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The map label for this gene is nuoE [H]

Identifier: 74317164

GI number: 74317164

Start: 1199795

End: 1200301

Strand: Direct

Name: nuoE [H]

Synonym: Tbd_1146

Alternate gene names: 74317164

Gene position: 1199795-1200301 (Clockwise)

Preceding gene: 74317163

Following gene: 74317165

Centisome position: 41.23

GC content: 61.74

Gene sequence:

>507_bases
TTGATGGCCGATCAGGATGTGAAAGACAAGGTCGAGCTCAGCGCCGAGGCGCTGGCTTTGATCGACGCCGAAGTCGCCAA
ATACCCGGCGGACCAGAAGCAGTCCGCGGTCATGGCCGCGCTCAGGATCGCGCAGGTCGAGAAGGGCTGGCTCAAGCCGG
AACTGATCGACTATGTCGCCGACTACCTGCAGATGCCGCCGATCGCGGCCTACGAAGTGGCGACCTTCTACAACATGTAC
GACACCCAGCCCGTCGGTCGCCACAAGATCACGGTGTGCACGAATCTTCCCTGTGCCTTGAGGGGGGCGGGCGAGATCGC
CGCGCACCTCAAGGAAAAACTCGGCATCGGCTTCGGCGAGACGACCGAGGACGGGCGCTACACGCTGAAGGAAGGCGAGT
GCATGGGGGCATGCGGCGATGCGCCGATGTGCCTGCACAACAATCACACGATGCACACGCACCTTACGCCAGAGAAGGTC
GACGAGTTGCTGGACAAGCTGAAATGA

Upstream 100 bases:

>100_bases
CCCATCTCGAGGCGCTCGACGAGATGAGCCGCGGGCACATGATTGCCGACGTCGTCGCGATCATCGGGACGCAGGATATC
GTTTTCGGGGAGATCGATCG

Downstream 100 bases:

>100_bases
GTCTGCTCACGCCCACGCCGCAGGTCTGCAGCTGGACGCAGACGCTCGACGATCCGGCATCGCTCGCCACCTACGTCGCC
AACGGCGGGTACCAGGCTCT

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MMADQDVKDKVELSAEALALIDAEVAKYPADQKQSAVMAALRIAQVEKGWLKPELIDYVADYLQMPPIAAYEVATFYNMY
DTQPVGRHKITVCTNLPCALRGAGEIAAHLKEKLGIGFGETTEDGRYTLKEGECMGACGDAPMCLHNNHTMHTHLTPEKV
DELLDKLK

Sequences:

>Translated_168_residues
MMADQDVKDKVELSAEALALIDAEVAKYPADQKQSAVMAALRIAQVEKGWLKPELIDYVADYLQMPPIAAYEVATFYNMY
DTQPVGRHKITVCTNLPCALRGAGEIAAHLKEKLGIGFGETTEDGRYTLKEGECMGACGDAPMCLHNNHTMHTHLTPEKV
DELLDKLK
>Mature_168_residues
MMADQDVKDKVELSAEALALIDAEVAKYPADQKQSAVMAALRIAQVEKGWLKPELIDYVADYLQMPPIAAYEVATFYNMY
DTQPVGRHKITVCTNLPCALRGAGEIAAHLKEKLGIGFGETTEDGRYTLKEGECMGACGDAPMCLHNNHTMHTHLTPEKV
DELLDKLK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=157, Percent_Identity=43.9490445859873, Blast_Score=138, Evalue=2e-33,
Organism=Escherichia coli, GI1788621, Length=164, Percent_Identity=39.0243902439024, Blast_Score=107, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17561328, Length=173, Percent_Identity=42.7745664739884, Blast_Score=135, Evalue=7e-33,
Organism=Drosophila melanogaster, GI18859877, Length=158, Percent_Identity=40.5063291139241, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21355353, Length=159, Percent_Identity=37.1069182389937, Blast_Score=113, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18524; Mature: 18524

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMADQDVKDKVELSAEALALIDAEVAKYPADQKQSAVMAALRIAQVEKGWLKPELIDYVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DYLQMPPIAAYEVATFYNMYDTQPVGRHKITVCTNLPCALRGAGEIAAHLKEKLGIGFGE
HHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHCCHHHHHHHHHHHHCCCCCC
TTEDGRYTLKEGECMGACGDAPMCLHNNHTMHTHLTPEKVDELLDKLK
CCCCCCEEECCCCCCCCCCCCCEEEECCCEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MMADQDVKDKVELSAEALALIDAEVAKYPADQKQSAVMAALRIAQVEKGWLKPELIDYVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DYLQMPPIAAYEVATFYNMYDTQPVGRHKITVCTNLPCALRGAGEIAAHLKEKLGIGFGE
HHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHCCHHHHHHHHHHHHCCCCCC
TTEDGRYTLKEGECMGACGDAPMCLHNNHTMHTHLTPEKVDELLDKLK
CCCCCCEEECCCCCCCCCCCCCEEEECCCEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA