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The map label for this gene is echA12 [H]

Identifier: 73541870

GI number: 73541870

Start: 2407461

End: 2408369

Strand: Reverse

Name: echA12 [H]

Synonym: Reut_A2182

Alternate gene names: 73541870

Gene position: 2408369-2407461 (Counterclockwise)

Preceding gene: 73541871

Following gene: 73541869

Centisome position: 63.27

GC content: 64.25

Gene sequence:

>909_bases
GTGCTGAGAGCAAGCGGCAGCACCAGAACACCGAATCAGACAAGACAGAGAGAAACCATGACCGACATCGCACTCCACAT
GCGCCATCACAAGCGCAAGTTCGCGGACTACTCGCCGAAGCACTTCCTGTGGTCCGTCTCCGACGATGGAAAGGTAGGCA
CCATCACGCTCAACCGCCCGGAGCGCAAGAACCCGCTAACGTTCGACTCGTATGCCGAACTGCGCGACCTGTTCCGTGCG
CTGTGCTATGCGAGCGATATCAAGACCGTGGTGGTCACGGGCGCCGGCGGCAACTTCTGCTCGGGCGGCGACGTGCACGA
GATCATCGGGCCGCTCACGAAGATGACCATGCCGGAGTTGCTCGACTTCACGCGCATGACCGGCGACCTCGTCAAGGCCA
TGCGTGCGTGCCCGCAGCCGGTCATCAGCGCGATCGACGGCATCTGCGCCGGCGCTGGCGCCATGATGGCACTGGCCTCC
GATATGCGAGTGGGCACGGCGCAGGCCAAGACCGCTTTCCTGTTTGTGCGCGTAGGGCTGGCCGGCGCCGACATGGGCGC
GTGCTCGTTGCTGCCGCGCGTGATCGGGCAGGGCCGGGCCAGCGAACTGCTTTACACCGGCCGCGTGATGACCGCGGAAG
AAGGACTGCAGTGGGGCTTCTTCAACGCGCTGCATGCGTCTGACAAGGTGCTGGCCGAGGCCCATGTGCTAGCCGCGCAG
CTCGCTGCTGGCCCAACCTTCGCGCATGGCGTGACCAAGAAGCTGCTGCACCAGGAATGGAATATGGGCCTCGACGAAGC
GATCGAGGCCGAAGCCGAGGCGCAGGCCATCTGCATGCAGACGCGTGATTTCCGGCGCGCCTACGAGGCATTCGTGGCGA
AGAACAAGCCGGTGTTCGAGGGCGACTGA

Upstream 100 bases:

>100_bases
GTCGCGGACGCGGTGGCCTGGCTGTGCCAGCCATCGGCGAGCTCGATGACGGGACAGGCGATCGCCGTGGCAGGCGGCGA
AGTCATGACAGGATGATTGC

Downstream 100 bases:

>100_bases
ACGCAAACGAAGGCGCAACCAAAAGGATTTTCGATGTCCGACAAGACTTACCTCGAGCTGCCTCTGCTTGACGATTCGCA
CCGCATGCTCGAACGCGATC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLRASGSTRTPNQTRQRETMTDIALHMRHHKRKFADYSPKHFLWSVSDDGKVGTITLNRPERKNPLTFDSYAELRDLFRA
LCYASDIKTVVVTGAGGNFCSGGDVHEIIGPLTKMTMPELLDFTRMTGDLVKAMRACPQPVISAIDGICAGAGAMMALAS
DMRVGTAQAKTAFLFVRVGLAGADMGACSLLPRVIGQGRASELLYTGRVMTAEEGLQWGFFNALHASDKVLAEAHVLAAQ
LAAGPTFAHGVTKKLLHQEWNMGLDEAIEAEAEAQAICMQTRDFRRAYEAFVAKNKPVFEGD

Sequences:

>Translated_302_residues
MLRASGSTRTPNQTRQRETMTDIALHMRHHKRKFADYSPKHFLWSVSDDGKVGTITLNRPERKNPLTFDSYAELRDLFRA
LCYASDIKTVVVTGAGGNFCSGGDVHEIIGPLTKMTMPELLDFTRMTGDLVKAMRACPQPVISAIDGICAGAGAMMALAS
DMRVGTAQAKTAFLFVRVGLAGADMGACSLLPRVIGQGRASELLYTGRVMTAEEGLQWGFFNALHASDKVLAEAHVLAAQ
LAAGPTFAHGVTKKLLHQEWNMGLDEAIEAEAEAQAICMQTRDFRRAYEAFVAKNKPVFEGD
>Mature_302_residues
MLRASGSTRTPNQTRQRETMTDIALHMRHHKRKFADYSPKHFLWSVSDDGKVGTITLNRPERKNPLTFDSYAELRDLFRA
LCYASDIKTVVVTGAGGNFCSGGDVHEIIGPLTKMTMPELLDFTRMTGDLVKAMRACPQPVISAIDGICAGAGAMMALAS
DMRVGTAQAKTAFLFVRVGLAGADMGACSLLPRVIGQGRASELLYTGRVMTAEEGLQWGFFNALHASDKVLAEAHVLAAQ
LAAGPTFAHGVTKKLLHQEWNMGLDEAIEAEAEAQAICMQTRDFRRAYEAFVAKNKPVFEGD

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=245, Percent_Identity=28.1632653061224, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI68989263, Length=236, Percent_Identity=28.8135593220339, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI31542718, Length=251, Percent_Identity=23.5059760956175, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI194097323, Length=255, Percent_Identity=24.3137254901961, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI116235487, Length=165, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4502327, Length=298, Percent_Identity=25.503355704698, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI20127408, Length=240, Percent_Identity=23.75, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787660, Length=266, Percent_Identity=34.2105263157895, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1787659, Length=257, Percent_Identity=28.0155642023346, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI221142681, Length=270, Percent_Identity=25.1851851851852, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788597, Length=194, Percent_Identity=28.8659793814433, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788682, Length=203, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790281, Length=199, Percent_Identity=23.1155778894472, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17560910, Length=197, Percent_Identity=34.010152284264, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17536985, Length=262, Percent_Identity=25.1908396946565, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=233, Percent_Identity=27.8969957081545, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=256, Percent_Identity=26.5625, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17554946, Length=272, Percent_Identity=25.7352941176471, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=247, Percent_Identity=23.4817813765182, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=253, Percent_Identity=23.7154150197628, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920382, Length=281, Percent_Identity=28.1138790035587, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653139, Length=259, Percent_Identity=30.5019305019305, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21357171, Length=226, Percent_Identity=32.3008849557522, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI20129971, Length=259, Percent_Identity=25.8687258687259, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653477, Length=259, Percent_Identity=25.8687258687259, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650670, Length=201, Percent_Identity=28.8557213930348, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922422, Length=266, Percent_Identity=22.9323308270677, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24654903, Length=259, Percent_Identity=25.4826254826255, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 32898; Mature: 32898

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRASGSTRTPNQTRQRETMTDIALHMRHHKRKFADYSPKHFLWSVSDDGKVGTITLNRP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCC
ERKNPLTFDSYAELRDLFRALCYASDIKTVVVTGAGGNFCSGGDVHEIIGPLTKMTMPEL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
LDFTRMTGDLVKAMRACPQPVISAIDGICAGAGAMMALASDMRVGTAQAKTAFLFVRVGL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEEECC
AGADMGACSLLPRVIGQGRASELLYTGRVMTAEEGLQWGFFNALHASDKVLAEAHVLAAQ
CCCCCHHHHHHHHHHCCCCHHHHEECCEEEEHHCCCCHHHHHHHHCCHHHHHHHHHHHHH
LAAGPTFAHGVTKKLLHQEWNMGLDEAIEAEAEAQAICMQTRDFRRAYEAFVAKNKPVFE
HHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GD
CC
>Mature Secondary Structure
MLRASGSTRTPNQTRQRETMTDIALHMRHHKRKFADYSPKHFLWSVSDDGKVGTITLNRP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCC
ERKNPLTFDSYAELRDLFRALCYASDIKTVVVTGAGGNFCSGGDVHEIIGPLTKMTMPEL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
LDFTRMTGDLVKAMRACPQPVISAIDGICAGAGAMMALASDMRVGTAQAKTAFLFVRVGL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEEECC
AGADMGACSLLPRVIGQGRASELLYTGRVMTAEEGLQWGFFNALHASDKVLAEAHVLAAQ
CCCCCHHHHHHHHHHCCCCHHHHEECCEEEEHHCCCCHHHHHHHHCCHHHHHHHHHHHHH
LAAGPTFAHGVTKKLLHQEWNMGLDEAIEAEAEAQAICMQTRDFRRAYEAFVAKNKPVFE
HHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]