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The map label for this gene is nuoD [H]

Identifier: 73540667

GI number: 73540667

Start: 1050819

End: 1052072

Strand: Direct

Name: nuoD [H]

Synonym: Reut_A0964

Alternate gene names: 73540667

Gene position: 1050819-1052072 (Clockwise)

Preceding gene: 73540666

Following gene: 73540668

Centisome position: 27.61

GC content: 61.48

Gene sequence:

>1254_bases
ATGGCAGACATCAAGAATTACACCCTGAACTTCGGACCGCAGCACCCGGCCGCGCACGGCGTGCTGCGCCTCGTGCTGGA
GCTGGACGGCGAAGTGATCCAGCGTGCCGACCCGCACATCGGCCTGCTGCATCGTGCCACCGAAAAGCTGGCAGAGCAGA
AGAGCTGGATCCAGAACGTTCCATACATGGACCGTCTCGACTACGTGTCGATGATGTCCAACGAACACGCCTATGTGATG
GCGATCGAGCGGCTGCTTGGCATCGAAGTGCCGATCCGCGCGCAGTACATCCGTGTGATGTTCGACGAAATCACTCGCCT
GCTGAACCACCTGATGTGGATCGGTGCGCATGCGCTCGACGTGGGCGCGATGGCGGTGTTCCTCTACGCGTTCCGCGAGC
GCGAGGACATGTTCGACATGTACGAGGCGGTGTCGGGCGCGCGCATGCACGCGGCCTACTACCGTCCGGGCGGCGTGTAT
CGCGACCTGCCTGACACAATGCCGCAATATCGCGCGTCCAAGGTTCACAACGAGCGTGCCATCAAGGTCATGAACGAAGC
CCGTTCAGGCTCGCTGCTGGACTTTATCGAGGACTTCACCAACCGGTTCCCGAAGTACGTCGACGAGTACGAGACGCTGC
TGACCGACAACCGGATCTGGAAGCAGCGTCTGGTCGATATCGGCGTGGTCAGCCCGGAGCGCGCGCTGCAGATGGGTTTC
ACCGGTCCGATGCTGCGTGGTTCGGGCATTGCCTGGGACCTGCGCAAGAAGCAGCCGTACGAGGTGTACGACAAGATGGA
CTTCGATGTGCCGGTGGGCGTGGGCGGCGACTGCTACGCGCGCTACCTGGTCCGTGTCGAAGAGATGCGCCAGTCCAACC
GCATCATCAAGCAGTGCATCGAATGGCTGCGCCGTAATCCGGGCCCGGTGATCACGGACAACCACAAGGTTGCGCCGCCG
TCGCGGGTGGACATGAAGTCGAACATGGAAGAACTGATCCACCACTTCAAGCTGTTCACCGAAGGCATGCACGTGCCGGA
AGGTGAAGCGTATGCAGCGGTGGAGCACCCGAAGGGTGAATTCGGTATCTACGCGATCTCTGACGGCGCGAACAAGCCGT
ACCGCCTGAAGATCCGCGCACCCGGCTTCCCCCACCTGGCCGCCCTCGACGAGATGGCCAAGGGACACATGATTGCTGAC
GCGGTAACGATCATCGGCACGCAAGACATCGTCTTCGGCGAGATCGACCGCTAA

Upstream 100 bases:

>100_bases
ACGGGTCATCTACCAGCCGGTCACGATCGAACCTCGCGAAATCACGCCGCGCGTGATCCGCGAGGAAAACTACGGCGGCA
CGCAGCACTGATTAGGCGCC

Downstream 100 bases:

>100_bases
ACACGGACCGCTGGCCCGGACGACGATCCGGGCGCTTCCTTGCCGCGACCGGTGTGTCATCGGGGAGCGGCGGGGAAACC
CACGGCGGAACGGCAGGGCC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKSWIQNVPYMDRLDYVSMMSNEHAYVM
AIERLLGIEVPIRAQYIRVMFDEITRLLNHLMWIGAHALDVGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVY
RDLPDTMPQYRASKVHNERAIKVMNEARSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVDIGVVSPERALQMGF
TGPMLRGSGIAWDLRKKQPYEVYDKMDFDVPVGVGGDCYARYLVRVEEMRQSNRIIKQCIEWLRRNPGPVITDNHKVAPP
SRVDMKSNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFPHLAALDEMAKGHMIAD
AVTIIGTQDIVFGEIDR

Sequences:

>Translated_417_residues
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKSWIQNVPYMDRLDYVSMMSNEHAYVM
AIERLLGIEVPIRAQYIRVMFDEITRLLNHLMWIGAHALDVGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVY
RDLPDTMPQYRASKVHNERAIKVMNEARSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVDIGVVSPERALQMGF
TGPMLRGSGIAWDLRKKQPYEVYDKMDFDVPVGVGGDCYARYLVRVEEMRQSNRIIKQCIEWLRRNPGPVITDNHKVAPP
SRVDMKSNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFPHLAALDEMAKGHMIAD
AVTIIGTQDIVFGEIDR
>Mature_416_residues
ADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKSWIQNVPYMDRLDYVSMMSNEHAYVMA
IERLLGIEVPIRAQYIRVMFDEITRLLNHLMWIGAHALDVGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVYR
DLPDTMPQYRASKVHNERAIKVMNEARSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVDIGVVSPERALQMGFT
GPMLRGSGIAWDLRKKQPYEVYDKMDFDVPVGVGGDCYARYLVRVEEMRQSNRIIKQCIEWLRRNPGPVITDNHKVAPPS
RVDMKSNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFPHLAALDEMAKGHMIADA
VTIIGTQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=61.5942028985507, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=60.7843137254902, Blast_Score=503, Evalue=1e-142,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=37.5609756097561, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1789076, Length=420, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=27.4509803921569, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=57.5903614457831, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=56.3855421686747, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=60.4819277108434, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221459469, Length=412, Percent_Identity=54.3689320388349, Blast_Score=459, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47802; Mature: 47671

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKSWIQNV
CCCCCCCEECCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
PYMDRLDYVSMMSNEHAYVMAIERLLGIEVPIRAQYIRVMFDEITRLLNHLMWIGAHALD
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVYRDLPDTMPQYRASKVHNERA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
IKVMNEARSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVDIGVVSPERALQMGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCC
TGPMLRGSGIAWDLRKKQPYEVYDKMDFDVPVGVGGDCYARYLVRVEEMRQSNRIIKQCI
CCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EWLRRNPGPVITDNHKVAPPSRVDMKSNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYAISDGANKPYRLKIRAPGFPHLAALDEMAKGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCCEEECCCCC
>Mature Secondary Structure 
ADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKSWIQNV
CCCCCCEECCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
PYMDRLDYVSMMSNEHAYVMAIERLLGIEVPIRAQYIRVMFDEITRLLNHLMWIGAHALD
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVYRDLPDTMPQYRASKVHNERA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
IKVMNEARSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVDIGVVSPERALQMGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCC
TGPMLRGSGIAWDLRKKQPYEVYDKMDFDVPVGVGGDCYARYLVRVEEMRQSNRIIKQCI
CCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EWLRRNPGPVITDNHKVAPPSRVDMKSNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYAISDGANKPYRLKIRAPGFPHLAALDEMAKGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA