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The map label for this gene is hutC [H]

Identifier: 73542402

GI number: 73542402

Start: 2983999

End: 2984766

Strand: Reverse

Name: hutC [H]

Synonym: Reut_A2717

Alternate gene names: 73542402

Gene position: 2984766-2983999 (Counterclockwise)

Preceding gene: 73542403

Following gene: 73542401

Centisome position: 78.41

GC content: 67.58

Gene sequence:

>768_bases
ATGAACCACGCCGTCGGCCAGGGGCCTGCCACTTCCGCTACGAACTCTCCCACCGCGCTCTACCAGCAGGTGAAAGAGTA
CATCGCCCGCCAGATCCAGAGCGGTGCGTGGCAGCCGGGCGACCGGGTGCCGTCGGAGCAGGAGCTGGTGACCCGCTTCG
GTGTGTCGCGCATGACCGTCAACCGCGCACTGCGCGAGCTGTCCGAGCAGGGCAGGGTGGTGCGCGTGGCCGGCGTGGGT
ACCTTCGTGGCGGAGCACAAGCCGCAGTCCACGCTGCTTAGCGTGGTCAACCTGCAGGACGAAATCCGCATGCGCGGCCA
TGACTATGCCTGCGACGTGATCCTGGTGGAGCGCGTGGCCGCGTCGATCGAAGTGGCCGCGGCGCTGGAGTTGCGCACGG
GCGAGTCGGTCTTCCACTCCGTCTGCGTGCACCGCGAGGACGGCGTGCCCGTGCAGCTCGAAGACCGCTATGTCAATCCG
CGCGTGGCACCGGATTTCATTACGCAGGACTTCAGCGGCATCAAGCCCGGCGAGTACCTGCTGCGCAATGTGCCCTACGA
TCAGGTCGAGCACGTGGTCGACGCCATCTCCGCCACGCCCGAGCAGGCCGCGCAACTCGAAATGCCGCCGACGCAACCTT
GCCTGATGCTGACACGCCGCACGTGGACCAATGGCGTGCCCGTGACCTTCGTGCGTTGCCTGCACCCCGGCAACCGCTAC
CGCCTCGGCAGCCGCTTCCGCGCCGACGGCAATCCCGCCTTCGGCTGA

Upstream 100 bases:

>100_bases
ATTACACGATCAAGACGTCGCCGGAGTTTTCCGCGCTCAAGGCGCGGCTGACCGAGGAGATCCGCGCCGAGGCCATGGCC
GCGGCCGAGCACTGAACGCC

Downstream 100 bases:

>100_bases
TTTCCGACAGAAGTCAGCCATCTCACCCAAATTTTGTTCTAAGCTGTATAGACAGGAACATACAAGACAGGAATCACTCA
TGAGCGCCAGCCAAACCAAC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MNHAVGQGPATSATNSPTALYQQVKEYIARQIQSGAWQPGDRVPSEQELVTRFGVSRMTVNRALRELSEQGRVVRVAGVG
TFVAEHKPQSTLLSVVNLQDEIRMRGHDYACDVILVERVAASIEVAAALELRTGESVFHSVCVHREDGVPVQLEDRYVNP
RVAPDFITQDFSGIKPGEYLLRNVPYDQVEHVVDAISATPEQAAQLEMPPTQPCLMLTRRTWTNGVPVTFVRCLHPGNRY
RLGSRFRADGNPAFG

Sequences:

>Translated_255_residues
MNHAVGQGPATSATNSPTALYQQVKEYIARQIQSGAWQPGDRVPSEQELVTRFGVSRMTVNRALRELSEQGRVVRVAGVG
TFVAEHKPQSTLLSVVNLQDEIRMRGHDYACDVILVERVAASIEVAAALELRTGESVFHSVCVHREDGVPVQLEDRYVNP
RVAPDFITQDFSGIKPGEYLLRNVPYDQVEHVVDAISATPEQAAQLEMPPTQPCLMLTRRTWTNGVPVTFVRCLHPGNRY
RLGSRFRADGNPAFG
>Mature_255_residues
MNHAVGQGPATSATNSPTALYQQVKEYIARQIQSGAWQPGDRVPSEQELVTRFGVSRMTVNRALRELSEQGRVVRVAGVG
TFVAEHKPQSTLLSVVNLQDEIRMRGHDYACDVILVERVAASIEVAAALELRTGESVFHSVCVHREDGVPVQLEDRYVNP
RVAPDFITQDFSGIKPGEYLLRNVPYDQVEHVVDAISATPEQAAQLEMPPTQPCLMLTRRTWTNGVPVTFVRCLHPGNRY
RLGSRFRADGNPAFG

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=200, Percent_Identity=28.5, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI87082252, Length=238, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790118, Length=156, Percent_Identity=26.2820512820513, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790540, Length=209, Percent_Identity=27.7511961722488, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28246; Mature: 28246

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHAVGQGPATSATNSPTALYQQVKEYIARQIQSGAWQPGDRVPSEQELVTRFGVSRMTV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHH
NRALRELSEQGRVVRVAGVGTFVAEHKPQSTLLSVVNLQDEIRMRGHDYACDVILVERVA
HHHHHHHHHCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ASIEVAAALELRTGESVFHSVCVHREDGVPVQLEDRYVNPRVAPDFITQDFSGIKPGEYL
HHHHHHHHEEECCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHCCCCCCCHHHH
LRNVPYDQVEHVVDAISATPEQAAQLEMPPTQPCLMLTRRTWTNGVPVTFVRCLHPGNRY
HHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHEECCCCCCE
RLGSRFRADGNPAFG
ECCCEECCCCCCCCC
>Mature Secondary Structure
MNHAVGQGPATSATNSPTALYQQVKEYIARQIQSGAWQPGDRVPSEQELVTRFGVSRMTV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHHH
NRALRELSEQGRVVRVAGVGTFVAEHKPQSTLLSVVNLQDEIRMRGHDYACDVILVERVA
HHHHHHHHHCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ASIEVAAALELRTGESVFHSVCVHREDGVPVQLEDRYVNPRVAPDFITQDFSGIKPGEYL
HHHHHHHHEEECCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHCCCCCCCHHHH
LRNVPYDQVEHVVDAISATPEQAAQLEMPPTQPCLMLTRRTWTNGVPVTFVRCLHPGNRY
HHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHEECCCCCCE
RLGSRFRADGNPAFG
ECCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]