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The map label for this gene is pepA [H]

Identifier: 74316598

GI number: 74316598

Start: 609534

End: 611045

Strand: Reverse

Name: pepA [H]

Synonym: Tbd_0580

Alternate gene names: 74316598

Gene position: 611045-609534 (Counterclockwise)

Preceding gene: 74316602

Following gene: 74316597

Centisome position: 21.0

GC content: 65.48

Gene sequence:

>1512_bases
ATGGAAAACAGGGAAATCGAACTCGAATTTAGCATAAAAAGCGGTGCGCCCGAAAAGCAGCGCACGGCCTGCGTCGTCGT
CGGCGTCTTCGAAAGCCGCAAACTTTCGGCACCGGCGATCGACATCGATCGGGCGAGCGACGGCTATCTGTCGGACATCG
TGCGCGGCGGCGACATGGACGGCAAGGCCGGCAGCACGCTGCTGCTGCACCGGGTGCCGAACATCCTGGCCGACCGCGTG
CTGCTTGTTGGCCTCGGCAAGGAGCGGGAGTTCCACGAGAAATCGTACCGCGACGCGATCGCCCGCGCGATCCGCACCCT
GCGCGACACCGGGTCGATGGAAGCCGTCATCACCCTGAGCGAAATCGCGGTCCGTAAGCGTGACGTCACCTGGAATATCG
AACAGGCGGTCATCAGTGCCCAGGAAGCCCTGTACCGCTTCGACCGCATGAAGAGCAAGACCGACGAAATGCGGCGCCCG
CTCAAGCGCGTCGTCTTCGCGGTGTCGCGGCGCGGCGAACTGAAGTTCGGCGAAGCGGGCCTGACGCGAGGCCTGGCGAT
CGCACGCGGCATCGCGCTGGCCAAGGACCTCGGCAACACGCCATCGAATGTCTGCACGCCCGAGTATCTGGCGGCGGAAG
CGCGCAAGCTCGCGAAGACCCACGGCTTCGGCTGCGAGATTCTCGATTTCGCGGCATGCGAGAAGCTCGGCATGGGCTCC
TTTCTCTCGGTCGGCAAGGGCAGCGACAAGCCGCCGCGCTTCATCGTGCTGAAACACATGGGGGGAGCCAAGGGTGACAA
GCCCGTGGTCCTGGTCGGCAAGGCCGTCACCTTCGACGCCGGCGGGATTTCGCTGAAGCCGCCTGCCGAAATGGACGAGA
TGAACTACGACATGAGCGGCGGCGGCGCGGTCATCGGCACCTTCCGCGCGATCGGCGAACTCGGCCTGCCGCTCAACGTC
GTCGGCCTGATCCCGGCCTGCGAGAACCTGCCCGACGCCCAAGCCAACAAGCCGGGGGACATCGTCACGTCGATGTCGGG
TCAGACGATCGAGATCCTCAACACCGACGCCGAGGGGCGCCTGATTCTGTGCGACGCCCTGACCTACGCCGAGCGCTTCG
AGCCCGACGCGGTCATCGACGTCGCCACGCTGACCGGCGCCTGTGTGATCGCCCTCGGCGCCCATCCGAGCGCGCTTTAC
AGCAACCACGACCCGCTCGCCCGCGAGATCGAGCACGCCGCCGATCACGCCTGGGACCGCGTGTGGCGCATGCCCCTGTG
GGACGACTACCAGGATCAGCTGAAGAGCAGCCTTGCCGACGTCGCGAACATCGGCGGCCGTCCCGGCGGTTCGATCACCG
CCGCCTGCTTCCTGTCGCGCTTCGCCAAGAAATACCATTGGGCCCACCTCGACATCGCCGGCACGGCATACAAGGGTGGT
CGCGAAAAGGGCTCGACCGGCCGTCCGGTCTCCTTGCTCGTGCATTTCCTGTTGAATCGCACGGAAAAGTGA

Upstream 100 bases:

>100_bases
AACGCGCTTTTGACATTCCCCTGCGACAACGCCAATAATTCCTCCATTGGCGCGGCCGGCAGCCGGCGCATCGACAAATT
GTATTTTTTTGAGCACAGAC

Downstream 100 bases:

>100_bases
CCGAGATCATCTTCTATACCTTTGCCGAAGACCGCCTCGACGTCGCGCGCCGCGTGGCGGCCAAGGCCTACGGTCAAGGC
AAGCAGGTGATGATCTATGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MENREIELEFSIKSGAPEKQRTACVVVGVFESRKLSAPAIDIDRASDGYLSDIVRGGDMDGKAGSTLLLHRVPNILADRV
LLVGLGKEREFHEKSYRDAIARAIRTLRDTGSMEAVITLSEIAVRKRDVTWNIEQAVISAQEALYRFDRMKSKTDEMRRP
LKRVVFAVSRRGELKFGEAGLTRGLAIARGIALAKDLGNTPSNVCTPEYLAAEARKLAKTHGFGCEILDFAACEKLGMGS
FLSVGKGSDKPPRFIVLKHMGGAKGDKPVVLVGKAVTFDAGGISLKPPAEMDEMNYDMSGGGAVIGTFRAIGELGLPLNV
VGLIPACENLPDAQANKPGDIVTSMSGQTIEILNTDAEGRLILCDALTYAERFEPDAVIDVATLTGACVIALGAHPSALY
SNHDPLAREIEHAADHAWDRVWRMPLWDDYQDQLKSSLADVANIGGRPGGSITAACFLSRFAKKYHWAHLDIAGTAYKGG
REKGSTGRPVSLLVHFLLNRTEK

Sequences:

>Translated_503_residues
MENREIELEFSIKSGAPEKQRTACVVVGVFESRKLSAPAIDIDRASDGYLSDIVRGGDMDGKAGSTLLLHRVPNILADRV
LLVGLGKEREFHEKSYRDAIARAIRTLRDTGSMEAVITLSEIAVRKRDVTWNIEQAVISAQEALYRFDRMKSKTDEMRRP
LKRVVFAVSRRGELKFGEAGLTRGLAIARGIALAKDLGNTPSNVCTPEYLAAEARKLAKTHGFGCEILDFAACEKLGMGS
FLSVGKGSDKPPRFIVLKHMGGAKGDKPVVLVGKAVTFDAGGISLKPPAEMDEMNYDMSGGGAVIGTFRAIGELGLPLNV
VGLIPACENLPDAQANKPGDIVTSMSGQTIEILNTDAEGRLILCDALTYAERFEPDAVIDVATLTGACVIALGAHPSALY
SNHDPLAREIEHAADHAWDRVWRMPLWDDYQDQLKSSLADVANIGGRPGGSITAACFLSRFAKKYHWAHLDIAGTAYKGG
REKGSTGRPVSLLVHFLLNRTEK
>Mature_503_residues
MENREIELEFSIKSGAPEKQRTACVVVGVFESRKLSAPAIDIDRASDGYLSDIVRGGDMDGKAGSTLLLHRVPNILADRV
LLVGLGKEREFHEKSYRDAIARAIRTLRDTGSMEAVITLSEIAVRKRDVTWNIEQAVISAQEALYRFDRMKSKTDEMRRP
LKRVVFAVSRRGELKFGEAGLTRGLAIARGIALAKDLGNTPSNVCTPEYLAAEARKLAKTHGFGCEILDFAACEKLGMGS
FLSVGKGSDKPPRFIVLKHMGGAKGDKPVVLVGKAVTFDAGGISLKPPAEMDEMNYDMSGGGAVIGTFRAIGELGLPLNV
VGLIPACENLPDAQANKPGDIVTSMSGQTIEILNTDAEGRLILCDALTYAERFEPDAVIDVATLTGACVIALGAHPSALY
SNHDPLAREIEHAADHAWDRVWRMPLWDDYQDQLKSSLADVANIGGRPGGSITAACFLSRFAKKYHWAHLDIAGTAYKGG
REKGSTGRPVSLLVHFLLNRTEK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=505, Percent_Identity=36.4356435643564, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI47155554, Length=417, Percent_Identity=29.9760191846523, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1790710, Length=496, Percent_Identity=57.258064516129, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=36.0501567398119, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17556903, Length=296, Percent_Identity=35.8108108108108, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=153, Percent_Identity=37.2549019607843, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24661038, Length=472, Percent_Identity=33.8983050847458, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21355725, Length=325, Percent_Identity=37.8461538461538, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI20129969, Length=489, Percent_Identity=31.2883435582822, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI161077148, Length=517, Percent_Identity=30.5609284332689, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI20130057, Length=517, Percent_Identity=30.5609284332689, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI21355645, Length=493, Percent_Identity=30.0202839756592, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24662223, Length=493, Percent_Identity=30.0202839756592, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24662227, Length=502, Percent_Identity=30.0796812749004, Blast_Score=204, Evalue=2e-52,
Organism=Drosophila melanogaster, GI19922386, Length=488, Percent_Identity=28.6885245901639, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI20129963, Length=501, Percent_Identity=28.3433133732535, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21357381, Length=322, Percent_Identity=29.8136645962733, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221379063, Length=322, Percent_Identity=29.8136645962733, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221379062, Length=322, Percent_Identity=29.8136645962733, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646701, Length=172, Percent_Identity=31.9767441860465, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646703, Length=172, Percent_Identity=31.9767441860465, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358201, Length=172, Percent_Identity=31.9767441860465, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54442; Mature: 54442

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENREIELEFSIKSGAPEKQRTACVVVGVFESRKLSAPAIDIDRASDGYLSDIVRGGDMD
CCCCEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCEEECCCCCCCHHHHHHCCCCCC
GKAGSTLLLHRVPNILADRVLLVGLGKEREFHEKSYRDAIARAIRTLRDTGSMEAVITLS
CCCCCEEHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
EIAVRKRDVTWNIEQAVISAQEALYRFDRMKSKTDEMRRPLKRVVFAVSRRGELKFGEAG
HHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHH
LTRGLAIARGIALAKDLGNTPSNVCTPEYLAAEARKLAKTHGFGCEILDFAACEKLGMGS
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
FLSVGKGSDKPPRFIVLKHMGGAKGDKPVVLVGKAVTFDAGGISLKPPAEMDEMNYDMSG
CEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHCCCCCCC
GGAVIGTFRAIGELGLPLNVVGLIPACENLPDAQANKPGDIVTSMSGQTIEILNTDAEGR
CCEEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCC
LILCDALTYAERFEPDAVIDVATLTGACVIALGAHPSALYSNHDPLAREIEHAADHAWDR
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHH
VWRMPLWDDYQDQLKSSLADVANIGGRPGGSITAACFLSRFAKKYHWAHLDIAGTAYKGG
HCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
REKGSTGRPVSLLVHFLLNRTEK
CCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MENREIELEFSIKSGAPEKQRTACVVVGVFESRKLSAPAIDIDRASDGYLSDIVRGGDMD
CCCCEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCEEECCCCCCCHHHHHHCCCCCC
GKAGSTLLLHRVPNILADRVLLVGLGKEREFHEKSYRDAIARAIRTLRDTGSMEAVITLS
CCCCCEEHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
EIAVRKRDVTWNIEQAVISAQEALYRFDRMKSKTDEMRRPLKRVVFAVSRRGELKFGEAG
HHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHH
LTRGLAIARGIALAKDLGNTPSNVCTPEYLAAEARKLAKTHGFGCEILDFAACEKLGMGS
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
FLSVGKGSDKPPRFIVLKHMGGAKGDKPVVLVGKAVTFDAGGISLKPPAEMDEMNYDMSG
CEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHCCCCCCC
GGAVIGTFRAIGELGLPLNVVGLIPACENLPDAQANKPGDIVTSMSGQTIEILNTDAEGR
CCEEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCC
LILCDALTYAERFEPDAVIDVATLTGACVIALGAHPSALYSNHDPLAREIEHAADHAWDR
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHH
VWRMPLWDDYQDQLKSSLADVANIGGRPGGSITAACFLSRFAKKYHWAHLDIAGTAYKGG
HCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
REKGSTGRPVSLLVHFLLNRTEK
CCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA