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The map label for this gene is guaA

Identifier: 74317769

GI number: 74317769

Start: 1842350

End: 1843912

Strand: Reverse

Name: guaA

Synonym: Tbd_1751

Alternate gene names: 74317769

Gene position: 1843912-1842350 (Counterclockwise)

Preceding gene: 74317770

Following gene: 74317766

Centisome position: 63.37

GC content: 64.36

Gene sequence:

>1563_bases
ATGCACCAGAAAATCCTCATTCTCGATTTCGGTTCCCAGTACACCCAGCTGATCGCGCGCCGCGTGCGCGAGGCCGGGGT
CTATTGCGAACTCCACCCCAACGACGTGAGCGAGGATTTCGTGCGCGAGTTCGCGCCGCAGGGGATCATCCTGTCGGGCG
GACCGAATTCGGTGTACGAGGACGAGACGCCGCGTGCGCCCGACGTCGTGTTCACGCTCGGTGTGCCGGTGCTCGGCATC
TGCTACGGCATGCAGACGATGGCCGCGCAGTTGGGCGGAGCGGTCGAGTCTGCGGCCAAGCGCGAGTTCGGCTACGCCGA
AATCCGCGCGCGCGGGCATACGCAGCTTCTGCGTGACATCCAGGATCGCGTCACCGGCGAGGGACACGGCATGCTCGACG
TATGGATGAGCCACGGCGACAAGGTCACCGCGCTGCCGGAAGGTTTCAAGCTCATGGCGAGCAACGCCGCGACGCCGATC
GCCGGCATGGCCGACGAAGCCCGCCGCTTCTACGGCGTGCAGTTCCATCCCGAAGTGACGCACACGTTGCAGGGCAAGCA
CATCCTCAACCGCTTCGTGCACGACATCTGCGGCTGCGGCTCCGACTGGAACATGCCCGACTACGTCGAGGAAGCGATCG
GCAAGGTGCGTAGCGAAGTCGGCAGCGACGAAGTCATCCTCGGTCTTTCGGGCGGTGTCGATTCCTCCGTCGTCGCCGCG
CTTCTGCATCGCGCGGTCGGCGACCAGCTCACCTGCGTCTTCGTCGACAACGGCTTGCTGCGCCTGAACGAAGCCGAGCA
GGTGATGGAGACCTTCGCCCAGAACCTTGGTGTCAAGGTCATCCACGTCGACGCGACCGAGCGTTTCATGCGCGAACTGG
CAGGCGTCAGCGACCCCGAGCAGAAGCGCAAGATCATCGGCCGCGAATTCGTTCACGTCTTCCAGGAAGAAGCCGAAAAG
CTGCCCAAAGCCAAGTGGCTCGCCCAGGGCACGATCTACCCCGACGTGATCGAGTCGGCCAGCGCCAAGACAAAGAAGGC
GCATACGATCAAGAGCCATCACAACGTCGGCGGCCTGCCGGAGACGCTGCACCTGCAACTGCTCGAGCCGCTGCGCGAAC
TCTTCAAGGACGAGGTGCGCGAACTCGGCATCGCGCTGGGGCTGCCGCACGACATGGTCTATCGCCATCCCTTCCCGGGG
CCGGGCCTCGGCGTGCGCATCCTCGGCAAGGTCAAGCGCGAATACGCCGACCTGCTGCGCCGCGCCGACGCGATCTTCAT
CGAGGAATTGCGCGCGTCGGGCTGGTACGAGAAAACGAGCCAGGCGTTCACCGTCTTCCTGCCCGTGAAATCGGTCGGCG
TCATGGGCGACGGTCGCACCTACGACTACGTCGTCGCGTTGCGTGCCGTGCAGACCCAGGATTTCATGACCGCCCACTGG
GCCGAACTGCCGTACACGCTGCTCGGCAAGGTCTCCAACCGCATCATCAACGAAGTGCGCGGCATCAATCGTGTCGTCTA
CGACGTCAGCGGCAAGCCGCCGGCGACGATCGAGTGGGAATAG

Upstream 100 bases:

>100_bases
CAGGGGTCAGGGAAAGTCACGCTGCGCGTGGCTTTTTCTTTTGCGCCACGCCGAATCCACCCCATCCCTGACCCCTGAAT
CCTGAATCCTGACCCCTGAC

Downstream 100 bases:

>100_bases
TCCGCCGCGGATAGCGGCAACACATACCTAAGCATTCTGTCGGCCGGCCCGAGCCTTGTGCGGAGCGAGGTGCCGCAGCG
TTTTCCTCACCCCTCCGCCG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MHQKILILDFGSQYTQLIARRVREAGVYCELHPNDVSEDFVREFAPQGIILSGGPNSVYEDETPRAPDVVFTLGVPVLGI
CYGMQTMAAQLGGAVESAAKREFGYAEIRARGHTQLLRDIQDRVTGEGHGMLDVWMSHGDKVTALPEGFKLMASNAATPI
AGMADEARRFYGVQFHPEVTHTLQGKHILNRFVHDICGCGSDWNMPDYVEEAIGKVRSEVGSDEVILGLSGGVDSSVVAA
LLHRAVGDQLTCVFVDNGLLRLNEAEQVMETFAQNLGVKVIHVDATERFMRELAGVSDPEQKRKIIGREFVHVFQEEAEK
LPKAKWLAQGTIYPDVIESASAKTKKAHTIKSHHNVGGLPETLHLQLLEPLRELFKDEVRELGIALGLPHDMVYRHPFPG
PGLGVRILGKVKREYADLLRRADAIFIEELRASGWYEKTSQAFTVFLPVKSVGVMGDGRTYDYVVALRAVQTQDFMTAHW
AELPYTLLGKVSNRIINEVRGINRVVYDVSGKPPATIEWE

Sequences:

>Translated_520_residues
MHQKILILDFGSQYTQLIARRVREAGVYCELHPNDVSEDFVREFAPQGIILSGGPNSVYEDETPRAPDVVFTLGVPVLGI
CYGMQTMAAQLGGAVESAAKREFGYAEIRARGHTQLLRDIQDRVTGEGHGMLDVWMSHGDKVTALPEGFKLMASNAATPI
AGMADEARRFYGVQFHPEVTHTLQGKHILNRFVHDICGCGSDWNMPDYVEEAIGKVRSEVGSDEVILGLSGGVDSSVVAA
LLHRAVGDQLTCVFVDNGLLRLNEAEQVMETFAQNLGVKVIHVDATERFMRELAGVSDPEQKRKIIGREFVHVFQEEAEK
LPKAKWLAQGTIYPDVIESASAKTKKAHTIKSHHNVGGLPETLHLQLLEPLRELFKDEVRELGIALGLPHDMVYRHPFPG
PGLGVRILGKVKREYADLLRRADAIFIEELRASGWYEKTSQAFTVFLPVKSVGVMGDGRTYDYVVALRAVQTQDFMTAHW
AELPYTLLGKVSNRIINEVRGINRVVYDVSGKPPATIEWE
>Mature_520_residues
MHQKILILDFGSQYTQLIARRVREAGVYCELHPNDVSEDFVREFAPQGIILSGGPNSVYEDETPRAPDVVFTLGVPVLGI
CYGMQTMAAQLGGAVESAAKREFGYAEIRARGHTQLLRDIQDRVTGEGHGMLDVWMSHGDKVTALPEGFKLMASNAATPI
AGMADEARRFYGVQFHPEVTHTLQGKHILNRFVHDICGCGSDWNMPDYVEEAIGKVRSEVGSDEVILGLSGGVDSSVVAA
LLHRAVGDQLTCVFVDNGLLRLNEAEQVMETFAQNLGVKVIHVDATERFMRELAGVSDPEQKRKIIGREFVHVFQEEAEK
LPKAKWLAQGTIYPDVIESASAKTKKAHTIKSHHNVGGLPETLHLQLLEPLRELFKDEVRELGIALGLPHDMVYRHPFPG
PGLGVRILGKVKREYADLLRRADAIFIEELRASGWYEKTSQAFTVFLPVKSVGVMGDGRTYDYVVALRAVQTQDFMTAHW
AELPYTLLGKVSNRIINEVRGINRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=562, Percent_Identity=37.0106761565836, Blast_Score=323, Evalue=3e-88,
Organism=Escherichia coli, GI1788854, Length=518, Percent_Identity=67.9536679536679, Blast_Score=746, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=576, Percent_Identity=36.8055555555556, Blast_Score=308, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI133901714, Length=576, Percent_Identity=36.8055555555556, Blast_Score=308, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI71992717, Length=576, Percent_Identity=36.9791666666667, Blast_Score=308, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6323873, Length=529, Percent_Identity=50.8506616257089, Blast_Score=549, Evalue=1e-157,
Organism=Drosophila melanogaster, GI281365319, Length=561, Percent_Identity=36.8983957219251, Blast_Score=315, Evalue=5e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_THIDA (Q3SI29)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315509.1
- ProteinModelPortal:   Q3SI29
- SMR:   Q3SI29
- STRING:   Q3SI29
- GeneID:   3671336
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1751
- NMPDR:   fig|292415.3.peg.1848
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   Q3SI29
- ProtClustDB:   PRK00074
- BioCyc:   TDEN292415:TBD_1751-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57705; Mature: 57705

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 81-81 ACT_SITE 176-176 ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQKILILDFGSQYTQLIARRVREAGVYCELHPNDVSEDFVREFAPQGIILSGGPNSVYE
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DETPRAPDVVFTLGVPVLGICYGMQTMAAQLGGAVESAAKREFGYAEIRARGHTQLLRDI
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHCCHHHHHHHH
QDRVTGEGHGMLDVWMSHGDKVTALPEGFKLMASNAATPIAGMADEARRFYGVQFHPEVT
HHHHCCCCCCHHHHHHCCCCEEEECCCCHHHHHCCCCCCCCCCHHHHHHHCCCEECCCHH
HTLQGKHILNRFVHDICGCGSDWNMPDYVEEAIGKVRSEVGSDEVILGLSGGVDSSVVAA
HHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LLHRAVGDQLTCVFVDNGLLRLNEAEQVMETFAQNLGVKVIHVDATERFMRELAGVSDPE
HHHHHCCCCEEEEEECCCEEEECHHHHHHHHHHHHCCEEEEEECHHHHHHHHHCCCCCHH
QKRKIIGREFVHVFQEEAEKLPKAKWLAQGTIYPDVIESASAKTKKAHTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCC
ETLHLQLLEPLRELFKDEVRELGIALGLPHDMVYRHPFPGPGLGVRILGKVKREYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRASGWYEKTSQAFTVFLPVKSVGVMGDGRTYDYVVALRAVQTQDFMTAHW
HHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AELPYTLLGKVSNRIINEVRGINRVVYDVSGKPPATIEWE
HHCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MHQKILILDFGSQYTQLIARRVREAGVYCELHPNDVSEDFVREFAPQGIILSGGPNSVYE
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DETPRAPDVVFTLGVPVLGICYGMQTMAAQLGGAVESAAKREFGYAEIRARGHTQLLRDI
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHCCHHHHHHHH
QDRVTGEGHGMLDVWMSHGDKVTALPEGFKLMASNAATPIAGMADEARRFYGVQFHPEVT
HHHHCCCCCCHHHHHHCCCCEEEECCCCHHHHHCCCCCCCCCCHHHHHHHCCCEECCCHH
HTLQGKHILNRFVHDICGCGSDWNMPDYVEEAIGKVRSEVGSDEVILGLSGGVDSSVVAA
HHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LLHRAVGDQLTCVFVDNGLLRLNEAEQVMETFAQNLGVKVIHVDATERFMRELAGVSDPE
HHHHHCCCCEEEEEECCCEEEECHHHHHHHHHHHHCCEEEEEECHHHHHHHHHCCCCCHH
QKRKIIGREFVHVFQEEAEKLPKAKWLAQGTIYPDVIESASAKTKKAHTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCC
ETLHLQLLEPLRELFKDEVRELGIALGLPHDMVYRHPFPGPGLGVRILGKVKREYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRASGWYEKTSQAFTVFLPVKSVGVMGDGRTYDYVVALRAVQTQDFMTAHW
HHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AELPYTLLGKVSNRIINEVRGINRVVYDVSGKPPATIEWE
HHCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA