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The map label for this gene is pdhB [H]

Identifier: 73538802

GI number: 73538802

Start: 1704150

End: 1705127

Strand: Direct

Name: pdhB [H]

Synonym: Reut_B4977

Alternate gene names: 73538802

Gene position: 1704150-1705127 (Clockwise)

Preceding gene: 73538801

Following gene: 73538803

Centisome position: 62.51

GC content: 67.48

Gene sequence:

>978_bases
ATGGCTGAAATCACTCTGGTCGAGGCCGTCAACCAGGCGCTCGGCTACGCGCTGGAGCACGACCCCGATGTCATGCTGCT
CGGCGAGGACATCGGCGTGAATGGCGGCGTGTTCCGCGCCACGGTAGGGCTGCAGGCACGATTCGGTCCGCAGCGCGTGC
TCGACACCCCGCTGGCCGAAGCCGGCATTGTCGGCGCCGCGATCGGCATGGCGGCGATGGGGCTCAAGCCCGTGGCGGAG
ATCCAGTTCACGGGCTTTATCTATCCGGCCATCGACAACATCATCAACCACGCCGGGCGCATGCGGCACCGTACGCGCAA
CCGGCTTAGCTGTCCGCTGGTGGTGCGCTCGCCGTTCGGCGCGGGCATCCACGCGCCCGAGCACCACTCGGAAAGCCCGG
AGGCGATGTTTGCCCACATGCCGGGCATCCGCGTGGTCATCCCGTCATCGCCGGCACGCGCCTATGGCCTGCTGCTCGCT
GCGATCAACGATCCCGACCCGGTGATCTTCCTGGAGCCGACGCGGCTATACCGGCTGTTCCGGCAGGAAGTCGCGGACGA
CGGCGCGGCATTGCCACTCGACGCCTGTTTCACGTTGCGCGATGGCAGCGACGTCACGCTGGTGAGCTGGGGCGCAATGG
TGCAGGAAACGCTGGCCGCAGCCGATCAGCTTGCCGAGGAAGGCATATCGGCTGCCGTGATCGACGTGGCGACGCTCAAG
CCGCTCGACATGCAGACCATCCTCGAATCAGTGGCGCGCACGAGCCGCTGCGTGATCGTGCACGAAGCACCACGCACGGC
GGGATTCGGCGCGGAGATCGCTGCGGGGCTGGCTGATGCGGGCCTGTACTCGCTTGCGGCGCCGGTGCAGCGCGTGACGG
GCTTCGACACCGTGGTGCCGCTTGCGCGGCTGGAACACACCTATCTGCCGAGCGTGGCGCGCATTGTCGATGCCGTGCGC
AAGGCGCTGTCGGCATAG

Upstream 100 bases:

>100_bases
GTACGCGACCATGCCCGCAGCATTGCAAGAGCAGCTCGCGACGGCACGGCGCTATGCCGCGCCGCATGGCCAGACCAACC
CGAACTGAGGCGAGCGCACC

Downstream 100 bases:

>100_bases
TGGCAATAGTCTTACGGGGACGCAACGATGAGAGTCTTCAAGCTGCCCGACCTGGGCGAAGGCCTGCAGGAAGCCGAGAT
CGTGACGTGGCATGTGAAGG

Product: transketolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAEITLVEAVNQALGYALEHDPDVMLLGEDIGVNGGVFRATVGLQARFGPQRVLDTPLAEAGIVGAAIGMAAMGLKPVAE
IQFTGFIYPAIDNIINHAGRMRHRTRNRLSCPLVVRSPFGAGIHAPEHHSESPEAMFAHMPGIRVVIPSSPARAYGLLLA
AINDPDPVIFLEPTRLYRLFRQEVADDGAALPLDACFTLRDGSDVTLVSWGAMVQETLAAADQLAEEGISAAVIDVATLK
PLDMQTILESVARTSRCVIVHEAPRTAGFGAEIAAGLADAGLYSLAAPVQRVTGFDTVVPLARLEHTYLPSVARIVDAVR
KALSA

Sequences:

>Translated_325_residues
MAEITLVEAVNQALGYALEHDPDVMLLGEDIGVNGGVFRATVGLQARFGPQRVLDTPLAEAGIVGAAIGMAAMGLKPVAE
IQFTGFIYPAIDNIINHAGRMRHRTRNRLSCPLVVRSPFGAGIHAPEHHSESPEAMFAHMPGIRVVIPSSPARAYGLLLA
AINDPDPVIFLEPTRLYRLFRQEVADDGAALPLDACFTLRDGSDVTLVSWGAMVQETLAAADQLAEEGISAAVIDVATLK
PLDMQTILESVARTSRCVIVHEAPRTAGFGAEIAAGLADAGLYSLAAPVQRVTGFDTVVPLARLEHTYLPSVARIVDAVR
KALSA
>Mature_324_residues
AEITLVEAVNQALGYALEHDPDVMLLGEDIGVNGGVFRATVGLQARFGPQRVLDTPLAEAGIVGAAIGMAAMGLKPVAEI
QFTGFIYPAIDNIINHAGRMRHRTRNRLSCPLVVRSPFGAGIHAPEHHSESPEAMFAHMPGIRVVIPSSPARAYGLLLAA
INDPDPVIFLEPTRLYRLFRQEVADDGAALPLDACFTLRDGSDVTLVSWGAMVQETLAAADQLAEEGISAAVIDVATLKP
LDMQTILESVARTSRCVIVHEAPRTAGFGAEIAAGLADAGLYSLAAPVQRVTGFDTVVPLARLEHTYLPSVARIVDAVRK
ALSA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=324, Percent_Identity=44.4444444444444, Blast_Score=280, Evalue=9e-76,
Organism=Homo sapiens, GI34101272, Length=324, Percent_Identity=44.4444444444444, Blast_Score=280, Evalue=9e-76,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=35.1681957186544, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=33.9449541284404, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI225637463, Length=251, Percent_Identity=26.6932270916335, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI225637459, Length=251, Percent_Identity=26.6932270916335, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI225637461, Length=251, Percent_Identity=26.6932270916335, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=44.7852760736196, Blast_Score=270, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=38.6503067484663, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=37.3088685015291, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI160714828, Length=319, Percent_Identity=42.6332288401254, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI160714832, Length=319, Percent_Identity=42.6332288401254, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=38.3435582822086, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=38.3435582822086, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=38.4615384615385, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=38.4615384615385, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 34466; Mature: 34335

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEITLVEAVNQALGYALEHDPDVMLLGEDIGVNGGVFRATVGLQARFGPQRVLDTPLAE
CCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEEECCEECCCCHHHHCCCHHH
AGIVGAAIGMAAMGLKPVAEIQFTGFIYPAIDNIINHAGRMRHRTRNRLSCPLVVRSPFG
HHHHHHHHHHHHHCCCCHHHEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
AGIHAPEHHSESPEAMFAHMPGIRVVIPSSPARAYGLLLAAINDPDPVIFLEPTRLYRLF
CCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCHHHEEEEEEECCCCCEEEECHHHHHHHH
RQEVADDGAALPLDACFTLRDGSDVTLVSWGAMVQETLAAADQLAEEGISAAVIDVATLK
HHHHCCCCCCCCHHHEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCC
PLDMQTILESVARTSRCVIVHEAPRTAGFGAEIAAGLADAGLYSLAAPVQRVTGFDTVVP
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LARLEHTYLPSVARIVDAVRKALSA
HHHHHHHHCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEITLVEAVNQALGYALEHDPDVMLLGEDIGVNGGVFRATVGLQARFGPQRVLDTPLAE
CCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEEECCEECCCCHHHHCCCHHH
AGIVGAAIGMAAMGLKPVAEIQFTGFIYPAIDNIINHAGRMRHRTRNRLSCPLVVRSPFG
HHHHHHHHHHHHHCCCCHHHEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
AGIHAPEHHSESPEAMFAHMPGIRVVIPSSPARAYGLLLAAINDPDPVIFLEPTRLYRLF
CCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCHHHEEEEEEECCCCCEEEECHHHHHHHH
RQEVADDGAALPLDACFTLRDGSDVTLVSWGAMVQETLAAADQLAEEGISAAVIDVATLK
HHHHCCCCCCCCHHHEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCC
PLDMQTILESVARTSRCVIVHEAPRTAGFGAEIAAGLADAGLYSLAAPVQRVTGFDTVVP
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LARLEHTYLPSVARIVDAVRKALSA
HHHHHHHHCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]