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The map label for this gene is acdA [H]

Identifier: 73541869

GI number: 73541869

Start: 2406258

End: 2407427

Strand: Reverse

Name: acdA [H]

Synonym: Reut_A2181

Alternate gene names: 73541869

Gene position: 2407427-2406258 (Counterclockwise)

Preceding gene: 73541870

Following gene: 73541868

Centisome position: 63.24

GC content: 67.44

Gene sequence:

>1170_bases
ATGTCCGACAAGACTTACCTCGAGCTGCCTCTGCTTGACGATTCGCACCGCATGCTCGAACGCGATCTGGATGCGTGGTG
CGAGGCGAACCTGAAGGTGGACCACAGCGATACCGATGCCGCATGTCGCACGTTGGTGCGCCAGCTTGGCGAAGCCGGCT
GGCTTCGCTACTGCGTGCCGGCCGCGCATGGCGGCGCGTTGCCGGCGCTCGATTCGCGTTCGCTGTGCCTGTTGCGTGAA
ACGCTGGCCCGTCACGATGGGCTGGCCGATTTTGCATTCGCCATGCAAGGGCTTGGATCGGGCGCGATCTCGCTCGCCGG
CAGCGACGCCGTGCGCAAACGCTATCTGCCGCGCGTTGCCCGTGGCGAAGCCATCGCGGCGTTTGCGCTGTCCGAGCCGG
ACGCCGGTTCGGACGTGGCGGCGATGCGGTGCAGCGCGCAGCTCGACGCAGGCGGCACCCACTATGTGATCGACGGGGCC
AAGACGTGGATCTCCAACGGCGGCATTGCCGATTTCTACTGCGTGTTCGTGCGTACCGGCGAGGCGCCCGGCGCGCGCGG
CATCTCCGCGTTCGTGGTCGATGCCGACACGCCGGGCTTGAGCATTGCCGAGCGCATCGACGTCATGGCGCCGCATCCGC
TCGCCACACTGCGCTTCGACAACTGCCGCGTGCCGGTAGGCAATCGCCTGGGCGAAGCGGGGCAGGGCTTCAAGGTGGCA
ATGATGACGCTGGACATCTTCCGCGCGTCAGTGGCGGCAGCCGCGCTTGGCTTCGGCCGCGCTGCACTTGATGAAGCGTT
GGCACGTGCGCGTGCACGGCCGATGTTCGGCGGCGTGCTGGCGGACCTCCAGCTCACGCAGGCGGCCATTGGCGACATGG
CCACGGCCATCGATGCCGCGGCGCTGTTGACCTACCGCGCGGCGTGGCTGCGTGACGTGAAGGGCGTGCGCACCACGCGC
GAAGCGGCCATGGCCAAGATGGTGGCCACCGAAAACGCGCAGCAGGTCATCGACCGCGCGGTGCAGATGTTCGGTGGCCT
CGGCGTCAAGGTCGGCACGCGCGTAGAAGGGCTCTATCGGGAGATCCGCTCGCTGCGCATTTATGAAGGCGCGACGGAGG
TCCAGAAGCTCATCATCGCGCGCGAAACGCTGGCGGCGCAGGTCGCCTGA

Upstream 100 bases:

>100_bases
GCGTGATTTCCGGCGCGCCTACGAGGCATTCGTGGCGAAGAACAAGCCGGTGTTCGAGGGCGACTGAACGCAAACGAAGG
CGCAACCAAAAGGATTTTCG

Downstream 100 bases:

>100_bases
AGCGGCACGGCCCGACACACATCATCAAGTCAGCGACACAGCAGACAGGAGACAAGTCATGGCGACCACCGCCCACCTCG
ATACCTTCGCCCAGGATCGG

Product: Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSDKTYLELPLLDDSHRMLERDLDAWCEANLKVDHSDTDAACRTLVRQLGEAGWLRYCVPAAHGGALPALDSRSLCLLRE
TLARHDGLADFAFAMQGLGSGAISLAGSDAVRKRYLPRVARGEAIAAFALSEPDAGSDVAAMRCSAQLDAGGTHYVIDGA
KTWISNGGIADFYCVFVRTGEAPGARGISAFVVDADTPGLSIAERIDVMAPHPLATLRFDNCRVPVGNRLGEAGQGFKVA
MMTLDIFRASVAAAALGFGRAALDEALARARARPMFGGVLADLQLTQAAIGDMATAIDAAALLTYRAAWLRDVKGVRTTR
EAAMAKMVATENAQQVIDRAVQMFGGLGVKVGTRVEGLYREIRSLRIYEGATEVQKLIIARETLAAQVA

Sequences:

>Translated_389_residues
MSDKTYLELPLLDDSHRMLERDLDAWCEANLKVDHSDTDAACRTLVRQLGEAGWLRYCVPAAHGGALPALDSRSLCLLRE
TLARHDGLADFAFAMQGLGSGAISLAGSDAVRKRYLPRVARGEAIAAFALSEPDAGSDVAAMRCSAQLDAGGTHYVIDGA
KTWISNGGIADFYCVFVRTGEAPGARGISAFVVDADTPGLSIAERIDVMAPHPLATLRFDNCRVPVGNRLGEAGQGFKVA
MMTLDIFRASVAAAALGFGRAALDEALARARARPMFGGVLADLQLTQAAIGDMATAIDAAALLTYRAAWLRDVKGVRTTR
EAAMAKMVATENAQQVIDRAVQMFGGLGVKVGTRVEGLYREIRSLRIYEGATEVQKLIIARETLAAQVA
>Mature_388_residues
SDKTYLELPLLDDSHRMLERDLDAWCEANLKVDHSDTDAACRTLVRQLGEAGWLRYCVPAAHGGALPALDSRSLCLLRET
LARHDGLADFAFAMQGLGSGAISLAGSDAVRKRYLPRVARGEAIAAFALSEPDAGSDVAAMRCSAQLDAGGTHYVIDGAK
TWISNGGIADFYCVFVRTGEAPGARGISAFVVDADTPGLSIAERIDVMAPHPLATLRFDNCRVPVGNRLGEAGQGFKVAM
MTLDIFRASVAAAALGFGRAALDEALARARARPMFGGVLADLQLTQAAIGDMATAIDAAALLTYRAAWLRDVKGVRTTRE
AAMAKMVATENAQQVIDRAVQMFGGLGVKVGTRVEGLYREIRSLRIYEGATEVQKLIIARETLAAQVA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=388, Percent_Identity=37.6288659793814, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4557231, Length=345, Percent_Identity=36.5217391304348, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI187960098, Length=345, Percent_Identity=36.5217391304348, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=31.5789473684211, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI76496475, Length=393, Percent_Identity=31.8066157760814, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI4557235, Length=362, Percent_Identity=33.7016574585635, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI21361497, Length=343, Percent_Identity=33.2361516034985, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=33.2352941176471, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI4501859, Length=380, Percent_Identity=31.5789473684211, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI7656849, Length=280, Percent_Identity=35, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4501857, Length=382, Percent_Identity=26.9633507853403, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI211971008, Length=292, Percent_Identity=33.2191780821918, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI48976061, Length=292, Percent_Identity=33.2191780821918, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4503943, Length=353, Percent_Identity=28.328611898017, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI7669494, Length=315, Percent_Identity=29.2063492063492, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI38505218, Length=298, Percent_Identity=29.5302013422819, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1786223, Length=264, Percent_Identity=27.2727272727273, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI87081958, Length=284, Percent_Identity=29.2253521126761, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87081702, Length=279, Percent_Identity=27.2401433691756, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17569725, Length=347, Percent_Identity=34.8703170028818, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17534899, Length=344, Percent_Identity=35.4651162790698, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71985184, Length=362, Percent_Identity=34.5303867403315, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17570075, Length=347, Percent_Identity=33.7175792507205, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17508101, Length=348, Percent_Identity=33.6206896551724, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17533517, Length=347, Percent_Identity=31.4121037463977, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17538396, Length=378, Percent_Identity=31.7460317460317, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17506239, Length=337, Percent_Identity=32.0474777448071, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71985192, Length=309, Percent_Identity=32.6860841423948, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71990804, Length=226, Percent_Identity=35.8407079646018, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17505929, Length=382, Percent_Identity=27.4869109947644, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17551932, Length=287, Percent_Identity=31.0104529616725, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI71982178, Length=283, Percent_Identity=27.9151943462898, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=30.4721030042918, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17534353, Length=284, Percent_Identity=28.5211267605634, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=30.1652892561983, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17562446, Length=295, Percent_Identity=30.1694915254237, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=37.2703412073491, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21356377, Length=384, Percent_Identity=37.5, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24660351, Length=347, Percent_Identity=35.7348703170029, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24666513, Length=389, Percent_Identity=32.9048843187661, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI281363737, Length=389, Percent_Identity=31.6195372750643, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21355753, Length=360, Percent_Identity=30.8333333333333, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI19920834, Length=347, Percent_Identity=28.2420749279539, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41412; Mature: 41281

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKTYLELPLLDDSHRMLERDLDAWCEANLKVDHSDTDAACRTLVRQLGEAGWLRYCVP
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCEEEEEC
AAHGGALPALDSRSLCLLRETLARHDGLADFAFAMQGLGSGAISLAGSDAVRKRYLPRVA
CCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHCCHHH
RGEAIAAFALSEPDAGSDVAAMRCSAQLDAGGTHYVIDGAKTWISNGGIADFYCVFVRTG
CCCEEEEEEECCCCCCCCHHHHEECCEECCCCCEEEECCHHHHHCCCCCEEEEEEEEEEC
EAPGARGISAFVVDADTPGLSIAERIDVMAPHPLATLRFDNCRVPVGNRLGEAGQGFKVA
CCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEH
MMTLDIFRASVAAAALGFGRAALDEALARARARPMFGGVLADLQLTQAAIGDMATAIDAA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLTYRAAWLRDVKGVRTTREAAMAKMVATENAQQVIDRAVQMFGGLGVKVGTRVEGLYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECHHHHHHHH
EIRSLRIYEGATEVQKLIIARETLAAQVA
HHHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDKTYLELPLLDDSHRMLERDLDAWCEANLKVDHSDTDAACRTLVRQLGEAGWLRYCVP
CCCEEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCEEEEEC
AAHGGALPALDSRSLCLLRETLARHDGLADFAFAMQGLGSGAISLAGSDAVRKRYLPRVA
CCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHCCHHH
RGEAIAAFALSEPDAGSDVAAMRCSAQLDAGGTHYVIDGAKTWISNGGIADFYCVFVRTG
CCCEEEEEEECCCCCCCCHHHHEECCEECCCCCEEEECCHHHHHCCCCCEEEEEEEEEEC
EAPGARGISAFVVDADTPGLSIAERIDVMAPHPLATLRFDNCRVPVGNRLGEAGQGFKVA
CCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEH
MMTLDIFRASVAAAALGFGRAALDEALARARARPMFGGVLADLQLTQAAIGDMATAIDAA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLTYRAAWLRDVKGVRTTREAAMAKMVATENAQQVIDRAVQMFGGLGVKVGTRVEGLYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECHHHHHHHH
EIRSLRIYEGATEVQKLIIARETLAAQVA
HHHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]