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The map label for this gene is degS [H]

Identifier: 74317605

GI number: 74317605

Start: 1672042

End: 1673523

Strand: Direct

Name: degS [H]

Synonym: Tbd_1587

Alternate gene names: 74317605

Gene position: 1672042-1673523 (Clockwise)

Preceding gene: 74317598

Following gene: 74317606

Centisome position: 57.46

GC content: 67.88

Gene sequence:

>1482_bases
ATGCGGGGGAGTATGGTTGCATCGAAAGCCGTCGACGAAAGGACACTGTTGAGGGCTCTGCTCCGCGAATCTCCGAGTGA
AGTGCTCGTTCTCGATCCCGAAACGCTGCTGATCGTCCAGGCCAACCCGGCCGCGCTGAAGAACCTGCGCTACCGACTCA
AGGAAGTCCGAGAACTTTCCCCGCTGCAGTTTCTGACCCCCGACGACGCCCCGGCGTTCCAAGCCTTGCTGAACCAATTG
CGCAGCGGCCGGAAACGCAGCGCCAGGATCAAGGCGCGATGCCAGCGCGCCGACGGCACCCGCTATCCGGTCGAGGCCCG
CCTGGTCTATTCGAACGAGAACGGTCGCCCATTCTTCCTGTGCGTGGCCGACGACGTCAGCCAGCGCGACGCGACCCGCG
CCGCGCTCGCGCATTCGGCCTCCGACATGCAGGCGATCGTCTCGCACATCCCCGGAATGGCCTTTCAGATCGTCCGCCGC
CCCGGGGAGGCGCCGGTGCTGCGCTACGTCAGCGAGCAATCACGGCAGTTGCTCGGCGTCCGCGCCTCCGCCCTGTGCGC
CGACCCGCAAGCCTTCTTCGCGCTGATCCTCGAGGAAGACCGCCCGGGCTACCTTGAGCGGCTCGCCGAGACCGCGGGCG
GCCACTTGAGTTTCAACTGGGAAGGCCGGATCTGGCTGCAAGCCTGGAAGGACGTGAAATGGATCACGATCCGCGTCAGC
GAGCGCGTCACCGCGGACTGCACCCTCTGGGACGGGATCATGCTCAACATCACGCGCAGCAAGGAAGCCGAGGCCGAAAT
CGACCATTCGCGGGCGCGCCTGCGCGCTTTGGCCGCCCACGTCGAATCCGCGAAGGAGCAGGAACGGCTGTACCTCGCGC
GCGAGGTCCATGACGACCTTGGCGGCAACCTCACGACCATCAAGATCGGCCTGTCCTGCCTCGCCCGCCAGTTCCCCTCG
GAGTCGACGCCGCTGACCGAGCGCGTGCGCTATCTCGACAATCTCGTCGACCAGACCTTCGAGGCGGCTCACCGCATCGC
CTCCAACCTGCGGCCGGCGGCACTCGACTTCGGTATCGTACCGGCGATCGACAGCCAGTTGCAGCGCTTCGGGCGCAATA
CCGAGATCGCCTACGAATTCCGCGCCCCCACGGACGAGATCCCGCTCGATTCGGCCGCTGCGATCGCCGTGTTCCGCATC
GTCCAGGAGGGCCTGACCAACGTCGCCAAGCACGCGCGCGCGACACGGGTGCGGCTGGAACTCGTCCGCGATCGCGACAC
CCTGCATCTCACGCTCACCGACAACGGCCGCGGCCTGCCCGCCGCACCGAACGGCATGGCGCGGCCGGTCTTCGGCATCC
TCGGCATGAGCGAGCGCGCCGCGGCCCTCGGCGGGCAGCTCGTCGTGCGGCCGGCGCCGGACCAGGGCACCGAACTGAGC
CTGCGCATCCCCTTGTCCGGCCCCGCGGCCGCGGCGGGATGA

Upstream 100 bases:

>100_bases
CTCTAGATGCGGTGCATGGACGGGATTTTCAAGACACGGTTGTCTGAAAATGCATCTGCTACTATTCCGCGCAAACGACC
GGGGTCGTCATCGTTTCAGC

Downstream 100 bases:

>100_bases
CGCATAATGTGCGCCAACCCCCCGCAGAGCCTTCCCCGTGTCCGCCGCAAAACCTTACCGCATCCTGATCGTCGACGACC
ACGCCATCGTCCGTGAAGGG

Product: sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MRGSMVASKAVDERTLLRALLRESPSEVLVLDPETLLIVQANPAALKNLRYRLKEVRELSPLQFLTPDDAPAFQALLNQL
RSGRKRSARIKARCQRADGTRYPVEARLVYSNENGRPFFLCVADDVSQRDATRAALAHSASDMQAIVSHIPGMAFQIVRR
PGEAPVLRYVSEQSRQLLGVRASALCADPQAFFALILEEDRPGYLERLAETAGGHLSFNWEGRIWLQAWKDVKWITIRVS
ERVTADCTLWDGIMLNITRSKEAEAEIDHSRARLRALAAHVESAKEQERLYLAREVHDDLGGNLTTIKIGLSCLARQFPS
ESTPLTERVRYLDNLVDQTFEAAHRIASNLRPAALDFGIVPAIDSQLQRFGRNTEIAYEFRAPTDEIPLDSAAAIAVFRI
VQEGLTNVAKHARATRVRLELVRDRDTLHLTLTDNGRGLPAAPNGMARPVFGILGMSERAAALGGQLVVRPAPDQGTELS
LRIPLSGPAAAAG

Sequences:

>Translated_493_residues
MRGSMVASKAVDERTLLRALLRESPSEVLVLDPETLLIVQANPAALKNLRYRLKEVRELSPLQFLTPDDAPAFQALLNQL
RSGRKRSARIKARCQRADGTRYPVEARLVYSNENGRPFFLCVADDVSQRDATRAALAHSASDMQAIVSHIPGMAFQIVRR
PGEAPVLRYVSEQSRQLLGVRASALCADPQAFFALILEEDRPGYLERLAETAGGHLSFNWEGRIWLQAWKDVKWITIRVS
ERVTADCTLWDGIMLNITRSKEAEAEIDHSRARLRALAAHVESAKEQERLYLAREVHDDLGGNLTTIKIGLSCLARQFPS
ESTPLTERVRYLDNLVDQTFEAAHRIASNLRPAALDFGIVPAIDSQLQRFGRNTEIAYEFRAPTDEIPLDSAAAIAVFRI
VQEGLTNVAKHARATRVRLELVRDRDTLHLTLTDNGRGLPAAPNGMARPVFGILGMSERAAALGGQLVVRPAPDQGTELS
LRIPLSGPAAAAG
>Mature_493_residues
MRGSMVASKAVDERTLLRALLRESPSEVLVLDPETLLIVQANPAALKNLRYRLKEVRELSPLQFLTPDDAPAFQALLNQL
RSGRKRSARIKARCQRADGTRYPVEARLVYSNENGRPFFLCVADDVSQRDATRAALAHSASDMQAIVSHIPGMAFQIVRR
PGEAPVLRYVSEQSRQLLGVRASALCADPQAFFALILEEDRPGYLERLAETAGGHLSFNWEGRIWLQAWKDVKWITIRVS
ERVTADCTLWDGIMLNITRSKEAEAEIDHSRARLRALAAHVESAKEQERLYLAREVHDDLGGNLTTIKIGLSCLARQFPS
ESTPLTERVRYLDNLVDQTFEAAHRIASNLRPAALDFGIVPAIDSQLQRFGRNTEIAYEFRAPTDEIPLDSAAAIAVFRI
VQEGLTNVAKHARATRVRLELVRDRDTLHLTLTDNGRGLPAAPNGMARPVFGILGMSERAAALGGQLVVRPAPDQGTELS
LRIPLSGPAAAAG

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=239, Percent_Identity=30.9623430962343, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787474, Length=215, Percent_Identity=28.3720930232558, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788812, Length=200, Percent_Identity=26, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54477; Mature: 54477

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS50112 PAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGSMVASKAVDERTLLRALLRESPSEVLVLDPETLLIVQANPAALKNLRYRLKEVRELS
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHCC
PLQFLTPDDAPAFQALLNQLRSGRKRSARIKARCQRADGTRYPVEARLVYSNENGRPFFL
CCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEE
CVADDVSQRDATRAALAHSASDMQAIVSHIPGMAFQIVRRPGEAPVLRYVSEQSRQLLGV
EEECCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RASALCADPQAFFALILEEDRPGYLERLAETAGGHLSFNWEGRIWLQAWKDVKWITIRVS
HHHHHHCCHHHHEEEEECCCCCHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEEEEEC
ERVTADCTLWDGIMLNITRSKEAEAEIDHSRARLRALAAHVESAKEQERLYLAREVHDDL
CCCEECEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGNLTTIKIGLSCLARQFPSESTPLTERVRYLDNLVDQTFEAAHRIASNLRPAALDFGIV
CCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
PAIDSQLQRFGRNTEIAYEFRAPTDEIPLDSAAAIAVFRIVQEGLTNVAKHARATRVRLE
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVRDRDTLHLTLTDNGRGLPAAPNGMARPVFGILGMSERAAALGGQLVVRPAPDQGTELS
EEECCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCCEEEEECCCCCCCEEE
LRIPLSGPAAAAG
EEECCCCCCCCCC
>Mature Secondary Structure
MRGSMVASKAVDERTLLRALLRESPSEVLVLDPETLLIVQANPAALKNLRYRLKEVRELS
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHCC
PLQFLTPDDAPAFQALLNQLRSGRKRSARIKARCQRADGTRYPVEARLVYSNENGRPFFL
CCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEE
CVADDVSQRDATRAALAHSASDMQAIVSHIPGMAFQIVRRPGEAPVLRYVSEQSRQLLGV
EEECCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RASALCADPQAFFALILEEDRPGYLERLAETAGGHLSFNWEGRIWLQAWKDVKWITIRVS
HHHHHHCCHHHHEEEEECCCCCHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEEEEEC
ERVTADCTLWDGIMLNITRSKEAEAEIDHSRARLRALAAHVESAKEQERLYLAREVHDDL
CCCEECEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGNLTTIKIGLSCLARQFPSESTPLTERVRYLDNLVDQTFEAAHRIASNLRPAALDFGIV
CCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
PAIDSQLQRFGRNTEIAYEFRAPTDEIPLDSAAAIAVFRIVQEGLTNVAKHARATRVRLE
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVRDRDTLHLTLTDNGRGLPAAPNGMARPVFGILGMSERAAALGGQLVVRPAPDQGTELS
EEECCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCCEEEEECCCCCCCEEE
LRIPLSGPAAAAG
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]