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The map label for this gene is nadC [H]

Identifier: 73537583

GI number: 73537583

Start: 342405

End: 343238

Strand: Reverse

Name: nadC [H]

Synonym: Reut_B3748

Alternate gene names: 73537583

Gene position: 343238-342405 (Counterclockwise)

Preceding gene: 73537584

Following gene: 73537581

Centisome position: 12.59

GC content: 62.95

Gene sequence:

>834_bases
ATGTACGACATTTTCTCCACCGACAAGCTCATCGATCTCTGGCTGACCGAAGACATCGGCATCTGCGACCTGACCGTCCA
GACGATGATCGAACCGGGTGAAACCGGCACGTTCTGCATGAATGCGCGGGAACCGATGATCATTGCCGGCATTGACGTGG
CCGCACGCATCTTTGCCCGCTATGACCCCAGCCTTTCGATCGACGTGCGCGCGGCCGATGGCGACAAGGTCGAAAAAGGC
GCGGTGCTGCTCAACGTCAGCGGCAATGCACGCAGCGTACTGACCGCCGAACGGACGGCGCTCAACATCATGCAGCGGCT
GTGCGGCATCGCCAACCTGACGGCGCGGTATGCCGATGAAATCGCGCATACGAAAGCGCGCCTGATCGACAGCCGCAAGA
CCACGCCGGGCCTGCGCGCGCTGGAGAAGCATGCCGTAACCTGCGGTGGCGGCCTGAACCACCGGCTCAGCCTCGACAAC
GGTGTGATGATTAAGGACAACCACATCGCCGTGTGCGGCAGCATTGCCGCGGCCGTGGCGCGTGTGCGCAGGAAGCTGCC
GGTGCTGACCAAGCTCGAGGTCGAATGCGATCGACTCGATCAGGTGCGTGAAGCGCTGGACGCCGGCGTGGATGTGATCA
TGCTCGACAACATGTCGCTGCCCGACATGAAGGAAGCCGTGCAGATCGTCAACGGCCGGACCAAGGTCGAGGCGTCGGGC
GGCATTCGCCTGGAGACAATCCGCGCGGTGGCGGAAACCGGCGTCGACTACATCTCCACCAGCAAGATCACGCAATCGGC
GCCCGCCGTGGATATCGGGCTCGACGACGCCTGA

Upstream 100 bases:

>100_bases
GAAATATTATTGACACGGTACGCCGAGGTGCTAGTATTGCGCCATGTACTTCGATATCTAAGATTATTGAGTACAGCCAC
CGACCACTCAGGAGCGACAT

Downstream 100 bases:

>100_bases
GCGGCGCGCAAGGCTGTTCCTCGTCTACCCGAGGGCACTTCCCCTTCGCCGGTACCTGCCGGCGCGGGGCTTTTTCGTCT
TCGCTTTCTGCGTCAGAGAT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MYDIFSTDKLIDLWLTEDIGICDLTVQTMIEPGETGTFCMNAREPMIIAGIDVAARIFARYDPSLSIDVRAADGDKVEKG
AVLLNVSGNARSVLTAERTALNIMQRLCGIANLTARYADEIAHTKARLIDSRKTTPGLRALEKHAVTCGGGLNHRLSLDN
GVMIKDNHIAVCGSIAAAVARVRRKLPVLTKLEVECDRLDQVREALDAGVDVIMLDNMSLPDMKEAVQIVNGRTKVEASG
GIRLETIRAVAETGVDYISTSKITQSAPAVDIGLDDA

Sequences:

>Translated_277_residues
MYDIFSTDKLIDLWLTEDIGICDLTVQTMIEPGETGTFCMNAREPMIIAGIDVAARIFARYDPSLSIDVRAADGDKVEKG
AVLLNVSGNARSVLTAERTALNIMQRLCGIANLTARYADEIAHTKARLIDSRKTTPGLRALEKHAVTCGGGLNHRLSLDN
GVMIKDNHIAVCGSIAAAVARVRRKLPVLTKLEVECDRLDQVREALDAGVDVIMLDNMSLPDMKEAVQIVNGRTKVEASG
GIRLETIRAVAETGVDYISTSKITQSAPAVDIGLDDA
>Mature_277_residues
MYDIFSTDKLIDLWLTEDIGICDLTVQTMIEPGETGTFCMNAREPMIIAGIDVAARIFARYDPSLSIDVRAADGDKVEKG
AVLLNVSGNARSVLTAERTALNIMQRLCGIANLTARYADEIAHTKARLIDSRKTTPGLRALEKHAVTCGGGLNHRLSLDN
GVMIKDNHIAVCGSIAAAVARVRRKLPVLTKLEVECDRLDQVREALDAGVDVIMLDNMSLPDMKEAVQIVNGRTKVEASG
GIRLETIRAVAETGVDYISTSKITQSAPAVDIGLDDA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=271, Percent_Identity=32.1033210332103, Blast_Score=132, Evalue=2e-31,
Organism=Escherichia coli, GI1786299, Length=202, Percent_Identity=43.5643564356436, Blast_Score=158, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6321162, Length=276, Percent_Identity=34.4202898550725, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29876; Mature: 29876

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDIFSTDKLIDLWLTEDIGICDLTVQTMIEPGETGTFCMNAREPMIIAGIDVAARIFAR
CCCCCCCCCEEEEEECCCCCEEEEEHHHEECCCCCCEEEECCCCCEEEECHHHHHHHHHH
YDPSLSIDVRAADGDKVEKGAVLLNVSGNARSVLTAERTALNIMQRLCGIANLTARYADE
CCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHTKARLIDSRKTTPGLRALEKHAVTCGGGLNHRLSLDNGVMIKDNHIAVCGSIAAAVA
HHHHHHHHHHCCCCCCHHHHHHHHCEEECCCCCEEEECCCCEEEECCCEEEHHHHHHHHH
RVRRKLPVLTKLEVECDRLDQVREALDAGVDVIMLDNMSLPDMKEAVQIVNGRTKVEASG
HHHHHCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCEEEECCC
GIRLETIRAVAETGVDYISTSKITQSAPAVDIGLDDA
CEEHHHHHHHHHCCCCHHHHCCHHCCCCEEEECCCCC
>Mature Secondary Structure
MYDIFSTDKLIDLWLTEDIGICDLTVQTMIEPGETGTFCMNAREPMIIAGIDVAARIFAR
CCCCCCCCCEEEEEECCCCCEEEEEHHHEECCCCCCEEEECCCCCEEEECHHHHHHHHHH
YDPSLSIDVRAADGDKVEKGAVLLNVSGNARSVLTAERTALNIMQRLCGIANLTARYADE
CCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHTKARLIDSRKTTPGLRALEKHAVTCGGGLNHRLSLDNGVMIKDNHIAVCGSIAAAVA
HHHHHHHHHHCCCCCCHHHHHHHHCEEECCCCCEEEECCCCEEEECCCEEEHHHHHHHHH
RVRRKLPVLTKLEVECDRLDQVREALDAGVDVIMLDNMSLPDMKEAVQIVNGRTKVEASG
HHHHHCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCCEEEECCC
GIRLETIRAVAETGVDYISTSKITQSAPAVDIGLDDA
CEEHHHHHHHHHCCCCHHHHCCHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]