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The map label for this gene is deoA [C]

Identifier: 73537581

GI number: 73537581

Start: 339607

End: 340959

Strand: Reverse

Name: deoA [C]

Synonym: Reut_B3746

Alternate gene names: 73537581

Gene position: 340959-339607 (Counterclockwise)

Preceding gene: 73537583

Following gene: 73537580

Centisome position: 12.51

GC content: 70.07

Gene sequence:

>1353_bases
ATGCCCGACGGCGTGCACTGCGTCACGGTGACGAACGACAGCACGCTCGATCTCGGCGTGGCGCGCTTCACCGATGCGCT
GCGGAACGGCGCGAACGCAGGCTCTGTGCCGCAGCCCGCCAGCCGCCGCCATCTTGCGGCCAAGCTGGACGGCCAGCCGC
TCGACGAAGGCGCCTACGAAGCCATCCTGCGCGACGCCATCGCAGGCCGCTACACCGCGCAGGAACTCACCGCCTTCCTG
ACTGCCGCCACACGCTCGCTCGACGACCGCGAAGTGGTTGCACTGGCCCGCGCGCGCACACGCTTTACCGCGCGCATCGA
GTGGGATGAGCCAATCGTCGTGGACAAGCACTCCATGGGCGGCATACCGGGCAGCCGCATCACGCTGATCGTGGTGCCGA
TCGTCGCCGCATACGGACTGGCCATGCCAAAGACGTCTTCGCGCGCGATCACGTCGGCGGCCGGCACCGCCGACGCCATG
GAAACCGTGGCGCGCGTGGACCTGACCCACGACGACGTGCGCCGTTGCGTCGCCCAGGCGCGCGCGTGCATTGCGTGGAA
CGGGCGTCTGAACCATTCGGTCATCGATGACGTGATGAACGCGATCACGCGGCCCCTCGGTCTCGACTCACGCCGCTGGG
CAGTGGCCTCCATCCTGTCGAAGAAAGCCACGGCCGGCGCCACGCACGTCATCGTCGATATCCCCTACGGCCCGCAGACC
AAGCTTTCCGCGCGTGCCGACGCCGACGCGCTGGCCGGGTTGTTCGAGGAGGTCGGCAAAGGACTGGGCCTGCACGTGCG
CGCGCTGGTCACGGACGGCAGCCGGCCGATCGGCCGCGGCGTCGGTCCCGCGCTCGAGGTGCGCGATGTGCGGCAAGTGC
TGGAGAACCACCCCGACGCCCCGATGGACCTGCGCGAAAAGGCGCTGCGCTTCGCCGGCGAGATCATCGCCTTCGATCCG
CGTGTGGCGTCCGCGGCGCAAGGCATGCGCATTGCGACGGCGCTGCTCGACGAAGGAAGCGCCAGGGCCGCGTTCGATCG
GATTGTCGCCACGCAGGGAATCCGCCCGGATCCGGTGGCGCCGGGCGCGCATACCCACGTGATCGTTGCACCGGCAGAGG
GCCGTGTCGCAGCGATCAACGGGTGGCAGATCTCCGGCATTGCGCGCGCCGCGGGCGCGCCGCGCAGTGCCGGTGCGGGC
ATCGACCTGCTTTGCACGATCGGCGAGCGCGTTGCGGCCGGCGAGCCGCTGTACCGGATCCATGCGGAGTCCGCCGCGGA
TCTCGCCACGGCCGTCGCCATGACGGGCCCGGCCGGTGAAGCCTCCACGGCCGTGCGTGTTGATCCCGATTGA

Upstream 100 bases:

>100_bases
TGTGACTGCGCCCCAGGACGTGCTGGCGCAGCGCATTGCCGCACGCGGCCGTGAATCCGGCGACGATGTCATGCGCCGCG
TCGCACGCCAGGCCCCGCCG

Downstream 100 bases:

>100_bases
CCTGGCTTCCTGTTTCCCCCACCCTAACCGACGAGGCAAATCAATGAGACCCCTAACCGTCGTCCGCAGTCTTGCATCGC
TGCTGTTCGTGGCAGGCAGC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase 1

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MPDGVHCVTVTNDSTLDLGVARFTDALRNGANAGSVPQPASRRHLAAKLDGQPLDEGAYEAILRDAIAGRYTAQELTAFL
TAATRSLDDREVVALARARTRFTARIEWDEPIVVDKHSMGGIPGSRITLIVVPIVAAYGLAMPKTSSRAITSAAGTADAM
ETVARVDLTHDDVRRCVAQARACIAWNGRLNHSVIDDVMNAITRPLGLDSRRWAVASILSKKATAGATHVIVDIPYGPQT
KLSARADADALAGLFEEVGKGLGLHVRALVTDGSRPIGRGVGPALEVRDVRQVLENHPDAPMDLREKALRFAGEIIAFDP
RVASAAQGMRIATALLDEGSARAAFDRIVATQGIRPDPVAPGAHTHVIVAPAEGRVAAINGWQISGIARAAGAPRSAGAG
IDLLCTIGERVAAGEPLYRIHAESAADLATAVAMTGPAGEASTAVRVDPD

Sequences:

>Translated_450_residues
MPDGVHCVTVTNDSTLDLGVARFTDALRNGANAGSVPQPASRRHLAAKLDGQPLDEGAYEAILRDAIAGRYTAQELTAFL
TAATRSLDDREVVALARARTRFTARIEWDEPIVVDKHSMGGIPGSRITLIVVPIVAAYGLAMPKTSSRAITSAAGTADAM
ETVARVDLTHDDVRRCVAQARACIAWNGRLNHSVIDDVMNAITRPLGLDSRRWAVASILSKKATAGATHVIVDIPYGPQT
KLSARADADALAGLFEEVGKGLGLHVRALVTDGSRPIGRGVGPALEVRDVRQVLENHPDAPMDLREKALRFAGEIIAFDP
RVASAAQGMRIATALLDEGSARAAFDRIVATQGIRPDPVAPGAHTHVIVAPAEGRVAAINGWQISGIARAAGAPRSAGAG
IDLLCTIGERVAAGEPLYRIHAESAADLATAVAMTGPAGEASTAVRVDPD
>Mature_449_residues
PDGVHCVTVTNDSTLDLGVARFTDALRNGANAGSVPQPASRRHLAAKLDGQPLDEGAYEAILRDAIAGRYTAQELTAFLT
AATRSLDDREVVALARARTRFTARIEWDEPIVVDKHSMGGIPGSRITLIVVPIVAAYGLAMPKTSSRAITSAAGTADAME
TVARVDLTHDDVRRCVAQARACIAWNGRLNHSVIDDVMNAITRPLGLDSRRWAVASILSKKATAGATHVIVDIPYGPQTK
LSARADADALAGLFEEVGKGLGLHVRALVTDGSRPIGRGVGPALEVRDVRQVLENHPDAPMDLREKALRFAGEIIAFDPR
VASAAQGMRIATALLDEGSARAAFDRIVATQGIRPDPVAPGAHTHVIVAPAEGRVAAINGWQISGIARAAGAPRSAGAGI
DLLCTIGERVAAGEPLYRIHAESAADLATAVAMTGPAGEASTAVRVDPD

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=421, Percent_Identity=29.4536817102138, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4503445, Length=421, Percent_Identity=29.4536817102138, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI166158922, Length=421, Percent_Identity=29.4536817102138, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1790842, Length=328, Percent_Identity=28.9634146341463, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH1_CUPPJ (Q46UT0)

Other databases:

- EMBL:   CP000091
- RefSeq:   YP_297948.1
- ProteinModelPortal:   Q46UT0
- GeneID:   3613838
- GenomeReviews:   CP000091_GR
- KEGG:   reu:Reut_B3746
- NMPDR:   fig|264198.3.peg.4614
- HOGENOM:   HBG460532
- ProtClustDB:   PRK04350
- BioCyc:   REUT264198:REUT_B3746-MONOMER
- HAMAP:   MF_00703
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR012699
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- SMART:   SM00941
- TIGRFAMs:   TIGR02322

Pfam domain/function: PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 47082; Mature: 46951

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDGVHCVTVTNDSTLDLGVARFTDALRNGANAGSVPQPASRRHLAAKLDGQPLDEGAYE
CCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCHHHHCCCCCCCCHHHHH
AILRDAIAGRYTAQELTAFLTAATRSLDDREVVALARARTRFTARIEWDEPIVVDKHSMG
HHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEECCCCEEEECCCCC
GIPGSRITLIVVPIVAAYGLAMPKTSSRAITSAAGTADAMETVARVDLTHDDVRRCVAQA
CCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
RACIAWNGRLNHSVIDDVMNAITRPLGLDSRRWAVASILSKKATAGATHVIVDIPYGPQT
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCC
KLSARADADALAGLFEEVGKGLGLHVRALVTDGSRPIGRGVGPALEVRDVRQVLENHPDA
CCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCC
PMDLREKALRFAGEIIAFDPRVASAAQGMRIATALLDEGSARAAFDRIVATQGIRPDPVA
CHHHHHHHHHHHCCEEEECCCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
PGAHTHVIVAPAEGRVAAINGWQISGIARAAGAPRSAGAGIDLLCTIGERVAAGEPLYRI
CCCCEEEEEECCCCCEEEECCEEEECHHHHCCCCCCCCCCEEEEEECCCHHHCCCCEEEE
HAESAADLATAVAMTGPAGEASTAVRVDPD
ECCHHHHHHHHHHCCCCCCCCCCEEEECCC
>Mature Secondary Structure 
PDGVHCVTVTNDSTLDLGVARFTDALRNGANAGSVPQPASRRHLAAKLDGQPLDEGAYE
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCHHHHCCCCCCCCHHHHH
AILRDAIAGRYTAQELTAFLTAATRSLDDREVVALARARTRFTARIEWDEPIVVDKHSMG
HHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEECCCCEEEECCCCC
GIPGSRITLIVVPIVAAYGLAMPKTSSRAITSAAGTADAMETVARVDLTHDDVRRCVAQA
CCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
RACIAWNGRLNHSVIDDVMNAITRPLGLDSRRWAVASILSKKATAGATHVIVDIPYGPQT
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCC
KLSARADADALAGLFEEVGKGLGLHVRALVTDGSRPIGRGVGPALEVRDVRQVLENHPDA
CCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCC
PMDLREKALRFAGEIIAFDPRVASAAQGMRIATALLDEGSARAAFDRIVATQGIRPDPVA
CHHHHHHHHHHHCCEEEECCCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
PGAHTHVIVAPAEGRVAAINGWQISGIARAAGAPRSAGAGIDLLCTIGERVAAGEPLYRI
CCCCEEEEEECCCCCEEEECCEEEECHHHHCCCCCCCCCCEEEEEECCCHHHCCCCEEEE
HAESAADLATAVAMTGPAGEASTAVRVDPD
ECCHHHHHHHHHHCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA