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The map label for this gene is cvrA [H]

Identifier: 71908366

GI number: 71908366

Start: 2948663

End: 2949991

Strand: Reverse

Name: cvrA [H]

Synonym: Daro_2753

Alternate gene names: 71908366

Gene position: 2949991-2948663 (Counterclockwise)

Preceding gene: 71908367

Following gene: 71908365

Centisome position: 65.54

GC content: 59.37

Gene sequence:

>1329_bases
ATGAAATACGGAAAAATTGCCGGTCTCTTTGTCCTGGCCTTCGTGTTGAACCACATTGCGCCGGAGATACTGGCGCGCCT
GGCTATGCTTGAAGGAACCGAAGCCGCCATCGCCAATGCCCTCTGGTGCATGGGGCTGTTCCTGGTCTTTGGCTGGGCCT
GCAGCAAAGCCGCCGAAGGCACGGTGTTCCCCAACTTTACCCTGCAACTGCTGGTCGGTATCGTGCTGCATGATGCCCTG
GCCCCGATTGCCCCGCAGATCATGATCCCGGTCGTCGTGTGTACGGCACTCGCTGCCATCATCCTGAAAGGTGGCGGCGA
TGAGGTGGACCGCTTCGATTTCCTCAAGATCGCCTTTCCGACCTTGATGATCGCTGTTGTCGGTTATCTCGTTACGTTCT
TCGTGATGTTCCCGATCCTGATGGCCTTTGGACTGGATGGAAAAACCGCCGCCTTGCTTTCGGCCATTCTCGGCTCCACC
GATCCGGCCGCACTGATCCCGACCTTGAAAAAGATCGTCTTCAAGGAAGAATACAAGCGTCTCAACGATATTGCCGTTGC
CGAAAGTGCCCTCAACGACGCCGTTGGGGCCATCTTCACGGCCGCAGTCGCCGCCATGATCCTGGCCGGCACCGCGGTCG
ACTCGCTGACAGCCCTGGCTGCCGGGCTGTTCAGCGCAGAAAACATGCTGCTGCTCGGCAAGCAGTTCCTGTTTGGCTCC
ATCGCCGGGGTTATCGGCTGGGGCGCCATGTACAGCTACGAAGTGTACAAGTCCAGGGACCACGTCCGTGATGTCGGCGA
AACCAGCTACGACTTCGCCATCGTGCTCGCCGTCCCGCTGGTCACCTTCCTGCTGGCCCAGGTCATCCATGGCAATGGCT
TCCTGGCCGCCTTTGTCGCTGGTCTGCTGGCCAATTACAACCACGGCAAGACGTATTTCCACAAAACGCTGCACACCATG
GAAATCAAGATCGAAAGCATCGCCAAGCCGACGATCTTCATGATGGTCGGTCCGTTCGTCGCCCTCGGTGACCTGTGGGA
AAGCGCGCTCCTTGGCCTGGTCGTGTCGCTCGCGTTCATCCTGATCGCCCGGCCCGTGGCTGTCATGCTGTCGCTGCTGC
CGACCGACCTGAACATGAAAGACAAGCTGTTCATGAGCATCGTCCGGGAAACCGGGGTTATCCCGGTCGTGCTGGCCGTG
ATCACCGTCGCCCAGTTTCCGGAACTGAAGCTGCTGATGCCACTGACGGCCTGGGTGGTGATCTGGACGCTGACCTTGCT
GCCGGCAATTACGCCGTGGTGGACCCGAAAGCTCGGGATCGCGCAATAG

Upstream 100 bases:

>100_bases
TCGCCAGGTGCTAGCGGGATTGCCTTGTCAAAGCTCTGTGACGTGTTGTTTACGCTAATTGTCCGCGTCCCTTTTTTCGC
TAATTTTGAAAAATGACCCC

Downstream 100 bases:

>100_bases
TTGAGTCTGGCCGGGCGGGCTGGTGGTGGCGTCGTGCTCCCAGGTCATTGTGAAAACGGAGAACTTTGGCCTTCGTGGCT
AATCTATGACCAATGCCCAA

Product: Sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKYGKIAGLFVLAFVLNHIAPEILARLAMLEGTEAAIANALWCMGLFLVFGWACSKAAEGTVFPNFTLQLLVGIVLHDAL
APIAPQIMIPVVVCTALAAIILKGGGDEVDRFDFLKIAFPTLMIAVVGYLVTFFVMFPILMAFGLDGKTAALLSAILGST
DPAALIPTLKKIVFKEEYKRLNDIAVAESALNDAVGAIFTAAVAAMILAGTAVDSLTALAAGLFSAENMLLLGKQFLFGS
IAGVIGWGAMYSYEVYKSRDHVRDVGETSYDFAIVLAVPLVTFLLAQVIHGNGFLAAFVAGLLANYNHGKTYFHKTLHTM
EIKIESIAKPTIFMMVGPFVALGDLWESALLGLVVSLAFILIARPVAVMLSLLPTDLNMKDKLFMSIVRETGVIPVVLAV
ITVAQFPELKLLMPLTAWVVIWTLTLLPAITPWWTRKLGIAQ

Sequences:

>Translated_442_residues
MKYGKIAGLFVLAFVLNHIAPEILARLAMLEGTEAAIANALWCMGLFLVFGWACSKAAEGTVFPNFTLQLLVGIVLHDAL
APIAPQIMIPVVVCTALAAIILKGGGDEVDRFDFLKIAFPTLMIAVVGYLVTFFVMFPILMAFGLDGKTAALLSAILGST
DPAALIPTLKKIVFKEEYKRLNDIAVAESALNDAVGAIFTAAVAAMILAGTAVDSLTALAAGLFSAENMLLLGKQFLFGS
IAGVIGWGAMYSYEVYKSRDHVRDVGETSYDFAIVLAVPLVTFLLAQVIHGNGFLAAFVAGLLANYNHGKTYFHKTLHTM
EIKIESIAKPTIFMMVGPFVALGDLWESALLGLVVSLAFILIARPVAVMLSLLPTDLNMKDKLFMSIVRETGVIPVVLAV
ITVAQFPELKLLMPLTAWVVIWTLTLLPAITPWWTRKLGIAQ
>Mature_442_residues
MKYGKIAGLFVLAFVLNHIAPEILARLAMLEGTEAAIANALWCMGLFLVFGWACSKAAEGTVFPNFTLQLLVGIVLHDAL
APIAPQIMIPVVVCTALAAIILKGGGDEVDRFDFLKIAFPTLMIAVVGYLVTFFVMFPILMAFGLDGKTAALLSAILGST
DPAALIPTLKKIVFKEEYKRLNDIAVAESALNDAVGAIFTAAVAAMILAGTAVDSLTALAAGLFSAENMLLLGKQFLFGS
IAGVIGWGAMYSYEVYKSRDHVRDVGETSYDFAIVLAVPLVTFLLAQVIHGNGFLAAFVAGLLANYNHGKTYFHKTLHTM
EIKIESIAKPTIFMMVGPFVALGDLWESALLGLVVSLAFILIARPVAVMLSLLPTDLNMKDKLFMSIVRETGVIPVVLAV
ITVAQFPELKLLMPLTAWVVIWTLTLLPAITPWWTRKLGIAQ

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 47534; Mature: 47534

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHHHCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]