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The map label for this gene is hldE [H]

Identifier: 74316980

GI number: 74316980

Start: 1024259

End: 1025203

Strand: Direct

Name: hldE [H]

Synonym: Tbd_0962

Alternate gene names: 74316980

Gene position: 1024259-1025203 (Clockwise)

Preceding gene: 74316979

Following gene: 74316981

Centisome position: 35.2

GC content: 67.72

Gene sequence:

>945_bases
TTGCGTGACGCGATCGCGCGCACCCGCATCCTCGTCGCGGGTGACGTGATGCTCGACCGCTACTGGTTCGGCGAGGTTTC
GCGCATTTCGCCCGAAGCGCCGGTGCCGGTCGTGCATGTCACGCGCAACGAGGATCGCATCGGCGGCGCAGGCAACGTCG
CACGCAACGCCGCGGCGCTCGGTGCGCAGGTAACCCTGCTGTCGGTGGCGGGGCGCGACGAAGCCGGATTGGCCTTGCGC
CGCCTGCTCGACGCCGAGCCGTTCGCCGTGCAGTTGCACGAGGACCCGGCGTATTCGACGATCACCAAGCTGCGTGTCAT
CGGCCGGCAGCAGCAACTCCTGCGCGTCGATTTCGAAACCCAGCCCGGCCATGAAGTGCTCGCCGCCAAGCTCGAAGCCT
TCGCTCGGCTTCTCGCGGAGTGCGACGTGGTGATTCTCTCCGACTACGGCAAGGGCGGGCTGACGCACGTCGGCCGCATG
ATCGAATTGGCGCGCGACGCGAAGAAGCCTATTCTGGTCGATCCCAAGGGTGACGACTGGGCGCGTTACGCCGGTGCGAC
GCTGATCACGCCGAACCGCAGCGAATTCCGCGAGATCGCGGGCGGCTGGAAATCGGAGCGCGAGCTCGCCGACAAGGCAG
CGGAGGTACGTCGCAAATTCCGCTTCGACGCCCTGCTCGTGACACGCAGCGAGGAGGGCATGAGTCTCTTCGACGCCGAG
GGCGCGCACCACGAAGCGACGCGCGCGCAGGAGGTGTTCGACGTCTCGGGCGCCGGCGATACCGTCATCGCTGCCCTCGC
GGTTGCGTTGGGTGCGGGGGCGAGCAGCGTCGAGGCGATGCGGCTGGCGAACCGCGCCGCAGGCATCGTCGTCGGCAAGT
TCGGCACCGCGGTCGCGACGGCGGACGAGGTTTTTGCAAACAGCTCAACCGGAGGACAGCCATGA

Upstream 100 bases:

>100_bases
TGAAGGCGCCGTTGATCTTCGACGGCCGCAACCTCTACGAGCCGCGCGCGATGCGCGAAATGGGCTTCGACTATTTCCCG
ATCGGGCGCCCGTGACGCCG

Downstream 100 bases:

>100_bases
GCCAGTACACCGTGGTCACCGGCGCCGCCGGTTTCATCGGCGCCAACATCGTCAAGGCGCTGAACGAGCGCGGCGAGACG
AACATCATCGCAGTCGACAA

Product: D-alpha,beta-D-heptose 7-phosphate 1-kinase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MRDAIARTRILVAGDVMLDRYWFGEVSRISPEAPVPVVHVTRNEDRIGGAGNVARNAAALGAQVTLLSVAGRDEAGLALR
RLLDAEPFAVQLHEDPAYSTITKLRVIGRQQQLLRVDFETQPGHEVLAAKLEAFARLLAECDVVILSDYGKGGLTHVGRM
IELARDAKKPILVDPKGDDWARYAGATLITPNRSEFREIAGGWKSERELADKAAEVRRKFRFDALLVTRSEEGMSLFDAE
GAHHEATRAQEVFDVSGAGDTVIAALAVALGAGASSVEAMRLANRAAGIVVGKFGTAVATADEVFANSSTGGQP

Sequences:

>Translated_314_residues
MRDAIARTRILVAGDVMLDRYWFGEVSRISPEAPVPVVHVTRNEDRIGGAGNVARNAAALGAQVTLLSVAGRDEAGLALR
RLLDAEPFAVQLHEDPAYSTITKLRVIGRQQQLLRVDFETQPGHEVLAAKLEAFARLLAECDVVILSDYGKGGLTHVGRM
IELARDAKKPILVDPKGDDWARYAGATLITPNRSEFREIAGGWKSERELADKAAEVRRKFRFDALLVTRSEEGMSLFDAE
GAHHEATRAQEVFDVSGAGDTVIAALAVALGAGASSVEAMRLANRAAGIVVGKFGTAVATADEVFANSSTGGQP
>Mature_314_residues
MRDAIARTRILVAGDVMLDRYWFGEVSRISPEAPVPVVHVTRNEDRIGGAGNVARNAAALGAQVTLLSVAGRDEAGLALR
RLLDAEPFAVQLHEDPAYSTITKLRVIGRQQQLLRVDFETQPGHEVLAAKLEAFARLLAECDVVILSDYGKGGLTHVGRM
IELARDAKKPILVDPKGDDWARYAGATLITPNRSEFREIAGGWKSERELADKAAEVRRKFRFDALLVTRSEEGMSLFDAE
GAHHEATRAQEVFDVSGAGDTVIAALAVALGAGASSVEAMRLANRAAGIVVGKFGTAVATADEVFANSSTGGQP

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=306, Percent_Identity=49.3464052287582, Blast_Score=275, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 33610; Mature: 33610

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAIARTRILVAGDVMLDRYWFGEVSRISPEAPVPVVHVTRNEDRIGGAGNVARNAAAL
CCCHHHHHEEEEECHHHHHHHHCCCHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHH
GAQVTLLSVAGRDEAGLALRRLLDAEPFAVQLHEDPAYSTITKLRVIGRQQQLLRVDFET
CCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCC
QPGHEVLAAKLEAFARLLAECDVVILSDYGKGGLTHVGRMIELARDAKKPILVDPKGDDW
CCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCH
ARYAGATLITPNRSEFREIAGGWKSERELADKAAEVRRKFRFDALLVTRSEEGMSLFDAE
HHHCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEECC
GAHHEATRAQEVFDVSGAGDTVIAALAVALGAGASSVEAMRLANRAAGIVVGKFGTAVAT
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCHHHH
ADEVFANSSTGGQP
HHHHHCCCCCCCCC
>Mature Secondary Structure
MRDAIARTRILVAGDVMLDRYWFGEVSRISPEAPVPVVHVTRNEDRIGGAGNVARNAAAL
CCCHHHHHEEEEECHHHHHHHHCCCHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHH
GAQVTLLSVAGRDEAGLALRRLLDAEPFAVQLHEDPAYSTITKLRVIGRQQQLLRVDFET
CCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCC
QPGHEVLAAKLEAFARLLAECDVVILSDYGKGGLTHVGRMIELARDAKKPILVDPKGDDW
CCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCH
ARYAGATLITPNRSEFREIAGGWKSERELADKAAEVRRKFRFDALLVTRSEEGMSLFDAE
HHHCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEECC
GAHHEATRAQEVFDVSGAGDTVIAALAVALGAGASSVEAMRLANRAAGIVVGKFGTAVAT
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCHHHH
ADEVFANSSTGGQP
HHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]