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The map label for this gene is luxQ [H]

Identifier: 73538800

GI number: 73538800

Start: 1700866

End: 1702848

Strand: Direct

Name: luxQ [H]

Synonym: Reut_B4975

Alternate gene names: 73538800

Gene position: 1700866-1702848 (Clockwise)

Preceding gene: 73538799

Following gene: 73538801

Centisome position: 62.39

GC content: 63.04

Gene sequence:

>1983_bases
ATGCCGGATAGCGTCGACGTCGTCCCGGGCGGACACGCAGCGGGCGGCGCCGTCCAGCCGCTGGTGCTGGTGGTGGACGA
CAATCCCGTCACGCGGTACGCGACGGTGCGCGTACTGGCAACCGCCGGGTTCCGGACCGTAGAAGCCGAGATCGGGCAGC
GGGCCCTGGAGATCGCCGATGTCAGCGTGTCGGCCGTGGTGCTCGATGTCAACCTGCCCGATATCGATGGCTTCCAGGTC
TGCAGGATCCTGCGCGGACGGCCGGAAACCGCCACCATACCCGTGGTGCATCTGTCGGCCACCTATATGGCCGATTGCGA
CAAGGTGCGCGGCCTTGATGCAGGTGCCAGCGCCTACCTGACGCACCCGGCCGAGCCAGCCATACTGGTGGCCACGATCT
CGTCACTGATACGCGCAAGTGCCGCCGAACAGTCCTTGCGCGAAAGCGAGGCGCGCTTTCGCGCGATCTATCACCAGGCC
ATCGGAGGCATCTGTACGCTGGACCTGTCCGGGCGCTTTGTCGACGTGAACCCTGCCATGGTGACGCTGCTGCAGCGGTC
AGGAGCGGAACTCGCGGGGCAGCCCGTCGCTGAGTTTGCACCGCAGGACTGGCGAGAGCGAGTGGCCGAGTCCACCGGGC
GCCTGCAGGAGCACGGATGGCAAGGCACTTTTCCGCTTTGCAACGCCCAAGGCGAAATCATGCACCTCGAGTGGAGTATC
TCTGCCGTGCTCCAGTCGGGTGTCAAGGTCGCCGTCGTGTCAAACATTACTGACCGGGTCAACCTTGAACGCCAGCGCGA
GCAGCTGATAGAGCGCGAGCAAGCGGCACGTGCAGCGATGGAGCGTCTGAACCGCATGAAGGATGACTTCATCGCGATCC
TGTCGCACGAATTGCGCAGTCCGCTAAACGTGATTTCCATCTGGACCCATGTCCTGAACCAACACATCAACTCCGACGAA
GGCCGGCGCGGACTGGCCGCTGTCGAACGCAATATCACGATTCAACGCCGCTTGATCGCGGATCTGGTCGACGTGTCGAT
GCTCAACGTTGGCAAACTGAAACTGGAGCTCGAGCGGGTCAATCCGGCCGAACTCGTCCGCGTTGCGGTCGAGAGCATGC
AGCGCCAGGCTCAGGAGCGCAACGTGACACTGGTCACGGAGATGCCGCCTGTGTTGGCAGATGCTGCGTGGCTGGACCCT
TCCCGTTTCGAACAGATCCTGTGGAACCTGGTATCGAACGCGATCAAATTCTCGCCCGAAGGGGGCATCGTGCGGATCGA
GGTGGCATCAAATGGCGGTGCCTTGCGCGTTCGCGTCATCGATCACGGACGAGGTATTACCGCAGAGTTTCTGCCGCTGC
TGTTTGACCGGTTTACCCAGAGCGAAGATGCCAACCGTCGACAGCATGGCGGGTTGGGACTGGGCTTGGCCATCGTCAGG
CAACTGGTGGAAATGCACGGCGGTACGGTGCAGGCATCCAGCGCCGGCGTGGGGCTGGGCTCGACCTTCGAGGTCACGAT
TCCATTGACCGCCCCCGCGCGAAGCGACGAGGACGCCCCGCTCGCCGTAGCTCCTTCAGCACCGGATGCCATGCCACTAA
GCGGCCTGGACGTACTGTTGGTAGAGGATGACATGGATGCGCTCGCCGCGCTCACGGCGATCCTGACTGGCTACGGCGCA
CTTGTGCGCCCGGCCGGTGACGGCGAGGAGGCATTCGATCAGGTGACCACCAGCATGCCGGATCTGATCATCAGTGACAT
CGGTCTTCCCGGATGCGATGGCAACGACCTGATTCGCAGGATTCGTGTGCGCGAGGCCGTTGCCTCTCTGGACCATGTTC
CCGCCGTGGCGCTGACGGCATTCACGCGACAGCAGGATCGACGCGCCGCAATGGAATCCGGATTCGATGCGGTGTGCGGA
AAGCCTCTGCGACTGCAGGAATTGTTGAACGCGATCGAGAAGGCGTTCGCGCTGGCGGGATAA

Upstream 100 bases:

>100_bases
TCGATAGGCTTCGAAAGTCAGGTCGGGGTCGGTTCGCGCTTCTACGTGACCTTGCCCGCGACGTTCCCGAGCCAGAGCCA
GGCGCCCGCTGGAGACGGTC

Downstream 100 bases:

>100_bases
CACGCCCGTGGATCCACGCCCCACGGCCGAAGCGGGGCCCCAGGCCCCTTTTGCGCCCCGTGCAACATAAACGCCGCTTT
CCAATCCCCGCGCGCGCGCC

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MPDSVDVVPGGHAAGGAVQPLVLVVDDNPVTRYATVRVLATAGFRTVEAEIGQRALEIADVSVSAVVLDVNLPDIDGFQV
CRILRGRPETATIPVVHLSATYMADCDKVRGLDAGASAYLTHPAEPAILVATISSLIRASAAEQSLRESEARFRAIYHQA
IGGICTLDLSGRFVDVNPAMVTLLQRSGAELAGQPVAEFAPQDWRERVAESTGRLQEHGWQGTFPLCNAQGEIMHLEWSI
SAVLQSGVKVAVVSNITDRVNLERQREQLIEREQAARAAMERLNRMKDDFIAILSHELRSPLNVISIWTHVLNQHINSDE
GRRGLAAVERNITIQRRLIADLVDVSMLNVGKLKLELERVNPAELVRVAVESMQRQAQERNVTLVTEMPPVLADAAWLDP
SRFEQILWNLVSNAIKFSPEGGIVRIEVASNGGALRVRVIDHGRGITAEFLPLLFDRFTQSEDANRRQHGGLGLGLAIVR
QLVEMHGGTVQASSAGVGLGSTFEVTIPLTAPARSDEDAPLAVAPSAPDAMPLSGLDVLLVEDDMDALAALTAILTGYGA
LVRPAGDGEEAFDQVTTSMPDLIISDIGLPGCDGNDLIRRIRVREAVASLDHVPAVALTAFTRQQDRRAAMESGFDAVCG
KPLRLQELLNAIEKAFALAG

Sequences:

>Translated_660_residues
MPDSVDVVPGGHAAGGAVQPLVLVVDDNPVTRYATVRVLATAGFRTVEAEIGQRALEIADVSVSAVVLDVNLPDIDGFQV
CRILRGRPETATIPVVHLSATYMADCDKVRGLDAGASAYLTHPAEPAILVATISSLIRASAAEQSLRESEARFRAIYHQA
IGGICTLDLSGRFVDVNPAMVTLLQRSGAELAGQPVAEFAPQDWRERVAESTGRLQEHGWQGTFPLCNAQGEIMHLEWSI
SAVLQSGVKVAVVSNITDRVNLERQREQLIEREQAARAAMERLNRMKDDFIAILSHELRSPLNVISIWTHVLNQHINSDE
GRRGLAAVERNITIQRRLIADLVDVSMLNVGKLKLELERVNPAELVRVAVESMQRQAQERNVTLVTEMPPVLADAAWLDP
SRFEQILWNLVSNAIKFSPEGGIVRIEVASNGGALRVRVIDHGRGITAEFLPLLFDRFTQSEDANRRQHGGLGLGLAIVR
QLVEMHGGTVQASSAGVGLGSTFEVTIPLTAPARSDEDAPLAVAPSAPDAMPLSGLDVLLVEDDMDALAALTAILTGYGA
LVRPAGDGEEAFDQVTTSMPDLIISDIGLPGCDGNDLIRRIRVREAVASLDHVPAVALTAFTRQQDRRAAMESGFDAVCG
KPLRLQELLNAIEKAFALAG
>Mature_659_residues
PDSVDVVPGGHAAGGAVQPLVLVVDDNPVTRYATVRVLATAGFRTVEAEIGQRALEIADVSVSAVVLDVNLPDIDGFQVC
RILRGRPETATIPVVHLSATYMADCDKVRGLDAGASAYLTHPAEPAILVATISSLIRASAAEQSLRESEARFRAIYHQAI
GGICTLDLSGRFVDVNPAMVTLLQRSGAELAGQPVAEFAPQDWRERVAESTGRLQEHGWQGTFPLCNAQGEIMHLEWSIS
AVLQSGVKVAVVSNITDRVNLERQREQLIEREQAARAAMERLNRMKDDFIAILSHELRSPLNVISIWTHVLNQHINSDEG
RRGLAAVERNITIQRRLIADLVDVSMLNVGKLKLELERVNPAELVRVAVESMQRQAQERNVTLVTEMPPVLADAAWLDPS
RFEQILWNLVSNAIKFSPEGGIVRIEVASNGGALRVRVIDHGRGITAEFLPLLFDRFTQSEDANRRQHGGLGLGLAIVRQ
LVEMHGGTVQASSAGVGLGSTFEVTIPLTAPARSDEDAPLAVAPSAPDAMPLSGLDVLLVEDDMDALAALTAILTGYGAL
VRPAGDGEEAFDQVTTSMPDLIISDIGLPGCDGNDLIRRIRVREAVASLDHVPAVALTAFTRQQDRRAAMESGFDAVCGK
PLRLQELLNAIEKAFALAG

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=385, Percent_Identity=31.9480519480519, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788713, Length=387, Percent_Identity=28.9405684754522, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI145693157, Length=268, Percent_Identity=33.2089552238806, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI87081816, Length=387, Percent_Identity=28.1653746770026, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1789149, Length=259, Percent_Identity=34.3629343629344, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=28.0172413793103, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1786912, Length=265, Percent_Identity=30.5660377358491, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1786783, Length=248, Percent_Identity=28.2258064516129, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=30.1724137931034, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=28.6363636363636, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=28.6919831223629, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788549, Length=376, Percent_Identity=23.936170212766, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790861, Length=227, Percent_Identity=28.6343612334802, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=26.0683760683761, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=37.2881355932203, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI87082012, Length=139, Percent_Identity=32.3741007194245, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71148; Mature: 71017

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSVDVVPGGHAAGGAVQPLVLVVDDNPVTRYATVRVLATAGFRTVEAEIGQRALEIAD
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHC
VSVSAVVLDVNLPDIDGFQVCRILRGRPETATIPVVHLSATYMADCDKVRGLDAGASAYL
CEEEEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHCCCCCCCCEEE
THPAEPAILVATISSLIRASAAEQSLRESEARFRAIYHQAIGGICTLDLSGRFVDVNPAM
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEECCHHH
VTLLQRSGAELAGQPVAEFAPQDWRERVAESTGRLQEHGWQGTFPLCNAQGEIMHLEWSI
HHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCEEEEEHHH
SAVLQSGVKVAVVSNITDRVNLERQREQLIEREQAARAAMERLNRMKDDFIAILSHELRS
HHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PLNVISIWTHVLNQHINSDEGRRGLAAVERNITIQRRLIADLVDVSMLNVGKLKLELERV
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECC
NPAELVRVAVESMQRQAQERNVTLVTEMPPVLADAAWLDPSRFEQILWNLVSNAIKFSPE
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHEEECCC
GGIVRIEVASNGGALRVRVIDHGRGITAEFLPLLFDRFTQSEDANRRQHGGLGLGLAIVR
CCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHH
QLVEMHGGTVQASSAGVGLGSTFEVTIPLTAPARSDEDAPLAVAPSAPDAMPLSGLDVLL
HHHHHCCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCEEEE
VEDDMDALAALTAILTGYGALVRPAGDGEEAFDQVTTSMPDLIISDIGLPGCDGNDLIRR
EECCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHH
IRVREAVASLDHVPAVALTAFTRQQDRRAAMESGFDAVCGKPLRLQELLNAIEKAFALAG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PDSVDVVPGGHAAGGAVQPLVLVVDDNPVTRYATVRVLATAGFRTVEAEIGQRALEIAD
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHC
VSVSAVVLDVNLPDIDGFQVCRILRGRPETATIPVVHLSATYMADCDKVRGLDAGASAYL
CEEEEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHCCCCCCCCEEE
THPAEPAILVATISSLIRASAAEQSLRESEARFRAIYHQAIGGICTLDLSGRFVDVNPAM
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEECCHHH
VTLLQRSGAELAGQPVAEFAPQDWRERVAESTGRLQEHGWQGTFPLCNAQGEIMHLEWSI
HHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCEEEEEHHH
SAVLQSGVKVAVVSNITDRVNLERQREQLIEREQAARAAMERLNRMKDDFIAILSHELRS
HHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PLNVISIWTHVLNQHINSDEGRRGLAAVERNITIQRRLIADLVDVSMLNVGKLKLELERV
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECC
NPAELVRVAVESMQRQAQERNVTLVTEMPPVLADAAWLDPSRFEQILWNLVSNAIKFSPE
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHEEECCC
GGIVRIEVASNGGALRVRVIDHGRGITAEFLPLLFDRFTQSEDANRRQHGGLGLGLAIVR
CCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHH
QLVEMHGGTVQASSAGVGLGSTFEVTIPLTAPARSDEDAPLAVAPSAPDAMPLSGLDVLL
HHHHHCCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCEEEE
VEDDMDALAALTAILTGYGALVRPAGDGEEAFDQVTTSMPDLIISDIGLPGCDGNDLIRR
EECCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHH
IRVREAVASLDHVPAVALTAFTRQQDRRAAMESGFDAVCGKPLRLQELLNAIEKAFALAG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]