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The map label for this gene is frdA [H]

Identifier: 71907407

GI number: 71907407

Start: 1915477

End: 1917456

Strand: Reverse

Name: frdA [H]

Synonym: Daro_1777

Alternate gene names: 71907407

Gene position: 1917456-1915477 (Counterclockwise)

Preceding gene: 71907408

Following gene: 71907406

Centisome position: 42.6

GC content: 65.05

Gene sequence:

>1980_bases
ATGGAAACCATCCACACTGACGTGCTGGTCATCGGCGGCGGATTGGCCGGCCTGCGCGCCGCGCTGGCGGCCCGCAAGCG
TGGCAATAGCGTGCTGATTCTCAGCCTGGTGCCCCCCAAGCGTTCGCACTCGGCTGCGGCCCAGGGCGGCATGCAGGCCA
GTCTGGGCAATACAACCAAGGGCGCCGGCGACAACGAGGATGTGCATTTCGAAGACACGGTGCGCGGCAGCGACTGGGGC
AACGACCAGGAGGTCGCCCGCCTGTTCGTCCATACCGCCCCCAAGGCCGTGCGCGAACTGGCCAGCTGGGGCGTGCCGTG
GAATCGTGTTCAGGCCGGCGAGCGCGAGGCGATCATCGACAACCGGAGGGTCACGCTGAGCGAGCCGGAAGCGGCTCATG
GCCTGATTACCGCCCGCGACTTTGGCGGTACCAAGAAGTGGCGCACCTGCTATGTGTCCGATGGCACCGGCCATGCCATG
CTCTACGCCGTCAGCGACCAGACGATTGCCGAGGGCATTCCGGTCCATGAGCGCATGGAAGCCGTTTCGCTGATTCACGA
CGGCCTGCGCTGCTACGGCGCCATCGTCCGCAACCTGATCGACGGCAAGCTGGTGGCTTACATCGCCCGCGCCACCTGCA
TCGCCACCGGCGGGTTCGGCCGCATCTACCAGTCGACGACCAATGCGGTGATCAACGAAGGCATCGGCGCGGCGATTGCG
CTGGAAACCGGCGTCGTTCCGCTTGGCAACATGGAGGCGGTGCAGTTTCATCCGACCGCCATCTTCCCGGCCGGCATCCT
GGTCACCGAAGGTTGCCGTGGCGATGGTGGCTTGTTACGCGACGTCGATGGTCACCGCTTCATGCCCGACTACGAGCCGG
AAAAGAAGGAGCTGGCCTCGCGCGACGTGGTCTCGCGGCGGATGGAAGCCCATATCCGCAGCGGCAAGGGGGCAAGAAAC
CGTTTCGGCGAACATCTGTGGCTGGACATTACCCAGCTCGGCGCCCAGCACATCGACCACAAGCTGCGCGAAGTGAAGGA
AATCTGCCATTACTTCCTCGGCATCGACCCGGCCCGACAATGGATTCCGGTCCGCCCGGCCCAACACTATTCGATGGGCG
GCATCCGCACCAATGCGCACGGCGCCGCCTATGGCCTGAGCGGGCTGTTTGCCTGCGGCGAGGCTGCCTGCTGGGACCTG
CACGGCTTCAACCGCCTGGGTGGCAACTCGGTGGCCGAAACCGTCGTTTCAGGGATGATCGTCGGCGACGCGATTGCCGA
TTTTTGTACCTCCTCAGGCGGTGACATGTCCCTTTCGACAGCACTGCTGCGCGAATGTGCTGACAAGGTACGAGCCGAAT
TTTCGGCTATCGCCGATAACCACGGCCCGGAGAACCCGGCCGCCCTGCTCGGTGCGATGCAAGCGATCATGACCGACAAA
GTTGGTATCGTTCGCCATGGCGAGCAACTGGCCGAAGCCGTCAGGGAACTGACGGAACTGGCCGCGCGCAGCCGGCAGGT
TGGCCTGCGCACTCACCGGCCCGGCGCCAACCCTGAACTGACGCTGGCCTGGCGCCTGCAAAAGATGCTCAAGCTGGCCA
TCTGCGTGGCCCACGGGGCCCGCCAGCGGACCGAGAGCCGCGGCGCGCATTTCCGCACAGATTTTCCGCGGCGCAACGAC
GCAGAATGGCTGAAACGTACGCTGGCCTACTGGACCGATCCGGCGCAGCTGGTTCCCTCATTGCACTACGAAGCGCTCGA
TGTCCGCCACATGGAACTGCCGCCCGGCTGGCGCGGCTACGGCGCCCGCGATGCCATCGAACATCCGGAAACAGCCCATC
GGATGGCTCAAATCGAGACGATCAGGGCACAACTCGCCACAGCCGATCGCCATGCGGTGCAGGACGCGCTGATGCCATTC
CGCCACCTGCTCCCCACCCACCTGCGCGGCGACAATGCCCGCCCGGGAGAAAGCACATGA

Upstream 100 bases:

>100_bases
ACGCTGCTCACCTACATCGATCTCGGCCGGGTCCATGCCGACCATGCCGGAGAGCGCTACATCCCGCCCCAGAGCATTTC
TTCCGTGGACAGGCACTGAC

Downstream 100 bases:

>100_bases
TCCCCCTGCTCCGCCGCAAAAAGCCAGACGACCAGCCACGCCGCCTGACCCTGGAAATTCTCCGCCACAACCCGGCCGAC
CCGGCCAGCGTGCCGCACCT

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
METIHTDVLVIGGGLAGLRAALAARKRGNSVLILSLVPPKRSHSAAAQGGMQASLGNTTKGAGDNEDVHFEDTVRGSDWG
NDQEVARLFVHTAPKAVRELASWGVPWNRVQAGEREAIIDNRRVTLSEPEAAHGLITARDFGGTKKWRTCYVSDGTGHAM
LYAVSDQTIAEGIPVHERMEAVSLIHDGLRCYGAIVRNLIDGKLVAYIARATCIATGGFGRIYQSTTNAVINEGIGAAIA
LETGVVPLGNMEAVQFHPTAIFPAGILVTEGCRGDGGLLRDVDGHRFMPDYEPEKKELASRDVVSRRMEAHIRSGKGARN
RFGEHLWLDITQLGAQHIDHKLREVKEICHYFLGIDPARQWIPVRPAQHYSMGGIRTNAHGAAYGLSGLFACGEAACWDL
HGFNRLGGNSVAETVVSGMIVGDAIADFCTSSGGDMSLSTALLRECADKVRAEFSAIADNHGPENPAALLGAMQAIMTDK
VGIVRHGEQLAEAVRELTELAARSRQVGLRTHRPGANPELTLAWRLQKMLKLAICVAHGARQRTESRGAHFRTDFPRRND
AEWLKRTLAYWTDPAQLVPSLHYEALDVRHMELPPGWRGYGARDAIEHPETAHRMAQIETIRAQLATADRHAVQDALMPF
RHLLPTHLRGDNARPGEST

Sequences:

>Translated_659_residues
METIHTDVLVIGGGLAGLRAALAARKRGNSVLILSLVPPKRSHSAAAQGGMQASLGNTTKGAGDNEDVHFEDTVRGSDWG
NDQEVARLFVHTAPKAVRELASWGVPWNRVQAGEREAIIDNRRVTLSEPEAAHGLITARDFGGTKKWRTCYVSDGTGHAM
LYAVSDQTIAEGIPVHERMEAVSLIHDGLRCYGAIVRNLIDGKLVAYIARATCIATGGFGRIYQSTTNAVINEGIGAAIA
LETGVVPLGNMEAVQFHPTAIFPAGILVTEGCRGDGGLLRDVDGHRFMPDYEPEKKELASRDVVSRRMEAHIRSGKGARN
RFGEHLWLDITQLGAQHIDHKLREVKEICHYFLGIDPARQWIPVRPAQHYSMGGIRTNAHGAAYGLSGLFACGEAACWDL
HGFNRLGGNSVAETVVSGMIVGDAIADFCTSSGGDMSLSTALLRECADKVRAEFSAIADNHGPENPAALLGAMQAIMTDK
VGIVRHGEQLAEAVRELTELAARSRQVGLRTHRPGANPELTLAWRLQKMLKLAICVAHGARQRTESRGAHFRTDFPRRND
AEWLKRTLAYWTDPAQLVPSLHYEALDVRHMELPPGWRGYGARDAIEHPETAHRMAQIETIRAQLATADRHAVQDALMPF
RHLLPTHLRGDNARPGEST
>Mature_659_residues
METIHTDVLVIGGGLAGLRAALAARKRGNSVLILSLVPPKRSHSAAAQGGMQASLGNTTKGAGDNEDVHFEDTVRGSDWG
NDQEVARLFVHTAPKAVRELASWGVPWNRVQAGEREAIIDNRRVTLSEPEAAHGLITARDFGGTKKWRTCYVSDGTGHAM
LYAVSDQTIAEGIPVHERMEAVSLIHDGLRCYGAIVRNLIDGKLVAYIARATCIATGGFGRIYQSTTNAVINEGIGAAIA
LETGVVPLGNMEAVQFHPTAIFPAGILVTEGCRGDGGLLRDVDGHRFMPDYEPEKKELASRDVVSRRMEAHIRSGKGARN
RFGEHLWLDITQLGAQHIDHKLREVKEICHYFLGIDPARQWIPVRPAQHYSMGGIRTNAHGAAYGLSGLFACGEAACWDL
HGFNRLGGNSVAETVVSGMIVGDAIADFCTSSGGDMSLSTALLRECADKVRAEFSAIADNHGPENPAALLGAMQAIMTDK
VGIVRHGEQLAEAVRELTELAARSRQVGLRTHRPGANPELTLAWRLQKMLKLAICVAHGARQRTESRGAHFRTDFPRRND
AEWLKRTLAYWTDPAQLVPSLHYEALDVRHMELPPGWRGYGARDAIEHPETAHRMAQIETIRAQLATADRHAVQDALMPF
RHLLPTHLRGDNARPGEST

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=608, Percent_Identity=34.2105263157895, Blast_Score=293, Evalue=5e-79,
Organism=Escherichia coli, GI1786942, Length=573, Percent_Identity=37.347294938918, Blast_Score=318, Evalue=8e-88,
Organism=Escherichia coli, GI1790597, Length=588, Percent_Identity=35.0340136054422, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI1788928, Length=592, Percent_Identity=30.2364864864865, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17550100, Length=538, Percent_Identity=35.1301115241636, Blast_Score=283, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17505833, Length=545, Percent_Identity=34.6788990825688, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71986328, Length=464, Percent_Identity=24.3534482758621, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=35.3433835845896, Blast_Score=319, Evalue=9e-88,
Organism=Saccharomyces cerevisiae, GI6322416, Length=591, Percent_Identity=35.7021996615905, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI17137288, Length=607, Percent_Identity=33.4431630971993, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24655642, Length=607, Percent_Identity=33.4431630971993, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24655647, Length=607, Percent_Identity=33.4431630971993, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24663005, Length=567, Percent_Identity=33.6860670194003, Blast_Score=271, Evalue=9e-73,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 71757; Mature: 71757

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIHTDVLVIGGGLAGLRAALAARKRGNSVLILSLVPPKRSHSAAAQGGMQASLGNTTK
CCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHCCCCEECCCCCCC
GAGDNEDVHFEDTVRGSDWGNDQEVARLFVHTAPKAVRELASWGVPWNRVQAGEREAIID
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHCCCCCHHHHC
NRRVTLSEPEAAHGLITARDFGGTKKWRTCYVSDGTGHAMLYAVSDQTIAEGIPVHERME
CCCEEECCCCHHCCEEEEECCCCCCCEEEEEEECCCCCEEEEEECCCHHHCCCCHHHHHH
AVSLIHDGLRCYGAIVRNLIDGKLVAYIARATCIATGGFGRIYQSTTNAVINEGIGAAIA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCEEEE
LETGVVPLGNMEAVQFHPTAIFPAGILVTEGCRGDGGLLRDVDGHRFMPDYEPEKKELAS
EECCCCCCCCCCEEEECCCEECCCCEEEECCCCCCCCCEECCCCCCCCCCCCCHHHHHHH
RDVVSRRMEAHIRSGKGARNRFGEHLWLDITQLGAQHIDHKLREVKEICHYFLGIDPARQ
HHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
WIPVRPAQHYSMGGIRTNAHGAAYGLSGLFACGEAACWDLHGFNRLGGNSVAETVVSGMI
CCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCHHEEECCCCHHCCCHHHHHHHHHHHH
VGDAIADFCTSSGGDMSLSTALLRECADKVRAEFSAIADNHGPENPAALLGAMQAIMTDK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
VGIVRHGEQLAEAVRELTELAARSRQVGLRTHRPGANPELTLAWRLQKMLKLAICVAHGA
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEHHHHHHHHHHHHHHHHHHH
RQRTESRGAHFRTDFPRRNDAEWLKRTLAYWTDPAQLVPSLHYEALDVRHMELPPGWRGY
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCHHHHCEEEEECCCCCCCC
GARDAIEHPETAHRMAQIETIRAQLATADRHAVQDALMPFRHLLPTHLRGDNARPGEST
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
METIHTDVLVIGGGLAGLRAALAARKRGNSVLILSLVPPKRSHSAAAQGGMQASLGNTTK
CCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHCCCCEECCCCCCC
GAGDNEDVHFEDTVRGSDWGNDQEVARLFVHTAPKAVRELASWGVPWNRVQAGEREAIID
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHCCCCCHHHHC
NRRVTLSEPEAAHGLITARDFGGTKKWRTCYVSDGTGHAMLYAVSDQTIAEGIPVHERME
CCCEEECCCCHHCCEEEEECCCCCCCEEEEEEECCCCCEEEEEECCCHHHCCCCHHHHHH
AVSLIHDGLRCYGAIVRNLIDGKLVAYIARATCIATGGFGRIYQSTTNAVINEGIGAAIA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCEEEE
LETGVVPLGNMEAVQFHPTAIFPAGILVTEGCRGDGGLLRDVDGHRFMPDYEPEKKELAS
EECCCCCCCCCCEEEECCCEECCCCEEEECCCCCCCCCEECCCCCCCCCCCCCHHHHHHH
RDVVSRRMEAHIRSGKGARNRFGEHLWLDITQLGAQHIDHKLREVKEICHYFLGIDPARQ
HHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
WIPVRPAQHYSMGGIRTNAHGAAYGLSGLFACGEAACWDLHGFNRLGGNSVAETVVSGMI
CCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCHHEEECCCCHHCCCHHHHHHHHHHHH
VGDAIADFCTSSGGDMSLSTALLRECADKVRAEFSAIADNHGPENPAALLGAMQAIMTDK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
VGIVRHGEQLAEAVRELTELAARSRQVGLRTHRPGANPELTLAWRLQKMLKLAICVAHGA
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEHHHHHHHHHHHHHHHHHHH
RQRTESRGAHFRTDFPRRNDAEWLKRTLAYWTDPAQLVPSLHYEALDVRHMELPPGWRGY
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCHHHHCEEEEECCCCCCCC
GARDAIEHPETAHRMAQIETIRAQLATADRHAVQDALMPFRHLLPTHLRGDNARPGEST
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]