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The map label for this gene is uppS [H]

Identifier: 74316807

GI number: 74316807

Start: 831628

End: 832365

Strand: Direct

Name: uppS [H]

Synonym: Tbd_0789

Alternate gene names: 74316807

Gene position: 831628-832365 (Clockwise)

Preceding gene: 74316806

Following gene: 74316808

Centisome position: 28.58

GC content: 65.45

Gene sequence:

>738_bases
GTGTCTACCCGCACCAAGCAGGCGATCCCCGTGACCTCGGACGTGCCGCGGCACATTGCCATCATCATGGACGGCAACGG
GCGATGGGCGAAGCGCCGCTTCATGCCGCGCTTCGCCGGACATCGCAAGGGAGTCGAGGCGCTGCGCGGCGTGATCCGCG
CCTGCGCCGAGCGTGGCGTGACGCATCTGACCGTGTTCGCCTTCAGCTCGGAAAACTGGCGGCGCCCGCAGGAAGAAGTG
ACGCTGCTGATGGAGCTGTTCCTGCGCGCGCTCGAGAACGAAGTGGCCAAGCTGCACGAGAACGGCATTCGTTTTCGCGT
CATCGGCGACCTGTCGGGATTTTCCGAACGCATCCAGACGTTGATCCGCGAGGCCGAAACGCTGACACGGGACAACAGCC
GCCTCACGTTCACGGTCGCCGCGAATTACGGCGGACGCTGGGACGTCGTGCAGGCCGTCAAGAAACTCGTCGCGTCGGGC
GAACCGGTGAGCGAAGCGGCGCTGGCCGCGCACCTGAGCCTCGCCGATACACCCGAGCCCGATCTCTTCATCCGCACCGG
CGGGGAGCAACGCATCAGCAATTTCCTGCTGTGGCAGCTTGCCTACACTGAACTCTACTTTACCGACGCCCTCTGGCCCG
ACTTCGACGCCGCGGCGCTCGACGCCGCGATCGCTTCGTATCGCACGCGCGAACGTCGATTCGGTCGCACCAGCGAACAG
CTGCTGACGGCGTCGTGA

Upstream 100 bases:

>100_bases
GTGCAGAAGCTGACCGACAAATTCATCGGCGAAATCGACAAAATGCTCGCCGAAAAAGAGAAGGACCTGCTCGCGGTCTG
AGCGGCCCGAGTCCGTCGGC

Downstream 100 bases:

>100_bases
CCGCACATCGAGGATTGCCATGACACCCCTGGCACGACGCGTGTCCACGGCGCTGCTGTTGCTGGCCGTATTCGTACCGG
CCGCCCTGTGGGCGCCGGCC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSTRTKQAIPVTSDVPRHIAIIMDGNGRWAKRRFMPRFAGHRKGVEALRGVIRACAERGVTHLTVFAFSSENWRRPQEEV
TLLMELFLRALENEVAKLHENGIRFRVIGDLSGFSERIQTLIREAETLTRDNSRLTFTVAANYGGRWDVVQAVKKLVASG
EPVSEAALAAHLSLADTPEPDLFIRTGGEQRISNFLLWQLAYTELYFTDALWPDFDAAALDAAIASYRTRERRFGRTSEQ
LLTAS

Sequences:

>Translated_245_residues
MSTRTKQAIPVTSDVPRHIAIIMDGNGRWAKRRFMPRFAGHRKGVEALRGVIRACAERGVTHLTVFAFSSENWRRPQEEV
TLLMELFLRALENEVAKLHENGIRFRVIGDLSGFSERIQTLIREAETLTRDNSRLTFTVAANYGGRWDVVQAVKKLVASG
EPVSEAALAAHLSLADTPEPDLFIRTGGEQRISNFLLWQLAYTELYFTDALWPDFDAAALDAAIASYRTRERRFGRTSEQ
LLTAS
>Mature_244_residues
STRTKQAIPVTSDVPRHIAIIMDGNGRWAKRRFMPRFAGHRKGVEALRGVIRACAERGVTHLTVFAFSSENWRRPQEEVT
LLMELFLRALENEVAKLHENGIRFRVIGDLSGFSERIQTLIREAETLTRDNSRLTFTVAANYGGRWDVVQAVKKLVASGE
PVSEAALAAHLSLADTPEPDLFIRTGGEQRISNFLLWQLAYTELYFTDALWPDFDAAALDAAIASYRTRERRFGRTSEQL
LTAS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=37.7777777777778, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=36.8888888888889, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1786371, Length=239, Percent_Identity=50.6276150627615, Blast_Score=249, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=243, Percent_Identity=36.6255144032922, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=209, Percent_Identity=36.3636363636364, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=32.2869955156951, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=39.2857142857143, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27637; Mature: 27506

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRTKQAIPVTSDVPRHIAIIMDGNGRWAKRRFMPRFAGHRKGVEALRGVIRACAERGV
CCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC
THLTVFAFSSENWRRPQEEVTLLMELFLRALENEVAKLHENGIRFRVIGDLSGFSERIQT
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
LIREAETLTRDNSRLTFTVAANYGGRWDVVQAVKKLVASGEPVSEAALAAHLSLADTPEP
HHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
DLFIRTGGEQRISNFLLWQLAYTELYFTDALWPDFDAAALDAAIASYRTRERRFGRTSEQ
CEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
LLTAS
HHCCC
>Mature Secondary Structure 
STRTKQAIPVTSDVPRHIAIIMDGNGRWAKRRFMPRFAGHRKGVEALRGVIRACAERGV
CCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCC
THLTVFAFSSENWRRPQEEVTLLMELFLRALENEVAKLHENGIRFRVIGDLSGFSERIQT
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHH
LIREAETLTRDNSRLTFTVAANYGGRWDVVQAVKKLVASGEPVSEAALAAHLSLADTPEP
HHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
DLFIRTGGEQRISNFLLWQLAYTELYFTDALWPDFDAAALDAAIASYRTRERRFGRTSEQ
CEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
LLTAS
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]