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The map label for this gene is hutU [H]

Identifier: 73542400

GI number: 73542400

Start: 2980621

End: 2982321

Strand: Reverse

Name: hutU [H]

Synonym: Reut_A2715

Alternate gene names: 73542400

Gene position: 2982321-2980621 (Counterclockwise)

Preceding gene: 73542401

Following gene: 73542399

Centisome position: 78.35

GC content: 65.37

Gene sequence:

>1701_bases
ATGAACGCTCACGAATCCCGATTCCTCCAGCGCGGCCAGCGCGAAATCCGCGCGCCGCGTGGCACCGAGTTGCACTGCAA
GAACTGGCTGATCGAAGCGGCCTACCGCATGATCCAGAACAACCTGGACCCGGACGTGGCCGAGCGCCCGCAAGACCTGG
TGGTCTACGGTGGCATCGGCAAGGCCGCGCGCAACTGGGAATGCTTCGACGCGATCCTCGACAGCCTGCGCCGACTCGGC
GAAGACGAGTCGCTGCTTGTGCAGTCCGGCAAGCCGGTGGGCGTGTTCCGCACGCACGCCGATGCACCGCGCGTGCTGAT
TGCCAACTCCAACCTCGTGCCGCACTGGGCCAACTGGGACAAGTTCAACGAACTCGACCGCGCCGGCCTGATGATGTACG
GCCAGATGACCGCGGGTTCGTGGATCTACATCGGCACACAGGGCATCGTGCAGGGCACGTATGAAACCTTCGTCGAGGCG
GGTCGCCAGCACTACAACGGCGACCTGTCGGGCAAGTGGATACTGACGGCAGGCCTGGGCGGCATGGGCGGCGCGCAGCC
GCTGGCCGGTGTGCTGGCCGGTGCGTGCGTGCTCGCGATCGAATGCCAGGAATCGCGCATCGACTTCCGCCTGCGTACGC
GCTACCTCGACAAGAAGGCCACCACGCTCGACGAAGCGCTGGCGATGATCGCCGAGGCCACGCAGAAGAAGGAAGCCATC
TCCGTGGGGCTGCTCGGCAACGCGGCCGACATCGTCCCGGAACTCGTCAAGCGCGCGCAGGCCGGTGGCATGCGTCCGGA
CATCGTCACCGACCAGACTTCGGCACACGACCTCGTCAACGGCTACCTGCCTCAAGGCTGGACCGTTGACCAATGGGAAC
ACGCACGCCAGCACGATCCCAAGTCGGTGGAAGCCGCCGCGCGACCGTCGATTGTGAAACACGTGCAGGCAATGCTCGCG
TACCAGCAGATGGGCGTGCCGACTGTCGACTACGGCAACAACATTCGCCAGGTTGCGTTCGACGAGGGCGTGAAGAATGC
CTTCGATTTCCCCGGCTTCGTGCCGGCCTATATCCGGCCGCTGTTCTGCCGCGGCAAGGGCCCGTTCCGCTGGGTCGCGC
TATCCGGCGATCCCGAGGACATCTACAGGACCGACGCCAAGATGAAGGAGCTTTTCCCCGAGGACACGCACCTGCACCGC
TGGCTCGACATGGCGCACGACCGCATCGCGTTCCAGGGTTTGCCCGCGCGCATCTGCTGGGTTGGGCTGGACGAGCGTCA
TCGCGCGGGCCTTGCATTCAACGAGATGGTGAAGTCGGGCGAACTCAAGGCGCCCGTCGTGATCGGCCGTGACCATCTGG
ACTGCGGCTCGGTCGCTTCGCCGAACCGCGAAACCGAGTCCATGCGCGACGGCTCCGATGCCGTTTCCGACTGGCCGCTG
CTCAACGCGTTGCTGAACACCGCCGGCGGCGCGACGTGGGTCAGCCTGCATCATGGCGGTGGTGTCGGCATGGGTTTCTC
GCAGCATTCGGGCGTGGTGATCGTCTGCGACGGTACCGACGCGGCGGCTAAGCGCATTGAGCGCGTGCTGTGGAACGACC
CGGCCACGGGCGTGATGCGCCATGCCGATGCGGGCTACGAGCTTGCCATCGAATGCGCGCACGAGAAGGGCCTCAACTTG
CCGATGGTGAATCGCTCATGA

Upstream 100 bases:

>100_bases
AGTGGGTGGTGCAGGGCGATGCGGGGGCAGGCTGGCCTGCTGCGGTGCGCGACATCCTGCCGACGAATACCAAGAACGCC
TGAGCAAGGAGAGAGTCCCC

Downstream 100 bases:

>100_bases
CCCGCTTCGCACTTGACTCGATGGAACCTACGCCGTGGAAGAACGGCGGCGGCACCACGCGCGAAGTCGCGGTGTGGCCG
CCCGATGCCGGGCTCGACGA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MNAHESRFLQRGQREIRAPRGTELHCKNWLIEAAYRMIQNNLDPDVAERPQDLVVYGGIGKAARNWECFDAILDSLRRLG
EDESLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWDKFNELDRAGLMMYGQMTAGSWIYIGTQGIVQGTYETFVEA
GRQHYNGDLSGKWILTAGLGGMGGAQPLAGVLAGACVLAIECQESRIDFRLRTRYLDKKATTLDEALAMIAEATQKKEAI
SVGLLGNAADIVPELVKRAQAGGMRPDIVTDQTSAHDLVNGYLPQGWTVDQWEHARQHDPKSVEAAARPSIVKHVQAMLA
YQQMGVPTVDYGNNIRQVAFDEGVKNAFDFPGFVPAYIRPLFCRGKGPFRWVALSGDPEDIYRTDAKMKELFPEDTHLHR
WLDMAHDRIAFQGLPARICWVGLDERHRAGLAFNEMVKSGELKAPVVIGRDHLDCGSVASPNRETESMRDGSDAVSDWPL
LNALLNTAGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRIERVLWNDPATGVMRHADAGYELAIECAHEKGLNL
PMVNRS

Sequences:

>Translated_566_residues
MNAHESRFLQRGQREIRAPRGTELHCKNWLIEAAYRMIQNNLDPDVAERPQDLVVYGGIGKAARNWECFDAILDSLRRLG
EDESLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWDKFNELDRAGLMMYGQMTAGSWIYIGTQGIVQGTYETFVEA
GRQHYNGDLSGKWILTAGLGGMGGAQPLAGVLAGACVLAIECQESRIDFRLRTRYLDKKATTLDEALAMIAEATQKKEAI
SVGLLGNAADIVPELVKRAQAGGMRPDIVTDQTSAHDLVNGYLPQGWTVDQWEHARQHDPKSVEAAARPSIVKHVQAMLA
YQQMGVPTVDYGNNIRQVAFDEGVKNAFDFPGFVPAYIRPLFCRGKGPFRWVALSGDPEDIYRTDAKMKELFPEDTHLHR
WLDMAHDRIAFQGLPARICWVGLDERHRAGLAFNEMVKSGELKAPVVIGRDHLDCGSVASPNRETESMRDGSDAVSDWPL
LNALLNTAGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRIERVLWNDPATGVMRHADAGYELAIECAHEKGLNL
PMVNRS
>Mature_566_residues
MNAHESRFLQRGQREIRAPRGTELHCKNWLIEAAYRMIQNNLDPDVAERPQDLVVYGGIGKAARNWECFDAILDSLRRLG
EDESLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWDKFNELDRAGLMMYGQMTAGSWIYIGTQGIVQGTYETFVEA
GRQHYNGDLSGKWILTAGLGGMGGAQPLAGVLAGACVLAIECQESRIDFRLRTRYLDKKATTLDEALAMIAEATQKKEAI
SVGLLGNAADIVPELVKRAQAGGMRPDIVTDQTSAHDLVNGYLPQGWTVDQWEHARQHDPKSVEAAARPSIVKHVQAMLA
YQQMGVPTVDYGNNIRQVAFDEGVKNAFDFPGFVPAYIRPLFCRGKGPFRWVALSGDPEDIYRTDAKMKELFPEDTHLHR
WLDMAHDRIAFQGLPARICWVGLDERHRAGLAFNEMVKSGELKAPVVIGRDHLDCGSVASPNRETESMRDGSDAVSDWPL
LNALLNTAGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRIERVLWNDPATGVMRHADAGYELAIECAHEKGLNL
PMVNRS

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=561, Percent_Identity=34.4028520499109, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI260306182, Length=214, Percent_Identity=39.2523364485981, Blast_Score=159, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71997891, Length=565, Percent_Identity=35.5752212389381, Blast_Score=315, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 62291; Mature: 62291

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAHESRFLQRGQREIRAPRGTELHCKNWLIEAAYRMIQNNLDPDVAERPQDLVVYGGIG
CCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEECCCC
KAARNWECFDAILDSLRRLGEDESLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWD
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCH
KFNELDRAGLMMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQHYNGDLSGKWILTAGLG
HHHHHHHCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC
GMGGAQPLAGVLAGACVLAIECQESRIDFRLRTRYLDKKATTLDEALAMIAEATQKKEAI
CCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
SVGLLGNAADIVPELVKRAQAGGMRPDIVTDQTSAHDLVNGYLPQGWTVDQWEHARQHDP
EEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCC
KSVEAAARPSIVKHVQAMLAYQQMGVPTVDYGNNIRQVAFDEGVKNAFDFPGFVPAYIRP
CHHHHHHCHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHCC
LFCRGKGPFRWVALSGDPEDIYRTDAKMKELFPEDTHLHRWLDMAHDRIAFQGLPARICW
CEECCCCCEEEEEECCCHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
VGLDERHRAGLAFNEMVKSGELKAPVVIGRDHLDCGSVASPNRETESMRDGSDAVSDWPL
EECCCHHCCCCHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHH
LNALLNTAGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRIERVLWNDPATGVMR
HHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHH
HADAGYELAIECAHEKGLNLPMVNRS
HCCCCCEEEEEEHHHCCCCCCCCCCC
>Mature Secondary Structure
MNAHESRFLQRGQREIRAPRGTELHCKNWLIEAAYRMIQNNLDPDVAERPQDLVVYGGIG
CCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEECCCC
KAARNWECFDAILDSLRRLGEDESLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWD
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCH
KFNELDRAGLMMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQHYNGDLSGKWILTAGLG
HHHHHHHCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC
GMGGAQPLAGVLAGACVLAIECQESRIDFRLRTRYLDKKATTLDEALAMIAEATQKKEAI
CCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
SVGLLGNAADIVPELVKRAQAGGMRPDIVTDQTSAHDLVNGYLPQGWTVDQWEHARQHDP
EEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCC
KSVEAAARPSIVKHVQAMLAYQQMGVPTVDYGNNIRQVAFDEGVKNAFDFPGFVPAYIRP
CHHHHHHCHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHCC
LFCRGKGPFRWVALSGDPEDIYRTDAKMKELFPEDTHLHRWLDMAHDRIAFQGLPARICW
CEECCCCCEEEEEECCCHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
VGLDERHRAGLAFNEMVKSGELKAPVVIGRDHLDCGSVASPNRETESMRDGSDAVSDWPL
EECCCHHCCCCHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHH
LNALLNTAGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRIERVLWNDPATGVMR
HHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHH
HADAGYELAIECAHEKGLNLPMVNRS
HCCCCCEEEEEEHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]