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The map label for this gene is hutH [H]

Identifier: 73542401

GI number: 73542401

Start: 2982339

End: 2983919

Strand: Reverse

Name: hutH [H]

Synonym: Reut_A2716

Alternate gene names: 73542401

Gene position: 2983919-2982339 (Counterclockwise)

Preceding gene: 73542402

Following gene: 73542400

Centisome position: 78.39

GC content: 67.93

Gene sequence:

>1581_bases
ATGAGCGCCAGCCAAACCAACCAAGCCTCCCGCCCGCTGCTGACCCTGAATCCGGGCCAGGTCATCCTGGCTGACCTGCG
CCGCATCTACCGCGGCGAAGTTCGCCTGGAGATGGCGGACTCGGCCTGGGCCGGCGTACGTGCCGCACAGGCCACCGTGC
AGGACATCATCGACGCCGATGCCGTGGTCTACGGCATCAACACGGGCTTCGGCAAGCTTGCGCAAACGCGCATTCCGAAT
GACAAGCTCGCCACGCTGCAGCGCAATCTGGTGCTGTCGCACAGCGTCGGCACCGGCCCGGACCTGGCGGAGGATGTGGT
ACGCGTGATCCTCGCGATCAAGGCAGTGAGCCTCGCACGCGGCCACTCGGGCGTGCGGCCCGAAATCATTGAAGCGCTGC
TCGCGCTGGCCAACCACGGCGTGACCCCTTGCATCCCGGCCAAGGGCTCGGTGGGTGCCTCGGGCGACCTCGCGCCGCTC
GCGCATATGTCGTGCACGCTGATCGGCGTGGGCGATGTGATCGTTGATGGCCGTCGCGTGCCGGCTGCCGAAGGCCTCGC
ACATGCCGGCCTGTCGGCGTTTGAACTCGGTCCGAAGGAAGGGCTGGCGTTGCTCAACGGCACGCAAGTTTCCACGGCGC
TGGCGCTGGCCGGGCTGTTTGCCGCCGAAGATACCTTTGCCGCCGGCCTGGTGGCCGGCGCGCTGTCGCTCGAAGCGATC
AAGGGCTCGGTCAAGCCGTTCGACGCGCGAATCCATGAGGCGCGTGGCCAGGCTGGCCAGATCGCCGTGGCCGGCGCGGT
GCGCGCAATGCTCGATGGCAGCGAGATCGTCGACTCGCACAAGGCCTGCGGCCGCGTGCAGGACCCATACTCGATCCGTT
GCCAGCCGCAGGTGATGGGCGCGTGCCTGGACAACCTGCAGCATGCCGCGCGCATCTTGCGCATCGAAGCGAACGCCGCC
TCGGACAATCCGCTTGTCTTCTCCGCGCAGGGCGACGTGATTTCGGGCGGTAATTTCCACGCCGAGCCGGTTGCGTTCGC
GGCCGACATCATCGCGCTGGCGATTGCCGAGATCGGCGCGATTTCCGAGCGCCGCCTGGCGCTGCTGCTGGACACGGGCC
TGTCGGGCCTGCCGCCGTTCCTCGTGCGCGATGGCGGCCTGAACTCGGGCTTCATGATTGCGCAGGTCACCGCCGCGGCG
CTGGCCTCGGAGAACAAATCGCTCGCGCATCCGTCGAGCGTGGACAGCCTGCCGACTTCGGCCAACCAGGAGGACCATGT
GTCGATGGCCACCTACGGCGCACGCCGGCTTGGCGATATGGCGGCCAATACCGCGGTGGTGGTCGGCATCGAAGCGATGG
CGGCCGCGCAGGGCATCGAATTCCATCGCCCGCTGAAGTCGTCGCCGCTGGTGGAGCAGGAACTGGCCCGCATCCGCGCA
CGCGTGGCGTTCGTGGAGGCCGACCGCTACCTGGCGCCGGATATCGAGGCGATGAAGCAGTGGGTGGTGCAGGGCGATGC
GGGGGCAGGCTGGCCTGCTGCGGTGCGCGACATCCTGCCGACGAATACCAAGAACGCCTGA

Upstream 100 bases:

>100_bases
GGCAATCCCGCCTTCGGCTGATTTCCGACAGAAGTCAGCCATCTCACCCAAATTTTGTTCTAAGCTGTATAGACAGGAAC
ATACAAGACAGGAATCACTC

Downstream 100 bases:

>100_bases
GCAAGGAGAGAGTCCCCATGAACGCTCACGAATCCCGATTCCTCCAGCGCGGCCAGCGCGAAATCCGCGCGCCGCGTGGC
ACCGAGTTGCACTGCAAGAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSASQTNQASRPLLTLNPGQVILADLRRIYRGEVRLEMADSAWAGVRAAQATVQDIIDADAVVYGINTGFGKLAQTRIPN
DKLATLQRNLVLSHSVGTGPDLAEDVVRVILAIKAVSLARGHSGVRPEIIEALLALANHGVTPCIPAKGSVGASGDLAPL
AHMSCTLIGVGDVIVDGRRVPAAEGLAHAGLSAFELGPKEGLALLNGTQVSTALALAGLFAAEDTFAAGLVAGALSLEAI
KGSVKPFDARIHEARGQAGQIAVAGAVRAMLDGSEIVDSHKACGRVQDPYSIRCQPQVMGACLDNLQHAARILRIEANAA
SDNPLVFSAQGDVISGGNFHAEPVAFAADIIALAIAEIGAISERRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAA
LASENKSLAHPSSVDSLPTSANQEDHVSMATYGARRLGDMAANTAVVVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRA
RVAFVEADRYLAPDIEAMKQWVVQGDAGAGWPAAVRDILPTNTKNA

Sequences:

>Translated_526_residues
MSASQTNQASRPLLTLNPGQVILADLRRIYRGEVRLEMADSAWAGVRAAQATVQDIIDADAVVYGINTGFGKLAQTRIPN
DKLATLQRNLVLSHSVGTGPDLAEDVVRVILAIKAVSLARGHSGVRPEIIEALLALANHGVTPCIPAKGSVGASGDLAPL
AHMSCTLIGVGDVIVDGRRVPAAEGLAHAGLSAFELGPKEGLALLNGTQVSTALALAGLFAAEDTFAAGLVAGALSLEAI
KGSVKPFDARIHEARGQAGQIAVAGAVRAMLDGSEIVDSHKACGRVQDPYSIRCQPQVMGACLDNLQHAARILRIEANAA
SDNPLVFSAQGDVISGGNFHAEPVAFAADIIALAIAEIGAISERRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAA
LASENKSLAHPSSVDSLPTSANQEDHVSMATYGARRLGDMAANTAVVVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRA
RVAFVEADRYLAPDIEAMKQWVVQGDAGAGWPAAVRDILPTNTKNA
>Mature_525_residues
SASQTNQASRPLLTLNPGQVILADLRRIYRGEVRLEMADSAWAGVRAAQATVQDIIDADAVVYGINTGFGKLAQTRIPND
KLATLQRNLVLSHSVGTGPDLAEDVVRVILAIKAVSLARGHSGVRPEIIEALLALANHGVTPCIPAKGSVGASGDLAPLA
HMSCTLIGVGDVIVDGRRVPAAEGLAHAGLSAFELGPKEGLALLNGTQVSTALALAGLFAAEDTFAAGLVAGALSLEAIK
GSVKPFDARIHEARGQAGQIAVAGAVRAMLDGSEIVDSHKACGRVQDPYSIRCQPQVMGACLDNLQHAARILRIEANAAS
DNPLVFSAQGDVISGGNFHAEPVAFAADIIALAIAEIGAISERRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAAL
ASENKSLAHPSSVDSLPTSANQEDHVSMATYGARRLGDMAANTAVVVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRAR
VAFVEADRYLAPDIEAMKQWVVQGDAGAGWPAAVRDILPTNTKNA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=496, Percent_Identity=44.5564516129032, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17567831, Length=499, Percent_Identity=41.6833667334669, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54519; Mature: 54388

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASQTNQASRPLLTLNPGQVILADLRRIYRGEVRLEMADSAWAGVRAAQATVQDIIDAD
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
AVVYGINTGFGKLAQTRIPNDKLATLQRNLVLSHSVGTGPDLAEDVVRVILAIKAVSLAR
EEEEECCCCCHHHHHHCCCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GHSGVRPEIIEALLALANHGVTPCIPAKGSVGASGDLAPLAHMSCTLIGVGDVIVDGRRV
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCEEEEEEECCEEECCCCC
PAAEGLAHAGLSAFELGPKEGLALLNGTQVSTALALAGLFAAEDTFAAGLVAGALSLEAI
CHHHHHHHCCCHHHCCCHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGSVKPFDARIHEARGQAGQIAVAGAVRAMLDGSEIVDSHKACGRVQDPYSIRCQPQVMG
HCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECHHHHH
ACLDNLQHAARILRIEANAASDNPLVFSAQGDVISGGNFHAEPVAFAADIIALAIAEIGA
HHHHHHHHHHHEEEEECCCCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHCC
ISERRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAALASENKSLAHPSSVDSLPTS
CCCCCEEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ANQEDHVSMATYGARRLGDMAANTAVVVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRA
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
RVAFVEADRYLAPDIEAMKQWVVQGDAGAGWPAAVRDILPTNTKNA
HHHEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SASQTNQASRPLLTLNPGQVILADLRRIYRGEVRLEMADSAWAGVRAAQATVQDIIDAD
CCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
AVVYGINTGFGKLAQTRIPNDKLATLQRNLVLSHSVGTGPDLAEDVVRVILAIKAVSLAR
EEEEECCCCCHHHHHHCCCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GHSGVRPEIIEALLALANHGVTPCIPAKGSVGASGDLAPLAHMSCTLIGVGDVIVDGRRV
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCEEEEEEECCEEECCCCC
PAAEGLAHAGLSAFELGPKEGLALLNGTQVSTALALAGLFAAEDTFAAGLVAGALSLEAI
CHHHHHHHCCCHHHCCCHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGSVKPFDARIHEARGQAGQIAVAGAVRAMLDGSEIVDSHKACGRVQDPYSIRCQPQVMG
HCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEECHHHHH
ACLDNLQHAARILRIEANAASDNPLVFSAQGDVISGGNFHAEPVAFAADIIALAIAEIGA
HHHHHHHHHHHEEEEECCCCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHCC
ISERRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAALASENKSLAHPSSVDSLPTS
CCCCCEEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ANQEDHVSMATYGARRLGDMAANTAVVVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRA
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
RVAFVEADRYLAPDIEAMKQWVVQGDAGAGWPAAVRDILPTNTKNA
HHHEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA