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The map label for this gene is uvrY [H]

Identifier: 74317606

GI number: 74317606

Start: 1673561

End: 1674208

Strand: Direct

Name: uvrY [H]

Synonym: Tbd_1588

Alternate gene names: 74317606

Gene position: 1673561-1674208 (Clockwise)

Preceding gene: 74317605

Following gene: 74317607

Centisome position: 57.51

GC content: 63.73

Gene sequence:

>648_bases
GTGTCCGCCGCAAAACCTTACCGCATCCTGATCGTCGACGACCACGCCATCGTCCGTGAAGGGCTCAAGCAGATCCTCGC
TGAAGTCGATGACGTCAAAGTCGGCGGCGAGGCGGACTGCTCGAGCGGCGCCTTGCGCATGGCGCGTCAGGAAGCCTGGG
ATCTGGTGCTGATGGACATCTCGATGCCCGATCGCGGCGGGCTCGAAACGCTCGAACTCCTGAAAAAGGAACACCCCGGG
ATCAAGGTGTTGATGCTGTCGATGCATCGCGAAACGCAATTCGCGGTGCGCGCGCTCAAGTCGGGCGCGGCCGGCTACCT
CAACAAGCAGAGCGCGCCGGCCGAGCTGCTCGACGCCATCCGCCTCGTCGCCTCGGGAAAGAAGTACATCAGCTCCGAAG
TGGCGCAGGAACTCGCCAGCCAGGTCAGCGGGGAGCGCGACGGCCTGCCGCACGAGAGCCTCTCCAATCGCGAGTACCAG
ACCCTGTGCATGATCGCCTCCGGCCTCACGGTCAGCGGCATCGCCGACAAGCTCGCGCTTTCGGTCAAGACCGTCAGCAT
GTATCGCGGCCGGGTCCTGGCCAAGATGCAACTCAAGAACAACGCCGAGCTGACCCATTACGCGATCAAGCACGGCCTGC
TCGACTAG

Upstream 100 bases:

>100_bases
GACCAGGGCACCGAACTGAGCCTGCGCATCCCCTTGTCCGGCCCCGCGGCCGCGGCGGGATGACGCATAATGTGCGCCAA
CCCCCCGCAGAGCCTTCCCC

Downstream 100 bases:

>100_bases
CCCCCCCCGCCCCGGGCCAGCCGTTCTGCCGGCTCGCCGCGCCCGAGACCCGGCGTCCACGGAAATACCCGGCTTTTACC
GCCCTAATCGGCGCTTAAGC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MSAAKPYRILIVDDHAIVREGLKQILAEVDDVKVGGEADCSSGALRMARQEAWDLVLMDISMPDRGGLETLELLKKEHPG
IKVLMLSMHRETQFAVRALKSGAAGYLNKQSAPAELLDAIRLVASGKKYISSEVAQELASQVSGERDGLPHESLSNREYQ
TLCMIASGLTVSGIADKLALSVKTVSMYRGRVLAKMQLKNNAELTHYAIKHGLLD

Sequences:

>Translated_215_residues
MSAAKPYRILIVDDHAIVREGLKQILAEVDDVKVGGEADCSSGALRMARQEAWDLVLMDISMPDRGGLETLELLKKEHPG
IKVLMLSMHRETQFAVRALKSGAAGYLNKQSAPAELLDAIRLVASGKKYISSEVAQELASQVSGERDGLPHESLSNREYQ
TLCMIASGLTVSGIADKLALSVKTVSMYRGRVLAKMQLKNNAELTHYAIKHGLLD
>Mature_214_residues
SAAKPYRILIVDDHAIVREGLKQILAEVDDVKVGGEADCSSGALRMARQEAWDLVLMDISMPDRGGLETLELLKKEHPGI
KVLMLSMHRETQFAVRALKSGAAGYLNKQSAPAELLDAIRLVASGKKYISSEVAQELASQVSGERDGLPHESLSNREYQT
LCMIASGLTVSGIADKLALSVKTVSMYRGRVLAKMQLKNNAELTHYAIKHGLLD

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=208, Percent_Identity=44.2307692307692, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=36.734693877551, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786747, Length=204, Percent_Identity=31.3725490196078, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788521, Length=207, Percent_Identity=31.8840579710145, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1787473, Length=190, Percent_Identity=33.6842105263158, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=28.0788177339901, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788712, Length=200, Percent_Identity=25, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23429; Mature: 23297

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAKPYRILIVDDHAIVREGLKQILAEVDDVKVGGEADCSSGALRMARQEAWDLVLMDI
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEEEEEE
SMPDRGGLETLELLKKEHPGIKVLMLSMHRETQFAVRALKSGAAGYLNKQSAPAELLDAI
CCCCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RLVASGKKYISSEVAQELASQVSGERDGLPHESLSNREYQTLCMIASGLTVSGIADKLAL
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
SVKTVSMYRGRVLAKMQLKNNAELTHYAIKHGLLD
HHHHHHHHHCHHHEEEECCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SAAKPYRILIVDDHAIVREGLKQILAEVDDVKVGGEADCSSGALRMARQEAWDLVLMDI
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEEEEEE
SMPDRGGLETLELLKKEHPGIKVLMLSMHRETQFAVRALKSGAAGYLNKQSAPAELLDAI
CCCCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RLVASGKKYISSEVAQELASQVSGERDGLPHESLSNREYQTLCMIASGLTVSGIADKLAL
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
SVKTVSMYRGRVLAKMQLKNNAELTHYAIKHGLLD
HHHHHHHHHCHHHEEEECCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]