYSGDIAKALAAGANCVMLGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQQGSSDRY
FQDNEKSAEKLVPEGIEGRVPYKGSVLGVIHQMMGGLRSSMGYLGVATITDMHAKAEFVEITSAGVRESHVHDVQITKEA
PNYRVE

Sequences:

>Translated_486_residues
MRVLQKALTFDDVLLVPAHSAILPREVSLATQLTRSITLNLPLLSAAMDTVTEARLAIALAQEGGIGIVHKNMNTAMQAA
QVAAVKRFESGVVKDPITVAPQMTVRQVLEITRAKRISGLPVIEDGRVVGIVTNRDLRFESRLDQPVSAIMTPKERLVTV
KEGANRDEAMALLHKHRLERVLVVNDDFELRGLITVKDIQKSTEHPLACKDAMGRLRVGAAVGTGEGTEERVAALVEAGV
DVIVVDTAHGHSKGVLERVRWVKQTYPDVQVIGGNIATASAAAALVEHGADAVKVGIGPGSICTTRMVAGVGVPQISAVA
NVADALAGSGVGVIADGGIRYSGDIAKALAAGANCVMLGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQQGSSDRY
FQDNEKSAEKLVPEGIEGRVPYKGSVLGVIHQMMGGLRSSMGYLGVATITDMHAKAEFVEITSAGVRESHVHDVQITKEA
PNYRVE
>Mature_486_residues
MRVLQKALTFDDVLLVPAHSAILPREVSLATQLTRSITLNLPLLSAAMDTVTEARLAIALAQEGGIGIVHKNMNTAMQAA
QVAAVKRFESGVVKDPITVAPQMTVRQVLEITRAKRISGLPVIEDGRVVGIVTNRDLRFESRLDQPVSAIMTPKERLVTV
KEGANRDEAMALLHKHRLERVLVVNDDFELRGLITVKDIQKSTEHPLACKDAMGRLRVGAAVGTGEGTEERVAALVEAGV
DVIVVDTAHGHSKGVLERVRWVKQTYPDVQVIGGNIATASAAAALVEHGADAVKVGIGPGSICTTRMVAGVGVPQISAVA
NVADALAGSGVGVIADGGIRYSGDIAKALAAGANCVMLGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQQGSSDRY
FQDNEKSAEKLVPEGIEGRVPYKGSVLGVIHQMMGGLRSSMGYLGVATITDMHAKAEFVEITSAGVRESHVHDVQITKEA
PNYRVE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=40.5405405405405, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI217035146, Length=451, Percent_Identity=42.350332594235, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI34328928, Length=451, Percent_Identity=42.350332594235, Blast_Score=343, Evalue=3e-94,
Organism=Homo sapiens, GI156616279, Length=451, Percent_Identity=42.350332594235, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI34328930, Length=451, Percent_Identity=42.350332594235, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=42.2818791946309, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI217035148, Length=451, Percent_Identity=41.6851441241685, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI217035150, Length=451, Percent_Identity=39.9113082039911, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI156104880, Length=263, Percent_Identity=38.0228136882129, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=39.6761133603239, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=39.5161290322581, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=39.5161290322581, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=39.5161290322581, Blast_Score=172, Evalue=9e-43,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=65.2263374485597, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1786293, Length=243, Percent_Identity=34.5679012345679, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=484, Percent_Identity=36.7768595041322, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71994389, Length=428, Percent_Identity=38.785046728972, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17560440, Length=274, Percent_Identity=34.6715328467153, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.6694214876033, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=39.0495867768595, Blast_Score=323, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6322012, Length=484, Percent_Identity=38.2231404958678, Blast_Score=322, Evalue=9e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.1656804733728, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=112, Percent_Identity=41.9642857142857, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=41.1157024793388, Blast_Score=337, Evalue=8e-93,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=41.1157024793388, Blast_Score=337, Evalue=8e-93,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=41.4027149321267, Blast_Score=301, Evalue=8e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51422; Mature: 51422

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLQKALTFDDVLLVPAHSAILPREVSLATQLTRSITLNLPLLSAAMDTVTEARLAIAL
CCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHEEEE
AQEGGIGIVHKNMNTAMQAAQVAAVKRFESGVVKDPITVAPQMTVRQVLEITRAKRISGL
ECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
PVIEDGRVVGIVTNRDLRFESRLDQPVSAIMTPKERLVTVKEGANRDEAMALLHKHRLER
CEEECCEEEEEEECCCCCHHHHCCCCHHHHCCCHHHEEEECCCCCHHHHHHHHHHHCCCE
VLVVNDDFELRGLITVKDIQKSTEHPLACKDAMGRLRVGAAVGTGEGTEERVAALVEAGV
EEEECCCCCEEEEEEEHHHHHCCCCCCHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQTYPDVQVIGGNIATASAAAALVEHGADAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEECCCC
SICTTRMVAGVGVPQISAVANVADALAGSGVGVIADGGIRYSGDIAKALAAGANCVMLGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCCEEEECC
LLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQQGSSDRYFQDNEKSAEKLVPEGIEGRV
EEECCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
PYKGSVLGVIHQMMGGLRSSMGYLGVATITDMHAKAEFVEITSAGVRESHVHDVQITKEA
CCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHEEEECCCCCCCCCCCEEEEECCC
PNYRVE
CCCCCC
>Mature Secondary Structure
MRVLQKALTFDDVLLVPAHSAILPREVSLATQLTRSITLNLPLLSAAMDTVTEARLAIAL
CCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHEEEE
AQEGGIGIVHKNMNTAMQAAQVAAVKRFESGVVKDPITVAPQMTVRQVLEITRAKRISGL
ECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
PVIEDGRVVGIVTNRDLRFESRLDQPVSAIMTPKERLVTVKEGANRDEAMALLHKHRLER
CEEECCEEEEEEECCCCCHHHHCCCCHHHHCCCHHHEEEECCCCCHHHHHHHHHHHCCCE
VLVVNDDFELRGLITVKDIQKSTEHPLACKDAMGRLRVGAAVGTGEGTEERVAALVEAGV
EEEECCCCCEEEEEEEHHHHHCCCCCCHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQTYPDVQVIGGNIATASAAAALVEHGADAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEECCCC
SICTTRMVAGVGVPQISAVANVADALAGSGVGVIADGGIRYSGDIAKALAAGANCVMLGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCCEEEECC
LLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQQGSSDRYFQDNEKSAEKLVPEGIEGRV
EEECCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
PYKGSVLGVIHQMMGGLRSSMGYLGVATITDMHAKAEFVEITSAGVRESHVHDVQITKEA
CCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHEEEECCCCCCCCCCCEEEEECCC
PNYRVE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA