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The map label for this gene is iciA [H]

Identifier: 73537528

GI number: 73537528

Start: 278705

End: 279625

Strand: Reverse

Name: iciA [H]

Synonym: Reut_B3693

Alternate gene names: 73537528

Gene position: 279625-278705 (Counterclockwise)

Preceding gene: 73537530

Following gene: 73537526

Centisome position: 10.26

GC content: 65.36

Gene sequence:

>921_bases
ATGCTCGACTACGCCGCGCTTTCTGCTTTGGCTGCTGTAATCCGAGAAGGCAGCTTTGAGCGTGCCGCACGCGCATTGAG
CGTGACGCCTTCAGCCATCTCGCAGCGCATTCGGCTGCTGGAAGAGAAAGTTGGCTGCACGCTGGTGGTCCGCGATCAGC
CTTGTCGGCCGACGGAGACCGGACGGCGCCTGTGCCAGCACATCGACCGTGTGCGGCTACTCGAACAGGAGTTGCAGGAG
GCGTTGCCGGCTCTCGCTCCACAGGGGCTTGCCCGGGTAACGCTGCCTGTTGCGGTGAATGCCGACAGCCTGGCGACGTG
GATCGCTCCGGCGATTGCCCGGTTCGCCGCGGAAAATCCCGTGCTGATGGACGTGGCCGTGGATGACCAGGACCATACGA
CCGAGTGGTTGCGCTGCGGCGCGGTGCTGGCCGCCGTGACCGCTACGGCGCGCCCTGCCGCAGGCTGCAACAGCAGCCCT
CTTGGCTCCATGCGTTATCGGGCTGCTGCGAGCCCCGGATTCATGCGACGCCACTTTGCCGACGGCGTTGGCGCTGGGAG
CCTGGCGAAAGCGCCCAGCCTGGTGTTCAACACCAAGGATGAATTGCAGGCGCGCTGGGCGCGGCGTCTGTGCCACCGGC
ACGTGGAACTGCCCCGGCACACATTGCCTTCGGCCCACGCTTTCGTGTCCGCAGCCATTGCGGGCATGGGCTGGGGCCTA
CATCCGGAGTCGCTCATCGAGCCATATCTTGACGACGGCGCACTCGTCGAGTTGGTGGCGGATACACCGCTGGATGTACC
GCTTCACTGGCAACACGCCCGTGCGACGTCGGGATTGATTGAAGGCTTGAGTCGCGAGGTGCTGGCGGCGGCCCGGGTAG
CGCTCTTGCCGCCGTTGTCGGCTAAAGTATTTCCCCGGTGA

Upstream 100 bases:

>100_bases
GGAAGCGGTGTCAGGCAGGGAGTTCATGCCCCCAGCTTGCCTGCTCCTTTTTGTGAAGACAAACTATCCTTCCTTCACCC
AGTTTAGAAAAACTTAACAT

Downstream 100 bases:

>100_bases
ACATAAAAGCGGCTCAACTTCGCCAACGCATTACCTCGGCCATCGCCATGTCGGCTCGGAGAGATGCTCCGCAAAATAGT
CGGACAGCGCAGCCACCTTC

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: OriC replication inhibitor [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MLDYAALSALAAVIREGSFERAARALSVTPSAISQRIRLLEEKVGCTLVVRDQPCRPTETGRRLCQHIDRVRLLEQELQE
ALPALAPQGLARVTLPVAVNADSLATWIAPAIARFAAENPVLMDVAVDDQDHTTEWLRCGAVLAAVTATARPAAGCNSSP
LGSMRYRAAASPGFMRRHFADGVGAGSLAKAPSLVFNTKDELQARWARRLCHRHVELPRHTLPSAHAFVSAAIAGMGWGL
HPESLIEPYLDDGALVELVADTPLDVPLHWQHARATSGLIEGLSREVLAAARVALLPPLSAKVFPR

Sequences:

>Translated_306_residues
MLDYAALSALAAVIREGSFERAARALSVTPSAISQRIRLLEEKVGCTLVVRDQPCRPTETGRRLCQHIDRVRLLEQELQE
ALPALAPQGLARVTLPVAVNADSLATWIAPAIARFAAENPVLMDVAVDDQDHTTEWLRCGAVLAAVTATARPAAGCNSSP
LGSMRYRAAASPGFMRRHFADGVGAGSLAKAPSLVFNTKDELQARWARRLCHRHVELPRHTLPSAHAFVSAAIAGMGWGL
HPESLIEPYLDDGALVELVADTPLDVPLHWQHARATSGLIEGLSREVLAAARVALLPPLSAKVFPR
>Mature_306_residues
MLDYAALSALAAVIREGSFERAARALSVTPSAISQRIRLLEEKVGCTLVVRDQPCRPTETGRRLCQHIDRVRLLEQELQE
ALPALAPQGLARVTLPVAVNADSLATWIAPAIARFAAENPVLMDVAVDDQDHTTEWLRCGAVLAAVTATARPAAGCNSSP
LGSMRYRAAASPGFMRRHFADGVGAGSLAKAPSLVFNTKDELQARWARRLCHRHVELPRHTLPSAHAFVSAAIAGMGWGL
HPESLIEPYLDDGALVELVADTPLDVPLHWQHARATSGLIEGLSREVLAAARVALLPPLSAKVFPR

Specific function: Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=288, Percent_Identity=36.4583333333333, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32916; Mature: 32916

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYAALSALAAVIREGSFERAARALSVTPSAISQRIRLLEEKVGCTLVVRDQPCRPTET
CCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
GRRLCQHIDRVRLLEQELQEALPALAPQGLARVTLPVAVNADSLATWIAPAIARFAAENP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCC
VLMDVAVDDQDHTTEWLRCGAVLAAVTATARPAAGCNSSPLGSMRYRAAASPGFMRRHFA
EEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHH
DGVGAGSLAKAPSLVFNTKDELQARWARRLCHRHVELPRHTLPSAHAFVSAAIAGMGWGL
CCCCCCCHHCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
HPESLIEPYLDDGALVELVADTPLDVPLHWQHARATSGLIEGLSREVLAAARVALLPPLS
CHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AKVFPR
CCCCCC
>Mature Secondary Structure
MLDYAALSALAAVIREGSFERAARALSVTPSAISQRIRLLEEKVGCTLVVRDQPCRPTET
CCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
GRRLCQHIDRVRLLEQELQEALPALAPQGLARVTLPVAVNADSLATWIAPAIARFAAENP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCC
VLMDVAVDDQDHTTEWLRCGAVLAAVTATARPAAGCNSSPLGSMRYRAAASPGFMRRHFA
EEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHH
DGVGAGSLAKAPSLVFNTKDELQARWARRLCHRHVELPRHTLPSAHAFVSAAIAGMGWGL
CCCCCCCHHCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
HPESLIEPYLDDGALVELVADTPLDVPLHWQHARATSGLIEGLSREVLAAARVALLPPLS
CHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AKVFPR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA