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The map label for this gene is holC [H]

Identifier: 74316597

GI number: 74316597

Start: 609106

End: 609537

Strand: Reverse

Name: holC [H]

Synonym: Tbd_0579

Alternate gene names: 74316597

Gene position: 609537-609106 (Counterclockwise)

Preceding gene: 74316598

Following gene: 74316596

Centisome position: 20.95

GC content: 67.82

Gene sequence:

>432_bases
GTGACCGAGATCATCTTCTATACCTTTGCCGAAGACCGCCTCGACGTCGCGCGCCGCGTGGCGGCCAAGGCCTACGGTCA
AGGCAAGCAGGTGATGATCTATGCGCCCGATGCGGCCGTCGCAGGCGCGGTGGATCGCATGCTGTGGACGACACCGGCGC
TCGGTTTCGTGCCGCATGCCCGCGACAGCGACGCACTCGCGGCGGAAACGCCGGTGCTGATCGGCGCCGACGCCGGCGCA
CTCCGCCACGCCGACGTGATGATCAATCTCGATTCCGCGCAACCGCCGGCCTTCGGCCGCTTCGAGCGGCTCGTCGAAAT
CGTCGGCACGGACGACGCGGAGCGCGAACAGGGCCGCGCGCGCTATCGCTTCTATCAGTCGCGCGGCTACGCGCTGAAGA
CGCACGATCTGCGCCAGCAGAGCGAGGGATGA

Upstream 100 bases:

>100_bases
TCGACATCGCCGGCACGGCATACAAGGGTGGTCGCGAAAAGGGCTCGACCGGCCGTCCGGTCTCCTTGCTCGTGCATTTC
CTGTTGAATCGCACGGAAAA

Downstream 100 bases:

>100_bases
GAAAACGATGAGCGACGACCCCTTGCTGGACAAGATGGACGCCCTCCTCAAGAAACATCGCGGCGCCGGCGAGTCGGCTC
ATCTCGGCCCGCCGGCAGCC

Product: DNA polymerase III subunit chi

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MTEIIFYTFAEDRLDVARRVAAKAYGQGKQVMIYAPDAAVAGAVDRMLWTTPALGFVPHARDSDALAAETPVLIGADAGA
LRHADVMINLDSAQPPAFGRFERLVEIVGTDDAEREQGRARYRFYQSRGYALKTHDLRQQSEG

Sequences:

>Translated_143_residues
MTEIIFYTFAEDRLDVARRVAAKAYGQGKQVMIYAPDAAVAGAVDRMLWTTPALGFVPHARDSDALAAETPVLIGADAGA
LRHADVMINLDSAQPPAFGRFERLVEIVGTDDAEREQGRARYRFYQSRGYALKTHDLRQQSEG
>Mature_142_residues
TEIIFYTFAEDRLDVARRVAAKAYGQGKQVMIYAPDAAVAGAVDRMLWTTPALGFVPHARDSDALAAETPVLIGADAGAL
RHADVMINLDSAQPPAFGRFERLVEIVGTDDAEREQGRARYRFYQSRGYALKTHDLRQQSEG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 15773; Mature: 15642

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIIFYTFAEDRLDVARRVAAKAYGQGKQVMIYAPDAAVAGAVDRMLWTTPALGFVPHA
CCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCC
RDSDALAAETPVLIGADAGALRHADVMINLDSAQPPAFGRFERLVEIVGTDDAEREQGRA
CCCCCCCCCCCEEEECCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
RYRFYQSRGYALKTHDLRQQSEG
HHHHHHCCCCEEECHHHHHCCCC
>Mature Secondary Structure 
TEIIFYTFAEDRLDVARRVAAKAYGQGKQVMIYAPDAAVAGAVDRMLWTTPALGFVPHA
CEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCC
RDSDALAAETPVLIGADAGALRHADVMINLDSAQPPAFGRFERLVEIVGTDDAEREQGRA
CCCCCCCCCCCEEEECCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
RYRFYQSRGYALKTHDLRQQSEG
HHHHHHCCCCEEECHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9864319; 10984043 [H]