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The map label for this gene is cirA [H]

Identifier: 74317284

GI number: 74317284

Start: 1329050

End: 1331071

Strand: Direct

Name: cirA [H]

Synonym: Tbd_1266

Alternate gene names: 74317284

Gene position: 1329050-1331071 (Clockwise)

Preceding gene: 74317283

Following gene: 74317285

Centisome position: 45.67

GC content: 67.21

Gene sequence:

>2022_bases
ATGAGTCGTTTCCCGAAGCACCTTTCCGCTCTGCCCCGCCCGAACCACGCGCCTCGCACGTCCGGCCGCTTGCGCGCGCT
GTCTTTTCTGCTGCCCGCTTTGCCCCTGCTGGCTGGCCCGGTGCAGGCGTCGCCGCTCGACCTCGACATCACGCAGATGA
GCCTCGAACAGCTCATGGAAATCAGCGTCACCGGCGCGTCGAAGTACGAGCAGAAGCAGAGCGAGGTCGCGGCCGCCGTC
AGTGTGATCACGCGCGACGAGATCCGGACCTACGGCTGGCGAACGCTCGCCGAGGCGCTCGCGAGCCTGCCGGGCGTCCA
CACCACCTACGACCGCCAGTACAGCTATGTCGGCGCCCGCGGCTTCGGGCTGCCAGGGGATTTCAACTCGCGTTTGCTGC
TCACCGTCGACGGCAACCGCGCCAACGAGGTCGTGTACGGCACGGCGCTGATGGGCCGGGAATTCCTGGTCGATCTCGAC
CTGGTCGAACGCATCGAATACATCCCCGGTCCAGGGGGCGCGGTGTATGGGCAAAACGCATTGTTCGGCGTCGTCAATGT
CGTCACGCGGACGGGAGCGGACGTGAACGGTGGCGAGGTCGCGCTGGCCCACAGCACGCTCGACTCCGGCAACGAAGGCC
GCGCGACCTGGGGAGGCGTGCTCGACAACGGCGTCGATGTCCTGCTGTCCGCCAGCGCCTATGAAGCGGAGGGGCGCGAC
CTCTACTTCGACTACGGCAGTTCGGGTGTGGCCGGCGTCGCCTCCGGAATGGACGGTGAGCGCGACAAGCAGTTCTTCGG
TCGCGCGGGGCGGGGACCGTGGTCGTTCGATTTTTCCTACGGAGAGCGGCGCAAGGACGACCCGATCGCCGCCTACAAAA
GCGATCCGCTCGTACCGGGCCAGTACGCCGAGGATCGCCATCTGCTGACGCAACTGCAATACCAGGATCGCTTCGCCGGC
GGCACGCTGCAGGTCTCGGGTCGCCTGTTCCTCGGACGCGAGCGCTTCAGGGGGCTGTTCCACCGTTCCGGGGACGCGCA
TCGCTACGCGTTCTCGAGCGACTGGCAGGGCATGGAGGTCCGGCTGGTGTCGACCGCCCGGGCCGACCACAAGACCATGT
TCGGCTTCGAGTATCAGGACAACGCGCGCCAGGACCAGTCCGTCGTCGGCGCGGCCGCAGGCGTCATGATTCCGGGCGCC
GGCTGGCGCGCCGGCGTTTATGCGCAGGACGAGTGGACCCTCACGGAGACATTGAGCGCGACGCTCGGCGTGCGCGCCGA
CCGCAGCGACGTCTCCGGCAGCGCGCTGAGTCCTCGCCTCGCCCTGGTCTGGCAGATGACGCCCGACACCACGCTGAAGG
CCATGTACGGACGTGCCTTCCGGGCGCCGAACGCGCTCGAAAGCAATCTCGGCGACGGCGTGACCCAGCTTCCCAACCCC
AACCTCGACGCCGAGCGCATCGATACCCTCGAGTTGCTGGCCGAGCAGCGCGTTACGCCAAGCCTGCGCCTGCGCGCGAC
GGCCTACCGCTGGACGATGCAGGGGCTGGTCACGCTTGCGGGACTCCCCGGCGGCTTCACCCAATATCAGAACGGCGCCG
ACATCGAGGCGCGCGGGGTCGAGCTTTCCGCCGACAAGACCTGGGACTGGGGCGGGCGCATTCGCGGAAGTCTCTCGCGC
CAGGATGCCTGTTACGCCGACGGCCCGGTGTTGCTCAATTCGCCGCGGCTACTGGGCAAGCTCAATGTCTCGAGCCCCGT
TCCGCAGACGGGCCTGCGCCTCGGCTACGAGCTTCAATACTCCGCGGATCGTCGCGCGGTCGACGGGACCGACGTGCCGG
GTTACTGGCTTTCCAATCTCAATCTCGTCGCCGACAAATGGGCGAGGGGGCTCGAGCTGTCGCTTGGCCTTTACAACCTT
CTCGACCGCGACTACGCCCAGCCCGGCTCGGCGTTCAACTGGCAGAACGTTTTCGAGCAGGACGGGCGGAGTGCACGGCT
GAAGGCCGTGTACCGATTCTGA

Upstream 100 bases:

>100_bases
GTCGACGCCGAGGCCGCCGATAGGTAGGGAGGCTGGTCTCGCCAGGGCCGCCCCCGCCGCCGGCCCGGATCAAGGCTGTG
CAGTCGCGAACTTGCCCGCA

Downstream 100 bases:

>100_bases
GCGGACGATGGCGACGATTCGATTCCTTCGCCAGGCCGGGATGCTTGCGCTGGCATTCAGCCTGTTTGCAGGCAGTCCCG
CAGCCGCCCAGAACAACGCC

Product: TonB-dependent iron complex outermembrane receptor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSRFPKHLSALPRPNHAPRTSGRLRALSFLLPALPLLAGPVQASPLDLDITQMSLEQLMEISVTGASKYEQKQSEVAAAV
SVITRDEIRTYGWRTLAEALASLPGVHTTYDRQYSYVGARGFGLPGDFNSRLLLTVDGNRANEVVYGTALMGREFLVDLD
LVERIEYIPGPGGAVYGQNALFGVVNVVTRTGADVNGGEVALAHSTLDSGNEGRATWGGVLDNGVDVLLSASAYEAEGRD
LYFDYGSSGVAGVASGMDGERDKQFFGRAGRGPWSFDFSYGERRKDDPIAAYKSDPLVPGQYAEDRHLLTQLQYQDRFAG
GTLQVSGRLFLGRERFRGLFHRSGDAHRYAFSSDWQGMEVRLVSTARADHKTMFGFEYQDNARQDQSVVGAAAGVMIPGA
GWRAGVYAQDEWTLTETLSATLGVRADRSDVSGSALSPRLALVWQMTPDTTLKAMYGRAFRAPNALESNLGDGVTQLPNP
NLDAERIDTLELLAEQRVTPSLRLRATAYRWTMQGLVTLAGLPGGFTQYQNGADIEARGVELSADKTWDWGGRIRGSLSR
QDACYADGPVLLNSPRLLGKLNVSSPVPQTGLRLGYELQYSADRRAVDGTDVPGYWLSNLNLVADKWARGLELSLGLYNL
LDRDYAQPGSAFNWQNVFEQDGRSARLKAVYRF

Sequences:

>Translated_673_residues
MSRFPKHLSALPRPNHAPRTSGRLRALSFLLPALPLLAGPVQASPLDLDITQMSLEQLMEISVTGASKYEQKQSEVAAAV
SVITRDEIRTYGWRTLAEALASLPGVHTTYDRQYSYVGARGFGLPGDFNSRLLLTVDGNRANEVVYGTALMGREFLVDLD
LVERIEYIPGPGGAVYGQNALFGVVNVVTRTGADVNGGEVALAHSTLDSGNEGRATWGGVLDNGVDVLLSASAYEAEGRD
LYFDYGSSGVAGVASGMDGERDKQFFGRAGRGPWSFDFSYGERRKDDPIAAYKSDPLVPGQYAEDRHLLTQLQYQDRFAG
GTLQVSGRLFLGRERFRGLFHRSGDAHRYAFSSDWQGMEVRLVSTARADHKTMFGFEYQDNARQDQSVVGAAAGVMIPGA
GWRAGVYAQDEWTLTETLSATLGVRADRSDVSGSALSPRLALVWQMTPDTTLKAMYGRAFRAPNALESNLGDGVTQLPNP
NLDAERIDTLELLAEQRVTPSLRLRATAYRWTMQGLVTLAGLPGGFTQYQNGADIEARGVELSADKTWDWGGRIRGSLSR
QDACYADGPVLLNSPRLLGKLNVSSPVPQTGLRLGYELQYSADRRAVDGTDVPGYWLSNLNLVADKWARGLELSLGLYNL
LDRDYAQPGSAFNWQNVFEQDGRSARLKAVYRF
>Mature_672_residues
SRFPKHLSALPRPNHAPRTSGRLRALSFLLPALPLLAGPVQASPLDLDITQMSLEQLMEISVTGASKYEQKQSEVAAAVS
VITRDEIRTYGWRTLAEALASLPGVHTTYDRQYSYVGARGFGLPGDFNSRLLLTVDGNRANEVVYGTALMGREFLVDLDL
VERIEYIPGPGGAVYGQNALFGVVNVVTRTGADVNGGEVALAHSTLDSGNEGRATWGGVLDNGVDVLLSASAYEAEGRDL
YFDYGSSGVAGVASGMDGERDKQFFGRAGRGPWSFDFSYGERRKDDPIAAYKSDPLVPGQYAEDRHLLTQLQYQDRFAGG
TLQVSGRLFLGRERFRGLFHRSGDAHRYAFSSDWQGMEVRLVSTARADHKTMFGFEYQDNARQDQSVVGAAAGVMIPGAG
WRAGVYAQDEWTLTETLSATLGVRADRSDVSGSALSPRLALVWQMTPDTTLKAMYGRAFRAPNALESNLGDGVTQLPNPN
LDAERIDTLELLAEQRVTPSLRLRATAYRWTMQGLVTLAGLPGGFTQYQNGADIEARGVELSADKTWDWGGRIRGSLSRQ
DACYADGPVLLNSPRLLGKLNVSSPVPQTGLRLGYELQYSADRRAVDGTDVPGYWLSNLNLVADKWARGLELSLGLYNLL
DRDYAQPGSAFNWQNVFEQDGRSARLKAVYRF

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=499, Percent_Identity=24.0480961923848, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790405, Length=507, Percent_Identity=25.0493096646943, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 73586; Mature: 73455

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFPKHLSALPRPNHAPRTSGRLRALSFLLPALPLLAGPVQASPLDLDITQMSLEQLME
CCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
ISVTGASKYEQKQSEVAAAVSVITRDEIRTYGWRTLAEALASLPGVHTTYDRQYSYVGAR
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCC
GFGLPGDFNSRLLLTVDGNRANEVVYGTALMGREFLVDLDLVERIEYIPGPGGAVYGQNA
CCCCCCCCCCEEEEEECCCCCCEEEEEEHHHCCHHEEEHHHHHHHHHCCCCCCCCCCCCH
LFGVVNVVTRTGADVNGGEVALAHSTLDSGNEGRATWGGVLDNGVDVLLSASAYEAEGRD
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEECCHHHCCCEEEEECCCCCCCCCE
LYFDYGSSGVAGVASGMDGERDKQFFGRAGRGPWSFDFSYGERRKDDPIAAYKSDPLVPG
EEEECCCCCCHHHHCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCCCCCEEECCCCCCCC
QYAEDRHLLTQLQYQDRFAGGTLQVSGRLFLGRERFRGLFHRSGDAHRYAFSSDWQGMEV
CCCCHHHHHHHHHHHHHCCCCEEEECCEEEECHHHHHHHHHCCCCCEEEEECCCCCCEEE
RLVSTARADHKTMFGFEYQDNARQDQSVVGAAAGVMIPGAGWRAGVYAQDEWTLTETLSA
EEEEECCCCCCEEEEEECCCCCCHHHHHHHHHCCEEECCCCCCCCEEECCCCCHHHHHHH
TLGVRADRSDVSGSALSPRLALVWQMTPDTTLKAMYGRAFRAPNALESNLGDGVTQLPNP
HHCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
NLDAERIDTLELLAEQRVTPSLRLRATAYRWTMQGLVTLAGLPGGFTQYQNGADIEARGV
CCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHEECCCCCHHHCCCCCCCEECCE
ELSADKTWDWGGRIRGSLSRQDACYADGPVLLNSPRLLGKLNVSSPVPQTGLRLGYELQY
EEECCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCHHHHHCCEEEEE
SADRRAVDGTDVPGYWLSNLNLVADKWARGLELSLGLYNLLDRDYAQPGSAFNWQNVFEQ
CCCCCCCCCCCCCCHHHCCCHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHHH
DGRSARLKAVYRF
CCCCEEEEEEECC
>Mature Secondary Structure 
SRFPKHLSALPRPNHAPRTSGRLRALSFLLPALPLLAGPVQASPLDLDITQMSLEQLME
CCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
ISVTGASKYEQKQSEVAAAVSVITRDEIRTYGWRTLAEALASLPGVHTTYDRQYSYVGAR
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCC
GFGLPGDFNSRLLLTVDGNRANEVVYGTALMGREFLVDLDLVERIEYIPGPGGAVYGQNA
CCCCCCCCCCEEEEEECCCCCCEEEEEEHHHCCHHEEEHHHHHHHHHCCCCCCCCCCCCH
LFGVVNVVTRTGADVNGGEVALAHSTLDSGNEGRATWGGVLDNGVDVLLSASAYEAEGRD
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEECCHHHCCCEEEEECCCCCCCCCE
LYFDYGSSGVAGVASGMDGERDKQFFGRAGRGPWSFDFSYGERRKDDPIAAYKSDPLVPG
EEEECCCCCCHHHHCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCCCCCEEECCCCCCCC
QYAEDRHLLTQLQYQDRFAGGTLQVSGRLFLGRERFRGLFHRSGDAHRYAFSSDWQGMEV
CCCCHHHHHHHHHHHHHCCCCEEEECCEEEECHHHHHHHHHCCCCCEEEEECCCCCCEEE
RLVSTARADHKTMFGFEYQDNARQDQSVVGAAAGVMIPGAGWRAGVYAQDEWTLTETLSA
EEEEECCCCCCEEEEEECCCCCCHHHHHHHHHCCEEECCCCCCCCEEECCCCCHHHHHHH
TLGVRADRSDVSGSALSPRLALVWQMTPDTTLKAMYGRAFRAPNALESNLGDGVTQLPNP
HHCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
NLDAERIDTLELLAEQRVTPSLRLRATAYRWTMQGLVTLAGLPGGFTQYQNGADIEARGV
CCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHEECCCCCHHHCCCCCCCEECCE
ELSADKTWDWGGRIRGSLSRQDACYADGPVLLNSPRLLGKLNVSSPVPQTGLRLGYELQY
EEECCCCCCCCCCEECCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCHHHHHCCEEEEE
SADRRAVDGTDVPGYWLSNLNLVADKWARGLELSLGLYNLLDRDYAQPGSAFNWQNVFEQ
CCCCCCCCCCCCCCHHHCCCHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHHH
DGRSARLKAVYRF
CCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]