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The map label for this gene is cysM [H]

Identifier: 73542245

GI number: 73542245

Start: 2804996

End: 2805898

Strand: Reverse

Name: cysM [H]

Synonym: Reut_A2560

Alternate gene names: 73542245

Gene position: 2805898-2804996 (Counterclockwise)

Preceding gene: 73542246

Following gene: 73542240

Centisome position: 73.71

GC content: 62.68

Gene sequence:

>903_bases
ATGGCCTACAAGACAATCGAAGACACCATCGGCAATACGCCGCTGGTCAGACTGCAGCGCATTCCCGGTGCCGCCAACGA
CGCACGCGGCAACGTCATCCTGGGCAAGCTCGAGGGTAACAACCCGGCAGGGTCAGTCAAGGATCGCCCGGCCGTGTCGA
TGATCGCCCGTGCTGAGGCGCGCGGCCGCATCAAGCCCGGCGACACGCTGATCGAAGCCACGTCCGGAAATACCGGCATC
GCGCTCGCCATGGCCGCGGCCATCCGCGGCTACAAGATGGTGCTGATCATGCCGGAAGATCTGAGCCTGGAACGCCGCCA
GAGCATGGCCGCCTATGGGGCCGAGATCATCTTGACTCCGGTGAAGGGCGGCATGGAGTACGCGCGCGACCTCGCCGATT
CGATGGAGCGTGACGGCAAGGGCGTCATCCTGGACCAGTTCGGGAATCCGGATAATCCGCTGGCCCACTACGAAACCACC
GGCCCGGAAATCTGGCGCGATACGGAAGGGCGGATTACGCATTTCGTATCGGCCATGGGAACGACCGGCACAATCACCGG
CGTTTCGCGATACCTGAAAGAGCAGAACCCGGCCATTGAGATCGTCGGCGCGCAGCCGGCGGAAGGCTCGCGGATTCCAG
GCATTCGCAAGTGGCCGGAGGCTTATCTGCCGAAGATCTATGATGCGAAATACGTGGACCGTACCGAGCCCGTGAGCCAG
GCCGATGCGGAACATATGGCACGGCGCATGGCAAGCGAGGAAGGCATCTTTAGCGGTATCTCGGCGGCGGGCGCGCTGTG
CGTGGCCTTGCGAGTTGCTGAAGAGGTGGAAAACGCGACGATCGTTTTCGTGGTCTGCGACAGGGGAGATCGATACCTGT
CCACGGGCGTATTTCCCGCCTGA

Upstream 100 bases:

>100_bases
TAAGCCGGGGCATCCACACTGGCAGTGGGCCCAACGGGCCGCTGCCGGCGCGGGTCAGGGGCCTGGATTACAATGTGCAG
GACATTTTCGACCCCGCACC

Downstream 100 bases:

>100_bases
GTTTCCTCCGAAGTCGGAAATCTAAGTACCCTGTGACGGATAATCCCGTTGCAGGGTACTGGTGTATTCCTTATGCCGCG
GACTTGTCGCGGATCCAGCC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAYKTIEDTIGNTPLVRLQRIPGAANDARGNVILGKLEGNNPAGSVKDRPAVSMIARAEARGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMVLIMPEDLSLERRQSMAAYGAEIILTPVKGGMEYARDLADSMERDGKGVILDQFGNPDNPLAHYETT
GPEIWRDTEGRITHFVSAMGTTGTITGVSRYLKEQNPAIEIVGAQPAEGSRIPGIRKWPEAYLPKIYDAKYVDRTEPVSQ
ADAEHMARRMASEEGIFSGISAAGALCVALRVAEEVENATIVFVVCDRGDRYLSTGVFPA

Sequences:

>Translated_300_residues
MAYKTIEDTIGNTPLVRLQRIPGAANDARGNVILGKLEGNNPAGSVKDRPAVSMIARAEARGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMVLIMPEDLSLERRQSMAAYGAEIILTPVKGGMEYARDLADSMERDGKGVILDQFGNPDNPLAHYETT
GPEIWRDTEGRITHFVSAMGTTGTITGVSRYLKEQNPAIEIVGAQPAEGSRIPGIRKWPEAYLPKIYDAKYVDRTEPVSQ
ADAEHMARRMASEEGIFSGISAAGALCVALRVAEEVENATIVFVVCDRGDRYLSTGVFPA
>Mature_299_residues
AYKTIEDTIGNTPLVRLQRIPGAANDARGNVILGKLEGNNPAGSVKDRPAVSMIARAEARGRIKPGDTLIEATSGNTGIA
LAMAAAIRGYKMVLIMPEDLSLERRQSMAAYGAEIILTPVKGGMEYARDLADSMERDGKGVILDQFGNPDNPLAHYETTG
PEIWRDTEGRITHFVSAMGTTGTITGVSRYLKEQNPAIEIVGAQPAEGSRIPGIRKWPEAYLPKIYDAKYVDRTEPVSQA
DAEHMARRMASEEGIFSGISAAGALCVALRVAEEVENATIVFVVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=37.620578778135, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=37.620578778135, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=37.620578778135, Blast_Score=185, Evalue=4e-47,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=63.6054421768708, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1788754, Length=320, Percent_Identity=43.125, Blast_Score=205, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=44.5901639344262, Blast_Score=233, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=44.3708609271523, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=45.1178451178451, Blast_Score=220, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=42, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=41.7218543046358, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=36.5079365079365, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=37.2239747634069, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=39.1509433962264, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321594, Length=321, Percent_Identity=38.006230529595, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=33.033033033033, Blast_Score=132, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24643623, Length=310, Percent_Identity=37.741935483871, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI20129101, Length=310, Percent_Identity=37.741935483871, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32281; Mature: 32150

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKTIEDTIGNTPLVRLQRIPGAANDARGNVILGKLEGNNPAGSVKDRPAVSMIARAEA
CCCCCHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSLERRQSMAAYGAEIILTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMEYARDLADSMERDGKGVILDQFGNPDNPLAHYETTGPEIWRDTEGRITHFVSAMG
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCHHCCCCCCHHHHHHHHHC
TTGTITGVSRYLKEQNPAIEIVGAQPAEGSRIPGIRKWPEAYLPKIYDAKYVDRTEPVSQ
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCCCCHH
ADAEHMARRMASEEGIFSGISAAGALCVALRVAEEVENATIVFVVCDRGDRYLSTGVFPA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure 
AYKTIEDTIGNTPLVRLQRIPGAANDARGNVILGKLEGNNPAGSVKDRPAVSMIARAEA
CCCCHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSLERRQSMAAYGAEIILTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMEYARDLADSMERDGKGVILDQFGNPDNPLAHYETTGPEIWRDTEGRITHFVSAMG
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCHHCCCCCCHHHHHHHHHC
TTGTITGVSRYLKEQNPAIEIVGAQPAEGSRIPGIRKWPEAYLPKIYDAKYVDRTEPVSQ
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCCCCHH
ADAEHMARRMASEEGIFSGISAAGALCVALRVAEEVENATIVFVVCDRGDRYLSTGVFPA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]