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The map label for this gene is frdB [H]

Identifier: 71907406

GI number: 71907406

Start: 1914722

End: 1915480

Strand: Reverse

Name: frdB [H]

Synonym: Daro_1776

Alternate gene names: 71907406

Gene position: 1915480-1914722 (Counterclockwise)

Preceding gene: 71907407

Following gene: 71907405

Centisome position: 42.56

GC content: 62.58

Gene sequence:

>759_bases
ATGATCCCCCTGCTCCGCCGCAAAAAGCCAGACGACCAGCCACGCCGCCTGACCCTGGAAATTCTCCGCCACAACCCGGC
CGACCCGGCCAGCGTGCCGCACCTGCAAGCCTACGAAGTCGAGGAAGCCGAGGGCATGACGCTGTTCATCGCGCTCAACG
AGATCCGCGCCCAGCAGGATCCTTCGCTGATGTTCGATTTCGTCTGTCGGGCCGGCATTTGTGGAAGTTGCGCCATGCTG
GTCAATGGCCGCCCCGGCCTGGCCTGCCGCACCTTGACCCGCGACCTCGGCGAGCGCATCACGCTGGCCCCGCTGCCAGT
CTTCGAGCTGATCGGCGATCTGTCAGTCAATACTGGAAAATGGATGCGCGGCACCAGCGAACGCCTGCAAACCTGGATCC
ACAACGATACGGAAACCGATCTCGACGCCCTCGAAACACGGATGGAGCCGGCCACCGCCGAAGCCATCTACGAACTCGAT
CGCTGCATCGAATGCGGCTGCTGCATCGCCGGCTGCGGCACGGTGCAGATGCGCGAGCGTTTCGTCGGTGCCGTCGGCCT
CAACAAGATCGCCCGCTTCCGGCTCGATCCGCGGGATACACGTAGTGACGAGGATTTCTACGAACTGATCGGTGACGACG
ATGGCGTTTTTGGCTGCATGTCGCTGGTCGGCTGCCATGACGTTTGTCCCAAGCAGTTGCCGCTGCAAACGCAGATCGCC
TTCTTACGGCGAAAGATGGCCCTGCAAGGGATGCGCTGA

Upstream 100 bases:

>100_bases
CCACAGCCGATCGCCATGCGGTGCAGGACGCGCTGATGCCATTCCGCCACCTGCTCCCCACCCACCTGCGCGGCGACAAT
GCCCGCCCGGGAGAAAGCAC

Downstream 100 bases:

>100_bases
ACGGAGTGCCGCAGCATTGACCAAGAGAAAATGCCATTCAGCAAACACCAATTCGCGCTTACACAAATGCAAAGCATCTG
CAATACCTGCACTAATCTGC

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIPLLRRKKPDDQPRRLTLEILRHNPADPASVPHLQAYEVEEAEGMTLFIALNEIRAQQDPSLMFDFVCRAGICGSCAML
VNGRPGLACRTLTRDLGERITLAPLPVFELIGDLSVNTGKWMRGTSERLQTWIHNDTETDLDALETRMEPATAEAIYELD
RCIECGCCIAGCGTVQMRERFVGAVGLNKIARFRLDPRDTRSDEDFYELIGDDDGVFGCMSLVGCHDVCPKQLPLQTQIA
FLRRKMALQGMR

Sequences:

>Translated_252_residues
MIPLLRRKKPDDQPRRLTLEILRHNPADPASVPHLQAYEVEEAEGMTLFIALNEIRAQQDPSLMFDFVCRAGICGSCAML
VNGRPGLACRTLTRDLGERITLAPLPVFELIGDLSVNTGKWMRGTSERLQTWIHNDTETDLDALETRMEPATAEAIYELD
RCIECGCCIAGCGTVQMRERFVGAVGLNKIARFRLDPRDTRSDEDFYELIGDDDGVFGCMSLVGCHDVCPKQLPLQTQIA
FLRRKMALQGMR
>Mature_252_residues
MIPLLRRKKPDDQPRRLTLEILRHNPADPASVPHLQAYEVEEAEGMTLFIALNEIRAQQDPSLMFDFVCRAGICGSCAML
VNGRPGLACRTLTRDLGERITLAPLPVFELIGDLSVNTGKWMRGTSERLQTWIHNDTETDLDALETRMEPATAEAIYELD
RCIECGCCIAGCGTVQMRERFVGAVGLNKIARFRLDPRDTRSDEDFYELIGDDDGVFGCMSLVGCHDVCPKQLPLQTQIA
FLRRKMALQGMR

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=237, Percent_Identity=29.1139240506329, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1786943, Length=240, Percent_Identity=35.4166666666667, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790596, Length=219, Percent_Identity=30.5936073059361, Blast_Score=116, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17533915, Length=222, Percent_Identity=30.6306306306306, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322987, Length=242, Percent_Identity=29.7520661157025, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137106, Length=247, Percent_Identity=29.1497975708502, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24643156, Length=250, Percent_Identity=29.2, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28273; Mature: 28273

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
8.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLLRRKKPDDQPRRLTLEILRHNPADPASVPHLQAYEVEEAEGMTLFIALNEIRAQQD
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHCCCC
PSLMFDFVCRAGICGSCAMLVNGRPGLACRTLTRDLGERITLAPLPVFELIGDLSVNTGK
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEECCCCHHHHHHCCCCCCCC
WMRGTSERLQTWIHNDTETDLDALETRMEPATAEAIYELDRCIECGCCIAGCGTVQMRER
CCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHH
FVGAVGLNKIARFRLDPRDTRSDEDFYELIGDDDGVFGCMSLVGCHDVCPKQLPLQTQIA
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
FLRRKMALQGMR
HHHHHHHHCCCC
>Mature Secondary Structure
MIPLLRRKKPDDQPRRLTLEILRHNPADPASVPHLQAYEVEEAEGMTLFIALNEIRAQQD
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHCCCC
PSLMFDFVCRAGICGSCAMLVNGRPGLACRTLTRDLGERITLAPLPVFELIGDLSVNTGK
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEECCCCHHHHHHCCCCCCCC
WMRGTSERLQTWIHNDTETDLDALETRMEPATAEAIYELDRCIECGCCIAGCGTVQMRER
CCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHH
FVGAVGLNKIARFRLDPRDTRSDEDFYELIGDDDGVFGCMSLVGCHDVCPKQLPLQTQIA
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
FLRRKMALQGMR
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 10586875; 11248702 [H]