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The map label for this gene is pdhA [H]

Identifier: 73538801

GI number: 73538801

Start: 1703037

End: 1704137

Strand: Direct

Name: pdhA [H]

Synonym: Reut_B4976

Alternate gene names: 73538801

Gene position: 1703037-1704137 (Clockwise)

Preceding gene: 73538800

Following gene: 73538802

Centisome position: 62.47

GC content: 67.67

Gene sequence:

>1101_bases
ATGGGCACGGTTGCGAGCTTTGACATCGGCTACACACGATACCTCGACCCGCCGGGCGCAACCCCGGTTTCCTCTTCCCC
TCTCCCGCCATTCGCCAACGACCCGGACGCGCTGCTGCCGCTGTACCGTGCGATGGTGCTGACCCGCCAGTTCGACCTCA
AAGCCATTGCGATGCAGCGCACCGGCAAGATCGGCACGTTCGCATCGGCGCTCGGGCAGGAGGCGGTCGGCGTTGGCGTA
GCCAGCGCGATGCGGCCCGAGGACATACTGGTGCCGTCGTACCGCGATCACGCCGCGCAGTTTGTGCGCGGCGTCACCAT
GACCGAAAGCCTGCTGTACTGGGGCGGCGACGAGCGCGGCAGCGGTTTTGCGGCGGCGCCGCACGACTTCGGCAACAACG
TGCCGATCGGCACGCAGGTCTGCCATGCGGCAGGCGTGGCTTACGCGGTGCAGTTGCGCGGCGAGCCGCGCGTGGCAGTC
TGCATGCTTGGCGATGGTGGCACCTCGAAAGGCGATTTCTACGAGGGGATGAACATGGCCGGCGCGTGGCATGCGCCGCT
CGTGATCGTCGTCAACAACAACCAGTGGGCCATTTCGATGCCGCGCAGCCGCCAGACCGCTGCGCACACGCTCGCGCAAA
AAGCGATCGCCGCGGGCATTCCCGGCGAGCAGATCGACGGCAATGATGTCGTGGCAGTGCGTCACCGCGTAGGCGAAGCG
ATCGAGCGTGCGCGCGCCGGCGAGGGACCATCGCTGATCGAAGCGATCACGTACCGGCTCGGCGACCACACCACGGCTGA
CGATGCCTCGCGCTACCGTGACGAGTCCACGGTCAAGGCGCACTGGCAGGCCGAACCGCTGCTCAGGCTGCGCGAGCACC
TGGTAAAGCTCGGCGCGTGGGATGCGGGGCGCGAAGAAGCGCTGGTGCGCGAATGCTCGCAGCAGGTCGCGCAGGCCGTG
GAAGCTTACCTGGCGCTGCCGCCGCCCGATCCCGCCGCGATGTTCGACTGCCTGTACGCGACCATGCCCGCAGCATTGCA
AGAGCAGCTCGCGACGGCACGGCGCTATGCCGCGCCGCATGGCCAGACCAACCCGAACTGA

Upstream 100 bases:

>100_bases
CGCGCGCGCGCCCATGCCCTAAACTCAAAGCAACCCGACCCGATCCTGCCGTCCCACAAGGACGTGCGGAATCCCTGACA
CGCACATCGGAGGCGGCCAC

Downstream 100 bases:

>100_bases
GGCGAGCGCACCATGGCTGAAATCACTCTGGTCGAGGCCGTCAACCAGGCGCTCGGCTACGCGCTGGAGCACGACCCCGA
TGTCATGCTGCTCGGCGAGG

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MGTVASFDIGYTRYLDPPGATPVSSSPLPPFANDPDALLPLYRAMVLTRQFDLKAIAMQRTGKIGTFASALGQEAVGVGV
ASAMRPEDILVPSYRDHAAQFVRGVTMTESLLYWGGDERGSGFAAAPHDFGNNVPIGTQVCHAAGVAYAVQLRGEPRVAV
CMLGDGGTSKGDFYEGMNMAGAWHAPLVIVVNNNQWAISMPRSRQTAAHTLAQKAIAAGIPGEQIDGNDVVAVRHRVGEA
IERARAGEGPSLIEAITYRLGDHTTADDASRYRDESTVKAHWQAEPLLRLREHLVKLGAWDAGREEALVRECSQQVAQAV
EAYLALPPPDPAAMFDCLYATMPAALQEQLATARRYAAPHGQTNPN

Sequences:

>Translated_366_residues
MGTVASFDIGYTRYLDPPGATPVSSSPLPPFANDPDALLPLYRAMVLTRQFDLKAIAMQRTGKIGTFASALGQEAVGVGV
ASAMRPEDILVPSYRDHAAQFVRGVTMTESLLYWGGDERGSGFAAAPHDFGNNVPIGTQVCHAAGVAYAVQLRGEPRVAV
CMLGDGGTSKGDFYEGMNMAGAWHAPLVIVVNNNQWAISMPRSRQTAAHTLAQKAIAAGIPGEQIDGNDVVAVRHRVGEA
IERARAGEGPSLIEAITYRLGDHTTADDASRYRDESTVKAHWQAEPLLRLREHLVKLGAWDAGREEALVRECSQQVAQAV
EAYLALPPPDPAAMFDCLYATMPAALQEQLATARRYAAPHGQTNPN
>Mature_365_residues
GTVASFDIGYTRYLDPPGATPVSSSPLPPFANDPDALLPLYRAMVLTRQFDLKAIAMQRTGKIGTFASALGQEAVGVGVA
SAMRPEDILVPSYRDHAAQFVRGVTMTESLLYWGGDERGSGFAAAPHDFGNNVPIGTQVCHAAGVAYAVQLRGEPRVAVC
MLGDGGTSKGDFYEGMNMAGAWHAPLVIVVNNNQWAISMPRSRQTAAHTLAQKAIAAGIPGEQIDGNDVVAVRHRVGEAI
ERARAGEGPSLIEAITYRLGDHTTADDASRYRDESTVKAHWQAEPLLRLREHLVKLGAWDAGREEALVRECSQQVAQAVE
AYLALPPPDPAAMFDCLYATMPAALQEQLATARRYAAPHGQTNPN

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=341, Percent_Identity=32.8445747800587, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI258645172, Length=341, Percent_Identity=32.8445747800587, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI291084742, Length=304, Percent_Identity=29.6052631578947, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4505685, Length=304, Percent_Identity=29.6052631578947, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI291084744, Length=311, Percent_Identity=29.2604501607717, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI4885543, Length=304, Percent_Identity=28.9473684210526, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI291084757, Length=299, Percent_Identity=26.7558528428094, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=340, Percent_Identity=31.1764705882353, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI86563357, Length=340, Percent_Identity=31.1764705882353, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17536047, Length=321, Percent_Identity=28.0373831775701, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=321, Percent_Identity=28.0373831775701, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=313, Percent_Identity=29.7124600638978, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21355903, Length=339, Percent_Identity=28.6135693215339, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24639748, Length=287, Percent_Identity=30.3135888501742, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24639744, Length=294, Percent_Identity=28.9115646258503, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28571106, Length=294, Percent_Identity=28.9115646258503, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24639740, Length=294, Percent_Identity=28.9115646258503, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24639746, Length=256, Percent_Identity=30.078125, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39200; Mature: 39068

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTVASFDIGYTRYLDPPGATPVSSSPLPPFANDPDALLPLYRAMVLTRQFDLKAIAMQR
CCCCEEECCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
TGKIGTFASALGQEAVGVGVASAMRPEDILVPSYRDHAAQFVRGVTMTESLLYWGGDERG
CCCHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
SGFAAAPHDFGNNVPIGTQVCHAAGVAYAVQLRGEPRVAVCMLGDGGTSKGDFYEGMNMA
CCCEECCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCHHHCCCCC
GAWHAPLVIVVNNNQWAISMPRSRQTAAHTLAQKAIAAGIPGEQIDGNDVVAVRHRVGEA
CCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHH
IERARAGEGPSLIEAITYRLGDHTTADDASRYRDESTVKAHWQAEPLLRLREHLVKLGAW
HHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCC
DAGREEALVRECSQQVAQAVEAYLALPPPDPAAMFDCLYATMPAALQEQLATARRYAAPH
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GQTNPN
CCCCCC
>Mature Secondary Structure 
GTVASFDIGYTRYLDPPGATPVSSSPLPPFANDPDALLPLYRAMVLTRQFDLKAIAMQR
CCCEEECCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
TGKIGTFASALGQEAVGVGVASAMRPEDILVPSYRDHAAQFVRGVTMTESLLYWGGDERG
CCCHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCC
SGFAAAPHDFGNNVPIGTQVCHAAGVAYAVQLRGEPRVAVCMLGDGGTSKGDFYEGMNMA
CCCEECCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCHHHCCCCC
GAWHAPLVIVVNNNQWAISMPRSRQTAAHTLAQKAIAAGIPGEQIDGNDVVAVRHRVGEA
CCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHH
IERARAGEGPSLIEAITYRLGDHTTADDASRYRDESTVKAHWQAEPLLRLREHLVKLGAW
HHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCC
DAGREEALVRECSQQVAQAVEAYLALPPPDPAAMFDCLYATMPAALQEQLATARRYAAPH
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GQTNPN
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA