Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 73541805

GI number: 73541805

Start: 2332717

End: 2333043

Strand: Direct

Name: trxA [H]

Synonym: Reut_A2117

Alternate gene names: 73541805

Gene position: 2332717-2333043 (Clockwise)

Preceding gene: 73541790

Following gene: 73541806

Centisome position: 61.28

GC content: 60.24

Gene sequence:

>327_bases
ATGAGTGAACAAATCAAGTATGTGAGCGACGCCTCGTTCGATGCCGACGTCCTCCAGTCCGACAAGCCGGTCCTGCTCGA
CTTCTGGGCGGAATGGTGCGGCCCGTGCAAGATGATCGCCCCGATCCTGGACGAAGTGGCCAAGGACTATGGCGACAAGC
TGCAGATCGCCAAGATCAACGTCGATGAGAACCAGCAAGTGCCGGCCAAGTTTGGCATCCGCGGCATCCCGACGCTGATC
CTGTTCAAGAACGGCGCGGTCGCGGCCCAGAAGGTCGGCGCACTGTCCAAGTCGCAACTGACGGCGTTCCTCGACGGCAA
CCTGTAA

Upstream 100 bases:

>100_bases
CGCCGGAGTGCCTCAGGCGAATTCGGGGATTCTCGTGTAAGGTAACGGTTCGGCCATTCCCAGCCATTGACAAACTGAGC
GAAACCAGAGGTTTTCCGCC

Downstream 100 bases:

>100_bases
GCGATTGCCTGCCGGAGCCCTGACGACGCGGGCTCCGGGTTTCCCACGATCCGATGTGCGTGCGCCACGTCCTGGCGCGC
CGGTCGGATTGTGCTAAGAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSEQIKYVSDASFDADVLQSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKINVDENQQVPAKFGIRGIPTLI
LFKNGAVAAQKVGALSKSQLTAFLDGNL

Sequences:

>Translated_108_residues
MSEQIKYVSDASFDADVLQSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKINVDENQQVPAKFGIRGIPTLI
LFKNGAVAAQKVGALSKSQLTAFLDGNL
>Mature_107_residues
SEQIKYVSDASFDADVLQSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKINVDENQQVPAKFGIRGIPTLIL
FKNGAVAAQKVGALSKSQLTAFLDGNL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=39.7849462365591, Blast_Score=77, Evalue=2e-15,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=31.3131313131313, Blast_Score=65, Evalue=9e-12,
Organism=Homo sapiens, GI20070125, Length=80, Percent_Identity=36.25, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=65.7407407407407, Blast_Score=154, Evalue=1e-39,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=41.304347826087, Blast_Score=94, Evalue=2e-21,
Organism=Escherichia coli, GI87081747, Length=84, Percent_Identity=36.9047619047619, Blast_Score=66, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=39.7849462365591, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=36.7816091954023, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=73, Percent_Identity=43.8356164383562, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=82, Percent_Identity=32.9268292682927, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=83, Percent_Identity=38.5542168674699, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=39.0804597701149, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=67, Percent_Identity=40.2985074626866, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=87, Percent_Identity=34.4827586206897, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=87, Percent_Identity=34.4827586206897, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17507915, Length=101, Percent_Identity=32.6732673267327, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=87, Percent_Identity=34.4827586206897, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=41.4893617021277, Blast_Score=77, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=94, Percent_Identity=44.6808510638298, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=89, Percent_Identity=33.7078651685393, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=45, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=32.6086956521739, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=40, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=41.025641025641, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=41.025641025641, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=31.1827956989247, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17530795, Length=74, Percent_Identity=33.7837837837838, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11786; Mature: 11654

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQIKYVSDASFDADVLQSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKIN
CCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEC
VDENQQVPAKFGIRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDGNL
CCCCCCCCHHCCCCCCCEEEEEECCCHHHHHHCCCCHHHEEEEECCCC
>Mature Secondary Structure 
SEQIKYVSDASFDADVLQSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKIN
CCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEC
VDENQQVPAKFGIRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDGNL
CCCCCCCCHHCCCCCCCEEEEEECCCHHHHHHCCCCHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]