Click here to switch to the map view.

The map label for this gene is msrB

Identifier: 74317123

GI number: 74317123

Start: 1163588

End: 1163986

Strand: Reverse

Name: msrB

Synonym: Tbd_1105

Alternate gene names: 74317123

Gene position: 1163986-1163588 (Counterclockwise)

Preceding gene: 74317128

Following gene: 74317122

Centisome position: 40.0

GC content: 67.17

Gene sequence:

>399_bases
ATGAGCACTGACGAACCCAAAACCGACGCGCAGTGGCGCGCCGAACTGTCGCCGGAGCAGTACCGCATCCTGCGCGAACA
GGGCACCGAGCGGGCGTTTACCGGGGAGTACTGGGATCACCACGCGAACGGCGAATACCGCTGCGCGGCTTGTGGCGCGC
CGCTCTTCTCGTCGTCGGCGAAGTTCGACTCGGGCACCGGCTGGCCAAGCTTTTACGAGGCCCTGAACGCGCAGGCCGTG
CGCGAGCGCACCGACACCACCCACGGCATGGTCCGCACCGAAGCGCTGTGCAGCCGCTGCAACTCGCACCTCGGCCACGT
CTTCCCCGACGGGCCGCCGCCCACCGGTCTGCGCTACTGCATCAATTCGGCGTCGCTCAGTTTTCACCCGAAGGACTGA

Upstream 100 bases:

>100_bases
ATGCTGTCAACACGCGCGCGGCAAATCGTCGCGGTGCCGGAACGCCCGTACCACTTGCGGCGCGCAGTTACACTTTTTTG
CCCTCGAACGGAGAAGCGAG

Downstream 100 bases:

>100_bases
GCCTTGCACGTCTTTGAAGCCGAGATCGCGGCAGTCGTCGCCGCCACCCCCCAGATACGTGTTCTCCGCCTCGCCGTCGC
CGACCCCGGCTTCCGCTTCC

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MSTDEPKTDAQWRAELSPEQYRILREQGTERAFTGEYWDHHANGEYRCAACGAPLFSSSAKFDSGTGWPSFYEALNAQAV
RERTDTTHGMVRTEALCSRCNSHLGHVFPDGPPPTGLRYCINSASLSFHPKD

Sequences:

>Translated_132_residues
MSTDEPKTDAQWRAELSPEQYRILREQGTERAFTGEYWDHHANGEYRCAACGAPLFSSSAKFDSGTGWPSFYEALNAQAV
RERTDTTHGMVRTEALCSRCNSHLGHVFPDGPPPTGLRYCINSASLSFHPKD
>Mature_131_residues
STDEPKTDAQWRAELSPEQYRILREQGTERAFTGEYWDHHANGEYRCAACGAPLFSSSAKFDSGTGWPSFYEALNAQAVR
ERTDTTHGMVRTEALCSRCNSHLGHVFPDGPPPTGLRYCINSASLSFHPKD

Specific function: Unknown

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=122, Percent_Identity=54.9180327868852, Blast_Score=152, Evalue=6e-38,
Organism=Homo sapiens, GI301336162, Length=122, Percent_Identity=54.9180327868852, Blast_Score=152, Evalue=6e-38,
Organism=Homo sapiens, GI73089054, Length=122, Percent_Identity=54.9180327868852, Blast_Score=152, Evalue=6e-38,
Organism=Homo sapiens, GI37620216, Length=122, Percent_Identity=54.9180327868852, Blast_Score=152, Evalue=9e-38,
Organism=Homo sapiens, GI117606353, Length=134, Percent_Identity=47.0149253731343, Blast_Score=137, Evalue=2e-33,
Organism=Homo sapiens, GI7706511, Length=104, Percent_Identity=42.3076923076923, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788077, Length=118, Percent_Identity=50.8474576271186, Blast_Score=134, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17553450, Length=124, Percent_Identity=49.1935483870968, Blast_Score=125, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI115532676, Length=124, Percent_Identity=49.1935483870968, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6319816, Length=127, Percent_Identity=41.7322834645669, Blast_Score=105, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221378664, Length=119, Percent_Identity=52.1008403361345, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221378662, Length=126, Percent_Identity=50, Blast_Score=133, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45553335, Length=119, Percent_Identity=50.4201680672269, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI21356369, Length=119, Percent_Identity=50.4201680672269, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24645799, Length=119, Percent_Identity=50.4201680672269, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24645804, Length=130, Percent_Identity=46.1538461538462, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645801, Length=130, Percent_Identity=46.1538461538462, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRB_THIDA (Q3SJU1)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314863.1
- ProteinModelPortal:   Q3SJU1
- SMR:   Q3SJU1
- STRING:   Q3SJU1
- GeneID:   3673176
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1105
- NMPDR:   fig|292415.3.peg.1105
- eggNOG:   COG0229
- HOGENOM:   HBG715255
- OMA:   EVRCNHC
- PhylomeDB:   Q3SJU1
- BioCyc:   TDEN292415:TBD_1105-MONOMER
- HAMAP:   MF_01400
- InterPro:   IPR002579
- InterPro:   IPR011057
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01641 SelR; SSF51316 Mss4_like

EC number: =1.8.4.12

Molecular weight: Translated: 14742; Mature: 14611

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: ACT_SITE 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDEPKTDAQWRAELSPEQYRILREQGTERAFTGEYWDHHANGEYRCAACGAPLFSSSA
CCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHCCCC
KFDSGTGWPSFYEALNAQAVRERTDTTHGMVRTEALCSRCNSHLGHVFPDGPPPTGLRYC
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
INSASLSFHPKD
HCCCCCCCCCCC
>Mature Secondary Structure 
STDEPKTDAQWRAELSPEQYRILREQGTERAFTGEYWDHHANGEYRCAACGAPLFSSSA
CCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHCCCC
KFDSGTGWPSFYEALNAQAVRERTDTTHGMVRTEALCSRCNSHLGHVFPDGPPPTGLRYC
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
INSASLSFHPKD
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA